SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tvv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)		 4tvv TYROSINE PHOSPHATASE
II SUPERFAMILY
PROTEIN
(Legionella
pneumophila) 		5 / 10 GLY A  68
VAL A 254
ALA A  59
ASN A  65
ILE A  58
 None
CL  A 403 ( 4.1A)
None
CL  A 403 (-4.2A)
None
 0.89A 1likA-4tvvA:
undetectable		 1likA-4tvvA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_1
(DIPEPTIDYL PEPTIDASE
IV)		 4tvv TYROSINE PHOSPHATASE
II SUPERFAMILY
PROTEIN
(Legionella
pneumophila) 		5 / 12 TYR A 115
VAL A 188
TYR A 195
VAL A 105
HIS A 230
 None
 1.42A 1x70A-4tvvA:
undetectable		 1x70A-4tvvA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_B_CLMB1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 4tvv TYROSINE PHOSPHATASE
II SUPERFAMILY
PROTEIN
(Legionella
pneumophila) 		5 / 11 HIS A 113
ALA A 120
SER A  42
GLY A 118
VAL A 188
 None
 1.30A 2uxpB-4tvvA:
0.4		 2uxpB-4tvvA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_A_BJMA1_1
(DIPEPTIDYL PEPTIDASE
4)		 4tvv TYROSINE PHOSPHATASE
II SUPERFAMILY
PROTEIN
(Legionella
pneumophila) 		5 / 12 TYR A 115
VAL A 188
TYR A 195
VAL A 105
HIS A 230
 None
 1.41A 3bjmA-4tvvA:
undetectable		 3bjmA-4tvvA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_B_BJMB2_1
(DIPEPTIDYL PEPTIDASE
4)		 4tvv TYROSINE PHOSPHATASE
II SUPERFAMILY
PROTEIN
(Legionella
pneumophila) 		5 / 12 TYR A 115
VAL A 188
TYR A 195
VAL A 105
HIS A 230
 None
 1.37A 3bjmB-4tvvA:
undetectable		 3bjmB-4tvvA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)		 4tvv TYROSINE PHOSPHATASE
II SUPERFAMILY
PROTEIN
(Legionella
pneumophila) 		4 / 5 VAL A  49
GLN A  79
PHE A  46
ARG A 109
 None
 1.28A 3bjwB-4tvvA:
undetectable		 3bjwB-4tvvA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_A_LF7A801_1
(DIPEPTIDYL PEPTIDASE
4)		 4tvv TYROSINE PHOSPHATASE
II SUPERFAMILY
PROTEIN
(Legionella
pneumophila) 		5 / 12 TYR A 115
VAL A 188
TYR A 195
VAL A 105
HIS A 230
 None
 1.39A 3w2tA-4tvvA:
undetectable		 3w2tA-4tvvA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 4tvv TYROSINE PHOSPHATASE
II SUPERFAMILY
PROTEIN
(Legionella
pneumophila) 		5 / 12 TYR A 115
VAL A 188
TYR A 195
VAL A 105
HIS A 230
 None
 1.38A 3w2tB-4tvvA:
undetectable		 3w2tB-4tvvA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA804_1
(CATALASE-PEROXIDASE)		 4tvv TYROSINE PHOSPHATASE
II SUPERFAMILY
PROTEIN
(Legionella
pneumophila) 		3 / 3 ASN A  65
GLU A 258
ARG A 262
 CL  A 403 (-4.2A)
None
None
 0.90A 3wxoA-4tvvA:
undetectable		 3wxoA-4tvvA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_D_MIYD393_1
(TETX2 PROTEIN)		 4tvv TYROSINE PHOSPHATASE
II SUPERFAMILY
PROTEIN
(Legionella
pneumophila) 		4 / 5 ILE A  58
GLN A 263
ILE A 260
GLU A 257
 None
 1.08A 4a99D-4tvvA:
undetectable		 4a99D-4tvvA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 4tvv TYROSINE PHOSPHATASE
II SUPERFAMILY
PROTEIN
(Legionella
pneumophila) 		5 / 12 ARG A 237
GLY A 236
VAL A  39
ASN A 128
VAL A 124
 PO4  A 402 (-3.8A)
PO4  A 401 ( 3.4A)
None
None
None
 1.20A 4ffwA-4tvvA:
undetectable		 4ffwA-4tvvA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 4tvv TYROSINE PHOSPHATASE
II SUPERFAMILY
PROTEIN
(Legionella
pneumophila) 		5 / 12 TYR A 115
VAL A 188
TYR A 195
VAL A 105
HIS A 230
 None
 1.36A 4ffwA-4tvvA:
undetectable		 4ffwA-4tvvA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		 4tvv TYROSINE PHOSPHATASE
II SUPERFAMILY
PROTEIN
(Legionella
pneumophila) 		5 / 12 TYR A 115
VAL A 188
TYR A 195
VAL A 105
HIS A 230
 None
 1.35A 4ffwB-4tvvA:
undetectable		 4ffwB-4tvvA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA302_0
(THAUMATIN-1)		 4tvv TYROSINE PHOSPHATASE
II SUPERFAMILY
PROTEIN
(Legionella
pneumophila) 		3 / 3 ARG A 237
GLN A 110
GLU A 111
 PO4  A 402 (-3.8A)
None
None
 0.89A 4tvtA-4tvvA:
undetectable		 4tvtA-4tvvA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4tvv TYROSINE PHOSPHATASE
II SUPERFAMILY
PROTEIN
(Legionella
pneumophila) 		4 / 7 VAL A 188
TRP A  85
ILE A  88
LEU A 108
 None
 1.07A 4xo7B-4tvvA:
undetectable		 4xo7B-4tvvA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_E_SAME501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 4tvv TYROSINE PHOSPHATASE
II SUPERFAMILY
PROTEIN
(Legionella
pneumophila) 		5 / 9 HIS A 230
GLY A 233
SER A  75
VAL A 241
ARG A 289
 None
PO4  A 402 (-3.4A)
None
None
PO4  A 401 (-3.5A)
 1.42A 5o96E-4tvvA:
1.6
5o96F-4tvvA:
undetectable		 5o96E-4tvvA:
20.25
5o96F-4tvvA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B1E_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 4tvv TYROSINE PHOSPHATASE
II SUPERFAMILY
PROTEIN
(Legionella
pneumophila) 		5 / 12 TYR A 115
VAL A 188
TYR A 195
VAL A 105
HIS A 230
 None
 1.40A 6b1eB-4tvvA:
undetectable		 6b1eB-4tvvA:
18.07