SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tsk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_B_IPBB600_0
(ODORANT-BINDING
PROTEIN)		 4tsk KETOL-ACID
REDUCTOISOMERASE
(Alicyclobacillus
acidocaldarius) 		4 / 4 ILE A  45
MET A  77
VAL A 136
GLY A  24
 None
None
None
NDP  A 405 ( 3.8A)
 1.01A 1e06B-4tskA:
undetectable		 1e06B-4tskA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M8E_B_H4BB903_1
(INDUCIBLE NITRIC
OXIDE SYNTHASE)		 4tsk KETOL-ACID
REDUCTOISOMERASE
(Alicyclobacillus
acidocaldarius) 		3 / 3 ARG A  84
ILE A 291
TRP A 290
 None
 1.13A 1m8eB-4tskA:
undetectable		 1m8eB-4tskA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 4tsk KETOL-ACID
REDUCTOISOMERASE
(Alicyclobacillus
acidocaldarius) 		3 / 3 ARG A  84
ILE A 291
TRP A 290
 None
 1.13A 1nodB-4tskA:
undetectable		 1nodB-4tskA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QOM_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 4tsk KETOL-ACID
REDUCTOISOMERASE
(Alicyclobacillus
acidocaldarius) 		3 / 3 ARG A  84
ILE A 291
TRP A 290
 None
 1.10A 1qomA-4tskA:
undetectable		 1qomA-4tskA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4tsk KETOL-ACID
REDUCTOISOMERASE
(Alicyclobacillus
acidocaldarius) 		3 / 3 ASP A 123
ASP A  74
ASP A 162
 None
 0.74A 2igtA-4tskA:
4.1		 2igtA-4tskA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 4tsk KETOL-ACID
REDUCTOISOMERASE
(Alicyclobacillus
acidocaldarius) 		3 / 3 ASP A 123
ASP A  74
ASP A 162
 None
 0.75A 2igtB-4tskA:
3.9		 2igtB-4tskA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOD_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 4tsk KETOL-ACID
REDUCTOISOMERASE
(Alicyclobacillus
acidocaldarius) 		3 / 3 ARG A  84
ILE A 291
TRP A 290
 None
 1.11A 2nodB-4tskA:
undetectable		 2nodB-4tskA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_2
(PROTEASE RETROPEPSIN)		 4tsk KETOL-ACID
REDUCTOISOMERASE
(Alicyclobacillus
acidocaldarius) 		5 / 12 GLY A 172
ALA A 173
ILE A 150
ILE A  12
ILE A 178
 None
 0.93A 2rkgB-4tskA:
undetectable		 2rkgB-4tskA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E68_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4tsk KETOL-ACID
REDUCTOISOMERASE
(Alicyclobacillus
acidocaldarius) 		3 / 3 ARG A  84
ILE A 291
TRP A 290
 None
 1.10A 3e68A-4tskA:
undetectable		 3e68A-4tskA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E6T_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4tsk KETOL-ACID
REDUCTOISOMERASE
(Alicyclobacillus
acidocaldarius) 		3 / 3 ARG A  84
ILE A 291
TRP A 290
 None
 1.08A 3e6tB-4tskA:
undetectable		 3e6tB-4tskA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7I_B_H4BB2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4tsk KETOL-ACID
REDUCTOISOMERASE
(Alicyclobacillus
acidocaldarius) 		3 / 3 ARG A  84
ILE A 291
TRP A 290
 None
 1.12A 3e7iB-4tskA:
undetectable		 3e7iB-4tskA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 4tsk KETOL-ACID
REDUCTOISOMERASE
(Alicyclobacillus
acidocaldarius) 		5 / 11 THR A 180
THR A 181
ALA A 151
GLY A 177
ALA A 148
 None
 0.81A 3mg0N-4tskA:
undetectable		 3mg0N-4tskA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4tsk KETOL-ACID
REDUCTOISOMERASE
(Alicyclobacillus
acidocaldarius) 		3 / 3 ARG A  84
ILE A 291
TRP A 290
 None
 1.15A 3nw2A-4tskA:
undetectable		 3nw2A-4tskA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NW2_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 4tsk KETOL-ACID
REDUCTOISOMERASE
(Alicyclobacillus
acidocaldarius) 		3 / 3 ARG A  84
ILE A 291
TRP A 290
 None
 1.14A 3nw2B-4tskA:
undetectable		 3nw2B-4tskA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4tsk KETOL-ACID
REDUCTOISOMERASE
(Alicyclobacillus
acidocaldarius) 		5 / 12 THR A 180
THR A 181
ALA A 151
GLY A 177
ALA A 148
 None
 0.81A 4qvnV-4tskA:
undetectable
4qvnb-4tskA:
undetectable		 4qvnV-4tskA:
18.52
4qvnb-4tskA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4tsk KETOL-ACID
REDUCTOISOMERASE
(Alicyclobacillus
acidocaldarius) 		5 / 9 ALA A 168
ALA A 164
VAL A 146
GLY A 177
ALA A 148
 None
 1.09A 4qvnK-4tskA:
undetectable
4qvnL-4tskA:
undetectable		 4qvnK-4tskA:
18.52
4qvnL-4tskA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4tsk KETOL-ACID
REDUCTOISOMERASE
(Alicyclobacillus
acidocaldarius) 		5 / 12 THR A 180
THR A 181
ALA A 151
GLY A 177
ALA A 148
 None
 0.81A 4qvnH-4tskA:
undetectable
4qvnN-4tskA:
undetectable		 4qvnH-4tskA:
18.52
4qvnN-4tskA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4tsk KETOL-ACID
REDUCTOISOMERASE
(Alicyclobacillus
acidocaldarius) 		5 / 9 ALA A 168
ALA A 164
VAL A 146
GLY A 177
ALA A 148
 None
 1.09A 4qvnY-4tskA:
undetectable
4qvnZ-4tskA:
undetectable		 4qvnY-4tskA:
18.52
4qvnZ-4tskA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 4tsk KETOL-ACID
REDUCTOISOMERASE
(Alicyclobacillus
acidocaldarius) 		5 / 12 THR A 180
THR A 181
ALA A 151
GLY A 177
ALA A 148
 None
 0.85A 5lf7V-4tskA:
undetectable
5lf7b-4tskA:
undetectable		 5lf7V-4tskA:
21.61
5lf7b-4tskA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_B_BO2B201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 4tsk KETOL-ACID
REDUCTOISOMERASE
(Alicyclobacillus
acidocaldarius) 		5 / 12 THR A 180
THR A 181
ALA A 151
GLY A 177
ALA A 148
 None
 0.81A 6hwdV-4tskA:
undetectable
6hwdb-4tskA:
undetectable		 6hwdV-4tskA:
13.82
6hwdb-4tskA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_N_BO2N201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 4tsk KETOL-ACID
REDUCTOISOMERASE
(Alicyclobacillus
acidocaldarius) 		5 / 12 THR A 180
THR A 181
ALA A 151
GLY A 177
ALA A 148
 None
 0.81A 6hwdH-4tskA:
undetectable
6hwdN-4tskA:
undetectable		 6hwdH-4tskA:
13.82
6hwdN-4tskA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 4tsk KETOL-ACID
REDUCTOISOMERASE
(Alicyclobacillus
acidocaldarius) 		5 / 12 ILE A  23
GLY A  24
GLY A  26
ALA A  31
VAL A  66
 None
NDP  A 405 ( 3.8A)
NDP  A 405 (-3.3A)
None
None
 1.00A 6iftA-4tskA:
3.4		 6iftA-4tskA:
22.07