SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tsh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 4tsh SURFACE PROTEIN
ADHESIN
(Streptococcus
mutans) 		4 / 6 LEU B1031
ILE B1016
ARG B1197
VAL B1138
 None
 1.14A 1db1A-4tshB:
undetectable		 1db1A-4tshB:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRL_A_DOLA300_1
(STREPTOGRAMIN A
ACETYLTRANSFERASE)		 4tsh SURFACE PROTEIN
ADHESIN
(Streptococcus
mutans) 		5 / 11 TYR B1209
ILE B1316
PRO B1264
ASN B1325
VAL B1327
 None
None
None
None
MG  B1503 (-4.4A)
 1.25A 1mrlA-4tshB:
undetectable
1mrlB-4tshB:
undetectable		 1mrlA-4tshB:
19.76
1mrlB-4tshB:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O76_B_CAMB1420_0
(CYTOCHROME P450-CAM)		 4tsh SURFACE PROTEIN
ADHESIN
(Streptococcus
mutans) 		4 / 8 PHE B1070
THR B1033
LEU B1125
THR B1043
 None
 1.08A 1o76B-4tshB:
undetectable		 1o76B-4tshB:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_A_CAMA1416_0
(CYTOCHROME P450-CAM)		 4tsh SURFACE PROTEIN
ADHESIN
(Streptococcus
mutans) 		4 / 8 PHE B1070
THR B1033
LEU B1125
THR B1043
 None
 1.19A 1uyuA-4tshB:
undetectable		 1uyuA-4tshB:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 4tsh SURFACE PROTEIN
ADHESIN
(Streptococcus
mutans) 		5 / 12 ILE B1334
GLY B1370
LEU B1367
VAL B1402
ILE B1439
 None
 1.22A 1zq9A-4tshB:
undetectable		 1zq9A-4tshB:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA602_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 4tsh SURFACE PROTEIN
ADHESIN
(Streptococcus
mutans) 		4 / 7 ALA A 101
ALA A 100
ALA A 104
GLN A 142
 None
 0.81A 3a2qA-4tshA:
undetectable		 3a2qA-4tshA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4tsh SURFACE PROTEIN
ADHESIN
(Streptococcus
mutans) 		4 / 7 TYR B1383
ILE B1334
GLY B1369
LEU B1380
 None
 0.86A 3elzA-4tshB:
undetectable		 3elzA-4tshB:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_C_NCAC302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 4tsh SURFACE PROTEIN
ADHESIN
SURFACE PROTEIN
ADHESIN
(Streptococcus
mutans;
Streptococcus
mutans) 		5 / 10 TYR B1131
LEU B1036
ASP B1035
ALA A 125
ALA B1034
 None
 1.49A 3rodC-4tshB:
undetectable		 3rodC-4tshB:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 4tsh SURFACE PROTEIN
ADHESIN
(Streptococcus
mutans) 		3 / 3 TYR B1365
LEU B1422
ARG B1366
 None
 0.81A 3sufB-4tshB:
1.0		 3sufB-4tshB:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_D_ACTD502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4tsh SURFACE PROTEIN
ADHESIN
(Streptococcus
mutans) 		3 / 3 GLY B1116
THR B1142
ASN B1114
 None
 0.63A 3v4tD-4tshB:
undetectable		 3v4tD-4tshB:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4tsh SURFACE PROTEIN
ADHESIN
(Streptococcus
mutans) 		5 / 12 ILE B1104
LEU B1090
ALA B1091
PHE B1093
LEU B1036
 None
 1.02A 4psyA-4tshB:
undetectable		 4psyA-4tshB:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 4tsh SURFACE PROTEIN
ADHESIN
(Streptococcus
mutans) 		4 / 4 GLY B1398
VAL B1430
PHE B1385
ILE B1439
 None
 1.15A 4xv2B-4tshB:
undetectable		 4xv2B-4tshB:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_C_ACTC1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 4tsh SURFACE PROTEIN
ADHESIN
(Streptococcus
mutans) 		3 / 3 TYR B1386
THR B1478
THR B1438
 None
 0.78A 5aoxB-4tshB:
undetectable		 5aoxB-4tshB:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GSN_A_MMZA503_1
(FLAVIN-CONTAINING
MONOOXYGENASE)		 4tsh SURFACE PROTEIN
ADHESIN
(Streptococcus
mutans) 		3 / 3 ASN B1335
SER B1486
SER B1485
 None
 0.79A 5gsnA-4tshB:
undetectable		 5gsnA-4tshB:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 4tsh SURFACE PROTEIN
ADHESIN
(Streptococcus
mutans) 		3 / 3 THR B1202
SER B1025
ASP B1115
 None
None
MG  B1504 ( 4.4A)
 0.83A 5kvaA-4tshB:
undetectable		 5kvaA-4tshB:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1103_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 4tsh SURFACE PROTEIN
ADHESIN
(Streptococcus
mutans) 		4 / 8 THR B1160
PRO B1159
GLN B1312
GLY A  57
 None
 0.97A 5nzyA-4tshB:
undetectable		 5nzyA-4tshB:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VM8_B_SAMB301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4tsh SURFACE PROTEIN
ADHESIN
SURFACE PROTEIN
ADHESIN
(Streptococcus
mutans;
Streptococcus
mutans) 		5 / 10 VAL A  52
GLY A  53
GLY A  57
ILE B1157
ALA B1323
 None
 1.05A 5vm8B-4tshA:
undetectable		 5vm8B-4tshA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_F_FFOF403_0
(THYMIDYLATE SYNTHASE)		 4tsh SURFACE PROTEIN
ADHESIN
(Streptococcus
mutans) 		5 / 11 PHE B1403
LEU B1380
GLY B1369
ASN B1477
ALA B1454
 None
 1.32A 6r2eF-4tshB:
undetectable		 6r2eF-4tshB:
20.35