SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tw0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_B_DVAB6_0
(GRAMICIDIN A)		 4tw0 SCAVENGER RECEPTOR
CLASS B MEMBER 2
(Homo
sapiens) 		4 / 4 VAL A 140
TRP A 146
ALA A 333
VAL A 143
 None
 1.33A 1gmkA-4tw0A:
undetectable
1gmkB-4tw0A:
undetectable		 1gmkA-4tw0A:
7.48
1gmkB-4tw0A:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 4tw0 SCAVENGER RECEPTOR
CLASS B MEMBER 2
(Homo
sapiens) 		5 / 12 THR A 135
LEU A 167
ILE A 401
LEU A 176
TYR A 180
 None
 1.26A 3gwxB-4tw0A:
undetectable		 3gwxB-4tw0A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 4tw0 SCAVENGER RECEPTOR
CLASS B MEMBER 2
(Homo
sapiens) 		5 / 12 LEU A 324
PHE A  67
PHE A 273
ILE A 301
ALA A 303
 None
 1.00A 3nxuA-4tw0A:
undetectable		 3nxuA-4tw0A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_1
(CYTOCHROME P450 3A4)		 4tw0 SCAVENGER RECEPTOR
CLASS B MEMBER 2
(Homo
sapiens) 		5 / 12 LEU A 324
PHE A  67
PHE A 273
ILE A 301
ALA A 303
 None
 0.96A 3nxuB-4tw0A:
undetectable		 3nxuB-4tw0A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HV1_A_RFPA902_1
(PHOSPHOENOLPYRUVATE
SYNTHASE)		 4tw0 SCAVENGER RECEPTOR
CLASS B MEMBER 2
(Homo
sapiens) 		5 / 12 VAL A 389
PRO A 139
LEU A  76
LEU A 201
ILE A 133
 None
 1.15A 5hv1A-4tw0A:
undetectable		 5hv1A-4tw0A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4tw0 SCAVENGER RECEPTOR
CLASS B MEMBER 2
(Homo
sapiens) 		4 / 6 VAL A 173
VAL A 408
ILE A  75
PHE A 168
 None
 1.04A 5jw1B-4tw0A:
undetectable		 5jw1B-4tw0A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_A_ACTA402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4tw0 SCAVENGER RECEPTOR
CLASS B MEMBER 2
(Homo
sapiens) 		3 / 3 HIS A 189
SER A 186
LYS A 181
 None
 1.15A 5os7A-4tw0A:
undetectable		 5os7A-4tw0A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4tw0 SCAVENGER RECEPTOR
CLASS B MEMBER 2
(Homo
sapiens) 		3 / 3 GLY A  78
VAL A 389
MET A 404
 None
 0.60A 5ycpA-4tw0A:
undetectable		 5ycpA-4tw0A:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_B_ACTB402_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 4tw0 SCAVENGER RECEPTOR
CLASS B MEMBER 2
(Homo
sapiens) 		3 / 3 HIS A 189
SER A 186
LYS A 181
 None
 1.15A 6gmdB-4tw0A:
undetectable		 6gmdB-4tw0A:
21.72