SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tvs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_2
(VITAMIN D NUCLEAR
RECEPTOR)		 4tvs TORSIN-1A-INTERACTIN
G PROTEIN 1
(Homo
sapiens) 		4 / 6 LEU A 536
ILE A 409
TYR A 493
VAL A 568
 None
 1.11A 1db1A-4tvsA:
undetectable		 1db1A-4tvsA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 4tvs TORSIN-1A-INTERACTIN
G PROTEIN 1
(Homo
sapiens) 		5 / 12 LEU A 465
ALA A 475
ALA A 430
ALA A 476
VAL A 461
 None
 1.36A 1rbpA-4tvsA:
undetectable		 1rbpA-4tvsA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 4tvs TORSIN-1A-INTERACTIN
G PROTEIN 1
(Homo
sapiens) 		4 / 6 VAL A 509
LEU A 412
PHE A 368
MET A 372
 None
 1.00A 1wrlB-4tvsA:
undetectable		 1wrlB-4tvsA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_B_STIB600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 4tvs TORSIN-1A-INTERACTIN
G PROTEIN 1
(Homo
sapiens) 		4 / 6 LEU A 536
VAL A 506
VAL A 478
ILE A 409
 None
 1.07A 2hyyB-4tvsA:
undetectable		 2hyyB-4tvsA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_A_SAMA1001_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4tvs TORSIN-1A-INTERACTIN
G PROTEIN 1
(Homo
sapiens) 		5 / 12 PHE A 492
PHE A 503
ALA A 507
GLY A 468
GLY A 472
 None
 1.08A 2igtA-4tvsA:
undetectable		 2igtA-4tvsA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 4tvs TORSIN-1A-INTERACTIN
G PROTEIN 1
(Homo
sapiens) 		5 / 12 PHE A 492
PHE A 503
ALA A 507
GLY A 468
GLY A 472
 None
 1.09A 2igtB-4tvsA:
undetectable		 2igtB-4tvsA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA503_0
(CHORISMATE SYNTHASE)		 4tvs VHH DOMAIN BS-1
(Vicugna
pacos) 		4 / 5 THR a 102
ARG a  54
ALA a  34
ARG a  73
 None
 1.24A 2qhfA-4tvsa:
1.6		 2qhfA-4tvsa:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_ACTA1181_0
(WNT INHIBITORY
FACTOR 1)		 4tvs VHH DOMAIN BS-1
(Vicugna
pacos) 		3 / 3 TYR a  33
VAL a   3
THR a 100
 None
 0.90A 2ygnA-4tvsa:
undetectable		 2ygnA-4tvsa:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4tvs TORSIN-1A-INTERACTIN
G PROTEIN 1
(Homo
sapiens) 		4 / 6 LEU A 536
VAL A 506
VAL A 478
ILE A 409
 None
 1.14A 3k5vA-4tvsA:
undetectable		 3k5vA-4tvsA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_B_STIB2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4tvs TORSIN-1A-INTERACTIN
G PROTEIN 1
(Homo
sapiens) 		4 / 6 LEU A 536
VAL A 506
VAL A 478
ILE A 409
 None
 1.16A 3k5vB-4tvsA:
undetectable		 3k5vB-4tvsA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NHX_A_ASDA126_1
(STEROID
DELTA-ISOMERASE)		 4tvs TORSIN-1A-INTERACTIN
G PROTEIN 1
(Homo
sapiens) 		5 / 12 TYR A 433
LEU A 398
SER A 400
PHE A 436
ASN A 474
 None
 1.35A 3nhxA-4tvsA:
undetectable		 3nhxA-4tvsA:
22.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 4tvs VHH DOMAIN BS-1
(Vicugna
pacos) 		5 / 12 ALA a  25
ARG a  73
ASN a  78
VAL a  80
ALA a  99
 None
 0.76A 3qxtA-4tvsa:
22.8		 3qxtA-4tvsa:
73.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 4tvs VHH DOMAIN BS-1
(Vicugna
pacos) 		6 / 12 LEU a   5
ALA a  25
ARG a  73
VAL a  80
ALA a  99
TYR a 117
 None
 0.65A 3qxtB-4tvsa:
22.8		 3qxtB-4tvsa:
73.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4tvs VHH DOMAIN BS-1
(Vicugna
pacos) 		6 / 12 ALA a  25
ARG a  73
ASN a  75
VAL a  80
ALA a  99
TYR a 117
 None
 0.72A 3qxvA-4tvsa:
22.3		 3qxvA-4tvsa:
72.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4tvs VHH DOMAIN BS-1
(Vicugna
pacos) 		5 / 12 ALA a  25
ARG a  73
VAL a  80
ALA a  99
TYR a 117
 None
 0.80A 3qxvB-4tvsa:
22.3		 3qxvB-4tvsa:
72.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_C_MTXC2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4tvs VHH DOMAIN BS-1
(Vicugna
pacos) 		5 / 11 ALA a  25
ARG a  73
ASN a  75
VAL a  80
ALA a  99
 None
 0.81A 3qxvC-4tvsa:
22.6		 3qxvC-4tvsa:
72.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_D_MTXD2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4tvs VHH DOMAIN BS-1
(Vicugna
pacos) 		5 / 12 ALA a  25
ARG a  73
VAL a  80
ALA a  99
TYR a 117
 None
 0.79A 3qxvD-4tvsa:
22.1		 3qxvD-4tvsa:
72.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 4tvs VHH DOMAIN BS-1
(Vicugna
pacos) 		6 / 12 CYH a  23
ALA a  25
ARG a  73
VAL a  80
ALA a  99
TYR a 117
 None
 0.82A 3qxvE-4tvsa:
18.7		 3qxvE-4tvsa:
72.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_C_9PLC1_1
(CYTOCHROME P450 2A13)		 4tvs TORSIN-1A-INTERACTIN
G PROTEIN 1
(Homo
sapiens) 		4 / 7 PHE A 481
ALA A 486
THR A 489
LEU A 560
 None
 1.08A 3t3sC-4tvsA:
undetectable		 3t3sC-4tvsA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQA_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4tvs TORSIN-1A-INTERACTIN
G PROTEIN 1
(Homo
sapiens) 		5 / 10 TYR A 495
ASP A 462
PHE A 469
ILE A 444
PHE A 492
 None
 1.43A 3uqaA-4tvsA:
undetectable		 3uqaA-4tvsA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ3_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4tvs TORSIN-1A-INTERACTIN
G PROTEIN 1
(Homo
sapiens) 		5 / 10 TYR A 495
ASP A 462
PHE A 469
ILE A 444
PHE A 492
 None
 1.41A 4dz3A-4tvsA:
undetectable		 4dz3A-4tvsA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAX_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 4tvs TORSIN-1A-INTERACTIN
G PROTEIN 1
(Homo
sapiens) 		5 / 10 TYR A 495
ASP A 462
PHE A 469
ILE A 444
PHE A 492
 None
 1.47A 4laxA-4tvsA:
undetectable		 4laxA-4tvsA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NNR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)		 4tvs TORSIN-1A-INTERACTIN
G PROTEIN 1
(Homo
sapiens) 		5 / 10 TYR A 495
ASP A 462
PHE A 469
ILE A 444
PHE A 492
 None
 1.43A 4nnrB-4tvsA:
undetectable		 4nnrB-4tvsA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		 4tvs TORSIN-1A-INTERACTIN
G PROTEIN 1
(Homo
sapiens) 		4 / 8 PHE A 492
LEU A 510
LEU A 465
PHE A 469
 None
 0.86A 4qopC-4tvsA:
undetectable		 4qopC-4tvsA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BYK_A_OAQA302_0
(SULFOTRANSFERASE)		 4tvs TORSIN-1A-INTERACTIN
G PROTEIN 1
(Homo
sapiens) 		5 / 12 ILE A 564
LEU A 490
LEU A 411
PHE A 481
THR A 489
 None
 1.19A 5bykA-4tvsA:
undetectable		 5bykA-4tvsA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HUA_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 4tvs TORSIN-1A-INTERACTIN
G PROTEIN 1
(Homo
sapiens) 		5 / 11 TYR A 495
ASP A 462
PHE A 469
ILE A 444
PHE A 492
 None
 1.43A 5huaA-4tvsA:
undetectable		 5huaA-4tvsA:
20.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CJK_B_ACTB302_0
(IMMUNOGLOBULIN FAB
HEAVY CHAIN)		 4tvs VHH DOMAIN BS-1
(Vicugna
pacos) 		3 / 3 TYR a  61
GLY a  67
THR a  70
 None
 0.15A 6cjkB-4tvsa:
19.1		 6cjkB-4tvsa:
32.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 4tvs TORSIN-1A-INTERACTIN
G PROTEIN 1
VHH DOMAIN BS-1
(Homo
sapiens;
Vicugna
pacos) 		3 / 3 ARG a  54
LYS A 556
TYR A 493
 None
 1.12A 6gnaA-4tvsa:
undetectable		 6gnaA-4tvsa:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 4tvs TORSIN-1A-INTERACTIN
G PROTEIN 1
VHH DOMAIN BS-1
(Homo
sapiens;
Vicugna
pacos) 		3 / 3 ARG a  54
LYS A 556
TYR A 493
 None
 1.12A 6gnbA-4tvsa:
undetectable		 6gnbA-4tvsa:
14.69