SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tx2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FAP_A_RAPA108_2
(FK506-BINDING
PROTEIN
FRAP)		 4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Actinoplanes
teichomyceticus) 		4 / 8 LEU B 312
ARG B 451
PHE B 318
GLY B 449
 None
 0.95A 1fapB-4tx2B:
undetectable		 1fapB-4tx2B:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_A_ESTA600_1
(ESTROGEN RECEPTOR)		 4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Actinoplanes
teichomyceticus) 		5 / 11 LEU B 270
LEU B 267
ALA B 266
LEU B 441
LEU B 455
 None
 1.21A 1g50A-4tx2B:
undetectable		 1g50A-4tx2B:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_D_CCSD47_0
(GLUTATHIONE
S-TRANSFERASE)		 4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Actinoplanes
teichomyceticus) 		4 / 7 THR B 285
LEU B 363
GLY B 283
LEU B 395
 None
 0.96A 1gtiD-4tx2B:
undetectable		 1gtiD-4tx2B:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GWR_A_ESTA600_1
(OESTROGEN RECEPTOR)		 4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Actinoplanes
teichomyceticus) 		5 / 10 MET B 259
LEU B 262
ALA B 265
LEU B 319
LEU B 441
 None
 0.99A 1gwrA-4tx2B:
undetectable		 1gwrA-4tx2B:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H9Z_A_RWFA3001_1
(SERUM ALBUMIN)		 4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Actinoplanes
teichomyceticus) 		5 / 11 LEU B 156
LEU B 378
LEU B  45
SER B 384
ALA B 375
 None
 1.17A 1h9zA-4tx2B:
undetectable		 1h9zA-4tx2B:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Actinoplanes
teichomyceticus) 		4 / 4 ILE B 457
LEU B 455
VAL B 444
ALA B 251
 None
 0.92A 1mz9A-4tx2B:
undetectable		 1mz9A-4tx2B:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PCG_B_ESTB2_1
(ESTROGEN RECEPTOR)		 4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Actinoplanes
teichomyceticus) 		5 / 10 MET B 259
LEU B 262
ALA B 265
LEU B 319
LEU B 441
 None
 1.12A 1pcgB-4tx2B:
undetectable		 1pcgB-4tx2B:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Actinoplanes
teichomyceticus) 		4 / 7 VAL B  61
VAL B 139
LEU B  39
LEU B  68
 None
 0.85A 1pthA-4tx2B:
undetectable		 1pthA-4tx2B:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Actinoplanes
teichomyceticus) 		4 / 7 VAL B  61
VAL B 139
LEU B  39
LEU B  68
 None
 0.85A 1pthB-4tx2B:
undetectable		 1pthB-4tx2B:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_A_DESA459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Actinoplanes
teichomyceticus) 		5 / 12 ALA B 276
LEU B 280
VAL B 361
LEU B 437
ILE B 457
 None
 1.14A 1s9pA-4tx2B:
undetectable		 1s9pA-4tx2B:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Actinoplanes
teichomyceticus) 		5 / 12 ILE B 282
MET B 259
LEU B 363
LEU B 441
ILE B 414
 None
 1.19A 1xzxX-4tx2B:
undetectable		 1xzxX-4tx2B:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCF_A_ESTA596_1
(ESTROGEN RECEPTOR)		 4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Actinoplanes
teichomyceticus) 		5 / 10 MET B 259
LEU B 262
ALA B 266
HIS B 245
LEU B 240
 None
 1.40A 2ocfA-4tx2B:
undetectable		 2ocfA-4tx2B:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		 4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Actinoplanes
teichomyceticus) 		5 / 12 MET B 259
LEU B 262
LEU B 270
HIS B 245
LEU B 240
 None
 0.96A 2ouzA-4tx2B:
undetectable		 2ouzA-4tx2B:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_1
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Actinoplanes
teichomyceticus) 		4 / 4 SER B 148
GLY B 300
HIS B  38
ASP B 114
 None
 1.36A 2oxtC-4tx2B:
undetectable		 2oxtC-4tx2B:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QIS_A_RISA901_1
(FARNESYL
PYROPHOSPHATE
SYNTHETASE)		 4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Actinoplanes
teichomyceticus) 		5 / 10 LEU B 188
ASP B 337
GLN B 202
SER B 197
LYS B   4
 None
 1.46A 2qisA-4tx2B:
undetectable		 2qisA-4tx2B:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Actinoplanes
teichomyceticus) 		4 / 7 ALA B 421
ALA B 233
ARG B  35
PRO B 229
 None
 0.96A 2ql8A-4tx2B:
undetectable
2ql8B-4tx2B:
1.9		 2ql8A-4tx2B:
14.29
2ql8B-4tx2B:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Actinoplanes
teichomyceticus) 		5 / 12 LEU B 262
ALA B 265
ALA B 268
THR B 310
VAL B 325
 None
 1.20A 3cwkA-4tx2B:
undetectable		 3cwkA-4tx2B:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ERD_A_DESA600_1
(ESTROGEN RECEPTOR
ALPHA)		 4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Actinoplanes
teichomyceticus) 		5 / 12 MET B 259
LEU B 262
ALA B 265
LEU B 319
LEU B 441
 None
 1.03A 3erdA-4tx2B:
undetectable		 3erdA-4tx2B:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3008_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Actinoplanes
teichomyceticus) 		4 / 7 GLU B  66
HIS B  65
ALA B  86
ARG B  69
 None
 0.99A 3kp6B-4tx2B:
undetectable		 3kp6B-4tx2B:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Actinoplanes
teichomyceticus) 		5 / 12 VAL B  61
VAL B 139
LEU B  39
GLY B 300
LEU B  68
 None
 0.94A 3n8wA-4tx2B:
undetectable		 3n8wA-4tx2B:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Actinoplanes
teichomyceticus) 		5 / 12 VAL B  61
VAL B 139
LEU B  39
GLY B 300
LEU B  68
 None
 0.89A 3n8zA-4tx2B:
undetectable		 3n8zA-4tx2B:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OF4_B_ACTB313_0
(NITROREDUCTASE)		 4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Actinoplanes
teichomyceticus) 		3 / 3 ALA B 328
VAL B 325
GLN B 264
 None
 0.57A 3of4B-4tx2B:
undetectable		 3of4B-4tx2B:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OLS_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Actinoplanes
teichomyceticus) 		5 / 12 LEU B 270
LEU B 267
ALA B 266
LEU B 441
LEU B 455
 None
 1.11A 3olsA-4tx2B:
undetectable		 3olsA-4tx2B:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Actinoplanes
teichomyceticus) 		3 / 3 TYR B 181
ASP B 145
ASP B 150
 None
 0.94A 3ou6B-4tx2B:
undetectable		 3ou6B-4tx2B:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_A_FLPA701_1
(CYCLOOXYGENASE-2)		 4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Actinoplanes
teichomyceticus) 		5 / 12 VAL B  61
VAL B 139
LEU B  39
GLY B 300
LEU B  68
 None
 1.00A 3pghA-4tx2B:
undetectable		 3pghA-4tx2B:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)		 4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Actinoplanes
teichomyceticus) 		5 / 12 VAL B  61
VAL B 139
LEU B  39
GLY B 300
LEU B  68
 None
 1.01A 3pghC-4tx2B:
undetectable		 3pghC-4tx2B:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q95_A_ESLA700_1
(ESTROGEN RECEPTOR)		 4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Actinoplanes
teichomyceticus) 		5 / 12 MET B 259
LEU B 262
ALA B 265
LEU B 319
LEU B 441
 None
 0.99A 3q95A-4tx2B:
undetectable		 3q95A-4tx2B:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB502_1
(CYTOCHROME P450 2B6)		 4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Actinoplanes
teichomyceticus) 		5 / 10 GLN B 360
GLU B 394
PRO B 305
GLU B 341
PHE B 340
 None
 1.44A 3ua5B-4tx2B:
undetectable		 3ua5B-4tx2B:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Actinoplanes
teichomyceticus) 		5 / 11 MET B 259
LEU B 262
ALA B 265
LEU B 319
LEU B 441
 None
 1.03A 3uudA-4tx2B:
undetectable		 3uudA-4tx2B:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Actinoplanes
teichomyceticus) 		5 / 12 LEU B 248
LEU B 262
GLN B 264
MET B 269
VAL B 321
 None
 1.37A 3zqtA-4tx2B:
undetectable		 3zqtA-4tx2B:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Actinoplanes
teichomyceticus) 		4 / 8 LEU B 363
VAL B 365
LEU B 433
LEU B 418
 None
 0.98A 4l1xA-4tx2B:
undetectable		 4l1xA-4tx2B:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L78_A_ACTA1327_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Actinoplanes
teichomyceticus) 		4 / 4 VAL B 365
THR B 402
GLU B 403
GLU B 368
 None
 1.18A 4l78A-4tx2B:
undetectable		 4l78A-4tx2B:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_A_ESTA2000_1
(ESTROGEN RECEPTOR)		 4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Actinoplanes
teichomyceticus) 		5 / 12 MET B 259
LEU B 262
ALA B 265
LEU B 319
LEU B 441
 None
 1.01A 4pxmA-4tx2B:
undetectable		 4pxmA-4tx2B:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Actinoplanes
teichomyceticus) 		4 / 5 ARG B  11
GLN B  81
PRO B  16
ILE B 183
 None
 1.45A 4z4hA-4tx2B:
undetectable		 4z4hA-4tx2B:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_B_ESTB1000_1
(ESTROGEN RECEPTOR)		 4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Actinoplanes
teichomyceticus) 		5 / 10 MET B 259
LEU B 262
ALA B 265
LEU B 319
LEU B 441
 None
 1.03A 5dxeB-4tx2B:
undetectable		 5dxeB-4tx2B:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXE_B_ESTB1000_1
(ESTROGEN RECEPTOR)		 4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Actinoplanes
teichomyceticus) 		5 / 10 MET B 259
LEU B 262
ALA B 266
HIS B 245
LEU B 240
 None
 1.40A 5dxeB-4tx2B:
undetectable		 5dxeB-4tx2B:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HYR_A_ESTA601_1
(ESTROGEN RECEPTOR)		 4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Actinoplanes
teichomyceticus) 		5 / 10 MET B 259
LEU B 262
ALA B 265
LEU B 319
LEU B 441
 None
 1.01A 5hyrA-4tx2B:
undetectable		 5hyrA-4tx2B:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Actinoplanes
teichomyceticus) 		5 / 12 VAL B  61
VAL B 139
LEU B  39
GLY B 300
LEU B  68
 None
 0.94A 5iktB-4tx2B:
undetectable		 5iktB-4tx2B:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Actinoplanes
teichomyceticus) 		5 / 11 LEU B 397
LEU B 437
ALA B 434
VAL B 325
LEU B 280
 None
 1.21A 5ji0A-4tx2B:
undetectable		 5ji0A-4tx2B:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Actinoplanes
teichomyceticus) 		4 / 5 ARG B  11
GLN B  81
PRO B  16
ILE B 183
 None
 1.42A 5ki6A-4tx2B:
undetectable		 5ki6A-4tx2B:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Actinoplanes
teichomyceticus) 		5 / 12 LEU B 455
ALA B 265
PHE B 318
ARG B 439
LEU B 248
 None
 1.14A 5nd7B-4tx2B:
undetectable		 5nd7B-4tx2B:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_A_NIZA810_1
(CATALASE-PEROXIDASE)		 4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Actinoplanes
teichomyceticus) 		4 / 6 ARG B 405
HIS B 245
LEU B 262
PRO B 260
 None
 1.27A 5syjA-4tx2B:
undetectable		 5syjA-4tx2B:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Actinoplanes
teichomyceticus) 		4 / 7 ILE B  67
LEU B 115
PHE B 113
THR B 138
 None
 0.99A 5vc0A-4tx2B:
undetectable		 5vc0A-4tx2B:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Actinoplanes
teichomyceticus) 		4 / 7 GLN B  21
GLY B 300
GLN B 364
ASP B 146
 None
 1.16A 5vlmC-4tx2B:
undetectable		 5vlmC-4tx2B:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_E_CVIE301_1
(REGULATORY PROTEIN
TETR)		 4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Actinoplanes
teichomyceticus) 		4 / 7 GLN B  21
GLY B 300
GLN B 364
ASP B 146
 None
 1.01A 5vlmE-4tx2B:
undetectable		 5vlmE-4tx2B:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Actinoplanes
teichomyceticus) 		4 / 6 GLN B 264
VAL B 365
LEU B 312
ARG B 273
 None
 1.28A 6brdB-4tx2B:
1.3		 6brdB-4tx2B:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECE_C_DVAC3010_0
(VLM2
DODECADEPSIPEPTIDE)		 4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Actinoplanes
teichomyceticus) 		3 / 3 ALA B  24
PHE B  72
GLN B  81
 None
 0.79A 6eceA-4tx2B:
undetectable		 6eceA-4tx2B:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_2
(TUBULIN BETA CHAIN)		 4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Actinoplanes
teichomyceticus) 		4 / 5 LEU B 346
ARG B  23
PRO B 357
ARG B 355
 None
 1.31A 6ew0B-4tx2B:
undetectable		 6ew0B-4tx2B:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_2
(TUBULIN BETA CHAIN)		 4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Actinoplanes
teichomyceticus) 		4 / 5 LEU B 346
ARG B  23
PRO B 357
ARG B 355
 None
 1.31A 6ew0D-4tx2B:
undetectable		 6ew0D-4tx2B:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_2
(TUBULIN BETA CHAIN)		 4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Actinoplanes
teichomyceticus) 		4 / 5 LEU B 346
ARG B  23
PRO B 357
ARG B 355
 None
 1.31A 6ew0H-4tx2B:
undetectable		 6ew0H-4tx2B:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_2
(TUBULIN BETA CHAIN)		 4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Actinoplanes
teichomyceticus) 		4 / 5 LEU B 346
ARG B  23
PRO B 357
ARG B 355
 None
 1.31A 6ew0I-4tx2B:
undetectable		 6ew0I-4tx2B:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE
(Actinoplanes
teichomyceticus) 		3 / 3 ASP B 396
LEU B 424
ARG B 232
 None
 0.81A 7dfrA-4tx2B:
undetectable		 7dfrA-4tx2B:
14.96