SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tsm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4tsm MALTOSE-BINDING
PROTEIN, PILIN
CHIMERA
(Escherichia
coli;
Clostridioides
difficile) 		4 / 7 SER A1035
VAL A1107
GLY A1085
ILE A1100
 None
 0.79A 1gtnC-4tsmA:
undetectable
1gtnD-4tsmA:
undetectable		 1gtnC-4tsmA:
10.40
1gtnD-4tsmA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 4tsm MALTOSE-BINDING
PROTEIN, PILIN
CHIMERA
(Escherichia
coli;
Clostridioides
difficile) 		5 / 10 LEU A 192
LEU A 195
ILE A 161
GLU A 153
LEU A 151
 None
None
None
MTT  A1209 (-3.2A)
None
 1.23A 1wopA-4tsmA:
undetectable		 1wopA-4tsmA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4tsm MALTOSE-BINDING
PROTEIN, PILIN
CHIMERA
(Clostridioides
difficile;
Escherichia
coli) 		5 / 12 LEU A 262
ILE A 108
VAL A  97
LEU A  76
ILE A  79
 None
 0.97A 2h42C-4tsmA:
undetectable		 2h42C-4tsmA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)		 4tsm MALTOSE-BINDING
PROTEIN, PILIN
CHIMERA
(Clostridioides
difficile;
Escherichia
coli) 		5 / 12 ALA A 264
LEU A 280
PHE A 279
VAL A 293
GLY A  16
 None
 1.10A 2ve3A-4tsmA:
undetectable		 2ve3A-4tsmA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 4tsm MALTOSE-BINDING
PROTEIN, PILIN
CHIMERA
(Clostridioides
difficile;
Escherichia
coli) 		4 / 6 PHE A 258
ALA A 162
LEU A 247
PRO A 159
 None
 0.97A 3bgdA-4tsmA:
undetectable		 3bgdA-4tsmA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_1
(PHOSPHOLIPASE A2)		 4tsm MALTOSE-BINDING
PROTEIN, PILIN
CHIMERA
(Clostridioides
difficile;
Escherichia
coli) 		4 / 7 VAL A 110
GLY A 300
PRO A 229
LYS A 305
 None
 0.73A 3bjwC-4tsmA:
undetectable		 3bjwC-4tsmA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)		 4tsm MALTOSE-BINDING
PROTEIN, PILIN
CHIMERA
(Escherichia
coli;
Clostridioides
difficile) 		4 / 6 PRO A 126
LEU A 147
ALA A 223
PRO A 125
 None
 1.31A 3gv1A-4tsmA:
undetectable
3gv1C-4tsmA:
undetectable		 3gv1A-4tsmA:
15.58
3gv1C-4tsmA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)		 4tsm MALTOSE-BINDING
PROTEIN, PILIN
CHIMERA
(Escherichia
coli;
Clostridioides
difficile) 		4 / 6 LEU A 147
ALA A 223
PRO A 125
PRO A 126
 None
 1.30A 3gv1A-4tsmA:
undetectable
3gv1B-4tsmA:
undetectable		 3gv1A-4tsmA:
15.58
3gv1B-4tsmA:
15.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 4tsm MALTOSE-BINDING
PROTEIN, PILIN
CHIMERA
(Clostridioides
difficile;
Escherichia
coli) 		12 / 12 ASP A  14
LYS A  15
LYS A  42
GLU A  44
GLU A  45
ALA A  63
ASP A  65
ARG A  66
GLU A 111
PRO A 154
TRP A 230
TYR A 341
 MTT  A1209 (-3.0A)
MTT  A1209 (-2.9A)
MTT  A1209 (-3.3A)
MTT  A1209 (-3.1A)
MTT  A1209 (-3.6A)
MTT  A1209 (-3.2A)
MTT  A1209 (-2.7A)
MTT  A1209 (-3.9A)
MTT  A1209 (-2.9A)
MTT  A1209 (-3.5A)
MTT  A1209 (-4.3A)
MTT  A1209 (-4.5A)
 0.18A 3jyrA-4tsmA:
60.8		 3jyrA-4tsmA:
66.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 4tsm MALTOSE-BINDING
PROTEIN, PILIN
CHIMERA
(Clostridioides
difficile;
Escherichia
coli) 		6 / 7 ASN A  12
TRP A  62
GLU A 153
TYR A 155
MET A 330
TRP A 340
 MTT  A1209 ( 4.7A)
MTT  A1209 (-4.3A)
MTT  A1209 (-3.2A)
MTT  A1209 (-3.8A)
MTT  A1209 ( 4.1A)
MTT  A1209 (-3.8A)
 0.30A 3jyrA-4tsmA:
60.8		 3jyrA-4tsmA:
66.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 4tsm MALTOSE-BINDING
PROTEIN, PILIN
CHIMERA
(Clostridioides
difficile;
Escherichia
coli) 		6 / 7 ASN A  12
TRP A  62
TYR A 155
MET A 330
TRP A 340
ARG A 344
 MTT  A1209 ( 4.7A)
MTT  A1209 (-4.3A)
MTT  A1209 (-3.8A)
MTT  A1209 ( 4.1A)
MTT  A1209 (-3.8A)
MTT  A1209 (-4.0A)
 0.55A 3jyrA-4tsmA:
60.8		 3jyrA-4tsmA:
66.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_DIFB585_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4tsm MALTOSE-BINDING
PROTEIN, PILIN
CHIMERA
(Clostridioides
difficile;
Escherichia
coli) 		5 / 12 VAL A 196
LEU A 160
GLY A 187
ALA A 188
LEU A 361
 None
 0.98A 3n8yB-4tsmA:
undetectable		 3n8yB-4tsmA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)		 4tsm MALTOSE-BINDING
PROTEIN, PILIN
CHIMERA
(Escherichia
coli;
Clostridioides
difficile) 		5 / 9 ILE A 132
LEU A 198
LYS A 256
ILE A 226
GLY A 191
 None
 1.27A 3sj4X-4tsmA:
undetectable		 3sj4X-4tsmA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 4tsm MALTOSE-BINDING
PROTEIN, PILIN
CHIMERA
(Clostridioides
difficile;
Escherichia
coli) 		5 / 12 PHE A 156
GLY A 300
LEU A 299
GLU A 111
ALA A 231
 MTT  A1209 (-4.9A)
None
None
MTT  A1209 (-2.9A)
None
 0.85A 3tbgB-4tsmA:
undetectable		 3tbgB-4tsmA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 4tsm MALTOSE-BINDING
PROTEIN, PILIN
CHIMERA
(Clostridioides
difficile;
Escherichia
coli) 		5 / 12 PHE A 156
GLY A 300
LEU A 299
GLU A 111
ALA A 231
 MTT  A1209 (-4.9A)
None
None
MTT  A1209 (-2.9A)
None
 0.83A 3tbgD-4tsmA:
undetectable		 3tbgD-4tsmA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 4tsm MALTOSE-BINDING
PROTEIN, PILIN
CHIMERA
(Clostridioides
difficile;
Escherichia
coli) 		5 / 12 ALA A 231
TYR A  17
TYR A 210
ASN A 234
GLY A 228
 None
 1.32A 3vwqA-4tsmA:
undetectable		 3vwqA-4tsmA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)		 4tsm MALTOSE-BINDING
PROTEIN, PILIN
CHIMERA
(Escherichia
coli;
Clostridioides
difficile) 		4 / 5 GLU A 308
ASP A 314
ASP A 287
ASN A 294
 None
 1.39A 3vywD-4tsmA:
undetectable		 3vywD-4tsmA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB602_1
(SERUM ALBUMIN)		 4tsm MALTOSE-BINDING
PROTEIN, PILIN
CHIMERA
(Clostridioides
difficile;
Escherichia
coli) 		5 / 9 ALA A 264
ALA A 105
LEU A 103
LEU A 262
VAL A 261
 None
 1.13A 4or0B-4tsmA:
undetectable		 4or0B-4tsmA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_I_BEZI1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 4tsm MALTOSE-BINDING
PROTEIN, PILIN
CHIMERA
(Escherichia
coli;
Clostridioides
difficile) 		3 / 3 SER A1129
TYR A1127
TYR A1151
 None
 0.62A 5lakA-4tsmA:
undetectable
5lakI-4tsmA:
undetectable		 5lakA-4tsmA:
19.62
5lakI-4tsmA:
2.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_J_BEZJ1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 4tsm MALTOSE-BINDING
PROTEIN, PILIN
CHIMERA
(Escherichia
coli;
Clostridioides
difficile) 		3 / 3 SER A1129
TYR A1127
TYR A1151
 None
 0.62A 5lakC-4tsmA:
undetectable
5lakJ-4tsmA:
undetectable		 5lakC-4tsmA:
19.62
5lakJ-4tsmA:
2.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)		 4tsm MALTOSE-BINDING
PROTEIN, PILIN
CHIMERA
(Clostridioides
difficile;
Escherichia
coli) 		6 / 12 ALA A 342
ALA A 338
GLY A 166
ALA A 188
PHE A 169
VAL A 181
 None
TMO  A1207 ( 4.5A)
None
None
None
None
 1.39A 5w4zA-4tsmA:
undetectable		 5w4zA-4tsmA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)		 4tsm MALTOSE-BINDING
PROTEIN, PILIN
CHIMERA
(Clostridioides
difficile;
Escherichia
coli) 		6 / 12 ALA A 342
ALA A 338
GLY A 166
ALA A 188
PHE A 169
VAL A 181
 None
TMO  A1207 ( 4.5A)
None
None
None
None
 1.43A 5w4zB-4tsmA:
undetectable		 5w4zB-4tsmA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BM5_A_SAMA1301_0
(METHIONINE SYNTHASE)		 4tsm MALTOSE-BINDING
PROTEIN, PILIN
CHIMERA
(Escherichia
coli;
Clostridioides
difficile) 		5 / 11 PRO A 133
GLU A 130
PRO A 254
ALA A 163
PRO A 159
 None
 1.44A 6bm5A-4tsmA:
undetectable		 6bm5A-4tsmA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_V_BO2V301_0
(PROTEASOME SUBUNIT
BETA TYPE-2)		 4tsm MALTOSE-BINDING
PROTEIN, PILIN
CHIMERA
(Escherichia
coli;
Clostridioides
difficile) 		5 / 11 GLN A 365
ALA A 364
ALA A 162
GLY A 166
ALA A 188
 None
 1.08A 6hwdV-4tsmA:
undetectable		 6hwdV-4tsmA:
10.29