SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tw5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		 4tw5 EPS1P
(Saccharomyces
cerevisiae) 		3 / 3 GLU A  80
ILE A 134
ARG A 139
 None
 0.83A 1cd2A-4tw5A:
undetectable		 1cd2A-4tw5A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4tw5 EPS1P
(Saccharomyces
cerevisiae) 		4 / 6 TYR A 277
TYR A 284
GLN A 216
ILE A 213
 None
 1.21A 2pgzD-4tw5A:
undetectable
2pgzE-4tw5A:
undetectable		 2pgzD-4tw5A:
20.75
2pgzE-4tw5A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4tw5 EPS1P
(Saccharomyces
cerevisiae) 		4 / 7 TRP A  70
PHE A  88
GLU A  72
ARG A 138
 None
 1.02A 4jseA-4tw5A:
undetectable
4jseB-4tw5A:
undetectable		 4jseA-4tw5A:
21.46
4jseB-4tw5A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 4tw5 EPS1P
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 179
VAL A 227
GLN A 159
GLU A 157
 None
 1.14A 5tudA-4tw5A:
undetectable		 5tudA-4tw5A:
20.66