SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4twr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 4twr NAD BINDING
SITE:NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E:UDP-GLUCOSE
4-EPIMERASE
(Brucella
abortus) 		5 / 9 VAL A 265
GLY A 269
ALA A 200
THR A 272
ILE A 268
 None
 1.28A 1gtnL-4twrA:
undetectable
1gtnM-4twrA:
undetectable		 1gtnL-4twrA:
12.20
1gtnM-4twrA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDN_A_LEUA487_0
(L-AMINO ACID OXIDASE)		 4twr NAD BINDING
SITE:NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E:UDP-GLUCOSE
4-EPIMERASE
(Brucella
abortus) 		4 / 7 ASN A  95
HIS A  74
PHE A 116
TYR A 143
 None
 1.34A 1tdnA-4twrA:
3.4		 1tdnA-4twrA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_E_SAME301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4twr NAD BINDING
SITE:NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E:UDP-GLUCOSE
4-EPIMERASE
(Brucella
abortus) 		3 / 3 SER A 309
ASP A 224
CYH A 120
 None
 1.04A 2br4E-4twrA:
5.2		 2br4E-4twrA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)		 4twr NAD BINDING
SITE:NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E:UDP-GLUCOSE
4-EPIMERASE
(Brucella
abortus) 		5 / 12 GLY A  10
GLY A  13
HIS A  18
THR A  19
THR A  38
 NAD  A 400 (-3.4A)
NAD  A 400 (-3.3A)
None
None
NAD  A 400 (-3.5A)
 1.09A 2gluA-4twrA:
6.1		 2gluA-4twrA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 4twr NAD BINDING
SITE:NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E:UDP-GLUCOSE
4-EPIMERASE
(Brucella
abortus) 		5 / 11 GLY A  97
SER A 101
THR A  99
HIS A  74
PHE A  75
 None
 1.38A 2hmaA-4twrA:
3.1		 2hmaA-4twrA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 4twr NAD BINDING
SITE:NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E:UDP-GLUCOSE
4-EPIMERASE
(Brucella
abortus) 		4 / 6 THR A  19
ASP A  34
ASN A  35
ASP A  53
 None
NAD  A 400 (-2.7A)
NAD  A 400 (-3.2A)
NAD  A 400 (-3.1A)
 0.97A 2okcA-4twrA:
4.9		 2okcA-4twrA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 4twr NAD BINDING
SITE:NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E:UDP-GLUCOSE
4-EPIMERASE
(Brucella
abortus) 		3 / 3 ARG A 233
ASN A 172
THR A 255
 None
 0.65A 2q63A-4twrA:
undetectable		 2q63A-4twrA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_D_SAMD603_0
(HYPOTHETICAL PROTEIN)		 4twr NAD BINDING
SITE:NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E:UDP-GLUCOSE
4-EPIMERASE
(Brucella
abortus) 		5 / 12 GLY A 134
GLY A 132
ALA A 296
LEU A 297
ALA A 136
 None
 1.19A 2yvlD-4twrA:
5.7		 2yvlD-4twrA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHT_A_SAMA200_0
(S-ADENOSYL-L-METHION
INE METHYL
TRANSFERASE)		 4twr NAD BINDING
SITE:NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E:UDP-GLUCOSE
4-EPIMERASE
(Brucella
abortus) 		5 / 12 GLY A  10
GLY A  13
THR A  19
ASP A  53
ILE A  54
 NAD  A 400 (-3.4A)
NAD  A 400 (-3.3A)
None
NAD  A 400 (-3.1A)
NAD  A 400 (-3.8A)
 0.94A 3ihtA-4twrA:
5.1		 3ihtA-4twrA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 4twr NAD BINDING
SITE:NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E:UDP-GLUCOSE
4-EPIMERASE
(Brucella
abortus) 		4 / 5 ILE A 115
ALA A  71
HIS A 241
ARG A 164
 None
 0.86A 4ac9B-4twrA:
6.7
4ac9C-4twrA:
7.5		 4ac9B-4twrA:
21.54
4ac9C-4twrA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4twr NAD BINDING
SITE:NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E:UDP-GLUCOSE
4-EPIMERASE
(Brucella
abortus) 		4 / 5 ILE A 115
ALA A  71
HIS A 241
ARG A 164
 None
 0.87A 4acaB-4twrA:
6.8
4acaC-4twrA:
7.4		 4acaB-4twrA:
21.54
4acaC-4twrA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4twr NAD BINDING
SITE:NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E:UDP-GLUCOSE
4-EPIMERASE
(Brucella
abortus) 		4 / 7 GLY A  98
THR A  99
ILE A  54
THR A  38
 None
None
NAD  A 400 (-3.8A)
NAD  A 400 (-3.5A)
 0.95A 4acaC-4twrA:
7.4		 4acaC-4twrA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_1
(MEMBRANE LIPOPROTEIN
TPN38(B))		 4twr NAD BINDING
SITE:NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E:UDP-GLUCOSE
4-EPIMERASE
(Brucella
abortus) 		5 / 12 SER A  17
ALA A  79
ILE A  54
GLY A  16
ASP A  34
 None
None
NAD  A 400 (-3.8A)
None
NAD  A 400 (-2.7A)
 1.42A 4iilA-4twrA:
6.3		 4iilA-4twrA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_2
(ANCESTRAL STEROID
RECEPTOR 2)		 4twr NAD BINDING
SITE:NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E:UDP-GLUCOSE
4-EPIMERASE
(Brucella
abortus) 		4 / 8 ALA A 298
THR A  19
VAL A   8
PHE A  75
 None
 1.01A 4ltwA-4twrA:
undetectable		 4ltwA-4twrA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 4twr NAD BINDING
SITE:NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E:UDP-GLUCOSE
4-EPIMERASE
(Brucella
abortus) 		5 / 11 GLY A  10
GLY A  11
THR A  19
ASP A  34
ASP A  53
 NAD  A 400 (-3.4A)
None
None
NAD  A 400 (-2.7A)
NAD  A 400 (-3.1A)
 0.74A 4pghA-4twrA:
6.1		 4pghA-4twrA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 4twr NAD BINDING
SITE:NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E:UDP-GLUCOSE
4-EPIMERASE
(Brucella
abortus) 		5 / 12 GLY A  25
GLY A  27
PRO A  30
ALA A  29
ALA A  20
 None
 0.95A 5bw4B-4twrA:
undetectable		 5bw4B-4twrA:
29.28