SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tvr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS4_A_AZMA702_1
(CARBONIC ANHYDRASE 2)		 4tvr E3 UBIQUITIN-PROTEIN
LIGASE UHRF2
(Homo
sapiens) 		4 / 7 TYR A 127
TRP A 143
GLU A 309
PRO A 231
 None
 0.99A 3hs4A-4tvrA:
undetectable		 3hs4A-4tvrA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 4tvr E3 UBIQUITIN-PROTEIN
LIGASE UHRF2
(Homo
sapiens) 		3 / 3 GLY A 352
CYH A 350
CYH A 347
 None
ZN  A 402 (-2.3A)
ZN  A 402 (-2.3A)
 0.96A 5inzB-4tvrA:
undetectable		 5inzB-4tvrA:
5.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 4tvr E3 UBIQUITIN-PROTEIN
LIGASE UHRF2
(Homo
sapiens) 		4 / 5 ALA A 146
ALA A 135
ILE A 211
LEU A 222
 None
 0.68A 5jncD-4tvrA:
undetectable		 5jncD-4tvrA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 4tvr E3 UBIQUITIN-PROTEIN
LIGASE UHRF2
(Homo
sapiens) 		4 / 6 ARG A 230
ARG A 310
ALA A 313
PRO A 231
 None
 1.40A 5odqA-4tvrA:
undetectable		 5odqA-4tvrA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 4tvr E3 UBIQUITIN-PROTEIN
LIGASE UHRF2
(Homo
sapiens) 		3 / 3 LEU A 242
VAL A 302
ASP A 303
 None
UNX  A 409 ( 4.5A)
UNX  A 409 ( 3.6A)
 0.58A 5x23A-4tvrA:
undetectable		 5x23A-4tvrA:
22.11