SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tu3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 4tu3 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 74
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 269
ALA A 280
ALA A 284
VAL A 306
LEU A 255
 None
 1.10A 1cbsA-4tu3A:
undetectable		 1cbsA-4tu3A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4H_A_REAA500_1
(NUCLEAR RECEPTOR
ROR-BETA)		 4tu3 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 74
(Saccharomyces
cerevisiae) 		5 / 11 ILE A 160
VAL A 337
ARG A 340
MET A 341
ALA A 262
 None
 1.16A 1n4hA-4tu3A:
undetectable		 1n4hA-4tu3A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 4tu3 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 74
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 269
ALA A 280
ALA A 284
VAL A 306
LEU A 255
 None
 1.07A 2fr3A-4tu3A:
undetectable		 2fr3A-4tu3A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		 4tu3 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 74
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  69
THR A  68
LEU A  96
ILE A 101
LEU A 141
 None
 1.04A 2ouzA-4tu3A:
undetectable		 2ouzA-4tu3A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_E_RBFE200_1
(DODECIN)		 4tu3 PHOSPHOINOSITIDE
PHOSPHATASE SAC1
(Saccharomyces
cerevisiae) 		4 / 8 ARG X 154
GLN X 292
ARG X 138
GLN X 137
 None
 1.49A 2vxaD-4tu3X:
undetectable
2vxaE-4tu3X:
undetectable
2vxaL-4tu3X:
undetectable		 2vxaD-4tu3X:
7.91
2vxaE-4tu3X:
7.91
2vxaL-4tu3X:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VXA_J_RBFJ200_1
(DODECIN)		 4tu3 PHOSPHOINOSITIDE
PHOSPHATASE SAC1
(Saccharomyces
cerevisiae) 		4 / 8 ARG X 154
GLN X 292
ARG X 138
GLN X 137
 None
 1.49A 2vxaD-4tu3X:
undetectable
2vxaJ-4tu3X:
undetectable
2vxaL-4tu3X:
undetectable		 2vxaD-4tu3X:
7.91
2vxaJ-4tu3X:
7.91
2vxaL-4tu3X:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 4tu3 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 74
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 287
ALA A 254
PHE A 291
ILE A 318
LEU A 298
 None
 1.10A 2w3aB-4tu3A:
undetectable		 2w3aB-4tu3A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		 4tu3 PHOSPHOINOSITIDE
PHOSPHATASE SAC1
(Saccharomyces
cerevisiae) 		4 / 7 SER X  94
VAL X  53
TYR X   7
ILE X  72
 None
 1.25A 2x45B-4tu3X:
undetectable		 2x45B-4tu3X:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 4tu3 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 74
(Saccharomyces
cerevisiae) 		4 / 8 ASP A 114
LEU A 326
GLY A 323
TYR A 294
 None
 0.93A 3af0A-4tu3A:
undetectable		 3af0A-4tu3A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		 4tu3 PHOSPHOINOSITIDE
PHOSPHATASE SAC1
(Saccharomyces
cerevisiae) 		4 / 7 SER X  94
VAL X  53
TYR X   7
ILE X  72
 None
 1.22A 3bu1A-4tu3X:
undetectable		 3bu1A-4tu3X:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_1
(PROTEASE)		 4tu3 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 74
(Saccharomyces
cerevisiae) 		5 / 10 ALA A 105
ILE A 156
ILE A 100
ALA A 254
ILE A 331
 None
 1.03A 3ekwA-4tu3A:
undetectable		 3ekwA-4tu3A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 4tu3 PHOSPHOINOSITIDE
PHOSPHATASE SAC1
(Saccharomyces
cerevisiae) 		5 / 11 ASN X 299
LEU X 301
VAL X 259
PHE X 230
PHE X 155
 None
 1.29A 3n23C-4tu3X:
undetectable		 3n23C-4tu3X:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 4tu3 PHOSPHOINOSITIDE
PHOSPHATASE SAC1
(Saccharomyces
cerevisiae) 		5 / 12 GLN X  34
HIS X  30
GLY X  13
ARG X 174
GLY X  37
 None
 1.30A 3sueD-4tu3X:
undetectable		 3sueD-4tu3X:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U7S_A_017A202_2
(POL POLYPROTEIN)		 4tu3 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 74
(Saccharomyces
cerevisiae) 		5 / 9 GLY A 261
ALA A 262
ILE A 160
LEU A  69
VAL A  73
 None
 0.97A 3u7sB-4tu3A:
undetectable		 3u7sB-4tu3A:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 4tu3 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 74
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 261
GLY A 258
VAL A 264
CYH A  99
 None
 0.90A 4c5nA-4tu3A:
undetectable		 4c5nA-4tu3A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		 4tu3 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 74
(Saccharomyces
cerevisiae) 		4 / 6 ALA A 185
LEU A 194
VAL A 193
ASP A 190
 None
 0.97A 4g24A-4tu3A:
undetectable		 4g24A-4tu3A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_A_ESTA1000_1
(ESTROGEN RECEPTOR)		 4tu3 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 74
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 141
GLU A 143
LEU A 177
ARG A 183
GLY A  98
 None
 1.30A 5dxbA-4tu3A:
undetectable		 5dxbA-4tu3A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNW_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 4tu3 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 74
(Saccharomyces
cerevisiae) 		5 / 12 GLU A  72
LEU A 272
LEU A 228
LEU A 269
THR A 270
 None
 0.99A 5hnwB-4tu3A:
undetectable		 5hnwB-4tu3A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNY_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4tu3 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 74
(Saccharomyces
cerevisiae) 		5 / 12 GLU A  72
LEU A 272
LEU A 228
LEU A 269
THR A 270
 None
 1.01A 5hnyB-4tu3A:
undetectable		 5hnyB-4tu3A:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 4tu3 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 74
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 106
ILE A 250
ARG A 251
PHE A 335
VAL A 334
 None
 1.25A 5m0oA-4tu3A:
undetectable		 5m0oA-4tu3A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4tu3 PHOSPHOINOSITIDE
PHOSPHATASE SAC1
(Saccharomyces
cerevisiae) 		4 / 4 GLN X 254
THR X 390
LEU X 359
LEU X 356
 None
 1.14A 5m5kB-4tu3X:
undetectable		 5m5kB-4tu3X:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 4tu3 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 74
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 283
PHE A 296
LEU A 310
 None
 0.90A 5x1bC-4tu3A:
undetectable		 5x1bC-4tu3A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4tu3 PHOSPHOINOSITIDE
PHOSPHATASE SAC1
(Saccharomyces
cerevisiae) 		3 / 3 GLN X 292
TYR X 296
ASN X 299
 None
 1.04A 6dwdC-4tu3X:
undetectable		 6dwdC-4tu3X:
21.47