SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tv7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_1
(PROTEIN (PROTEASE))		 4tv7 HTH-TYPE
TRANSCRIPTIONAL
REGULATORY PROTEIN
GABR
(Bacillus
subtilis) 		5 / 11 ALA A 268
ILE A 234
ILE A 262
PRO A 246
ILE A 276
 None
 0.87A 1c6yA-4tv7A:
undetectable		 1c6yA-4tv7A:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_2
(PROTEIN (PROTEASE))		 4tv7 HTH-TYPE
TRANSCRIPTIONAL
REGULATORY PROTEIN
GABR
(Bacillus
subtilis) 		5 / 12 ALA A 268
ILE A 234
ILE A 262
PRO A 246
ILE A 276
 None
 0.83A 1c6zB-4tv7A:
undetectable		 1c6zB-4tv7A:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4tv7 HTH-TYPE
TRANSCRIPTIONAL
REGULATORY PROTEIN
GABR
(Bacillus
subtilis) 		3 / 3 MET A 200
ASN A 214
GLN A 186
 None
 1.03A 1xoqB-4tv7A:
undetectable		 1xoqB-4tv7A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		 4tv7 HTH-TYPE
TRANSCRIPTIONAL
REGULATORY PROTEIN
GABR
(Bacillus
subtilis) 		4 / 6 LEU A 423
GLY A 460
LEU A 452
ILE A 447
 None
 0.94A 1yajF-4tv7A:
undetectable		 1yajF-4tv7A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4tv7 HTH-TYPE
TRANSCRIPTIONAL
REGULATORY PROTEIN
GABR
(Bacillus
subtilis) 		4 / 6 ALA A 269
ASN A 303
ILE A 276
ASP A 299
 None
 0.83A 1yc2A-4tv7A:
3.2		 1yc2A-4tv7A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4tv7 HTH-TYPE
TRANSCRIPTIONAL
REGULATORY PROTEIN
GABR
(Bacillus
subtilis) 		4 / 5 ALA A 269
ASN A 303
ILE A 276
ASP A 299
 None
 0.89A 1yc2D-4tv7A:
3.5		 1yc2D-4tv7A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_1
(PROTEASE RETROPEPSIN)		 4tv7 HTH-TYPE
TRANSCRIPTIONAL
REGULATORY PROTEIN
GABR
(Bacillus
subtilis) 		5 / 12 ALA A 268
ILE A 234
ILE A 262
PRO A 246
ILE A 276
 None
 0.92A 2q64A-4tv7A:
undetectable		 2q64A-4tv7A:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 4tv7 HTH-TYPE
TRANSCRIPTIONAL
REGULATORY PROTEIN
GABR
(Bacillus
subtilis) 		4 / 6 THR A 350
PHE A 354
LEU A 318
LEU A 315
 None
 1.08A 3bgdA-4tv7A:
3.7		 3bgdA-4tv7A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_2
(PROTEASE)		 4tv7 HTH-TYPE
TRANSCRIPTIONAL
REGULATORY PROTEIN
GABR
(Bacillus
subtilis) 		5 / 11 ALA A 268
ILE A 234
ILE A 262
PRO A 246
ILE A 276
 None
 0.96A 3ekxB-4tv7A:
undetectable		 3ekxB-4tv7A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_2
(PROTEASE)		 4tv7 HTH-TYPE
TRANSCRIPTIONAL
REGULATORY PROTEIN
GABR
(Bacillus
subtilis) 		5 / 9 ARG A 160
ILE A 176
GLY A 150
ILE A 151
PRO A 172
 None
 1.21A 3ekyB-4tv7A:
undetectable		 3ekyB-4tv7A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 4tv7 HTH-TYPE
TRANSCRIPTIONAL
REGULATORY PROTEIN
GABR
(Bacillus
subtilis) 		4 / 7 TYR A 281
ILE A 446
THR A 403
GLY A 253
 LLP  A 312 ( 4.0A)
None
None
None
 0.85A 3gssA-4tv7A:
undetectable		 3gssA-4tv7A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 4tv7 HTH-TYPE
TRANSCRIPTIONAL
REGULATORY PROTEIN
GABR
(Bacillus
subtilis) 		4 / 7 TYR A 281
ILE A 446
THR A 403
GLY A 253
 LLP  A 312 ( 4.0A)
None
None
None
 0.81A 3gssB-4tv7A:
undetectable		 3gssB-4tv7A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_D_ROCD100_1
(PROTEASE)		 4tv7 HTH-TYPE
TRANSCRIPTIONAL
REGULATORY PROTEIN
GABR
(Bacillus
subtilis) 		5 / 12 ALA A 268
ILE A 234
ILE A 262
PRO A 246
ILE A 276
 None
 0.85A 3ndtC-4tv7A:
undetectable		 3ndtC-4tv7A:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_1
(PROTEASE)		 4tv7 HTH-TYPE
TRANSCRIPTIONAL
REGULATORY PROTEIN
GABR
(Bacillus
subtilis) 		5 / 12 ALA A 268
ILE A 234
ILE A 262
PRO A 246
ILE A 276
 None
 0.82A 3oxcA-4tv7A:
undetectable		 3oxcA-4tv7A:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_1
(PROTEASE)		 4tv7 HTH-TYPE
TRANSCRIPTIONAL
REGULATORY PROTEIN
GABR
(Bacillus
subtilis) 		5 / 12 ALA A 268
ILE A 234
ILE A 262
PRO A 246
ILE A 276
 None
 0.85A 3pwrA-4tv7A:
undetectable		 3pwrA-4tv7A:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPS_A_CHDA211_0
(CMER)		 4tv7 HTH-TYPE
TRANSCRIPTIONAL
REGULATORY PROTEIN
GABR
(Bacillus
subtilis) 		5 / 10 LEU A 378
ALA A 450
PHE A 449
GLY A 448
ILE A 447
 None
 1.28A 3qpsA-4tv7A:
undetectable		 3qpsA-4tv7A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GBO_A_CUA301_0
(E7)		 4tv7 HTH-TYPE
TRANSCRIPTIONAL
REGULATORY PROTEIN
GABR
(Bacillus
subtilis) 		4 / 5 HIS A 400
ALA A 397
HIS A 248
TYR A 281
 None
None
None
LLP  A 312 ( 4.0A)
 1.41A 4gboA-4tv7A:
undetectable		 4gboA-4tv7A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_2
(PROTEASE)		 4tv7 HTH-TYPE
TRANSCRIPTIONAL
REGULATORY PROTEIN
GABR
(Bacillus
subtilis) 		5 / 11 ALA A 268
ILE A 234
ILE A 262
PRO A 246
ILE A 276
 None
 0.93A 4qgiB-4tv7A:
undetectable		 4qgiB-4tv7A:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4tv7 HTH-TYPE
TRANSCRIPTIONAL
REGULATORY PROTEIN
GABR
(Bacillus
subtilis) 		4 / 6 TYR A 322
GLU A 284
TYR A 360
LEU A 314
 None
 1.29A 4twdF-4tv7A:
undetectable
4twdG-4tv7A:
undetectable		 4twdF-4tv7A:
21.03
4twdG-4tv7A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 4tv7 HTH-TYPE
TRANSCRIPTIONAL
REGULATORY PROTEIN
GABR
(Bacillus
subtilis) 		4 / 6 LEU A  24
ILE A  28
LEU A  63
TYR A  60
 None
 0.75A 4w5nA-4tv7A:
2.7		 4w5nA-4tv7A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HUA_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 4tv7 HTH-TYPE
TRANSCRIPTIONAL
REGULATORY PROTEIN
GABR
(Bacillus
subtilis) 		5 / 11 ASP A 282
ILE A 446
PHE A 449
LEU A 399
PHE A 250
 None
None
None
None
LLP  A 312 ( 3.7A)
 1.29A 5huaA-4tv7A:
undetectable		 5huaA-4tv7A:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HUA_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 4tv7 HTH-TYPE
TRANSCRIPTIONAL
REGULATORY PROTEIN
GABR
(Bacillus
subtilis) 		5 / 11 ASP A 282
VAL A 402
ILE A 446
PHE A 449
PHE A 250
 None
None
None
None
LLP  A 312 ( 3.7A)
 1.39A 5huaA-4tv7A:
undetectable		 5huaA-4tv7A:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_1
(PROTEASE PR5-SQV)		 4tv7 HTH-TYPE
TRANSCRIPTIONAL
REGULATORY PROTEIN
GABR
(Bacillus
subtilis) 		5 / 9 ALA A 268
ILE A 234
ILE A 262
THR A 244
PRO A 246
 None
 1.10A 5kr2C-4tv7A:
undetectable		 5kr2C-4tv7A:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIZ_A_CUA301_0
(AA10A)		 4tv7 HTH-TYPE
TRANSCRIPTIONAL
REGULATORY PROTEIN
GABR
(Bacillus
subtilis) 		4 / 5 HIS A 400
ALA A 397
HIS A 248
TYR A 281
 None
None
None
LLP  A 312 ( 4.0A)
 1.38A 5uizA-4tv7A:
undetectable		 5uizA-4tv7A:
16.77