SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4twg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4twg MOLYBDOPTERIN
BIOSYNTHESIS MOG
PROTEIN
(Mycobacterium
ulcerans) 		5 / 12 ILE A  10
CYH A 118
ALA A 150
LEU A 143
ILE A  67
 None
 1.33A 2xkwB-4twgA:
undetectable		 2xkwB-4twgA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_1
(HIV-1 PROTEASE)		 4twg MOLYBDOPTERIN
BIOSYNTHESIS MOG
PROTEIN
(Mycobacterium
ulcerans) 		5 / 12 GLY A 116
ASP A  98
GLY A 119
ILE A 126
ILE A 100
 None
 0.96A 3d1zA-4twgA:
undetectable		 3d1zA-4twgA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU3_B_478B401_1
(PROTEASE)		 4twg MOLYBDOPTERIN
BIOSYNTHESIS MOG
PROTEIN
(Mycobacterium
ulcerans) 		5 / 12 GLY A 116
ASP A  98
GLY A 119
ILE A 126
ILE A 100
 None
 0.89A 3nu3A-4twgA:
undetectable		 3nu3A-4twgA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_2
(HIV-1 PROTEASE)		 4twg MOLYBDOPTERIN
BIOSYNTHESIS MOG
PROTEIN
(Mycobacterium
ulcerans) 		5 / 12 GLY A 116
ASP A  98
GLY A 119
ILE A 126
ILE A 100
 None
 0.92A 4jecB-4twgA:
undetectable		 4jecB-4twgA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_B_VDYB201_1
(CDL2.2)		 4twg MOLYBDOPTERIN
BIOSYNTHESIS MOG
PROTEIN
(Mycobacterium
ulcerans) 		6 / 10 ILE A  29
VAL A  52
ILE A  67
LEU A  56
PRO A  51
LEU A 143
 None
 1.40A 5ienB-4twgA:
undetectable		 5ienB-4twgA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_1
(PROTEASE)		 4twg MOLYBDOPTERIN
BIOSYNTHESIS MOG
PROTEIN
(Mycobacterium
ulcerans) 		5 / 12 GLY A 116
ASP A  98
GLY A 119
ILE A 126
ILE A 100
 None
 0.97A 6dh3B-4twgA:
undetectable		 6dh3B-4twgA:
19.62