SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4twl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A27_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 12 SER A  35
GLY A 180
TYR A 178
VAL A 116
PHE A 182
GLU A 118
 None
None
None
ASC  A 303 (-4.2A)
None
None
 1.34A 1a27A-4twlA:
undetectable		 1a27A-4twlA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CIL_A_ETSA263_1
(CARBONIC ANHYDRASE
II)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 12 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.36A 1cilA-4twlA:
28.5		 1cilA-4twlA:
29.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DMY_B_AZMB900_1
(MURINE CARBONIC
ANHYDRASE V)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 12 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.40A 1dmyB-4twlA:
25.3		 1dmyB-4twlA:
30.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		4 / 5 HIS A  95
ALA A 222
SER A 100
HIS A 102
 ASC  A 303 (-2.7A)
None
None
None
 1.24A 1errA-4twlA:
undetectable
1errB-4twlA:
undetectable		 1errA-4twlA:
21.03
1errB-4twlA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_D_ESTD352_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		4 / 6 SER A  35
GLY A 180
TYR A 178
GLU A 118
 None
 0.90A 1fduD-4twlA:
undetectable		 1fduD-4twlA:
19.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1JD0_B_AZMB2401_1
(CARBONIC ANHYDRASE
XII)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 11 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.36A 1jd0B-4twlA:
27.4		 1jd0B-4twlA:
30.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_1
(CARBONIC ANHYDRASE
II)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 12 HIS A  97
VAL A 116
THR A 183
PRO A 186
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 (-3.4A)
None
ASC  A 303 (-4.3A)
 0.31A 1oq5A-4twlA:
28.8		 1oq5A-4twlA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 12 ALA A 113
ILE A 129
VAL A 202
ALA A 136
GLN A 169
 None
 1.24A 1udtA-4twlA:
undetectable		 1udtA-4twlA:
20.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YDB_A_AZMA264_1
(CARBONIC ANHYDRASE
II)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 11 HIS A  97
VAL A 116
VAL A 126
PHE A 182
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
None
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.33A 1ydbA-4twlA:
28.5		 1ydbA-4twlA:
30.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YNN_C_RFPC1120_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 12 GLN A 114
PHE A  96
ASP A  70
HIS A  97
SER A  35
 ASC  A 303 (-4.1A)
None
ASC  A 303 (-3.5A)
ASC  A 303 (-4.4A)
None
 1.35A 1ynnC-4twlA:
undetectable		 1ynnC-4twlA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9Y_A_FUNA500_1
(CARBONIC ANHYDRASE
II)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 12 HIS A  69
HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 None
ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.65A 1z9yA-4twlA:
28.6		 1z9yA-4twlA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGF_A_TRUA300_1
(CARBONIC ANHYDRASE
II)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 12 HIS A  69
HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 None
ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.59A 1zgfA-4twlA:
28.7		 1zgfA-4twlA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZSB_A_AZMA264_1
(CARBONIC ANHYDRASE
II)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 12 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.33A 1zsbA-4twlA:
28.6		 1zsbA-4twlA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AW1_A_COXA264_1
(CARBONIC ANHYDRASE
II)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 12 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.31A 2aw1A-4twlA:
28.6		 2aw1A-4twlA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GEH_A_NHYA300_1
(CARBONIC ANHYDRASE 2)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 8 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.30A 2gehA-4twlA:
28.6		 2gehA-4twlA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 12 PHE A  75
THR A 194
ALA A 125
ARG A 124
GLU A 118
 None
 1.11A 2j0dA-4twlA:
undetectable		 2j0dA-4twlA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 12 PHE A 182
THR A 194
ALA A 125
ARG A 124
GLU A 118
 None
 1.18A 2j0dA-4twlA:
undetectable		 2j0dA-4twlA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2POU_A_I7AA1000_1
(CARBONIC ANHYDRASE 2)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 12 HIS A  69
HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 None
ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.48A 2pouA-4twlA:
28.7		 2pouA-4twlA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BL1_A_BL1A300_1
(CARBONIC ANHYDRASE 2)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 12 HIS A  69
HIS A  97
VAL A 126
THR A 183
TRP A 193
 None
ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.57A 3bl1A-4twlA:
28.5		 3bl1A-4twlA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CAJ_A_EZLA265_1
(CARBONIC ANHYDRASE 2)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 10 HIS A  97
VAL A 116
THR A 183
PRO A 186
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 (-3.4A)
None
ASC  A 303 (-4.3A)
 0.28A 3cajA-4twlA:
28.6		 3cajA-4twlA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZV_A_AZMA263_1
(CARBONIC ANHYDRASE
13)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 12 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.34A 3czvA-4twlA:
28.4
3czvB-4twlA:
28.4		 3czvA-4twlA:
28.52
3czvB-4twlA:
28.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZV_B_AZMB263_1
(CARBONIC ANHYDRASE
13)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 10 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.33A 3czvB-4twlA:
28.4		 3czvB-4twlA:
28.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DC3_A_AZMA263_1
(CARBONIC ANHYDRASE 2)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 12 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.33A 3dc3A-4twlA:
28.6		 3dc3A-4twlA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCW_A_EZLA301_1
(CARBONIC ANHYDRASE 2)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 10 HIS A  97
VAL A 116
VAL A 126
THR A 183
PRO A 186
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
None
ASC  A 303 (-4.3A)
 0.32A 3dcwA-4twlA:
28.7		 3dcwA-4twlA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD0_A_EZLA301_1
(CARBONIC ANHYDRASE 2)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 10 HIS A  97
VAL A 116
VAL A 126
THR A 183
PRO A 186
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
None
ASC  A 303 (-4.3A)
 0.32A 3dd0A-4twlA:
28.5		 3dd0A-4twlA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F4X_A_KLTA300_1
(CARBONIC ANHYDRASE 2)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 12 HIS A  97
VAL A 116
VAL A 126
THR A 183
PRO A 186
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
None
ASC  A 303 (-4.3A)
 0.31A 3f4xA-4twlA:
28.4		 3f4xA-4twlA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW3_A_ETSA302_1
(CARBONIC ANHYDRASE 4)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 12 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.33A 3fw3A-4twlA:
27.0		 3fw3A-4twlA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW3_B_ETSB303_1
(CARBONIC ANHYDRASE 4)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 12 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.36A 3fw3B-4twlA:
26.8		 3fw3B-4twlA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS4_A_AZMA701_1
(CARBONIC ANHYDRASE 2)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 11 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.34A 3hs4A-4twlA:
28.9		 3hs4A-4twlA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAI_A_AZMA263_1
(CARBONIC ANHYDRASE 9)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 11 HIS A  97
GLU A 101
VAL A 116
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.36A 3iaiA-4twlA:
27.7		 3iaiA-4twlA:
28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAI_B_AZMB263_1
(CARBONIC ANHYDRASE 9)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 11 HIS A  97
GLU A 101
VAL A 116
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.35A 3iaiB-4twlA:
27.8		 3iaiB-4twlA:
28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAI_C_AZMC263_1
(CARBONIC ANHYDRASE 9)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 11 HIS A  97
GLU A 101
VAL A 116
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.31A 3iaiC-4twlA:
27.8		 3iaiC-4twlA:
28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAI_D_AZMD263_1
(CARBONIC ANHYDRASE 9)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 11 HIS A  97
GLU A 101
VAL A 116
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.33A 3iaiD-4twlA:
27.7		 3iaiD-4twlA:
28.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KWA_A_SPMA300_1
(CARBONIC ANHYDRASE 2)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 11 VAL A 116
VAL A 126
THR A 183
PRO A 186
TRP A 193
 ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
None
ASC  A 303 (-4.3A)
 0.34A 3kwaA-4twlA:
28.3		 3kwaA-4twlA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_A_TORA262_1
(CARBONIC ANHYDRASE 1)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 12 HIS A  69
HIS A  97
VAL A 126
THR A 183
TRP A 193
 None
ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.43A 3lxeA-4twlA:
28.1		 3lxeA-4twlA:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXE_B_TORB262_1
(CARBONIC ANHYDRASE 1)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 12 HIS A  69
HIS A  97
VAL A 126
THR A 183
TRP A 193
 None
ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.44A 3lxeB-4twlA:
28.2		 3lxeB-4twlA:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDZ_A_EZLA264_1
(CARBONIC ANHYDRASE 7)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 11 HIS A  97
GLU A 101
VAL A 116
THR A 183
PRO A 186
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 (-3.4A)
None
ASC  A 303 (-4.3A)
 0.31A 3mdzA-4twlA:
27.7		 3mdzA-4twlA:
28.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDZ_A_EZLA264_1
(CARBONIC ANHYDRASE 7)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 11 HIS A  97
GLU A 101
VAL A 126
THR A 183
PRO A 186
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
None
 0.92A 3mdzA-4twlA:
27.7		 3mdzA-4twlA:
28.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ML5_A_AZMA264_1
(CARBONIC ANHYDRASE 7)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 11 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.34A 3ml5A-4twlA:
28.2		 3ml5A-4twlA:
28.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		4 / 5 ARG A  55
LEU A  82
VAL A 127
ASP A 172
 None
 1.00A 3ufnA-4twlA:
undetectable
3ufnB-4twlA:
undetectable		 3ufnA-4twlA:
18.47
3ufnB-4twlA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V2J_A_AZMA302_1
(CARBONIC ANHYDRASE 2)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 11 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.36A 3v2jA-4twlA:
28.6		 3v2jA-4twlA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 12 ASN A 166
ILE A  94
LEU A  91
VAL A 163
ASP A 137
 None
 1.10A 3vaqB-4twlA:
undetectable		 3vaqB-4twlA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		3 / 3 ASP A 145
ARG A 205
LYS A 148
 None
 1.23A 3wipG-4twlA:
undetectable		 3wipG-4twlA:
22.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4COQ_A_SANA300_1
(CARBONATE
DEHYDRATASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 10 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.31A 4coqA-4twlA:
31.5		 4coqA-4twlA:
31.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4COQ_B_SANB300_1
(CARBONATE
DEHYDRATASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 9 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.33A 4coqB-4twlA:
31.3		 4coqB-4twlA:
31.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0C_A_AZMA302_1
(CARBONIC ANHYDRASE 2)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 11 HIS A  97
GLU A 101
VAL A 116
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.30A 4g0cA-4twlA:
28.5		 4g0cA-4twlA:
29.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G7A_A_AZMA302_1
(CARBONATE
DEHYDRATASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 11 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.31A 4g7aA-4twlA:
30.8		 4g7aA-4twlA:
34.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4G7A_B_AZMB302_1
(CARBONATE
DEHYDRATASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 11 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.34A 4g7aB-4twlA:
30.8		 4g7aB-4twlA:
34.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0S_A_AZMA302_1
(CARBONIC ANHYDRASE 2)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 11 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.34A 4k0sA-4twlA:
28.8		 4k0sA-4twlA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0Z_A_MZMA308_1
(CARBONIC ANHYDRASE 2)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 12 HIS A  97
VAL A 116
VAL A 126
THR A 183
PRO A 186
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
None
ASC  A 303 (-4.3A)
 0.31A 4k0zA-4twlA:
28.9		 4k0zA-4twlA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K13_A_ETSA304_1
(CARBONIC ANHYDRASE 2)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 12 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.33A 4k13A-4twlA:
28.9		 4k13A-4twlA:
29.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LU3_A_AZMA302_1
(CARBONIC ANHYDRASE
14)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 11 HIS A  97
GLU A 101
VAL A 116
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.34A 4lu3A-4twlA:
27.8		 4lu3A-4twlA:
30.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 12 HIS A  97
VAL A 116
VAL A 126
THR A 183
PRO A 186
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
None
ASC  A 303 (-4.3A)
 0.31A 4m2rA-4twlA:
28.6		 4m2rA-4twlA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_1
(CARBONIC ANHYDRASE 2)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 12 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.35A 4m2vA-4twlA:
28.6		 4m2vA-4twlA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2W_A_ETSA302_1
(CARBONIC ANHYDRASE 2)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 12 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.35A 4m2wA-4twlA:
28.6		 4m2wA-4twlA:
29.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWL_A_ASCA303_0
(DIOSCORIN 5)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		10 / 10 ASP A  70
HIS A  95
HIS A  97
GLN A 114
VAL A 116
VAL A 126
PHE A 182
THR A 183
ALA A 184
TRP A 193
 ASC  A 303 (-3.5A)
ASC  A 303 (-2.7A)
ASC  A 303 (-4.4A)
ASC  A 303 (-4.1A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
None
ASC  A 303 (-3.4A)
ASC  A 303 (-3.0A)
ASC  A 303 (-4.3A)
 0.00A 4twlA-4twlA:
45.1		 4twlA-4twlA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWL_B_ASCB304_0
(DIOSCORIN 5)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		10 / 10 ASP A  70
HIS A  95
HIS A  97
GLN A 114
VAL A 116
VAL A 126
PHE A 182
THR A 183
ALA A 184
TRP A 193
 ASC  A 303 (-3.5A)
ASC  A 303 (-2.7A)
ASC  A 303 (-4.4A)
ASC  A 303 (-4.1A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
None
ASC  A 303 (-3.4A)
ASC  A 303 (-3.0A)
ASC  A 303 (-4.3A)
 0.17A 4twlB-4twlA:
42.0		 4twlB-4twlA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4TWL_B_ASCB304_0
(DIOSCORIN 5)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 10 ASP A  70
HIS A  97
VAL A 116
PHE A 182
ALA A 184
 ASC  A 303 (-3.5A)
ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
None
ASC  A 303 (-3.0A)
 1.19A 4twlB-4twlA:
42.0		 4twlB-4twlA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UOV_A_AZMA299_1
(CARBONATE
DEHYDRATASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 11 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.34A 4uovA-4twlA:
31.1		 4uovA-4twlA:
31.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UOV_B_AZMB299_1
(CARBONATE
DEHYDRATASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 11 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.32A 4uovB-4twlA:
31.1		 4uovB-4twlA:
31.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UOV_C_AZMC299_1
(CARBONATE
DEHYDRATASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 11 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.35A 4uovC-4twlA:
31.1		 4uovC-4twlA:
31.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UOV_D_AZMD299_1
(CARBONATE
DEHYDRATASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 11 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.33A 4uovD-4twlA:
31.1		 4uovD-4twlA:
31.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UOV_E_AZME299_1
(CARBONATE
DEHYDRATASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 11 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.32A 4uovE-4twlA:
31.2		 4uovE-4twlA:
31.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UOV_F_AZMF299_1
(CARBONATE
DEHYDRATASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 11 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.32A 4uovF-4twlA:
31.3		 4uovF-4twlA:
31.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5S_A_AZMA302_1
(CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE))		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 11 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.35A 4x5sA-4twlA:
31.0		 4x5sA-4twlA:
39.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4X5S_B_AZMB302_1
(CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE))		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 11 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.36A 4x5sB-4twlA:
31.0		 4x5sB-4twlA:
39.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIW_A_AZMA402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 12 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.31A 4xiwA-4twlA:
26.1
4xiwH-4twlA:
25.9		 4xiwA-4twlA:
34.50
4xiwH-4twlA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIW_B_AZMB402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 12 HIS A  97
GLU A 101
VAL A 116
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.31A 4xiwB-4twlA:
26.1
4xiwE-4twlA:
26.0		 4xiwB-4twlA:
34.50
4xiwE-4twlA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIW_C_AZMC402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 11 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.37A 4xiwC-4twlA:
26.1		 4xiwC-4twlA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIW_D_AZMD402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 11 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.31A 4xiwD-4twlA:
26.3		 4xiwD-4twlA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIW_E_AZME402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 11 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.31A 4xiwE-4twlA:
26.0		 4xiwE-4twlA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIW_F_AZMF402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 11 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.29A 4xiwF-4twlA:
25.8		 4xiwF-4twlA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIW_G_AZMG402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 12 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.45A 4xiwG-4twlA:
25.9		 4xiwG-4twlA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4XIW_H_AZMH402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 11 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.34A 4xiwH-4twlA:
25.9		 4xiwH-4twlA:
34.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_A_AZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 11 HIS A  97
VAL A 116
VAL A 126
THR A 183
ALA A 184
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-3.0A)
ASC  A 303 (-4.3A)
 0.43A 4ygfA-4twlA:
28.7		 4ygfA-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_B_AZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 11 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.49A 4ygfB-4twlA:
28.1		 4ygfB-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_C_AZMC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 11 HIS A  97
VAL A 116
VAL A 126
THR A 183
ALA A 184
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-3.0A)
ASC  A 303 (-4.3A)
 0.37A 4ygfC-4twlA:
20.5		 4ygfC-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_D_AZMD303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		7 / 11 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
ALA A 184
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-3.0A)
ASC  A 303 (-4.3A)
 0.36A 4ygfD-4twlA:
4.5		 4ygfD-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_E_AZME303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 12 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.43A 4ygfE-4twlA:
29.0		 4ygfE-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_F_AZMF303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 9 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.30A 4ygfF-4twlA:
28.4		 4ygfF-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_G_AZMG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 12 HIS A  97
VAL A 116
VAL A 126
THR A 183
ALA A 184
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-3.0A)
ASC  A 303 (-4.3A)
 0.45A 4ygfG-4twlA:
28.7		 4ygfG-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_H_AZMH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 9 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.35A 4ygfH-4twlA:
28.6		 4ygfH-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 12 HIS A  97
VAL A 116
VAL A 126
THR A 183
ALA A 184
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-3.0A)
ASC  A 303 (-4.3A)
 0.43A 4yhaA-4twlA:
28.6		 4yhaA-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_B_MZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 10 HIS A  97
VAL A 116
VAL A 126
THR A 183
ALA A 184
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-3.0A)
 0.58A 4yhaB-4twlA:
27.6		 4yhaB-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_C_MZMC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 11 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.42A 4yhaC-4twlA:
29.1		 4yhaC-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_D_MZMD302_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 11 HIS A  97
GLU A 101
VAL A 116
THR A 183
ALA A 184
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 (-3.4A)
ASC  A 303 (-3.0A)
ASC  A 303 (-4.3A)
 0.41A 4yhaD-4twlA:
27.8		 4yhaD-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_E_MZME303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		7 / 12 HIS A  97
VAL A 116
VAL A 126
THR A 183
ALA A 184
PRO A 186
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-3.0A)
None
ASC  A 303 (-4.3A)
 0.44A 4yhaE-4twlA:
28.9		 4yhaE-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_E_MZME303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 12 HIS A  97
VAL A 126
THR A 183
ALA A 184
PRO A 186
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-3.0A)
None
 0.96A 4yhaE-4twlA:
28.9		 4yhaE-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_F_MZMF302_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 10 HIS A  97
VAL A 116
THR A 183
ALA A 184
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 (-3.4A)
ASC  A 303 (-3.0A)
ASC  A 303 (-4.3A)
 0.53A 4yhaF-4twlA:
26.1		 4yhaF-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_G_MZMG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 12 HIS A  97
VAL A 116
VAL A 126
THR A 183
ALA A 184
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-3.0A)
ASC  A 303 (-4.3A)
 0.43A 4yhaG-4twlA:
28.1		 4yhaG-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_H_MZMH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 10 HIS A  97
GLU A 101
VAL A 116
THR A 183
ALA A 184
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 (-3.4A)
ASC  A 303 (-3.0A)
ASC  A 303 (-4.3A)
 0.44A 4yhaH-4twlA:
28.6		 4yhaH-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8I_A_MZMA302_1
(CARBONIC ANHYDRASE 2)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		7 / 12 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
PRO A 186
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
None
ASC  A 303 (-4.3A)
 0.30A 5c8iA-4twlA:
28.6		 5c8iA-4twlA:
29.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JN8_A_AZMA701_1
(CARBONIC ANHYDRASE 4)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 10 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.37A 5jn8A-4twlA:
26.7		 5jn8A-4twlA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JN8_B_AZMB701_1
(CARBONIC ANHYDRASE 4)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 11 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.35A 5jn8B-4twlA:
26.7		 5jn8B-4twlA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JN8_D_AZMD701_1
(CARBONIC ANHYDRASE 4)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 10 HIS A  97
GLU A 101
VAL A 116
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.31A 5jn8D-4twlA:
26.5		 5jn8D-4twlA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JN9_A_EZLA302_1
(CARBONIC ANHYDRASE 4)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 10 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.35A 5jn9A-4twlA:
26.7		 5jn9A-4twlA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JN9_B_EZLB302_1
(CARBONIC ANHYDRASE 4)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 10 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.34A 5jn9B-4twlA:
26.9		 5jn9B-4twlA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JN9_D_EZLD302_1
(CARBONIC ANHYDRASE 4)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 10 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.35A 5jn9D-4twlA:
26.4		 5jn9D-4twlA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_A_TORA302_1
(CARBONIC ANHYDRASE 4)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 12 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
 0.32A 5jnaA-4twlA:
26.6		 5jnaA-4twlA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_B_TORB302_1
(CARBONIC ANHYDRASE 4)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 12 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.39A 5jnaB-4twlA:
26.7		 5jnaB-4twlA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNA_D_TORD302_1
(CARBONIC ANHYDRASE 4)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 12 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.39A 5jnaD-4twlA:
26.4		 5jnaD-4twlA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_A_6LHA302_0
(CARBONIC ANHYDRASE 4)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 11 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.36A 5jncA-4twlA:
26.7		 5jncA-4twlA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_B_6LHB302_0
(CARBONIC ANHYDRASE 4)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 10 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.35A 5jncB-4twlA:
26.8		 5jncB-4twlA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KU6_A_MZMA301_1
(CARBONIC ANHYDRASE 4)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 10 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.36A 5ku6A-4twlA:
26.7		 5ku6A-4twlA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KU6_B_MZMB302_1
(CARBONIC ANHYDRASE 4)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 10 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.36A 5ku6B-4twlA:
26.8		 5ku6B-4twlA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUJ_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		4 / 8 ALA A 136
PHE A  96
LEU A 111
ILE A 147
 None
 0.69A 5nujA-4twlA:
1.1		 5nujA-4twlA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUJ_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		4 / 8 VAL A 202
PHE A  96
LEU A 111
ILE A 147
 None
 0.86A 5nujA-4twlA:
1.1		 5nujA-4twlA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_A_EZLA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 10 HIS A  95
VAL A 116
THR A 183
ALA A 184
PRO A 186
 ASC  A 303 (-2.7A)
ASC  A 303 (-4.2A)
ASC  A 303 (-3.4A)
ASC  A 303 (-3.0A)
None
 0.92A 5tt3A-4twlA:
28.6		 5tt3A-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_A_EZLA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		7 / 10 HIS A  97
VAL A 116
VAL A 126
THR A 183
ALA A 184
PRO A 186
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-3.0A)
None
ASC  A 303 (-4.3A)
 0.37A 5tt3A-4twlA:
28.6		 5tt3A-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_B_EZLB303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 9 HIS A  95
HIS A  97
VAL A 116
THR A 183
ALA A 184
 ASC  A 303 (-2.7A)
ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 (-3.4A)
ASC  A 303 (-3.0A)
 0.89A 5tt3B-4twlA:
26.7		 5tt3B-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_B_EZLB303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 9 HIS A  97
VAL A 116
VAL A 126
THR A 183
ALA A 184
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-3.0A)
ASC  A 303 (-4.3A)
 0.54A 5tt3B-4twlA:
26.7		 5tt3B-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_C_EZLC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 10 HIS A  97
VAL A 116
THR A 183
ALA A 184
PRO A 186
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 (-3.4A)
ASC  A 303 (-3.0A)
None
 0.70A 5tt3C-4twlA:
28.9		 5tt3C-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_C_EZLC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		7 / 10 HIS A  97
VAL A 116
VAL A 126
THR A 183
ALA A 184
PRO A 186
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-3.0A)
None
ASC  A 303 (-4.3A)
 0.37A 5tt3C-4twlA:
28.9		 5tt3C-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_E_EZLE303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 9 HIS A  97
VAL A 116
VAL A 126
THR A 183
ALA A 184
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-3.0A)
ASC  A 303 (-4.3A)
 0.47A 5tt3E-4twlA:
28.8		 5tt3E-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_F_EZLF302_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 8 HIS A  97
VAL A 116
VAL A 126
THR A 183
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
 0.36A 5tt3F-4twlA:
27.9		 5tt3F-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_G_EZLG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 9 HIS A  97
VAL A 116
VAL A 126
THR A 183
ALA A 184
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-3.0A)
ASC  A 303 (-4.3A)
 0.44A 5tt3G-4twlA:
28.0		 5tt3G-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_H_EZLH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		5 / 8 HIS A  97
VAL A 116
THR A 183
ALA A 184
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 (-3.4A)
ASC  A 303 (-3.0A)
ASC  A 303 (-4.3A)
 0.42A 5tt3H-4twlA:
28.3		 5tt3H-4twlA:
29.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_I_PACI1_0
(SERINE PROTEASE NS3
SERINE PROTEASE
SUBUNIT NS2B
PEPTIDE
PAC-DLY-DLY-DAR)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		3 / 3 VAL A 195
TYR A 176
GLU A 112
 None
 0.90A 5zmqD-4twlA:
undetectable
5zmqE-4twlA:
undetectable		 5zmqD-4twlA:
19.76
5zmqE-4twlA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BCC_A_EZLA302_1
(CARBONIC ANHYDRASE 2)		 4twl DIOSCORIN 5
(Dioscorea
japonica) 		6 / 12 HIS A  97
VAL A 116
VAL A 126
THR A 183
PRO A 186
TRP A 193
 ASC  A 303 (-4.4A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
None
ASC  A 303 (-4.3A)
 0.32A 6bccA-4twlA:
28.6		 6bccA-4twlA:
16.67