SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tvm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_0
(ALCOHOL
DEHYDROGENASE)		 4tvm CITRATE SYNTHASE
(Mycobacterium
tuberculosis) 		3 / 3 MET A 134
LEU A 137
SER A 138
 None
 0.61A 1ee2A-4tvmA:
undetectable		 1ee2A-4tvmA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_1
(HISTONE
METHYLTRANSFERASE
DOT1L)		 4tvm CITRATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 4 THR A 107
GLN A 111
GLU A 198
ASP A 215
 None
 1.39A 1nw3A-4tvmA:
0.8		 1nw3A-4tvmA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_F_REAF177_1
(RETINOL BINDING
PROTEIN)		 4tvm CITRATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 137
ALA A 388
VAL A 141
LEU A 144
LEU A 167
 None
 0.99A 1rlbF-4tvmA:
undetectable		 1rlbF-4tvmA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4tvm CITRATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 5 ILE A 227
ILE A 329
ILE A 321
LEU A 201
 None
 0.78A 1zgyA-4tvmA:
undetectable		 1zgyA-4tvmA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4tvm CITRATE SYNTHASE
(Mycobacterium
tuberculosis) 		3 / 3 PRO A 317
GLY A  67
TYR A 315
 None
 0.57A 2vouA-4tvmA:
undetectable		 2vouA-4tvmA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4tvm CITRATE SYNTHASE
(Mycobacterium
tuberculosis) 		3 / 3 PRO A 317
GLY A  67
TYR A 315
 None
 0.67A 2vouB-4tvmA:
undetectable		 2vouB-4tvmA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 4tvm CITRATE SYNTHASE
(Mycobacterium
tuberculosis) 		3 / 3 PRO A 317
GLY A  67
TYR A 315
 None
 0.66A 2vouC-4tvmA:
undetectable		 2vouC-4tvmA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9H_A_TOPA1160_1
(DIHYDROFOLATE
REDUCTASE)		 4tvm CITRATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 221
LEU A 376
LEU A 201
VAL A 197
PHE A 226
 None
 1.02A 2w9hA-4tvmA:
undetectable		 2w9hA-4tvmA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4tvm CITRATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 5 GLN A 111
THR A 195
THR A 204
LEU A 389
 None
 1.35A 2zj0A-4tvmA:
undetectable		 2zj0A-4tvmA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4tvm CITRATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 5 GLN A 111
THR A 195
THR A 204
LEU A 389
 None
 1.38A 3ce6A-4tvmA:
undetectable		 3ce6A-4tvmA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 4tvm CITRATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 5 GLN A 111
THR A 195
THR A 204
LEU A 389
 None
 1.37A 3ce6C-4tvmA:
undetectable		 3ce6C-4tvmA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 4tvm CITRATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 221
LEU A 376
LEU A 201
VAL A 197
PHE A 226
 None
 1.18A 3freX-4tvmA:
undetectable		 3freX-4tvmA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 4tvm CITRATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 7 ILE A  68
TYR A  61
THR A  60
GLY A  27
 None
 0.98A 3gssB-4tvmA:
undetectable		 3gssB-4tvmA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4tvm CITRATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 262
VAL A 160
ILE A 396
ARG A 248
 None
 1.22A 3ik3A-4tvmA:
undetectable		 3ik3A-4tvmA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4tvm CITRATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 262
VAL A 160
ILE A 396
ARG A 248
 None
 1.24A 3ik3B-4tvmA:
undetectable		 3ik3B-4tvmA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 4tvm CITRATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 4 ARG A 282
ASP A 366
GLY A 269
THR A 380
 None
OAA  A 501 ( 4.6A)
None
None
 1.45A 3k4vB-4tvmA:
undetectable		 3k4vB-4tvmA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M6W_A_SAMA465_0
(RRNA METHYLASE)		 4tvm CITRATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 258
GLY A 257
PRO A 393
VAL A  88
LEU A  92
 None
 1.07A 3m6wA-4tvmA:
undetectable		 3m6wA-4tvmA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 4tvm CITRATE SYNTHASE
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 202
LEU A 194
THR A 114
 None
 0.90A 3oxcA-4tvmA:
undetectable		 3oxcA-4tvmA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 4tvm CITRATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 11 ILE A 174
PHE A  85
LEU A 196
ILE A 259
VAL A 141
 None
 1.10A 4h1nA-4tvmA:
undetectable		 4h1nA-4tvmA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4tvm CITRATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 321
ALA A  80
ALA A 221
LEU A 225
ILE A 329
 None
 1.05A 4lnwA-4tvmA:
undetectable		 4lnwA-4tvmA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4tvm CITRATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 5 GLN A 111
THR A 195
THR A 204
LEU A 389
 None
 1.23A 4lvcA-4tvmA:
undetectable		 4lvcA-4tvmA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 4tvm CITRATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 5 GLN A 111
THR A 195
THR A 204
LEU A 389
 None
 1.22A 4lvcC-4tvmA:
undetectable		 4lvcC-4tvmA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_2
(CDL2.2)		 4tvm CITRATE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 120
LEU A 392
LEU A 116
ILE A 110
TYR A 148
 None
 1.18A 5ienB-4tvmA:
undetectable		 5ienB-4tvmA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4tvm CITRATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 4 GLN A 111
THR A 195
THR A 204
LEU A 389
 None
 1.19A 5m5kA-4tvmA:
undetectable		 5m5kA-4tvmA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4tvm CITRATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 4 GLN A 111
THR A 195
THR A 204
LEU A 389
 None
 1.21A 5m5kC-4tvmA:
undetectable		 5m5kC-4tvmA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4tvm CITRATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 4 GLN A 111
THR A 195
THR A 204
LEU A 389
 None
 1.23A 5m66B-4tvmA:
undetectable		 5m66B-4tvmA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_B_ADNB502_2
(-)		 4tvm CITRATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 4 GLN A 111
THR A 195
THR A 204
LEU A 389
 None
 1.19A 6f3mB-4tvmA:
undetectable		 6f3mB-4tvmA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_2
(-)		 4tvm CITRATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 5 GLN A 111
THR A 195
THR A 204
LEU A 389
 None
 1.19A 6gbnA-4tvmA:
undetectable		 6gbnA-4tvmA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_D_ADND501_2
(-)		 4tvm CITRATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 5 GLN A 111
THR A 195
THR A 204
LEU A 389
 None
 1.21A 6gbnD-4tvmA:
undetectable		 6gbnD-4tvmA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HXI_B_ACTB706_0
(SUCCINYL-COA LIGASE
(ADP-FORMING)
SUBUNIT ALPHA)		 4tvm CITRATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 5 HIS A 232
ARG A 318
PHE A 387
ARG A 391
 OAA  A 501 (-3.9A)
OAA  A 501 (-4.1A)
OAA  A 501 (-4.7A)
OAA  A 501 (-3.1A)
 0.64A 6hxiB-4tvmA:
5.1		 6hxiB-4tvmA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HXI_D_ACTD703_0
(SUCCINYL-COA LIGASE
(ADP-FORMING)
SUBUNIT ALPHA)		 4tvm CITRATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 5 HIS A 232
ARG A 318
PHE A 387
ARG A 391
 OAA  A 501 (-3.9A)
OAA  A 501 (-4.1A)
OAA  A 501 (-4.7A)
OAA  A 501 (-3.1A)
 0.65A 6hxiD-4tvmA:
4.7		 6hxiD-4tvmA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4tvm CITRATE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 5 ARG A 381
MET A 382
THR A 384
LEU A 386
 None
 1.37A 6nknW-4tvmA:
undetectable		 6nknW-4tvmA:
9.70