SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tvo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4tvo MALATE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 11 VAL A  70
LEU A  42
ILE A  38
ALA A  27
LEU A  59
 None
 1.11A 1eqgB-4tvoA:
undetectable		 1eqgB-4tvoA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 4tvo MALATE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 7 SER A 322
ASP A 319
GLU A 326
GLU A 105
 None
NA  A 405 (-2.8A)
None
None
 1.19A 1knyA-4tvoA:
undetectable
1knyB-4tvoA:
undetectable		 1knyA-4tvoA:
19.94
1knyB-4tvoA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4tvo MALATE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 222
ALA A 268
SER A 284
SER A 190
HIS A 189
 NA  A 410 ( 3.8A)
None
None
None
SO4  A 401 (-4.4A)
 1.38A 1nbhA-4tvoA:
6.4		 1nbhA-4tvoA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4tvo MALATE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 222
ALA A 268
SER A 284
SER A 190
HIS A 189
 NA  A 410 ( 3.8A)
None
None
None
SO4  A 401 (-4.4A)
 1.37A 1nbhD-4tvoA:
6.1		 1nbhD-4tvoA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 4tvo MALATE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 8 ILE A 282
ASN A 188
SER A 313
SER A 284
 None
 1.03A 2zw9B-4tvoA:
4.4		 2zw9B-4tvoA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)		 4tvo MALATE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 11 GLY A  13
GLY A  16
GLU A  44
ILE A  45
ILE A 110
 NA  A 412 ( 4.1A)
NA  A 412 (-3.7A)
NA  A 412 (-2.9A)
None
None
 0.66A 3grvA-4tvoA:
5.5		 3grvA-4tvoA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4tvo MALATE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 VAL A  55
LEU A  59
GLY A  13
ALA A  14
LEU A  42
 None
None
NA  A 412 ( 4.1A)
None
None
 1.08A 3n8zA-4tvoA:
undetectable		 3n8zA-4tvoA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_B_FLPB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4tvo MALATE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 ARG A  92
LEU A 329
ILE A 110
GLY A 108
LEU A 103
 None
 1.06A 3n8zB-4tvoA:
undetectable		 3n8zB-4tvoA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4tvo MALATE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 252
GLY A 129
SER A 155
MET A 267
LEU A  87
 None
 1.27A 3ou6C-4tvoA:
4.2		 3ou6C-4tvoA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4tvo MALATE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 252
GLY A 129
SER A 155
MET A 267
LEU A  87
 None
 1.26A 3ou6D-4tvoA:
4.5		 3ou6D-4tvoA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4tvo MALATE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 252
GLY A 129
SER A 155
MET A 267
LEU A  87
 None
 1.27A 3ou7C-4tvoA:
4.5		 3ou7C-4tvoA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4tvo MALATE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 252
GLY A 129
SER A 155
MET A 267
LEU A  87
 None
 1.23A 3ou7D-4tvoA:
4.1		 3ou7D-4tvoA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 4tvo MALATE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 153
PRO A 147
PHE A 154
 None
None
NA  A 404 ( 4.8A)
 0.97A 3thrC-4tvoA:
undetectable		 3thrC-4tvoA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4tvo MALATE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 9 ALA A  15
GLY A  19
LEU A  59
LEU A  42
LEU A  22
 NA  A 412 ( 4.9A)
None
None
None
None
 1.10A 3wdmC-4tvoA:
3.9		 3wdmC-4tvoA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4tvo MALATE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 8 LEU A  22
VAL A  11
LEU A 160
LEU A 157
 None
None
NA  A 403 (-4.4A)
None
 0.88A 4l1xA-4tvoA:
undetectable		 4l1xA-4tvoA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4tvo MALATE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 6 VAL A   9
LEU A  40
LEU A  22
PHE A 111
 None
 0.97A 4o1zA-4tvoA:
undetectable		 4o1zA-4tvoA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 4tvo MALATE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		4 / 5 VAL A 324
THR A 137
ASN A 138
LEU A 104
 None
 1.32A 5m0iB-4tvoA:
undetectable		 5m0iB-4tvoA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4tvo MALATE DEHYDROGENASE
(Mycobacterium
tuberculosis) 		5 / 12 ASP A  60
GLU A  58
LEU A  22
ARG A  41
LEU A  52
 None
 1.04A 5nd7B-4tvoA:
5.6		 5nd7B-4tvoA:
23.64