SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4ttp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_2
(PROTEIN (PROTEASE))		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		5 / 12 ALA A 175
ASP A 176
ASP A 177
GLY A  12
ILE A 118
 None
 0.79A 1c6yB-4ttpA:
undetectable		 1c6yB-4ttpA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_1
(PROTEIN (HIV-1
PROTEASE))		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		5 / 10 LEU A 168
ALA A 175
ASP A 176
ASP A 177
ILE A 118
 None
 0.85A 1d4yA-4ttpA:
undetectable		 1d4yA-4ttpA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_1
(PROTEIN (HIV-1
PROTEASE))		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		5 / 10 LEU A 168
ALA A 175
ASP A 177
GLY A  12
ILE A 118
 None
 1.01A 1d4yA-4ttpA:
undetectable		 1d4yA-4ttpA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_3
(HIV-1 PROTEASE)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		5 / 12 LEU A 168
ALA A 175
ASP A 177
GLY A  12
ILE A 118
 None
 1.02A 1hxbB-4ttpA:
undetectable		 1hxbB-4ttpA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_2
(POL POLYPROTEIN)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		5 / 12 ALA A 175
ASP A 176
ASP A 177
GLY A  12
ILE A 118
 None
 0.83A 1k6cB-4ttpA:
undetectable		 1k6cB-4ttpA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		4 / 8 TYR A 127
ILE A 116
ILE A 102
GLU A 103
 None
 0.84A 1mrjA-4ttpA:
undetectable		 1mrjA-4ttpA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		5 / 12 ALA A 175
ASP A 176
ASP A 177
GLY A  12
ILE A 118
 None
 0.81A 1sdtB-4ttpA:
undetectable		 1sdtB-4ttpA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		5 / 12 ALA A 175
ASP A 176
ASP A 177
GLY A  12
ILE A 118
 None
 0.86A 1sduB-4ttpA:
undetectable		 1sduB-4ttpA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDV_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		5 / 11 ALA A 175
ASP A 176
ASP A 177
GLY A  12
ILE A 118
 None
 0.81A 1sdvB-4ttpA:
undetectable		 1sdvB-4ttpA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_1
(PROTEASE RETROPEPSIN)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		6 / 10 LEU A 168
ALA A 175
ASP A 176
ASP A 177
GLY A  12
ILE A 118
 None
 1.05A 1t3rA-4ttpA:
undetectable		 1t3rA-4ttpA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_1
(POL POLYPROTEIN)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		6 / 10 LEU A 168
ALA A 175
ASP A 176
ASP A 177
GLY A  12
ILE A 118
 None
 1.04A 1t7iA-4ttpA:
undetectable		 1t7iA-4ttpA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_1
(POL POLYPROTEIN)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		6 / 11 LEU A 168
ALA A 175
ASP A 176
ASP A 177
GLY A  12
ILE A 118
 None
 1.05A 1t7jA-4ttpA:
undetectable		 1t7jA-4ttpA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_3
(POL POLYPROTEIN)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		5 / 12 ALA A 175
ASP A 176
ASP A 177
GLY A  12
ILE A 118
 None
 0.91A 2avvE-4ttpA:
undetectable		 2avvE-4ttpA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_2
(PROTEASE)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		6 / 9 LEU A 168
ALA A 175
ASP A 176
ASP A 177
GLY A  12
ILE A 118
 None
 1.03A 2idwB-4ttpA:
undetectable		 2idwB-4ttpA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_1
(PROTEASE)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		5 / 12 LEU A 168
ALA A 175
ASP A 176
ASP A 177
GLY A  12
 None
 0.97A 2nnkA-4ttpA:
undetectable		 2nnkA-4ttpA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_1
(PROTEASE)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		5 / 11 ALA A 175
ASP A 176
ASP A 177
GLY A  12
ILE A 118
 None
 0.85A 2nnpA-4ttpA:
undetectable		 2nnpA-4ttpA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_1
(PROTEASE)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		5 / 12 LEU A 168
ALA A 175
ASP A 176
ASP A 177
ILE A 118
 None
 0.95A 2o4nA-4ttpA:
undetectable		 2o4nA-4ttpA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_1
(PROTEASE)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		5 / 12 LEU A 168
ALA A 175
ASP A 176
GLY A  12
ILE A 118
 None
 0.98A 2o4nA-4ttpA:
undetectable		 2o4nA-4ttpA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_1
(PROTEASE)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		5 / 11 ALA A 175
ASP A 176
ASP A 177
GLY A  12
ILE A 118
 None
 0.81A 2o4pA-4ttpA:
undetectable		 2o4pA-4ttpA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4P_A_TPVA300_1
(PROTEASE)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		5 / 11 LEU A 168
ALA A 175
ASP A 176
ASP A 177
ILE A 118
 None
 0.93A 2o4pA-4ttpA:
undetectable		 2o4pA-4ttpA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_2
(PROTEASE)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		5 / 12 ALA A 175
ASP A 176
ASP A 177
GLY A  12
ILE A 118
 None
 0.80A 2r5pD-4ttpA:
undetectable		 2r5pD-4ttpA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_2
(PROTEASE)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		5 / 10 ALA A 175
ASP A 176
ASP A 177
GLY A  12
ILE A 118
 None
 0.91A 2r5qD-4ttpA:
undetectable		 2r5qD-4ttpA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKF_A_AB1A501_1
(PROTEASE RETROPEPSIN)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		5 / 12 LEU A 168
ALA A 175
ASP A 176
ASP A 177
ILE A 118
 None
 0.86A 2rkfA-4ttpA:
undetectable		 2rkfA-4ttpA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_2
(HIV-1 PROTEASE)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		5 / 12 ALA A 175
ASP A 176
ASP A 177
GLY A  12
ILE A 118
 None
 0.93A 2z54B-4ttpA:
undetectable		 2z54B-4ttpA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_1
(HIV-1 PROTEASE)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		5 / 12 ALA A 175
ASP A 176
ASP A 177
GLY A  12
ILE A 118
 None
 0.83A 3d1xA-4ttpA:
undetectable		 3d1xA-4ttpA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_1
(HIV-1 PROTEASE)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		5 / 12 ALA A 175
ASP A 176
ASP A 177
GLY A  12
ILE A 118
 None
 0.87A 3d1yA-4ttpA:
undetectable		 3d1yA-4ttpA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_2
(HIV-1 PROTEASE)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		5 / 12 LEU A 168
ALA A 175
ASP A 176
ASP A 177
ILE A 118
 None
 0.85A 3d1zB-4ttpA:
undetectable		 3d1zB-4ttpA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_1
(PROTEASE)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		6 / 12 ALA A 175
ASP A 176
ASP A 177
VAL A  11
GLY A  12
ILE A 118
 None
 1.15A 3ekqA-4ttpA:
undetectable		 3ekqA-4ttpA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_1
(PROTEASE)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		5 / 9 LEU A 168
ALA A 175
ASP A 176
ASP A 177
GLY A  12
 None
 1.05A 3ektA-4ttpA:
undetectable		 3ektA-4ttpA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_1
(PROTEASE)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		6 / 10 LEU A 168
ALA A 175
ASP A 176
ASP A 177
GLY A  12
ILE A 118
 None
 0.99A 3ekvA-4ttpA:
undetectable		 3ekvA-4ttpA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_1
(PROTEASE)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		5 / 12 ALA A 175
ASP A 176
ASP A 177
GLY A  12
ILE A 118
 None
 0.85A 3el4A-4ttpA:
undetectable		 3el4A-4ttpA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_1
(PROTEASE)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		5 / 10 LEU A 168
ALA A 175
ASP A 177
GLY A  12
ILE A 118
 None
 1.04A 3el5A-4ttpA:
undetectable		 3el5A-4ttpA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_F_H3PF552_1
(GLUTAMATE
DEHYDROGENASE)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		4 / 7 MET A   7
ILE A 107
LYS A 100
ILE A 102
 None
 1.13A 3eteD-4ttpA:
undetectable
3eteF-4ttpA:
undetectable		 3eteD-4ttpA:
16.56
3eteF-4ttpA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_A_ROCA101_1
(PROTEASE)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		5 / 12 LEU A 168
ALA A 175
ASP A 176
ASP A 177
ILE A 118
 None
 0.88A 3nduA-4ttpA:
undetectable		 3nduA-4ttpA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_2
(PROTEASE)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		5 / 12 LEU A 168
ALA A 175
ASP A 176
ASP A 177
ILE A 118
 None
 0.90A 3nduD-4ttpA:
undetectable		 3nduD-4ttpA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_2
(HIV-1 PROTEASE)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		6 / 10 LEU A 168
ALA A 175
ASP A 176
ASP A 177
GLY A  12
ILE A 118
 None
 1.04A 3oy4B-4ttpA:
undetectable		 3oy4B-4ttpA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		5 / 10 ILE A  98
ILE A 102
ILE A 118
HIS A 126
HIS A 125
 None
 1.23A 3qgzA-4ttpA:
undetectable		 3qgzA-4ttpA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S45_B_478B201_2
(PROTEASE)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		5 / 11 ALA A 175
ASP A 176
ASP A 177
GLY A  12
ILE A 118
 None
 0.84A 3s45B-4ttpA:
undetectable		 3s45B-4ttpA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_1
(PROTEASE)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		5 / 9 ALA A 175
ASP A 176
ASP A 177
GLY A  12
ILE A 118
 None
 0.89A 3s53A-4ttpA:
undetectable		 3s53A-4ttpA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_1
(PROTEASE)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		5 / 12 ALA A 175
ASP A 176
ASP A 177
GLY A  12
ILE A 118
 None
 0.78A 3s56A-4ttpA:
undetectable		 3s56A-4ttpA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_1
(HIV-1 PROTEASE)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		6 / 11 LEU A 168
ALA A 175
ASP A 176
ASP A 177
GLY A  12
ILE A 118
 None
 1.08A 3spkA-4ttpA:
undetectable		 3spkA-4ttpA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_2
(HIV-1 PROTEASE)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		5 / 12 LEU A 168
ALA A 175
ASP A 176
ASP A 177
ILE A 118
 None
 0.83A 3spkB-4ttpA:
undetectable		 3spkB-4ttpA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_2
(HIV-1 PROTEASE)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		5 / 12 LEU A 168
ALA A 175
ASP A 177
GLY A  12
ILE A 118
 None
 1.01A 3spkB-4ttpA:
undetectable		 3spkB-4ttpA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A201_1
(POL POLYPROTEIN)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		5 / 9 LEU A 168
ALA A 175
ASP A 176
ASP A 177
ILE A 118
 None
 0.83A 3u7sA-4ttpA:
undetectable		 3u7sA-4ttpA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_1
(POL POLYPROTEIN)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		5 / 9 LEU A 168
ALA A 175
ASP A 177
GLY A  12
ILE A 118
 None
 0.98A 3u7sA-4ttpA:
undetectable		 3u7sA-4ttpA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BVV_A_CPFA1081_1
(APOLIPOPROTEIN(A))		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		5 / 9 HIS A 196
ASP A 177
ASP A 176
TYR A 113
LEU A 115
 None
 1.48A 4bvvA-4ttpA:
undetectable		 4bvvA-4ttpA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQB_B_017B101_2
(ASPARTYL PROTEASE)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		6 / 10 LEU A 168
ALA A 175
ASP A 176
ASP A 177
GLY A  12
ILE A 118
 None
 1.04A 4dqbB-4ttpA:
undetectable		 4dqbB-4ttpA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_2
(ASPARTYL PROTEASE)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		6 / 9 LEU A 168
ALA A 175
ASP A 176
ASP A 177
GLY A  12
ILE A 118
 None
 1.05A 4dqcB-4ttpA:
undetectable		 4dqcB-4ttpA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQE_B_017B101_2
(ASPARTYL PROTEASE)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		6 / 10 LEU A 168
ALA A 175
ASP A 176
ASP A 177
GLY A  12
ILE A 118
 None
 1.05A 4dqeB-4ttpA:
undetectable		 4dqeB-4ttpA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_2
(ASPARTYL PROTEASE)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		6 / 10 LEU A 168
ALA A 175
ASP A 176
ASP A 177
GLY A  12
ILE A 118
 None
 1.04A 4dqfB-4ttpA:
undetectable		 4dqfB-4ttpA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_2
(WILD-TYPE HIV-1
PROTEASE DIMER)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		6 / 10 LEU A 168
ALA A 175
ASP A 176
ASP A 177
GLY A  12
ILE A 118
 None
 1.04A 4dqhB-4ttpA:
undetectable		 4dqhB-4ttpA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_2
(PROTEASE)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		5 / 11 LEU A 168
ALA A 175
ASP A 176
ASP A 177
ILE A 118
 None
 0.86A 4hlaB-4ttpA:
undetectable		 4hlaB-4ttpA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0
(UNCHARACTERIZED
PROTEIN)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		4 / 5 VAL A  24
LEU A 134
VAL A  11
PHE A  28
 None
 0.92A 4lb0B-4ttpA:
undetectable		 4lb0B-4ttpA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_B_017B101_2
(PROTEASE)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		6 / 10 LEU A 168
ALA A 175
ASP A 176
ASP A 177
GLY A  12
ILE A 118
 None
 1.08A 4njtB-4ttpA:
undetectable		 4njtB-4ttpA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_2
(PROTEASE)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		5 / 9 LEU A 168
ALA A 175
ASP A 176
ASP A 177
ILE A 118
 None
 0.89A 4njtD-4ttpA:
undetectable		 4njtD-4ttpA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_1
(PROTEASE)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		6 / 12 LEU A 168
ALA A 175
ASP A 176
ASP A 177
GLY A  12
ILE A 118
 None
 1.05A 4njuA-4ttpA:
undetectable		 4njuA-4ttpA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_1
(PROTEASE)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		6 / 12 LEU A 168
ALA A 175
ASP A 176
ASP A 177
GLY A  12
ILE A 118
 None
 1.06A 4njuC-4ttpA:
undetectable		 4njuC-4ttpA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_1
(ASPARTYL PROTEASE)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		6 / 9 LEU A 168
ALA A 175
ASP A 176
ASP A 177
GLY A  12
ILE A 118
 None
 1.02A 4q1wA-4ttpA:
undetectable		 4q1wA-4ttpA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_1
(ASPARTYL PROTEASE)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		6 / 11 LEU A 168
ALA A 175
ASP A 176
ASP A 177
GLY A  12
ILE A 118
 None
 1.02A 4q1xA-4ttpA:
undetectable		 4q1xA-4ttpA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_1
(ASPARTYL PROTEASE)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		6 / 10 LEU A 168
ALA A 175
ASP A 176
ASP A 177
GLY A  12
ILE A 118
 None
 1.02A 4q1yA-4ttpA:
undetectable		 4q1yA-4ttpA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_1
(PROTEASE)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		5 / 11 ALA A 175
ASP A 176
ASP A 177
GLY A  12
ILE A 118
 None
 0.85A 4qgiA-4ttpA:
undetectable		 4qgiA-4ttpA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		4 / 4 LEU A 115
ILE A  36
GLY A  12
ILE A 102
 None
 0.70A 5dzk3-4ttpA:
undetectable
5dzkm-4ttpA:
undetectable		 5dzk3-4ttpA:
1.96
5dzkm-4ttpA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		4 / 5 ILE A  36
GLY A  12
ILE A 102
LEU A 115
 None
 0.70A 5dzkB-4ttpA:
undetectable
5dzkI-4ttpA:
undetectable
5dzkW-4ttpA:
undetectable		 5dzkB-4ttpA:
22.69
5dzkI-4ttpA:
24.29
5dzkW-4ttpA:
1.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		4 / 5 ILE A  36
GLY A  12
ILE A 102
LEU A 115
 None
 0.68A 5dzki-4ttpA:
undetectable
5dzkj-4ttpA:
undetectable
5dzkx-4ttpA:
undetectable		 5dzki-4ttpA:
24.29
5dzkj-4ttpA:
24.29
5dzkx-4ttpA:
1.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Y_BEZY801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		4 / 5 ILE A  36
GLY A  12
ILE A 102
LEU A 115
 None
 0.71A 5dzkd-4ttpA:
undetectable
5dzkk-4ttpA:
undetectable
5dzky-4ttpA:
undetectable		 5dzkd-4ttpA:
22.69
5dzkk-4ttpA:
24.29
5dzky-4ttpA:
1.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		4 / 4 ILE A  36
GLY A  12
ILE A 102
LEU A 115
 None
 0.72A 5dzkl-4ttpA:
undetectable
5dzkz-4ttpA:
undetectable		 5dzkl-4ttpA:
24.29
5dzkz-4ttpA:
1.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_1
(PROTEASE E35D-SQV)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		5 / 12 ALA A 175
ASP A 176
ASP A 177
GLY A  12
ILE A 118
 None
 0.83A 5kqxA-4ttpA:
undetectable		 5kqxA-4ttpA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_2
(PROTEASE E35D-APV)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		5 / 9 LEU A 168
ALA A 175
ASP A 177
GLY A  12
ILE A 118
 None
 1.00A 5kr0B-4ttpA:
undetectable		 5kr0B-4ttpA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_2
(PROTEASE PR5-DRV)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		5 / 8 ALA A 175
ASP A 176
ASP A 177
GLY A  12
ILE A 118
 None
 0.86A 5kr1B-4ttpA:
undetectable		 5kr1B-4ttpA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_1
(PROTEASE PR5-SQV)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		5 / 9 ALA A 175
ASP A 176
ASP A 177
GLY A  12
ILE A 118
 None
 0.78A 5kr2A-4ttpA:
undetectable		 5kr2A-4ttpA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_1
(PROTEASE PR5-SQV)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		5 / 9 ALA A 175
ASP A 176
ASP A 177
GLY A  12
ILE A 118
 None
 0.84A 5kr2C-4ttpA:
undetectable		 5kr2C-4ttpA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_1
(PROTEASE)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		5 / 12 ALA A 175
ASP A 176
ASP A 177
GLY A  12
ILE A 118
 None
 0.79A 5t8hA-4ttpA:
undetectable		 5t8hA-4ttpA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_1
(PROTEASE)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		5 / 12 LEU A 168
ALA A 175
ASP A 176
ASP A 177
ILE A 118
 None
 0.91A 5t8hA-4ttpA:
undetectable		 5t8hA-4ttpA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_0
(PROTEASE)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		5 / 12 LEU A 168
ALA A 175
ASP A 176
ASP A 177
ILE A 118
 None
 0.89A 6dgxA-4ttpA:
undetectable		 6dgxA-4ttpA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_0
(PROTEASE)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		5 / 12 LEU A 168
ALA A 175
ASP A 176
ASP A 177
ILE A 118
 None
 0.93A 6dh0A-4ttpA:
undetectable		 6dh0A-4ttpA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_0
(PROTEASE)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		5 / 12 LEU A 168
ALA A 175
ASP A 176
ASP A 177
ILE A 118
 None
 0.92A 6dh3A-4ttpA:
undetectable		 6dh3A-4ttpA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_0
(HIV-1 PROTEASE)		 4ttp DEPHOSPHO-COA KINASE
(Legionella
pneumophila) 		6 / 12 LEU A 168
ALA A 175
ASP A 176
ASP A 177
GLY A  12
ILE A 118
 None
 1.03A 6dilA-4ttpA:
undetectable		 6dilA-4ttpA:
21.95