SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4txv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQF_A_SAMA430_1
(SUN PROTEIN)		 4txv THIOL:DISULFIDE
INTERCHANGE PROTEIN
TLPA
(Bradyrhizobium
diazoefficiens) 		3 / 3 PRO A  87
ASP A  82
ASP A  92
 None
 0.72A 1sqfA-4txvA:
undetectable		 1sqfA-4txvA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EFJ_A_37TA502_1
(3,7-DIMETHYLXANTHINE
METHYLTRANSFERASE)		 4txv CYTOCHROME C OXIDASE
SUBUNIT 2
(Bradyrhizobium
diazoefficiens) 		5 / 12 PHE B 156
ILE B 135
ILE B 183
ILE B 244
TYR B 146
 None
 1.38A 2efjA-4txvB:
undetectable		 2efjA-4txvB:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCD_A_RAPA138_1
(OUTER MEMBRANE
PROTEIN MIP)		 4txv CYTOCHROME C OXIDASE
SUBUNIT 2
(Bradyrhizobium
diazoefficiens) 		5 / 11 PHE B 156
VAL B 185
ILE B 135
TYR B 148
VAL B 256
 None
 1.46A 2vcdA-4txvB:
undetectable		 2vcdA-4txvB:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 4txv CYTOCHROME C OXIDASE
SUBUNIT 2
(Bradyrhizobium
diazoefficiens) 		4 / 7 ILE B 183
PHE B 217
ARG B 245
MET B 175
 None
 1.04A 3ag4N-4txvB:
undetectable
3ag4W-4txvB:
undetectable		 3ag4N-4txvB:
14.96
3ag4W-4txvB:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 4txv CYTOCHROME C OXIDASE
SUBUNIT 2
THIOL:DISULFIDE
INTERCHANGE PROTEIN
TLPA
(Bradyrhizobium
diazoefficiens) 		5 / 10 ALA B 200
ILE A 195
GLY B 227
ILE B 242
VAL B 246
 None
 1.07A 3ogpA-4txvB:
undetectable		 3ogpA-4txvB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 4txv THIOL:DISULFIDE
INTERCHANGE PROTEIN
TLPA
(Bradyrhizobium
diazoefficiens) 		5 / 12 GLN A 121
LEU A 120
LEU A  98
THR A 214
ILE A 210
 None
 1.06A 4o5fA-4txvA:
undetectable
4o5fB-4txvA:
undetectable		 4o5fA-4txvA:
26.16
4o5fB-4txvA:
26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4txv CYTOCHROME C OXIDASE
SUBUNIT 2
(Bradyrhizobium
diazoefficiens) 		4 / 6 GLY B 223
PHE B 201
ILE B 244
PHE B 217
 None
 1.01A 4qogA-4txvB:
undetectable
4qogB-4txvB:
undetectable		 4qogA-4txvB:
25.00
4qogB-4txvB:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 4txv THIOL:DISULFIDE
INTERCHANGE PROTEIN
TLPA
(Bradyrhizobium
diazoefficiens) 		5 / 12 LEU A  98
THR A 214
ILE A 210
GLN A 121
LEU A 120
 None
 1.06A 5b8hA-4txvA:
2.4
5b8hB-4txvA:
undetectable		 5b8hA-4txvA:
22.82
5b8hB-4txvA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 4txv THIOL:DISULFIDE
INTERCHANGE PROTEIN
TLPA
(Bradyrhizobium
diazoefficiens) 		5 / 12 GLN A 121
LEU A 120
LEU A  98
THR A 214
ILE A 210
 None
 1.08A 5b8hA-4txvA:
2.4
5b8hB-4txvA:
undetectable		 5b8hA-4txvA:
22.82
5b8hB-4txvA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA812_0
(GEPHYRIN)		 4txv CYTOCHROME C OXIDASE
SUBUNIT 2
(Bradyrhizobium
diazoefficiens) 		4 / 6 GLU B 125
PHE B 123
VAL B 128
PRO B 129
 None
 1.48A 6fgdA-4txvB:
undetectable		 6fgdA-4txvB:
18.45