SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tx1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)		 4tx1 ESTERASE
(Sinorhizobium
meliloti) 		5 / 10 GLY A  50
SER A  10
PHE A 149
LEU A  11
HIS A 190
 None
 1.45A 1a8uA-4tx1A:
4.4		 1a8uA-4tx1A:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 4tx1 ESTERASE
(Sinorhizobium
meliloti) 		4 / 4 GLY A  47
LEU A  48
GLY A   8
ARG A  51
 None
 1.44A 1j7kA-4tx1A:
undetectable		 1j7kA-4tx1A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_0
(PUTATIVE RRNA
METHYLASE)		 4tx1 ESTERASE
(Sinorhizobium
meliloti) 		5 / 12 GLY A  50
ASP A  91
LEU A  48
THR A  12
THR A 196
 None
 1.11A 3eeyC-4tx1A:
4.3		 3eeyC-4tx1A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_0
(PUTATIVE RRNA
METHYLASE)		 4tx1 ESTERASE
(Sinorhizobium
meliloti) 		5 / 12 GLY A  50
ASP A  91
LEU A  48
THR A  12
THR A 196
 None
 1.07A 3eeyE-4tx1A:
4.1		 3eeyE-4tx1A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_B_PNNB5002_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4tx1 ESTERASE
(Sinorhizobium
meliloti) 		4 / 5 ASN A  65
ALA A  54
ALA A  67
ARG A 109
 None
 1.43A 3kp2B-4tx1A:
undetectable		 3kp2B-4tx1A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 4tx1 ESTERASE
(Sinorhizobium
meliloti) 		4 / 7 TYR A  15
LEU A  11
ASN A  49
ASP A 187
 None
 0.82A 3lm8A-4tx1A:
undetectable
3lm8C-4tx1A:
2.4		 3lm8A-4tx1A:
21.16
3lm8C-4tx1A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_C_VIBC223_1
(THIAMINE
PYROPHOSPHOKINASE)		 4tx1 ESTERASE
(Sinorhizobium
meliloti) 		4 / 8 ASP A 187
TYR A  15
LEU A  11
ASN A  49
 None
 0.92A 3lm8A-4tx1A:
undetectable
3lm8C-4tx1A:
2.4		 3lm8A-4tx1A:
21.16
3lm8C-4tx1A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_D_VIBD223_1
(THIAMINE
PYROPHOSPHOKINASE)		 4tx1 ESTERASE
(Sinorhizobium
meliloti) 		4 / 8 ASP A 187
TYR A  15
LEU A  11
ASN A  49
 None
 0.83A 3lm8B-4tx1A:
3.1
3lm8D-4tx1A:
2.7		 3lm8B-4tx1A:
21.16
3lm8D-4tx1A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3M_A_DLUA398_1
(PFV INTEGRASE)		 4tx1 ESTERASE
(Sinorhizobium
meliloti) 		4 / 8 ASP A 176
GLY A 177
TYR A 163
PRO A 161
 None
 0.96A 3s3mA-4tx1A:
undetectable		 3s3mA-4tx1A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3N_A_DLUA398_1
(PFV INTEGRASE)		 4tx1 ESTERASE
(Sinorhizobium
meliloti) 		4 / 8 ASP A 176
GLY A 177
TYR A 163
PRO A 161
 None
 0.98A 3s3nA-4tx1A:
undetectable		 3s3nA-4tx1A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAN_B_2FAB301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 4tx1 ESTERASE
(Sinorhizobium
meliloti) 		5 / 12 ARG A 164
GLY A 177
VAL A 132
SER A 179
VAL A 199
 None
 1.27A 4danA-4tx1A:
2.2
4danB-4tx1A:
undetectable		 4danA-4tx1A:
24.45
4danB-4tx1A:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4tx1 ESTERASE
(Sinorhizobium
meliloti) 		5 / 11 HIS A  23
THR A 140
THR A 184
THR A 183
ALA A  17
 None
 1.18A 4qvlV-4tx1A:
undetectable
4qvlb-4tx1A:
undetectable		 4qvlV-4tx1A:
20.33
4qvlb-4tx1A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4tx1 ESTERASE
(Sinorhizobium
meliloti) 		5 / 11 HIS A  23
THR A 140
THR A 184
THR A 183
ALA A  17
 None
 1.19A 4qvlH-4tx1A:
undetectable
4qvlN-4tx1A:
undetectable		 4qvlH-4tx1A:
20.33
4qvlN-4tx1A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4tx1 ESTERASE
(Sinorhizobium
meliloti) 		5 / 11 HIS A  23
THR A 140
THR A 184
THR A 183
ALA A  17
 None
 1.18A 4qvmV-4tx1A:
undetectable
4qvmb-4tx1A:
undetectable		 4qvmV-4tx1A:
20.33
4qvmb-4tx1A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4tx1 ESTERASE
(Sinorhizobium
meliloti) 		5 / 11 HIS A  23
THR A 140
THR A 184
THR A 183
ALA A  17
 None
 1.18A 4qvmH-4tx1A:
undetectable
4qvmN-4tx1A:
undetectable		 4qvmH-4tx1A:
20.33
4qvmN-4tx1A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4tx1 ESTERASE
(Sinorhizobium
meliloti) 		5 / 12 HIS A  23
THR A 140
THR A 184
THR A 183
ALA A  17
 None
 1.19A 4qvnV-4tx1A:
undetectable
4qvnb-4tx1A:
undetectable		 4qvnV-4tx1A:
20.33
4qvnb-4tx1A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4tx1 ESTERASE
(Sinorhizobium
meliloti) 		5 / 12 HIS A  23
THR A 140
THR A 184
THR A 183
ALA A  17
 None
 1.19A 4qvnH-4tx1A:
undetectable
4qvnN-4tx1A:
undetectable		 4qvnH-4tx1A:
20.33
4qvnN-4tx1A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4tx1 ESTERASE
(Sinorhizobium
meliloti) 		5 / 11 HIS A  23
THR A 140
THR A 184
THR A 183
ALA A  17
 None
 1.20A 4qvpV-4tx1A:
undetectable
4qvpb-4tx1A:
undetectable		 4qvpV-4tx1A:
20.33
4qvpb-4tx1A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4tx1 ESTERASE
(Sinorhizobium
meliloti) 		5 / 11 HIS A  23
THR A 140
THR A 184
THR A 183
ALA A  17
 None
 1.20A 4qvpH-4tx1A:
undetectable
4qvpN-4tx1A:
undetectable		 4qvpH-4tx1A:
20.33
4qvpN-4tx1A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4tx1 ESTERASE
(Sinorhizobium
meliloti) 		5 / 11 HIS A  23
THR A 140
THR A 184
THR A 183
ALA A  17
 None
 1.20A 4qvqV-4tx1A:
undetectable
4qvqb-4tx1A:
undetectable		 4qvqV-4tx1A:
20.33
4qvqb-4tx1A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4tx1 ESTERASE
(Sinorhizobium
meliloti) 		5 / 10 HIS A  23
THR A 140
THR A 184
THR A 183
ALA A  17
 None
 1.18A 4qvvH-4tx1A:
undetectable
4qvvN-4tx1A:
undetectable		 4qvvH-4tx1A:
20.33
4qvvN-4tx1A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4tx1 ESTERASE
(Sinorhizobium
meliloti) 		5 / 11 HIS A  23
THR A 140
THR A 184
THR A 183
ALA A  17
 None
 1.16A 4qvwV-4tx1A:
undetectable
4qvwb-4tx1A:
undetectable		 4qvwV-4tx1A:
20.33
4qvwb-4tx1A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4tx1 ESTERASE
(Sinorhizobium
meliloti) 		5 / 11 HIS A  23
THR A 140
THR A 184
THR A 183
ALA A  17
 None
 1.17A 4qvwH-4tx1A:
undetectable
4qvwN-4tx1A:
undetectable		 4qvwH-4tx1A:
20.33
4qvwN-4tx1A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4tx1 ESTERASE
(Sinorhizobium
meliloti) 		5 / 11 HIS A  23
THR A 140
THR A 184
THR A 183
ALA A  17
 None
 1.15A 4qw0V-4tx1A:
undetectable
4qw0b-4tx1A:
undetectable		 4qw0V-4tx1A:
20.33
4qw0b-4tx1A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4tx1 ESTERASE
(Sinorhizobium
meliloti) 		5 / 11 HIS A  23
THR A 140
THR A 184
THR A 183
ALA A  17
 None
 1.16A 4qw0H-4tx1A:
undetectable
4qw0N-4tx1A:
undetectable		 4qw0H-4tx1A:
20.33
4qw0N-4tx1A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4tx1 ESTERASE
(Sinorhizobium
meliloti) 		5 / 11 HIS A  23
THR A 140
THR A 184
THR A 183
ALA A  17
 None
 1.17A 4qw1V-4tx1A:
undetectable
4qw1b-4tx1A:
undetectable		 4qw1V-4tx1A:
20.33
4qw1b-4tx1A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4tx1 ESTERASE
(Sinorhizobium
meliloti) 		5 / 11 HIS A  23
THR A 140
THR A 184
THR A 183
ALA A  17
 None
 1.18A 4qw1H-4tx1A:
undetectable
4qw1N-4tx1A:
undetectable		 4qw1H-4tx1A:
20.33
4qw1N-4tx1A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4tx1 ESTERASE
(Sinorhizobium
meliloti) 		5 / 11 HIS A  23
THR A 140
THR A 184
THR A 183
ALA A  17
 None
 1.19A 4qw3V-4tx1A:
undetectable
4qw3b-4tx1A:
undetectable		 4qw3V-4tx1A:
20.33
4qw3b-4tx1A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4tx1 ESTERASE
(Sinorhizobium
meliloti) 		5 / 11 HIS A  23
THR A 140
THR A 184
THR A 183
ALA A  17
 None
 1.19A 4qw3H-4tx1A:
undetectable
4qw3N-4tx1A:
undetectable		 4qw3H-4tx1A:
20.33
4qw3N-4tx1A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4tx1 ESTERASE
(Sinorhizobium
meliloti) 		5 / 11 HIS A  23
THR A 140
THR A 184
THR A 183
ALA A  17
 None
 1.19A 4qwuV-4tx1A:
undetectable
4qwub-4tx1A:
undetectable		 4qwuV-4tx1A:
20.33
4qwub-4tx1A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4tx1 ESTERASE
(Sinorhizobium
meliloti) 		5 / 11 HIS A  23
THR A 140
THR A 184
THR A 183
ALA A  17
 None
 1.19A 4qwuH-4tx1A:
undetectable
4qwuN-4tx1A:
undetectable		 4qwuH-4tx1A:
20.33
4qwuN-4tx1A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 4tx1 ESTERASE
(Sinorhizobium
meliloti) 		4 / 7 PRO A 161
SER A 156
ASP A 187
THR A 140
 None
 1.29A 4uacA-4tx1A:
1.5		 4uacA-4tx1A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4tx1 ESTERASE
(Sinorhizobium
meliloti) 		5 / 11 HIS A  23
THR A 140
THR A 184
THR A 183
ALA A  17
 None
 1.22A 5bxnV-4tx1A:
undetectable
5bxnb-4tx1A:
undetectable		 5bxnV-4tx1A:
22.40
5bxnb-4tx1A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4tx1 ESTERASE
(Sinorhizobium
meliloti) 		5 / 11 HIS A  23
THR A 140
THR A 184
THR A 183
ALA A  17
 None
 1.23A 5bxnH-4tx1A:
undetectable
5bxnN-4tx1A:
undetectable		 5bxnH-4tx1A:
22.40
5bxnN-4tx1A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4tx1 ESTERASE
(Sinorhizobium
meliloti) 		5 / 11 HIS A  23
THR A 140
THR A 184
THR A 183
ALA A  17
 None
 1.17A 5cz7H-4tx1A:
undetectable
5cz7N-4tx1A:
undetectable		 5cz7H-4tx1A:
20.33
5cz7N-4tx1A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4tx1 ESTERASE
(Sinorhizobium
meliloti) 		5 / 11 HIS A  23
THR A 140
THR A 184
THR A 183
ALA A  17
 None
 1.17A 5d0xV-4tx1A:
undetectable
5d0xb-4tx1A:
undetectable		 5d0xV-4tx1A:
20.33
5d0xb-4tx1A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4tx1 ESTERASE
(Sinorhizobium
meliloti) 		5 / 11 HIS A  23
THR A 140
THR A 184
THR A 183
ALA A  17
 None
 1.18A 5d0xH-4tx1A:
undetectable
5d0xN-4tx1A:
undetectable		 5d0xH-4tx1A:
20.33
5d0xN-4tx1A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 4tx1 ESTERASE
(Sinorhizobium
meliloti) 		4 / 8 ILE A  96
ASP A  91
GLY A  50
LEU A  48
 None
 1.03A 5hwaA-4tx1A:
undetectable		 5hwaA-4tx1A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4tx1 ESTERASE
(Sinorhizobium
meliloti) 		5 / 11 HIS A  23
THR A 140
THR A 184
THR A 183
ALA A  17
 None
 1.18A 5l5fV-4tx1A:
undetectable
5l5fb-4tx1A:
undetectable		 5l5fV-4tx1A:
20.33
5l5fb-4tx1A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4tx1 ESTERASE
(Sinorhizobium
meliloti) 		5 / 11 HIS A  23
THR A 140
THR A 184
THR A 183
ALA A  17
 None
 1.19A 5l5fH-4tx1A:
undetectable
5l5fN-4tx1A:
undetectable		 5l5fH-4tx1A:
20.33
5l5fN-4tx1A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4tx1 ESTERASE
(Sinorhizobium
meliloti) 		5 / 12 HIS A  23
THR A 140
THR A 184
THR A 183
ALA A  17
 None
 1.18A 5l5zV-4tx1A:
undetectable
5l5zb-4tx1A:
undetectable		 5l5zV-4tx1A:
20.33
5l5zb-4tx1A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4tx1 ESTERASE
(Sinorhizobium
meliloti) 		5 / 12 HIS A  23
THR A 140
THR A 184
THR A 183
ALA A  17
 None
 1.18A 5l5zH-4tx1A:
undetectable
5l5zN-4tx1A:
undetectable		 5l5zH-4tx1A:
20.33
5l5zN-4tx1A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4tx1 ESTERASE
(Sinorhizobium
meliloti) 		5 / 11 HIS A  23
THR A 140
THR A 184
THR A 183
ALA A  17
 None
 1.19A 5l66V-4tx1A:
undetectable
5l66b-4tx1A:
undetectable		 5l66V-4tx1A:
20.33
5l66b-4tx1A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4tx1 ESTERASE
(Sinorhizobium
meliloti) 		5 / 11 HIS A  23
THR A 140
THR A 184
THR A 183
ALA A  17
 None
 1.20A 5l66H-4tx1A:
undetectable
5l66N-4tx1A:
undetectable		 5l66H-4tx1A:
20.33
5l66N-4tx1A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M45_J_ACTJ803_0
(ACETONE CARBOXYLASE
ALPHA SUBUNIT)		 4tx1 ESTERASE
(Sinorhizobium
meliloti) 		4 / 4 GLU A 128
PRO A 127
ILE A  83
LEU A  82
 None
 1.30A 5m45J-4tx1A:
undetectable		 5m45J-4tx1A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 4tx1 ESTERASE
(Sinorhizobium
meliloti) 		5 / 12 GLY A  88
VAL A  73
LEU A   5
GLY A  47
SER A  10
 None
 1.08A 5vooE-4tx1A:
3.2		 5vooE-4tx1A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XU8_A_DX4A701_0
(UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2)		 4tx1 ESTERASE
(Sinorhizobium
meliloti) 		4 / 8 GLY A 188
SER A 143
ALA A 144
PHE A 145
 None
 0.81A 5xu8A-4tx1A:
undetectable		 5xu8A-4tx1A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4tx1 ESTERASE
(Sinorhizobium
meliloti) 		4 / 5 ARG A  68
GLY A  66
ASN A  65
ASP A  63
 None
 1.38A 6dwjB-4tx1A:
undetectable
6dwjD-4tx1A:
undetectable		 6dwjB-4tx1A:
19.02
6dwjD-4tx1A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 4tx1 ESTERASE
(Sinorhizobium
meliloti) 		5 / 12 GLY A 178
GLY A 177
VAL A 132
VAL A 206
GLY A 202
 None
 1.01A 6gneA-4tx1A:
2.3		 6gneA-4tx1A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 4tx1 ESTERASE
(Sinorhizobium
meliloti) 		5 / 12 GLY A 178
GLY A 177
VAL A 132
VAL A 206
GLY A 202
 None
 1.01A 6gneB-4tx1A:
5.5		 6gneB-4tx1A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_B_BO2B201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 4tx1 ESTERASE
(Sinorhizobium
meliloti) 		5 / 12 HIS A  23
THR A 140
THR A 184
THR A 183
ALA A  17
 None
 1.21A 6hwdV-4tx1A:
undetectable
6hwdb-4tx1A:
undetectable		 6hwdV-4tx1A:
13.45
6hwdb-4tx1A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_N_BO2N201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 4tx1 ESTERASE
(Sinorhizobium
meliloti) 		5 / 12 HIS A  23
THR A 140
THR A 184
THR A 183
ALA A  17
 None
 1.20A 6hwdH-4tx1A:
undetectable
6hwdN-4tx1A:
undetectable		 6hwdH-4tx1A:
13.45
6hwdN-4tx1A:
21.15