SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4txa'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDS_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 4txa ROQUIN-1
(Mus
musculus) 		5 / 12 LEU A 204
GLY A 196
PRO A 197
TYR A 276
PHE A 194
 None
 1.14A 1fdsA-4txaA:
undetectable		 1fdsA-4txaA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4txa ROQUIN-1
(Mus
musculus) 		5 / 12 GLY A 162
HIS A 389
LEU A 337
LEU A 106
TYR A 109
 None
 1.33A 1fm6D-4txaA:
undetectable		 1fm6D-4txaA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4txa ROQUIN-1
(Mus
musculus) 		5 / 12 HIS A 389
LEU A 337
LEU A 129
LEU A 106
TYR A 109
 None
 1.30A 1fm6D-4txaA:
undetectable		 1fm6D-4txaA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4txa ROQUIN-1
(Mus
musculus) 		4 / 6 ALA A 252
LEU A 204
GLU A 282
LEU A 307
 None
 1.00A 1mt1D-4txaA:
undetectable
1mt1E-4txaA:
undetectable		 1mt1D-4txaA:
12.29
1mt1E-4txaA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4txa ROQUIN-1
(Mus
musculus) 		5 / 12 GLY A 162
HIS A 389
LEU A 337
LEU A 106
TYR A 109
 None
 1.37A 1zgyA-4txaA:
undetectable		 1zgyA-4txaA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_1
(MINERALOCORTICOID
RECEPTOR)		 4txa ROQUIN-1
(Mus
musculus) 		5 / 12 LEU A 211
LEU A 204
ALA A 203
GLN A 200
LEU A 248
 None
 1.33A 2oaxD-4txaA:
undetectable		 2oaxD-4txaA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 4txa ROQUIN-1
(Mus
musculus) 		3 / 3 ARG A 280
GLU A 201
GLN A 200
 None
 1.09A 2p16A-4txaA:
undetectable		 2p16A-4txaA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_B_BRLB2_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4txa ROQUIN-1
(Mus
musculus) 		5 / 12 HIS A 389
LEU A 353
LEU A 129
LEU A 106
TYR A 109
 None
 1.25A 2prgB-4txaA:
undetectable		 2prgB-4txaA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 4txa ROQUIN-1
(Mus
musculus) 		5 / 12 ALA A 158
THR A 165
VAL A 392
LEU A 106
LEU A 353
 None
 1.29A 2rctA-4txaA:
undetectable		 2rctA-4txaA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4txa ROQUIN-1
(Mus
musculus) 		5 / 12 HIS A 389
LEU A 337
LEU A 129
LEU A 106
TYR A 109
 None
 1.25A 3adsA-4txaA:
undetectable		 3adsA-4txaA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4txa ROQUIN-1
(Mus
musculus) 		5 / 12 HIS A 389
LEU A 353
LEU A 129
LEU A 106
TYR A 109
 None
 1.22A 3adsA-4txaA:
undetectable		 3adsA-4txaA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4txa ROQUIN-1
(Mus
musculus) 		3 / 3 THR A 167
SER A 160
LYS A 136
 None
 1.13A 3aocC-4txaA:
undetectable		 3aocC-4txaA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA2_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 4txa ROQUIN-1
(Mus
musculus) 		3 / 3 LYS A 239
LYS A 220
VAL A 223
 None
 1.07A 3brfA-4txaA:
undetectable		 3brfA-4txaA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4txa ROQUIN-1
(Mus
musculus) 		5 / 12 HIS A 389
LEU A 353
LEU A 129
LEU A 106
TYR A 109
 None
 1.37A 4emaA-4txaA:
undetectable		 4emaA-4txaA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4txa ROQUIN-1
(Mus
musculus) 		5 / 12 HIS A 389
LEU A 353
LEU A 129
LEU A 106
TYR A 109
 None
 1.46A 4o8fB-4txaA:
undetectable		 4o8fB-4txaA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4txa ROQUIN-1
(Mus
musculus) 		5 / 12 HIS A 389
LEU A 129
LEU A 137
LEU A 106
TYR A 109
 None
 1.13A 4xumA-4txaA:
undetectable		 4xumA-4txaA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 4txa ROQUIN-1
(Mus
musculus) 		4 / 4 GLN A 335
THR A 338
THR A 165
LEU A 360
 None
 1.30A 5m5kA-4txaA:
undetectable		 5m5kA-4txaA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_0
(MINERALOCORTICOID
RECEPTOR)		 4txa ROQUIN-1
(Mus
musculus) 		5 / 12 LEU A 183
SER A 305
SER A 304
LEU A 307
MET A 317
 None
 1.15A 5mwyA-4txaA:
undetectable		 5mwyA-4txaA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2O_A_8N6A501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4txa ROQUIN-1
(Mus
musculus) 		5 / 12 HIS A 389
LEU A 353
LEU A 129
LEU A 106
TYR A 109
 None
 1.37A 5y2oA-4txaA:
undetectable		 5y2oA-4txaA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4txa ROQUIN-1
(Mus
musculus) 		5 / 12 HIS A 389
LEU A 353
LEU A 129
LEU A 106
TYR A 109
 None
 1.35A 5ycpA-4txaA:
undetectable		 5ycpA-4txaA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 4txa ROQUIN-1
(Mus
musculus) 		4 / 6 TRP A 184
GLY A 295
ALA A 186
LEU A 183
 None
 0.97A 6fosA-4txaA:
2.3		 6fosA-4txaA:
8.88