SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tv6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4tv6 2-DEHYDRO-3-DEOXYGLU
CARATE ALDOLASE
(Staphylococcus
aureus) 		3 / 3 GLN A 230
ILE A 159
HIS A 199
 None
 0.75A 1fm9A-4tv6A:
undetectable		 1fm9A-4tv6A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_2
(ASPARTYLPROTEASE)		 4tv6 2-DEHYDRO-3-DEOXYGLU
CARATE ALDOLASE
(Staphylococcus
aureus) 		5 / 9 VAL A 172
ILE A 233
ILE A  43
PRO A  95
ILE A 147
 None
None
None
OAA  A 301 (-4.8A)
None
 1.00A 1ohrB-4tv6A:
undetectable		 1ohrB-4tv6A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_C_REAC503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4tv6 2-DEHYDRO-3-DEOXYGLU
CARATE ALDOLASE
(Staphylococcus
aureus) 		5 / 10 ILE A  33
ALA A  34
ALA A  35
ALA A  65
ILE A 241
 None
 1.14A 2aclC-4tv6A:
undetectable		 2aclC-4tv6A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4tv6 2-DEHYDRO-3-DEOXYGLU
CARATE ALDOLASE
(Staphylococcus
aureus) 		5 / 10 ILE A  33
ALA A  34
ALA A  35
ALA A  65
ILE A 241
 None
 1.12A 3falA-4tv6A:
undetectable		 3falA-4tv6A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 4tv6 2-DEHYDRO-3-DEOXYGLU
CARATE ALDOLASE
(Staphylococcus
aureus) 		5 / 12 ARG A  90
ILE A  43
THR A  45
ILE A  67
LEU A  58
 None
 0.96A 3gcsA-4tv6A:
undetectable		 3gcsA-4tv6A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A81_A_DXCA1161_0
(MAJOR POLLEN
ALLERGEN BET V 1-A)		 4tv6 2-DEHYDRO-3-DEOXYGLU
CARATE ALDOLASE
(Staphylococcus
aureus) 		5 / 12 ILE A 233
GLY A 235
VAL A  48
ASP A  44
MET A  29
 None
 1.21A 4a81A-4tv6A:
undetectable		 4a81A-4tv6A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 4tv6 2-DEHYDRO-3-DEOXYGLU
CARATE ALDOLASE
(Staphylococcus
aureus) 		5 / 12 ILE A  30
ALA A  56
ALA A  89
GLY A  91
ALA A  62
 None
 1.13A 4enhA-4tv6A:
undetectable		 4enhA-4tv6A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4tv6 2-DEHYDRO-3-DEOXYGLU
CARATE ALDOLASE
(Staphylococcus
aureus) 		4 / 7 MET A  29
ILE A 241
ARG A 238
VAL A  48
 None
 1.36A 4f4dA-4tv6A:
undetectable		 4f4dA-4tv6A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		 4tv6 2-DEHYDRO-3-DEOXYGLU
CARATE ALDOLASE
(Staphylococcus
aureus) 		4 / 6 ALA A 213
LEU A 214
ASP A 220
GLU A 217
 None
 1.02A 4g24A-4tv6A:
undetectable		 4g24A-4tv6A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		 4tv6 2-DEHYDRO-3-DEOXYGLU
CARATE ALDOLASE
(Staphylococcus
aureus) 		5 / 12 PRO A 215
PHE A  21
LEU A 234
PHE A  40
MET A 149
 None
None
None
None
OAA  A 301 ( 4.2A)
 1.17A 4mubA-4tv6A:
undetectable		 4mubA-4tv6A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4tv6 2-DEHYDRO-3-DEOXYGLU
CARATE ALDOLASE
(Staphylococcus
aureus) 		4 / 5 ILE A 150
LYS A 209
HIS A 207
VAL A 203
 None
 1.17A 5jmnB-4tv6A:
undetectable		 5jmnB-4tv6A:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 4tv6 2-DEHYDRO-3-DEOXYGLU
CARATE ALDOLASE
(Staphylococcus
aureus) 		4 / 5 PHE A 211
VAL A  42
PRO A 215
VAL A 229
 None
 1.10A 6ekzA-4tv6A:
undetectable		 6ekzA-4tv6A:
16.60