SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4txw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_A_FK5A301_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 4txw HYALURONOGLUCOSAMINI
DASE
(Clostridium
perfringens) 		5 / 9 TYR A   7
VAL A 145
ILE A 146
TYR A  52
ILE A  67
 None
 1.43A 1q6iA-4txwA:
undetectable		 1q6iA-4txwA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_B_FK5B401_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 4txw HYALURONOGLUCOSAMINI
DASE
(Clostridium
perfringens) 		5 / 10 TYR A   7
VAL A 145
ILE A 146
TYR A  52
ILE A  67
 None
 1.45A 1q6iB-4txwA:
undetectable		 1q6iB-4txwA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 4txw HYALURONOGLUCOSAMINI
DASE
(Clostridium
perfringens) 		5 / 12 GLY A 154
VAL A 131
ASN A  49
LEU A  50
ILE A  67
 None
 1.01A 1zq9B-4txwA:
undetectable		 1zq9B-4txwA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 4txw HYALURONOGLUCOSAMINI
DASE
(Clostridium
perfringens) 		4 / 8 THR A  57
LEU A  55
ALA A 117
HIS A 104
 None
 1.03A 3kp6A-4txwA:
undetectable		 3kp6A-4txwA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 4txw HYALURONOGLUCOSAMINI
DASE
(Clostridium
perfringens) 		5 / 12 LEU A  41
VAL A 131
THR A  77
LEU A 124
VAL A  47
 None
 1.12A 3sp9B-4txwA:
undetectable		 3sp9B-4txwA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQA_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4txw HYALURONOGLUCOSAMINI
DASE
(Clostridium
perfringens) 		5 / 10 TYR A   7
VAL A 145
ILE A 146
TYR A  52
ILE A  67
 None
 1.43A 3uqaA-4txwA:
undetectable		 3uqaA-4txwA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 4txw HYALURONOGLUCOSAMINI
DASE
(Clostridium
perfringens) 		5 / 11 ILE A  82
ILE A  67
VAL A 131
LEU A  69
VAL A  47
 None
 1.15A 3w67A-4txwA:
undetectable		 3w67A-4txwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGA_A_ACTA1131_0
(LYSOZYME C)		 4txw HYALURONOGLUCOSAMINI
DASE
(Clostridium
perfringens) 		3 / 3 ASN A 100
ASP A  92
ASN A  88
 None
None
CA  A 202 (-3.2A)
 0.79A 4agaA-4txwA:
undetectable		 4agaA-4txwA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ2_B_FK5B200_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4txw HYALURONOGLUCOSAMINI
DASE
(Clostridium
perfringens) 		5 / 11 TYR A   7
VAL A 145
ILE A 146
TYR A  52
ILE A  67
 None
 1.40A 4dz2A-4txwA:
undetectable
4dz2B-4txwA:
undetectable		 4dz2A-4txwA:
22.49
4dz2B-4txwA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EVR_A_BEZA401_0
(PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT)		 4txw HYALURONOGLUCOSAMINI
DASE
(Clostridium
perfringens) 		5 / 11 TYR A  39
LEU A 149
PHE A 135
ALA A   6
PHE A  27
 None
 1.26A 4evrA-4txwA:
undetectable		 4evrA-4txwA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA304_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4txw HYALURONOGLUCOSAMINI
DASE
(Clostridium
perfringens) 		3 / 3 ARG A  63
HIS A  61
TYR A 139
 None
 1.31A 4fu8A-4txwA:
undetectable		 4fu8A-4txwA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA312_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 4txw HYALURONOGLUCOSAMINI
DASE
(Clostridium
perfringens) 		3 / 3 ARG A  63
HIS A  61
TYR A 139
 None
 1.25A 4fu9A-4txwA:
undetectable		 4fu9A-4txwA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAX_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)		 4txw HYALURONOGLUCOSAMINI
DASE
(Clostridium
perfringens) 		5 / 10 TYR A   7
VAL A 145
ILE A 146
TYR A  52
ILE A  67
 None
 1.43A 4laxA-4txwA:
undetectable		 4laxA-4txwA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT2_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)		 4txw HYALURONOGLUCOSAMINI
DASE
(Clostridium
perfringens) 		5 / 10 TYR A   7
VAL A 145
ILE A 146
TYR A  52
ILE A  67
 None
 1.39A 4qt2A-4txwA:
undetectable		 4qt2A-4txwA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT3_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)		 4txw HYALURONOGLUCOSAMINI
DASE
(Clostridium
perfringens) 		5 / 10 TYR A   7
VAL A 145
ILE A 146
TYR A  52
ILE A  67
 None
 1.35A 4qt3A-4txwA:
undetectable		 4qt3A-4txwA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 4txw HYALURONOGLUCOSAMINI
DASE
(Clostridium
perfringens) 		3 / 3 ARG A 129
ASP A  40
TYR A  -1
 None
 0.92A 4yo9B-4txwA:
undetectable		 4yo9B-4txwA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 4txw HYALURONOGLUCOSAMINI
DASE
(Clostridium
perfringens) 		3 / 3 THR A  57
THR A  96
PHE A  94
 None
 0.70A 5cxvA-4txwA:
undetectable		 5cxvA-4txwA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_1
(PEPTIDYLPROLYL
ISOMERASE)		 4txw HYALURONOGLUCOSAMINI
DASE
(Clostridium
perfringens) 		5 / 10 TYR A   7
VAL A 145
ILE A 146
TYR A  52
ILE A  67
 None
 1.40A 6mkeC-4txwA:
undetectable		 6mkeC-4txwA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_1
(PEPTIDYLPROLYL
ISOMERASE)		 4txw HYALURONOGLUCOSAMINI
DASE
(Clostridium
perfringens) 		5 / 10 TYR A   7
VAL A 145
ILE A 146
TYR A  52
ILE A  67
 None
 1.39A 6mkeD-4txwA:
undetectable		 6mkeD-4txwA:
18.71