SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tyh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
5 / 12 VAL B 102
LEU B  55
LEU B  75
LEU B 104
LEU B  74
None
None
39G  B 401 (-4.3A)
39G  B 401 ( 4.7A)
None
0.93A 1mx1C-4tyhB:
undetectable
1mx1C-4tyhB:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
5 / 12 VAL B 102
LEU B  55
LEU B  75
LEU B 104
LEU B  74
None
None
39G  B 401 (-4.3A)
39G  B 401 ( 4.7A)
None
1.06A 1mx1F-4tyhB:
undetectable
1mx1F-4tyhB:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
6 / 9 VAL B  38
LYS B  53
LEU B  86
LEU B 104
LEU B 108
MET B 109
None
39G  B 401 (-4.2A)
None
39G  B 401 ( 4.7A)
39G  B 401 ( 4.9A)
39G  B 401 (-4.8A)
0.68A 1xkkA-4tyhB:
20.6
1xkkA-4tyhB:
25.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDK_A_C2FA1410_0
(GLYCINE
N-METHYLTRANSFERASE)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
5 / 11 LEU B 232
HIS B 228
SER B 254
TYR B 258
LEU B 236
None
1.49A 2idkA-4tyhB:
undetectable
2idkB-4tyhB:
undetectable
2idkC-4tyhB:
undetectable
2idkD-4tyhB:
undetectable
2idkA-4tyhB:
22.19
2idkB-4tyhB:
22.19
2idkC-4tyhB:
22.19
2idkD-4tyhB:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDK_B_C2FB1420_0
(GLYCINE
N-METHYLTRANSFERASE)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
5 / 10 LEU B 236
SER B 254
TYR B 258
LEU B 232
HIS B 228
None
1.36A 2idkA-4tyhB:
1.2
2idkB-4tyhB:
1.2
2idkC-4tyhB:
0.0
2idkD-4tyhB:
1.3
2idkA-4tyhB:
22.19
2idkB-4tyhB:
22.19
2idkC-4tyhB:
22.19
2idkD-4tyhB:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
3 / 3 LEU B 104
LEU B 108
MET B 109
39G  B 401 ( 4.7A)
39G  B 401 ( 4.9A)
39G  B 401 (-4.8A)
0.51A 2itzA-4tyhB:
21.7
2itzA-4tyhB:
25.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA426_0
(FERROCHELATASE)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
4 / 4 LEU B 246
PRO B 242
LEU B 291
ARG B 296
None
1.38A 2qd2A-4tyhB:
undetectable
2qd2A-4tyhB:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CD2_A_MTXA307_1
(DIHYDROFOLATE
REDUCTASE)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
5 / 12 ILE B 131
LEU B 289
ILE B 206
LEU B 151
ILE B 212
None
1.16A 3cd2A-4tyhB:
undetectable
3cd2A-4tyhB:
19.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
6 / 12 GLU B  71
LEU B  74
LEU B  75
THR B 106
LEU B 167
ASP B 168
39G  B 401 (-3.4A)
None
39G  B 401 (-4.3A)
39G  B 401 (-3.6A)
39G  B 401 (-3.6A)
39G  B 401 (-3.5A)
1.26A 3gcsA-4tyhB:
29.9
3gcsA-4tyhB:
98.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
5 / 12 LEU B  75
ILE B  84
THR B 106
LEU B 167
ASP B 168
39G  B 401 (-4.3A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
39G  B 401 (-3.6A)
39G  B 401 (-3.5A)
0.95A 3gcsA-4tyhB:
29.9
3gcsA-4tyhB:
98.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
9 / 12 VAL B  38
ALA B  51
GLU B  71
LEU B  74
LEU B  75
THR B 106
ILE B 141
HIS B 148
LEU B 167
None
39G  B 401 (-3.5A)
39G  B 401 (-3.4A)
None
39G  B 401 (-4.3A)
39G  B 401 (-3.6A)
None
None
39G  B 401 (-3.6A)
0.95A 3gcsA-4tyhB:
29.9
3gcsA-4tyhB:
98.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
8 / 12 VAL B  38
ALA B  51
LEU B  75
ILE B  84
THR B 106
ILE B 141
HIS B 148
LEU B 167
None
39G  B 401 (-3.5A)
39G  B 401 (-4.3A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
None
None
39G  B 401 (-3.6A)
0.81A 3gcsA-4tyhB:
29.9
3gcsA-4tyhB:
98.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
5 / 12 VAL B 117
LEU B 164
ILE B 134
ILE B 141
HIS B 148
None
0.90A 3gcsA-4tyhB:
29.9
3gcsA-4tyhB:
98.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
5 / 6 MET B  78
VAL B  83
LEU B 108
ILE B 146
ILE B 166
None
None
39G  B 401 ( 4.9A)
None
None
0.62A 3gcsA-4tyhB:
29.9
3gcsA-4tyhB:
98.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GCS_A_BAXA401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
5 / 6 MET B  78
VAL B  83
LEU B 108
MET B 109
ILE B 166
None
None
39G  B 401 ( 4.9A)
39G  B 401 (-4.8A)
None
1.07A 3gcsA-4tyhB:
29.9
3gcsA-4tyhB:
98.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
8 / 12 ALA B  51
GLU B  71
LEU B  74
LEU B  75
ILE B  84
ALA B 157
LEU B 167
ASP B 168
39G  B 401 (-3.5A)
39G  B 401 (-3.4A)
None
39G  B 401 (-4.3A)
39G  B 401 ( 3.8A)
39G  B 401 ( 4.9A)
39G  B 401 (-3.6A)
39G  B 401 (-3.5A)
1.08A 3gp0A-4tyhB:
41.1
3gp0A-4tyhB:
75.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
8 / 12 ALA B  51
GLU B  71
LEU B  74
LEU B  75
ILE B  84
HIS B 148
ALA B 157
LEU B 167
39G  B 401 (-3.5A)
39G  B 401 (-3.4A)
None
39G  B 401 (-4.3A)
39G  B 401 ( 3.8A)
None
39G  B 401 ( 4.9A)
39G  B 401 (-3.6A)
0.85A 3gp0A-4tyhB:
41.1
3gp0A-4tyhB:
75.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
9 / 12 VAL B  38
ALA B  51
LEU B  74
LEU B  75
ILE B  84
THR B 106
ALA B 157
LEU B 167
ASP B 168
None
39G  B 401 (-3.5A)
None
39G  B 401 (-4.3A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
39G  B 401 ( 4.9A)
39G  B 401 (-3.6A)
39G  B 401 (-3.5A)
0.98A 3gp0A-4tyhB:
41.1
3gp0A-4tyhB:
75.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
9 / 12 VAL B  38
ALA B  51
LEU B  74
LEU B  75
ILE B  84
THR B 106
HIS B 148
ALA B 157
LEU B 167
None
39G  B 401 (-3.5A)
None
39G  B 401 (-4.3A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
None
39G  B 401 ( 4.9A)
39G  B 401 (-3.6A)
0.90A 3gp0A-4tyhB:
41.1
3gp0A-4tyhB:
75.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
5 / 12 GLU B  71
LEU B  75
ILE B  84
LEU B 167
ASP B 168
39G  B 401 (-3.4A)
39G  B 401 (-4.3A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
39G  B 401 (-3.5A)
0.79A 3hecA-4tyhB:
41.0
3hecA-4tyhB:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
5 / 12 LEU B  75
ILE B  84
THR B 106
LEU B 167
ASP B 168
39G  B 401 (-4.3A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
39G  B 401 (-3.6A)
39G  B 401 (-3.5A)
0.81A 3hecA-4tyhB:
41.0
3hecA-4tyhB:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
6 / 12 LYS B  53
ILE B  84
THR B 106
LEU B 108
LEU B 167
ASP B 168
39G  B 401 (-4.2A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
39G  B 401 ( 4.9A)
39G  B 401 (-3.6A)
39G  B 401 (-3.5A)
0.85A 3hecA-4tyhB:
41.0
3hecA-4tyhB:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
7 / 12 VAL B  30
ALA B  51
LEU B  74
ILE B  84
THR B 106
LEU B 108
LEU B 167
None
39G  B 401 (-3.5A)
None
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
39G  B 401 ( 4.9A)
39G  B 401 (-3.6A)
0.59A 3hecA-4tyhB:
41.0
3hecA-4tyhB:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
7 / 12 VAL B  30
ALA B  51
LEU B  74
LEU B  75
ILE B  84
THR B 106
LEU B 167
None
39G  B 401 (-3.5A)
None
39G  B 401 (-4.3A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
39G  B 401 (-3.6A)
0.63A 3hecA-4tyhB:
41.0
3hecA-4tyhB:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
7 / 12 VAL B  30
ALA B  51
LYS B  53
ILE B  84
THR B 106
LEU B 108
LEU B 167
None
39G  B 401 (-3.5A)
39G  B 401 (-4.2A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
39G  B 401 ( 4.9A)
39G  B 401 (-3.6A)
0.65A 3hecA-4tyhB:
41.0
3hecA-4tyhB:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEC_A_STIA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
6 / 12 VAL B  30
GLU B  71
LEU B  74
LEU B  75
ILE B  84
LEU B 167
None
39G  B 401 (-3.4A)
None
39G  B 401 (-4.3A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
0.66A 3hecA-4tyhB:
41.0
3hecA-4tyhB:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
7 / 12 VAL B  30
VAL B  38
ALA B  51
GLU B  71
LEU B  74
LEU B  75
ILE B 141
None
None
39G  B 401 (-3.5A)
39G  B 401 (-3.4A)
None
39G  B 401 (-4.3A)
None
0.84A 3hegA-4tyhB:
42.1
3hegA-4tyhB:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
7 / 12 VAL B  30
VAL B  38
ALA B  51
LEU B  74
LEU B  75
THR B 106
ILE B 141
None
None
39G  B 401 (-3.5A)
None
39G  B 401 (-4.3A)
39G  B 401 (-3.6A)
None
0.69A 3hegA-4tyhB:
42.1
3hegA-4tyhB:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
7 / 12 VAL B  30
VAL B  38
ALA B  51
LEU B  75
ILE B  84
THR B 106
ILE B 141
None
None
39G  B 401 (-3.5A)
39G  B 401 (-4.3A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
None
0.57A 3hegA-4tyhB:
42.1
3hegA-4tyhB:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
6 / 12 VAL B  38
ALA B  51
LYS B  53
ILE B  84
THR B 106
ILE B 141
None
39G  B 401 (-3.5A)
39G  B 401 (-4.2A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
None
0.84A 3hegA-4tyhB:
42.1
3hegA-4tyhB:
99.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEG_A_BAXA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
6 / 6 MET B  78
VAL B  83
ILE B 146
HIS B 148
ILE B 166
LEU B 167
None
None
None
None
None
39G  B 401 (-3.6A)
0.63A 3hegA-4tyhB:
42.1
3hegA-4tyhB:
99.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_1
(DIHYDROFOLATE
REDUCTASE)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
5 / 12 ALA B 302
GLN B 133
SER B 208
ILE B 212
LEU B 216
None
1.37A 3ia4A-4tyhB:
undetectable
3ia4A-4tyhB:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
5 / 10 ALA B 302
LEU B 138
ILE B 212
LEU B 156
ILE B 131
None
1.08A 3jw3A-4tyhB:
undetectable
3jw3A-4tyhB:
17.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
5 / 8 ALA B  51
LYS B  53
THR B 106
LEU B 108
MET B 109
39G  B 401 (-3.5A)
39G  B 401 (-4.2A)
39G  B 401 (-3.6A)
39G  B 401 ( 4.9A)
39G  B 401 (-4.8A)
0.61A 3lfaA-4tyhB:
42.6
3lfaA-4tyhB:
99.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
6 / 8 VAL B  30
ALA B  51
LEU B 104
THR B 106
LEU B 108
MET B 109
None
39G  B 401 (-3.5A)
39G  B 401 ( 4.7A)
39G  B 401 (-3.6A)
39G  B 401 ( 4.9A)
39G  B 401 (-4.8A)
0.54A 3lfaA-4tyhB:
42.6
3lfaA-4tyhB:
99.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OG7_A_032A1_1
(AKAP9-BRAF FUSION
PROTEIN)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
5 / 12 VAL B  38
ALA B  51
LYS B  53
LEU B  75
THR B 106
None
39G  B 401 (-3.5A)
39G  B 401 (-4.2A)
39G  B 401 (-4.3A)
39G  B 401 (-3.6A)
0.70A 3og7A-4tyhB:
19.2
3og7A-4tyhB:
25.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OHT_A_1N1A1000_1
(P38A)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
7 / 12 GLY B  31
VAL B  38
ALA B  51
LEU B  75
ILE B  84
THR B 106
ASN B 114
None
None
39G  B 401 (-3.5A)
39G  B 401 (-4.3A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
None
1.46A 3ohtA-4tyhB:
34.3
3ohtA-4tyhB:
86.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OHT_A_1N1A1000_1
(P38A)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
9 / 12 VAL B  30
GLY B  31
VAL B  38
ALA B  51
LYS B  53
LEU B  75
ILE B  84
THR B 106
LEU B 167
None
None
None
39G  B 401 (-3.5A)
39G  B 401 (-4.2A)
39G  B 401 (-4.3A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
39G  B 401 (-3.6A)
0.86A 3ohtA-4tyhB:
34.3
3ohtA-4tyhB:
86.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OHT_A_1N1A1000_1
(P38A)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
7 / 12 VAL B  30
GLY B  31
VAL B  38
LYS B  53
ILE B  84
LEU B 167
ASP B 168
None
None
None
39G  B 401 (-4.2A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
39G  B 401 (-3.5A)
1.21A 3ohtA-4tyhB:
34.3
3ohtA-4tyhB:
86.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OHT_A_1N1A1000_1
(P38A)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
9 / 12 VAL B  30
VAL B  38
ALA B  51
LYS B  53
LEU B  75
ILE B  84
THR B 106
ASN B 115
LEU B 167
None
None
39G  B 401 (-3.5A)
39G  B 401 (-4.2A)
39G  B 401 (-4.3A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
None
39G  B 401 (-3.6A)
0.86A 3ohtA-4tyhB:
34.3
3ohtA-4tyhB:
86.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OHT_B_1N1B1000_1
(P38A)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
7 / 12 GLY B  31
VAL B  38
ALA B  51
LYS B  53
ILE B  84
THR B 106
LEU B 167
None
None
39G  B 401 (-3.5A)
39G  B 401 (-4.2A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
39G  B 401 (-3.6A)
0.77A 3ohtB-4tyhB:
34.3
3ohtB-4tyhB:
86.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OHT_B_1N1B1000_1
(P38A)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
5 / 12 VAL B  38
ALA B  51
LEU B  75
ILE B  84
LEU B 167
None
39G  B 401 (-3.5A)
39G  B 401 (-4.3A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
0.45A 3ohtB-4tyhB:
34.3
3ohtB-4tyhB:
86.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OHT_B_1N1B1000_1
(P38A)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
6 / 12 VAL B  38
ALA B  51
LYS B  53
ILE B  84
THR B 106
ASN B 115
None
39G  B 401 (-3.5A)
39G  B 401 (-4.2A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
None
0.85A 3ohtB-4tyhB:
34.3
3ohtB-4tyhB:
86.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
5 / 7 PHE B 169
VAL B  83
ILE B 166
SER B 143
TYR B 140
None
1.42A 3pglA-4tyhB:
undetectable
3pglA-4tyhB:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QL0_A_FOLA160_0
(DIHYDROFOLATE
REDUCTASE)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
5 / 12 ALA B 302
MET B 288
LEU B 138
ILE B 212
LEU B 156
None
1.07A 3ql0A-4tyhB:
undetectable
3ql0A-4tyhB:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
4 / 4 SER B  56
ASP B 168
ASP B 112
ALA B  34
None
39G  B 401 (-3.5A)
None
None
1.37A 3uj6A-4tyhB:
undetectable
3uj6A-4tyhB:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI507_0
(RNA POLYMERASE
3D-POL)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
3 / 3 LYS B 152
PRO B 153
SER B 154
None
0.43A 4k50I-4tyhB:
0.8
4k50I-4tyhB:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
4 / 5 PHE B  42
HIS B  48
LEU B  87
PRO B 351
None
1.30A 4o8zA-4tyhB:
undetectable
4o8zA-4tyhB:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
4 / 8 LYS B 118
ILE B 116
ASN B 115
ALA B 111
None
0.91A 4ou1A-4tyhB:
undetectable
4ou1A-4tyhB:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZ7_A_1E8A901_1
(CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
5 / 10 ALA B  51
LYS B  53
ILE B  84
THR B 106
LEU B 108
39G  B 401 (-3.5A)
39G  B 401 (-4.2A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
39G  B 401 ( 4.9A)
0.83A 4rz7A-4tyhB:
17.6
4rz7A-4tyhB:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
4 / 7 VAL B  38
LYS B  53
ILE B  84
ILE B 166
None
39G  B 401 (-4.2A)
39G  B 401 ( 3.8A)
None
0.79A 4uxqA-4tyhB:
21.3
4uxqA-4tyhB:
27.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
4 / 8 LEU B  75
LEU B 167
TYR B 140
GLN B 202
39G  B 401 (-4.3A)
39G  B 401 (-3.6A)
None
None
1.19A 5hbsA-4tyhB:
undetectable
5hbsA-4tyhB:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_E_ADNE401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
5 / 10 GLY B  31
VAL B  38
ALA B  51
LEU B 108
MET B 109
None
None
39G  B 401 (-3.5A)
39G  B 401 ( 4.9A)
39G  B 401 (-4.8A)
0.77A 5lw1E-4tyhB:
36.8
5lw1E-4tyhB:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
5 / 9 GLY B  31
ALA B  51
LEU B 108
MET B 109
LEU B 167
None
39G  B 401 (-3.5A)
39G  B 401 ( 4.9A)
39G  B 401 (-4.8A)
39G  B 401 (-3.6A)
0.80A 5lw1H-4tyhB:
15.5
5lw1H-4tyhB:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LW1_H_ADNH401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 8)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
5 / 9 GLY B  31
VAL B  38
ALA B  51
LEU B 108
MET B 109
None
None
39G  B 401 (-3.5A)
39G  B 401 ( 4.9A)
39G  B 401 (-4.8A)
0.77A 5lw1H-4tyhB:
15.5
5lw1H-4tyhB:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
5 / 12 LEU B 138
ILE B 206
GLY B 210
ILE B 131
LEU B 238
None
0.90A 5ycnA-4tyhB:
undetectable
5ycnA-4tyhB:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus
musculus)
3 / 3 ARG B 256
ILE B 250
SER B 252
None
0.84A 5zw2A-4tyhB:
undetectable
5zw2A-4tyhB:
22.72