SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tum'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2A3B_B_CFFB2434_1 (CHITINASE)	4tum	ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 2 (Arabidopsis thaliana)	4 / 6	GLU A 219 ASP A 248 PHE A 257 ARG A 252	None	1.41A	2a3bB-4tumA: undetectable	2a3bB-4tumA: 17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PD5_A_GEOA501_1 (NUPC FAMILY PROTEIN)	4tum	ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 2 (Arabidopsis thaliana)	5 / 12	GLY A 293 GLN A 329 ALA A 291 VAL A 300 LEU A 336	None	1.11A	4pd5A-4tumA: undetectable	4pd5A-4tumA: 15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PD9_A_ADNA501_1 (NUPC FAMILY PROTEIN)	4tum	ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 2 (Arabidopsis thaliana)	5 / 12	GLY A 293 GLN A 329 ALA A 291 VAL A 300 LEU A 336	None	1.13A	4pd9A-4tumA: undetectable	4pd9A-4tumA: 15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MAF_A_XINA403_2 (MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE)	4tum	ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 2 (Arabidopsis thaliana)	4 / 5	LEU A 234 CYH A 299 LEU A 302 ASP A 272	None	1.35A	5mafA-4tumA: undetectable	5mafA-4tumA: 29.25

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2A3B_B_CFFB2434_1","CHITINASE","4tum","ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 2","Arabidopsis thaliana",4,"GLU A 219;ASP A 248;PHE A 257;ARG A 252","None","1.41A","2a3bB-4tumA:undetectable","2a3bB-4tumA:17.30"],["4PD5_A_GEOA501_1","NUPC FAMILY PROTEIN","4tum","ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 2","Arabidopsis thaliana",5,"GLY A 293;GLN A 329;ALA A 291;VAL A 300;LEU A 336","None","1.11A","4pd5A-4tumA:undetectable","4pd5A-4tumA:15.84"],["4PD9_A_ADNA501_1","NUPC FAMILY PROTEIN","4tum","ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 2","Arabidopsis thaliana",5,"GLY A 293;GLN A 329;ALA A 291;VAL A 300;LEU A 336","None","1.13A","4pd9A-4tumA:undetectable","4pd9A-4tumA:15.84"],["5MAF_A_XINA403_2","MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE","4tum","ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 2","Arabidopsis thaliana",4,"LEU A 234;CYH A 299;LEU A 302;ASP A 272","None","1.35A","5mafA-4tumA:undetectable","5mafA-4tumA:29.25"]]