SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4twb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_2
(ADENOSINE DEAMINASE)		 4twb RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Sulfolobus
solfataricus) 		4 / 4 HIS A 246
LEU A 132
LEU A 110
LEU A  67
 None
 1.26A 1a4lD-4twbA:
undetectable		 1a4lD-4twbA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 4twb RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Sulfolobus
solfataricus) 		5 / 12 LEU A 248
LEU A 249
HIS A 143
TYR A  88
ILE A 271
 None
 1.41A 1fmlA-4twbA:
undetectable		 1fmlA-4twbA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4twb RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Sulfolobus
solfataricus) 		4 / 6 ILE A  85
SER A 284
ASN A 269
THR A 268
 None
 1.15A 1h7xA-4twbA:
2.5		 1h7xA-4twbA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4twb RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Sulfolobus
solfataricus) 		4 / 6 ILE A  85
SER A 284
ASN A 269
THR A 268
 None
 1.16A 1h7xB-4twbA:
4.1		 1h7xB-4twbA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4twb RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Sulfolobus
solfataricus) 		4 / 6 ILE A  85
SER A 284
ASN A 269
THR A 268
 None
 1.16A 1h7xC-4twbA:
undetectable		 1h7xC-4twbA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 4twb RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Sulfolobus
solfataricus) 		4 / 6 ILE A  85
SER A 284
ASN A 269
THR A 268
 None
 1.16A 1h7xD-4twbA:
undetectable		 1h7xD-4twbA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_1
(HIV-II PROTEASE)		 4twb RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Sulfolobus
solfataricus) 		5 / 12 ASP A 165
GLY A 167
ALA A 168
ILE A 214
ILE A 218
 None
 0.96A 1hshC-4twbA:
undetectable		 1hshC-4twbA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 4twb RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Sulfolobus
solfataricus) 		5 / 12 ALA A 163
ILE A 214
GLU A 154
PRO A 159
ALA A 181
 None
 1.32A 1vq1A-4twbA:
3.3		 1vq1A-4twbA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 4twb RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Sulfolobus
solfataricus) 		4 / 5 PRO A  87
VAL A 124
VAL A 283
ILE A 287
 None
 0.97A 1z2bC-4twbA:
4.9		 1z2bC-4twbA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_2
(GAG-POL POLYPROTEIN)		 4twb RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Sulfolobus
solfataricus) 		5 / 11 ASP A 165
GLY A 167
ALA A 168
ILE A 214
ILE A 218
 None
 0.97A 2b60B-4twbA:
undetectable		 2b60B-4twbA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_2
(PROTEASE)		 4twb RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Sulfolobus
solfataricus) 		5 / 12 ASP A 165
GLY A 167
ALA A 168
ILE A 215
ILE A 218
 None
 0.96A 2o4sB-4twbA:
undetectable		 2o4sB-4twbA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAN_A_SVRA158_1
(UNCHARACTERIZED
PROTEIN AT3G22680)		 4twb RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Sulfolobus
solfataricus) 		5 / 11 ARG A  40
VAL A 116
TYR A  38
ILE A  39
ILE A   4
 None
 1.35A 3ganA-4twbA:
undetectable		 3ganA-4twbA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_1
(PROTEASE)		 4twb RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Sulfolobus
solfataricus) 		5 / 10 ASP A 217
ILE A 245
GLY A 267
ILE A 279
ILE A 215
 None
 1.02A 3nujA-4twbA:
undetectable		 3nujA-4twbA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_1
(PROTEASE)		 4twb RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Sulfolobus
solfataricus) 		5 / 9 ASP A 217
ILE A 245
GLY A 267
ILE A 279
ILE A 215
 None
 1.02A 3nuoA-4twbA:
undetectable		 3nuoA-4twbA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 4twb RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Sulfolobus
solfataricus) 		4 / 8 ASP A 216
ASP A 165
GLY A 167
GLN A 227
 None
 0.98A 3s3mA-4twbA:
undetectable		 3s3mA-4twbA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 4twb RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Sulfolobus
solfataricus) 		4 / 8 ASP A 216
ASP A 165
GLY A 167
GLN A 227
 None
 0.94A 3s3nA-4twbA:
undetectable		 3s3nA-4twbA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQF_B_017B101_1
(ASPARTYL PROTEASE)		 4twb RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Sulfolobus
solfataricus) 		5 / 12 ASP A 217
ILE A 245
GLY A 267
ILE A 279
ILE A 215
 None
 0.94A 4dqfA-4twbA:
undetectable		 4dqfA-4twbA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 4twb RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Sulfolobus
solfataricus) 		5 / 12 THR A  56
PRO A  87
ILE A 245
VAL A 283
ILE A 287
 None
 1.25A 4eb6B-4twbA:
3.6
4eb6C-4twbA:
undetectable		 4eb6B-4twbA:
20.05
4eb6C-4twbA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMU_C_RFPC1401_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 4twb RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Sulfolobus
solfataricus) 		5 / 12 GLN A  60
ASP A  95
SER A 220
LEU A 248
ILE A 218
 None
None
SO4  A 302 (-4.0A)
None
None
 1.41A 4kmuC-4twbA:
undetectable		 4kmuC-4twbA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMU_H_RFPH1401_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 4twb RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Sulfolobus
solfataricus) 		5 / 12 GLN A  60
ASP A  95
SER A 220
LEU A 248
ILE A 218
 None
None
SO4  A 302 (-4.0A)
None
None
 1.27A 4kmuH-4twbA:
undetectable		 4kmuH-4twbA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4twb RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Sulfolobus
solfataricus) 		4 / 4 LEU A  52
ILE A  85
GLY A   6
ILE A  12
 None
 0.84A 5dzk3-4twbA:
undetectable
5dzkm-4twbA:
undetectable		 5dzk3-4twbA:
0.69
5dzkm-4twbA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 4twb RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Sulfolobus
solfataricus) 		4 / 5 ILE A  85
GLY A   6
ILE A  12
LEU A  52
 None
 0.89A 5dzki-4twbA:
2.1
5dzkj-4twbA:
1.8
5dzkx-4twbA:
undetectable		 5dzki-4twbA:
22.87
5dzkj-4twbA:
22.87
5dzkx-4twbA:
0.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)		 4twb RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Sulfolobus
solfataricus) 		5 / 9 ASP A 217
ILE A 245
GLY A 267
ILE A 279
ILE A 215
 None
 1.00A 5kr0A-4twbA:
undetectable		 5kr0A-4twbA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_1
(PROTEASE PR5-DRV)		 4twb RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Sulfolobus
solfataricus) 		5 / 10 ASP A 217
ILE A 245
GLY A 267
ILE A 279
ILE A 215
 None
 0.99A 5kr1A-4twbA:
undetectable		 5kr1A-4twbA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 4twb RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Sulfolobus
solfataricus) 		4 / 9 ILE A 219
VAL A 262
THR A 229
ILE A 214
 SO4  A 302 ( 4.9A)
None
None
None
 1.06A 5lg3I-4twbA:
undetectable		 5lg3I-4twbA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4twb RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Sulfolobus
solfataricus) 		5 / 12 ARG A 230
GLY A 261
LEU A 247
GLY A 222
ILE A 225
 None
None
None
SO4  A 302 (-3.7A)
None
 1.20A 5vooE-4twbA:
2.9		 5vooE-4twbA:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)		 4twb RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Sulfolobus
solfataricus) 		5 / 12 ARG A 258
GLY A 252
ALA A 253
LEU A 247
LEU A 265
 None
 1.38A 5x23A-4twbA:
undetectable		 5x23A-4twbA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 4twb RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE
(Sulfolobus
solfataricus) 		4 / 8 ASP A 170
ARG A 171
GLU A 125
ASP A 217
 None
 1.17A 6mn4D-4twbA:
undetectable		 6mn4D-4twbA:
24.20