SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tvi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4tvi AMINOTRANSFERASE,
CLASS IV
(Brucella
abortus) 		5 / 12 GLY A 123
THR A 127
ALA A 132
GLY A  53
SER A  54
 None
 1.23A 1nbiC-4tviA:
undetectable		 1nbiC-4tviA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4tvi AMINOTRANSFERASE,
CLASS IV
(Brucella
abortus) 		5 / 12 GLY A 123
THR A 127
ALA A 132
GLY A  53
SER A  54
 None
 1.23A 1nbiD-4tviA:
undetectable		 1nbiD-4tviA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_A_ACTA2001_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 4tvi AMINOTRANSFERASE,
CLASS IV
(Brucella
abortus) 		4 / 5 SER A 210
SER A 267
THR A 207
ASN A 194
 None
 1.40A 1yvpA-4tviA:
undetectable		 1yvpA-4tviA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B9E_A_SAMA1201_0
(NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2)		 4tvi AMINOTRANSFERASE,
CLASS IV
(Brucella
abortus) 		5 / 12 PRO A  88
ASN A  78
LEU A 131
ASP A 124
SER A  54
 None
 1.46A 2b9eA-4tviA:
undetectable		 2b9eA-4tviA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 4tvi AMINOTRANSFERASE,
CLASS IV
(Brucella
abortus) 		5 / 12 SER A  74
LEU A 103
GLY A 102
VAL A 112
ALA A 143
 None
 1.19A 2kceB-4tviA:
undetectable		 2kceB-4tviA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 4tvi AMINOTRANSFERASE,
CLASS IV
(Brucella
abortus) 		5 / 12 GLY A 269
ILE A 233
ASP A  69
ARG A 237
VAL A 275
 LLP  A 172 ( 3.5A)
LLP  A 172 ( 4.1A)
None
None
None
 1.06A 2qe6B-4tviA:
undetectable		 2qe6B-4tviA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		 4tvi AMINOTRANSFERASE,
CLASS IV
(Brucella
abortus) 		4 / 8 ILE A 256
ALA A 262
VAL A 212
VAL A 204
 None
 0.84A 3me6B-4tviA:
undetectable		 3me6B-4tviA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_2
(SECRETED ASPARTIC
PROTEASE)		 4tvi AMINOTRANSFERASE,
CLASS IV
(Brucella
abortus) 		4 / 7 VAL A 212
ILE A 277
THR A 156
THR A 157
 None
 0.77A 3tneB-4tviA:
undetectable		 3tneB-4tviA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD507_1
(HEMOLYTIC LECTIN
CEL-III)		 4tvi AMINOTRANSFERASE,
CLASS IV
(Brucella
abortus) 		4 / 5 GLU A  34
GLY A  33
TYR A  31
ASP A 136
 None
 1.30A 3w9tD-4tviA:
undetectable		 3w9tD-4tviA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4tvi AMINOTRANSFERASE,
CLASS IV
(Brucella
abortus) 		4 / 8 ARG A  36
ILE A  42
ASP A 136
TRP A 119
 None
 0.75A 4d33A-4tviA:
undetectable		 4d33A-4tviA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 4tvi AMINOTRANSFERASE,
CLASS IV
(Brucella
abortus) 		4 / 8 ARG A  36
ILE A  42
ASP A 136
TRP A 119
 None
 0.75A 4d39A-4tviA:
undetectable		 4d39A-4tviA:
22.44