SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4twi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1
(Archaeoglobus
fulgidus) 		5 / 12 ALA A 221
THR A   8
ILE A   9
LEU A 236
THR A 218
 None
 1.14A 1ddsA-4twiA:
undetectable		 1ddsA-4twiA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1
(Archaeoglobus
fulgidus) 		5 / 12 ALA A 221
THR A   8
ILE A   9
LEU A 236
THR A 218
 None
 1.12A 1dyiA-4twiA:
undetectable		 1dyiA-4twiA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYI_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1
(Archaeoglobus
fulgidus) 		5 / 12 ALA A 221
THR A   8
ILE A   9
LEU A 236
THR A 218
 None
 1.05A 1dyiB-4twiA:
undetectable		 1dyiB-4twiA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1
(Archaeoglobus
fulgidus) 		5 / 12 ALA A 221
THR A   8
ILE A   9
LEU A 236
THR A 218
 None
 1.00A 1qzfA-4twiA:
undetectable		 1qzfA-4twiA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1
(Archaeoglobus
fulgidus) 		5 / 12 ALA A 221
THR A   8
ILE A   9
LEU A 236
THR A 218
 None
 1.01A 1qzfB-4twiA:
2.0		 1qzfB-4twiA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1
(Archaeoglobus
fulgidus) 		5 / 12 ALA A 221
THR A   8
ILE A   9
LEU A 236
THR A 218
 None
 1.01A 1qzfC-4twiA:
2.0		 1qzfC-4twiA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1
(Archaeoglobus
fulgidus) 		5 / 12 ALA A 221
THR A   8
ILE A   9
LEU A 236
THR A 218
 None
 1.01A 1qzfD-4twiA:
undetectable		 1qzfD-4twiA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1
(Archaeoglobus
fulgidus) 		5 / 12 ALA A 221
THR A   8
ILE A   9
LEU A 236
THR A 218
 None
 1.01A 1qzfE-4twiA:
undetectable		 1qzfE-4twiA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1
(Archaeoglobus
fulgidus) 		5 / 12 ALA A 221
THR A   8
ILE A   9
LEU A 236
THR A 218
 None
 0.98A 1rx7A-4twiA:
undetectable		 1rx7A-4twiA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1
(Archaeoglobus
fulgidus) 		5 / 11 THR A  19
GLU A 209
GLY A  22
ILE A 182
ALA A 229
 None
 0.99A 1x7pA-4twiA:
4.4
1x7pB-4twiA:
4.6		 1x7pA-4twiA:
23.92
1x7pB-4twiA:
23.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YC2_A_NCAA506_0
(NAD-DEPENDENT
DEACETYLASE 2)		 4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1
(Archaeoglobus
fulgidus) 		4 / 6 ALA A  21
SER A  24
ASN A  99
ASP A 101
 None
 0.15A 1yc2A-4twiA:
27.7		 1yc2A-4twiA:
47.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YC5_A_NCAA2001_0
(NAD-DEPENDENT
DEACETYLASE)		 4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1
(Archaeoglobus
fulgidus) 		5 / 7 ALA A  21
SER A  24
ILE A  29
ASN A  99
ASP A 101
 None
 0.49A 1yc5A-4twiA:
27.9		 1yc5A-4twiA:
40.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZEA_A_DHIA6_0
(MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
H CHAIN
MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
L CHAIN
SHORT SYNTHETIC
D-AMINO ACID PEPTIDE
D2)		 4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1
(Archaeoglobus
fulgidus) 		3 / 3 TRP A  61
ARG A 153
PHE A  53
 None
 1.40A 1zeaH-4twiA:
undetectable
1zeaL-4twiA:
undetectable		 1zeaH-4twiA:
20.54
1zeaL-4twiA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_C_ADNC903_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1
(Archaeoglobus
fulgidus) 		5 / 12 ILE A 182
THR A  97
ASN A  99
SER A  24
HIS A 104
 None
 1.17A 2gl0A-4twiA:
undetectable
2gl0C-4twiA:
undetectable		 2gl0A-4twiA:
22.18
2gl0C-4twiA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GL0_D_ADND904_1
(CONSERVED
HYPOTHETICAL PROTEIN)		 4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1
(Archaeoglobus
fulgidus) 		5 / 12 SER A  24
HIS A 104
ILE A 182
THR A  97
ASN A  99
 None
 1.19A 2gl0D-4twiA:
undetectable
2gl0E-4twiA:
undetectable		 2gl0D-4twiA:
22.18
2gl0E-4twiA:
22.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1
(Archaeoglobus
fulgidus) 		4 / 5 ALA A  21
ILE A  29
ASN A  99
ASP A 101
 None
 0.59A 2h4jA-4twiA:
27.2		 2h4jA-4twiA:
40.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1
(Archaeoglobus
fulgidus) 		5 / 12 ALA A  21
THR A  31
ALA A  48
TYR A  64
LEU A 163
 None
 1.03A 2nyrA-4twiA:
27.5		 2nyrA-4twiA:
39.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1
(Archaeoglobus
fulgidus) 		5 / 12 THR A  31
ALA A  48
TYR A  64
PHE A 159
LEU A 163
 None
 1.12A 2nyrA-4twiA:
27.5		 2nyrA-4twiA:
39.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NYR_B_SVRB401_3
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1
(Archaeoglobus
fulgidus) 		5 / 12 ARG A  67
HIS A 116
PHE A 159
GLY A 160
LEU A 168
 None
 1.05A 2nyrB-4twiA:
21.8		 2nyrB-4twiA:
39.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2NYR_B_SVRB401_3
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1
(Archaeoglobus
fulgidus) 		5 / 12 TYR A  64
ARG A  67
PHE A 159
GLY A 160
LEU A 168
 None
 0.78A 2nyrB-4twiA:
21.8		 2nyrB-4twiA:
39.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_A_TOPA1190_1
(DIHYDROFOLATE
REDUCTASE)		 4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1
(Archaeoglobus
fulgidus) 		5 / 11 ALA A 221
GLU A 209
THR A   8
ILE A   9
THR A 218
 None
 1.27A 2w3aA-4twiA:
undetectable		 2w3aA-4twiA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1
(Archaeoglobus
fulgidus) 		5 / 10 ALA A 221
THR A   8
ILE A   9
LEU A 236
THR A 218
 None
 1.17A 2w3aB-4twiA:
undetectable		 2w3aB-4twiA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1
(Archaeoglobus
fulgidus) 		4 / 5 PRO A 164
VAL A 167
THR A 186
GLY A  20
 None
 1.15A 3elzB-4twiA:
undetectable		 3elzB-4twiA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LBD_A_9CRA424_1
(RETINOIC ACID
RECEPTOR GAMMA)		 4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1
(Archaeoglobus
fulgidus) 		5 / 12 ALA A 171
LEU A  18
LEU A 196
ILE A 199
ILE A 113
 None
 1.43A 3lbdA-4twiA:
undetectable		 3lbdA-4twiA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MSS_D_STID1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1
(Archaeoglobus
fulgidus) 		4 / 6 VAL A 180
VAL A 232
VAL A 240
ILE A 182
 None
 0.89A 3mssD-4twiA:
undetectable		 3mssD-4twiA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1
(Archaeoglobus
fulgidus) 		5 / 12 ALA A 221
LEU A 225
THR A   8
ILE A   9
THR A 218
 None
 1.11A 3nrrA-4twiA:
undetectable		 3nrrA-4twiA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1
(Archaeoglobus
fulgidus) 		5 / 12 ALA A 221
LEU A 225
THR A   8
ILE A   9
THR A 218
 None
 1.13A 3nrrB-4twiA:
2.0		 3nrrB-4twiA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1
(Archaeoglobus
fulgidus) 		5 / 11 ALA A 221
THR A   8
ILE A   9
LEU A 236
THR A 218
 None
 1.06A 3tqbA-4twiA:
undetectable		 3tqbA-4twiA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1
(Archaeoglobus
fulgidus) 		4 / 4 ASN A  99
ALA A  21
GLY A  20
THR A 186
 None
 1.24A 4bboC-4twiA:
undetectable		 4bboC-4twiA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1
(Archaeoglobus
fulgidus) 		5 / 12 ALA A 221
THR A   8
ILE A   9
LEU A 236
THR A 218
 None
 1.11A 4ej1B-4twiA:
2.1		 4ej1B-4twiA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJL_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1
(Archaeoglobus
fulgidus) 		5 / 12 ALA A 221
THR A   8
ILE A   9
LEU A 236
THR A 218
 None
 0.98A 4kjlA-4twiA:
undetectable		 4kjlA-4twiA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		 4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1
(Archaeoglobus
fulgidus) 		5 / 12 LEU A  18
ALA A  79
ILE A 207
LEU A  15
GLY A 205
 None
 1.27A 4l9qA-4twiA:
undetectable		 4l9qA-4twiA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_2
(TUBULIN BETA-2B
CHAIN)		 4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1
(Archaeoglobus
fulgidus) 		5 / 12 LEU A  95
ALA A 184
ILE A 182
ALA A  17
ILE A 210
 None
 0.80A 4o2bD-4twiA:
3.8		 4o2bD-4twiA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1
(Archaeoglobus
fulgidus) 		5 / 12 ALA A 221
THR A   8
ILE A   9
LEU A 236
THR A 218
 None
 1.04A 4pstA-4twiA:
undetectable		 4pstA-4twiA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1
(Archaeoglobus
fulgidus) 		5 / 12 ALA A 221
THR A   8
ILE A   9
LEU A 236
THR A 218
 None
 1.01A 4pthA-4twiA:
undetectable		 4pthA-4twiA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1
(Archaeoglobus
fulgidus) 		5 / 12 ALA A 221
THR A   8
ILE A   9
LEU A 236
THR A 218
 None
 1.06A 4qleA-4twiA:
undetectable		 4qleA-4twiA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1
(Archaeoglobus
fulgidus) 		5 / 12 ALA A 221
THR A   8
ILE A   9
LEU A 236
THR A 218
 None
 1.10A 4qlgB-4twiA:
undetectable		 4qlgB-4twiA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1
(Archaeoglobus
fulgidus) 		5 / 12 ALA A 221
THR A   8
ILE A   9
LEU A 236
THR A 218
 None
 1.02A 4x5fA-4twiA:
undetectable		 4x5fA-4twiA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1
(Archaeoglobus
fulgidus) 		5 / 12 ALA A 221
THR A   8
ILE A   9
LEU A 236
THR A 218
 None
 1.04A 4x5fB-4twiA:
undetectable		 4x5fB-4twiA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1
(Archaeoglobus
fulgidus) 		5 / 12 ALA A 221
THR A   8
ILE A   9
LEU A 236
THR A 218
 None
 1.06A 4x5gA-4twiA:
undetectable		 4x5gA-4twiA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5H_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1
(Archaeoglobus
fulgidus) 		5 / 12 ALA A 221
THR A   8
ILE A   9
LEU A 236
THR A 218
 None
 1.08A 4x5hA-4twiA:
undetectable		 4x5hA-4twiA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDR_A_ADNA402_1
(FAD:PROTEIN FMN
TRANSFERASE)		 4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1
(Archaeoglobus
fulgidus) 		5 / 12 LEU A  95
VAL A 112
GLY A 108
ALA A 107
VAL A  23
 None
 0.84A 4xdrA-4twiA:
undetectable		 4xdrA-4twiA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1
(Archaeoglobus
fulgidus) 		5 / 12 ALA A 221
THR A   8
ILE A   9
LEU A 236
THR A 218
 None
 1.15A 5e8qB-4twiA:
2.3		 5e8qB-4twiA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1
(Archaeoglobus
fulgidus) 		5 / 12 LEU A  95
ALA A 184
ILE A 182
ALA A  17
ILE A 210
 None
 0.89A 5eypB-4twiA:
3.8		 5eypB-4twiA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1
(Archaeoglobus
fulgidus) 		5 / 9 LEU A  86
LEU A  92
ALA A  79
VAL A  23
ALA A  17
 None
 1.37A 5g44A-4twiA:
undetectable		 5g44A-4twiA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1
(Archaeoglobus
fulgidus) 		5 / 12 ALA A 221
THR A   8
ILE A   9
LEU A 236
THR A 218
 None
 1.11A 5ujxB-4twiA:
2.4		 5ujxB-4twiA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1
(Archaeoglobus
fulgidus) 		5 / 9 THR A  19
GLY A 185
ALA A 184
GLY A  22
GLU A  26
 None
 1.24A 5vw4A-4twiA:
undetectable		 5vw4A-4twiA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1
(Archaeoglobus
fulgidus) 		5 / 12 LEU A  95
ALA A 184
ILE A 182
ALA A  17
ILE A 210
 None
 0.99A 5xiwB-4twiA:
undetectable		 5xiwB-4twiA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 4twi NAD-DEPENDENT
PROTEIN DEACYLASE 1
(Archaeoglobus
fulgidus) 		5 / 12 LEU A  95
ALA A 184
ILE A 182
ALA A  17
ILE A 210
 None
 0.89A 5xiwD-4twiA:
3.9		 5xiwD-4twiA:
16.60