SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4twe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN
(Homo
sapiens) 		5 / 12 LEU A  45
LEU A  40
SER A 580
VAL A  48
LEU A 393
 None
 1.38A 1ie9A-4tweA:
undetectable		 1ie9A-4tweA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4G_B_RIOB501_0
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN
(Homo
sapiens) 		5 / 9 ASP A 512
GLY A 254
SER A 346
ASP A  76
ASP A 370
 None
 1.38A 1m4gB-4tweA:
undetectable		 1m4gB-4tweA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_A_ADNA1501_1
(CLASS B ACID
PHOSPHATASE)		 4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN
(Homo
sapiens) 		5 / 10 ASP A 555
PHE A 551
GLY A 561
ARG A  58
THR A 550
 None
 1.31A 1rmtA-4tweA:
undetectable		 1rmtA-4tweA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_1
(HEMK PROTEIN)		 4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN
(Homo
sapiens) 		3 / 3 ASP A 255
PHE A 418
ASN A 345
 None
None
NAG  A 808 (-1.8A)
 0.80A 1sg9B-4tweA:
2.2		 1sg9B-4tweA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WU8_C_ADNC502_1
(HYPOTHETICAL PROTEIN
PH0463)		 4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN
(Homo
sapiens) 		4 / 7 PHE A 108
TYR A 150
ASN A 115
ARG A 340
 GOL  A 815 ( 3.7A)
None
None
GOL  A 815 (-3.9A)
 1.39A 1wu8A-4tweA:
undetectable
1wu8C-4tweA:
1.6		 1wu8A-4tweA:
17.62
1wu8C-4tweA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B8J_B_ADNB331_1
(CLASS B ACID
PHOSPHATASE)		 4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN
(Homo
sapiens) 		5 / 10 ASP A 555
PHE A 551
GLY A 561
ARG A  58
THR A 550
 None
 1.30A 2b8jB-4tweA:
undetectable		 2b8jB-4tweA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C12_B_SPMB1433_1
(NITROALKANE OXIDASE)		 4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN
(Homo
sapiens) 		5 / 11 VAL A 575
ALA A 469
SER A 464
VAL A 462
MET A 525
 None
 1.38A 2c12B-4tweA:
1.2		 2c12B-4tweA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)		 4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN
(Homo
sapiens) 		4 / 7 ARG A 570
LEU A  52
PRO A 404
TRP A 402
 None
 1.27A 2hrcA-4tweA:
1.1		 2hrcA-4tweA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN
(Homo
sapiens) 		4 / 6 THR A 530
ASP A 526
ASN A 443
ASP A 512
 None
 1.26A 2okcA-4tweA:
undetectable		 2okcA-4tweA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEI_A_CXXA802_1
(TRANSPORTER)		 4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN
(Homo
sapiens) 		4 / 6 SER A 523
ARG A 664
PHE A 666
PHE A 628
 None
 1.15A 2qeiA-4tweA:
undetectable		 2qeiA-4tweA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_C_BEZC1222_0
(PEROXIREDOXIN 6)		 4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN
(Homo
sapiens) 		4 / 8 PRO A 262
PRO A 265
SER A 267
GLU A 429
 None
 0.94A 2v32C-4tweA:
undetectable
2v32D-4tweA:
undetectable		 2v32C-4tweA:
15.97
2v32D-4tweA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_C_BEZC1218_0
(PEROXIREDOXIN 6.)		 4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN
(Homo
sapiens) 		4 / 8 PRO A 262
PRO A 265
SER A 267
GLU A 429
 None
 0.95A 2v41C-4tweA:
undetectable
2v41D-4tweA:
undetectable		 2v41C-4tweA:
15.97
2v41D-4tweA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_H_BEZH1222_0
(PEROXIREDOXIN 6.)		 4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN
(Homo
sapiens) 		4 / 8 PRO A 262
PRO A 265
SER A 267
GLU A 429
 None
 1.00A 2v41G-4tweA:
undetectable
2v41H-4tweA:
undetectable		 2v41G-4tweA:
15.97
2v41H-4tweA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN
(Homo
sapiens) 		4 / 5 ILE A 483
SER A 475
PRO A 476
PRO A 478
 None
 1.18A 3bjwC-4tweA:
0.5		 3bjwC-4tweA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN
(Homo
sapiens) 		5 / 9 LEU A 294
SER A 129
ILE A 286
ILE A 281
GLY A 157
 None
 1.20A 3cv9A-4tweA:
undetectable		 3cv9A-4tweA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D2T_B_1FLB500_1
(TRANSTHYRETIN)		 4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN
(Homo
sapiens) 		4 / 6 ALA A 602
LEU A 600
THR A 692
VAL A 690
 None
 0.98A 3d2tB-4tweA:
undetectable		 3d2tB-4tweA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_C_ACTC800_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN
(Homo
sapiens) 		3 / 3 ASP A 173
ARG A 168
ALA A 170
 None
 0.79A 3mbgC-4tweA:
1.5		 3mbgC-4tweA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_A_STIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN
(Homo
sapiens) 		4 / 6 VAL A 409
VAL A 439
ILE A 576
ARG A 354
 None
 1.12A 3ms9A-4tweA:
undetectable		 3ms9A-4tweA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN
(Homo
sapiens) 		4 / 7 VAL A 409
VAL A 439
ILE A 576
ARG A 354
 None
 1.11A 3ms9B-4tweA:
undetectable		 3ms9B-4tweA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_B_T44B128_1
(TRANSTHYRETIN)		 4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN
(Homo
sapiens) 		4 / 7 ALA A 602
LEU A 600
THR A 692
VAL A 690
 None
 0.88A 3ozkB-4tweA:
undetectable		 3ozkB-4tweA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN
(Homo
sapiens) 		4 / 7 PHE A 693
PHE A 666
ALA A 726
LEU A 621
 None
 0.83A 4ejgA-4tweA:
undetectable		 4ejgA-4tweA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN
(Homo
sapiens) 		4 / 8 PHE A 693
PHE A 666
ALA A 726
LEU A 621
 None
 0.90A 4ejgB-4tweA:
undetectable		 4ejgB-4tweA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_A_ECNA403_1
(FLAVOHEMOGLOBIN)		 4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN
(Homo
sapiens) 		5 / 12 ALA A 567
THR A 571
LEU A 389
TYR A 365
ILE A 442
 None
 1.11A 4g1bA-4tweA:
2.1		 4g1bA-4tweA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_A_ECNA403_1
(FLAVOHEMOGLOBIN)		 4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN
(Homo
sapiens) 		5 / 12 THR A 571
VAL A 385
LEU A 389
TYR A 365
ILE A 442
 None
 0.99A 4g1bA-4tweA:
2.1		 4g1bA-4tweA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_A_198A601_1
(SERUM ALBUMIN)		 4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN
(Homo
sapiens) 		5 / 10 PRO A 461
ALA A 632
PHE A 628
GLU A 594
LEU A 682
 None
 1.48A 4la0A-4tweA:
undetectable		 4la0A-4tweA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_B_198B601_1
(SERUM ALBUMIN)		 4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN
(Homo
sapiens) 		5 / 9 PRO A 461
ALA A 632
PHE A 628
GLU A 594
LEU A 682
 None
 1.45A 4la0B-4tweA:
undetectable		 4la0B-4tweA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN
(Homo
sapiens) 		4 / 7 VAL A 448
ARG A  58
ILE A  57
ALA A  54
 None
 0.74A 4lv9B-4tweA:
undetectable		 4lv9B-4tweA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN
(Homo
sapiens) 		5 / 11 HIS A 368
ASP A 378
GLU A 416
GLU A 417
HIS A 545
 ZN  A 802 (-3.2A)
ZN  A 802 ( 2.5A)
ZN  A 802 ( 3.9A)
ZN  A 801 (-1.8A)
ZN  A 801 (-3.2A)
 0.34A 4pqaA-4tweA:
18.9		 4pqaA-4tweA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_C_377C401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN
(Homo
sapiens) 		4 / 6 GLU A 663
TYR A 592
LEU A 596
PHE A 666
 None
 1.28A 4twdB-4tweA:
undetectable
4twdC-4tweA:
undetectable		 4twdB-4tweA:
16.85
4twdC-4tweA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_E_377E401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN
(Homo
sapiens) 		4 / 6 GLU A 663
TYR A 592
LEU A 596
PHE A 666
 None
 1.26A 4twdD-4tweA:
undetectable
4twdE-4tweA:
undetectable		 4twdD-4tweA:
16.85
4twdE-4tweA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN
(Homo
sapiens) 		4 / 6 GLU A 663
TYR A 592
LEU A 596
PHE A 666
 None
 1.32A 4twdF-4tweA:
0.9
4twdG-4tweA:
undetectable		 4twdF-4tweA:
16.85
4twdG-4tweA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN
(Homo
sapiens) 		4 / 6 GLU A 663
TYR A 592
LEU A 596
PHE A 666
 None
 1.26A 4twdI-4tweA:
undetectable
4twdJ-4tweA:
undetectable		 4twdI-4tweA:
16.85
4twdJ-4tweA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_C_EF2C151_1
(CEREBLON ISOFORM 4)		 4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN
(Homo
sapiens) 		4 / 7 ASN A 235
PRO A 234
PHE A 233
PHE A 288
 None
 1.38A 4v32C-4tweA:
undetectable		 4v32C-4tweA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN
(Homo
sapiens) 		3 / 3 ASP A 224
ARG A 168
ARG A 539
 None
 0.88A 4x5iA-4tweA:
undetectable		 4x5iA-4tweA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJQ_A_ERYA1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN
(Homo
sapiens) 		5 / 11 SER A 511
GLU A 425
ASP A 370
GLU A 417
GLY A 414
 None
CA  A 803 (-2.2A)
None
ZN  A 801 (-1.8A)
None
 1.46A 4zjqA-4tweA:
0.5		 4zjqA-4tweA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)		 4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN
(Homo
sapiens) 		4 / 6 ALA A  71
SER A 346
SER A 412
PRO A 379
 None
None
None
ZN  A 802 ( 4.7A)
 1.08A 5c6pA-4tweA:
undetectable		 5c6pA-4tweA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_O_EVPO2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN
(Homo
sapiens) 		4 / 6 SER A 412
GLY A 254
ASP A 255
GLY A 419
 None
 0.82A 5cdnC-4tweA:
undetectable
5cdnD-4tweA:
undetectable		 5cdnC-4tweA:
21.83
5cdnD-4tweA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_1
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN
(Homo
sapiens) 		4 / 7 SER A 227
PHE A 288
HIS A 131
TYR A 315
 None
 1.42A 5dlvB-4tweA:
undetectable		 5dlvB-4tweA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_1
(DIHYDROFOLATE
REDUCTASE)		 4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN
(Homo
sapiens) 		3 / 3 ASP A 224
ARG A 168
ARG A 539
 None
 0.94A 5eajB-4tweA:
undetectable		 5eajB-4tweA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN
(Homo
sapiens) 		5 / 12 ASP A  76
ALA A  71
THR A 427
SER A 346
TYR A 102
 None
 1.31A 5hfjF-4tweA:
undetectable		 5hfjF-4tweA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NR3_A_95EA401_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3B)		 4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN
(Homo
sapiens) 		4 / 7 ILE A 540
PHE A 449
ASP A 445
SER A 381
 None
None
ZN  A 802 (-2.0A)
None
 1.44A 5nr3A-4tweA:
undetectable		 5nr3A-4tweA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA306_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN
(Homo
sapiens) 		4 / 7 ARG A 664
PHE A 666
LEU A 682
SER A 593
 None
 1.26A 5uxcA-4tweA:
2.5		 5uxcA-4tweA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN
(Homo
sapiens) 		5 / 10 LEU A 662
ALA A 632
PRO A 460
PHE A 693
VAL A 625
 None
 1.47A 6b89B-4tweA:
undetectable		 6b89B-4tweA:
7.86