SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tz0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 4tz0 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 7 GLU A 197
PHE A 258
MET A 228
ALA A 226
 None
 1.34A 1linA-4tz0A:
undetectable		 1linA-4tz0A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4tz0 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 438
LEU A 273
ASP A 270
LEU A 308
 None
 1.21A 1n13B-4tz0A:
undetectable
1n13C-4tz0A:
undetectable		 1n13B-4tz0A:
12.11
1n13C-4tz0A:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 4tz0 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 388
GLY A 560
ILE A 529
VAL A 530
 None
 0.77A 1p2yA-4tz0A:
undetectable		 1p2yA-4tz0A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 4tz0 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 299
ARG A 259
LEU A 288
ASN A 292
 None
 1.11A 1y0xX-4tz0A:
undetectable		 1y0xX-4tz0A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZQ_A_PCFA954_0
(CATECHOL
1,2-DIOXYGENASE)		 4tz0 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 246
ALA A 193
LEU A 194
GLU A 199
LEU A 163
 None
None
None
GDP  A 601 ( 4.2A)
None
 1.32A 2azqA-4tz0A:
undetectable		 2azqA-4tz0A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_P1ZA2002_1
(SERUM ALBUMIN)		 4tz0 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 LEU A 533
PHE A 352
ILE A 356
ILE A 451
ALA A 380
 None
 0.98A 2bxqA-4tz0A:
2.1		 2bxqA-4tz0A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)		 4tz0 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 8 ARG A 245
GLY A 244
THR A 283
ILE A 284
 A  B   7 ( 4.0A)
A  B   6 ( 3.4A)
None
None
 0.94A 2f9wA-4tz0A:
undetectable
2f9wB-4tz0A:
undetectable		 2f9wA-4tz0A:
19.34
2f9wB-4tz0A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 4tz0 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 499
ILE A 497
ALA A 338
THR A 154
ALA A 468
 None
None
None
BEF  A 602 (-4.4A)
None
 0.94A 2j0dA-4tz0A:
undetectable		 2j0dA-4tz0A:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1122_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 4tz0 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 7 SER A 345
LYS A 501
SER A 475
VAL A 477
 None
 1.03A 2j9cA-4tz0A:
undetectable
2j9cB-4tz0A:
undetectable
2j9cC-4tz0A:
undetectable		 2j9cA-4tz0A:
13.75
2j9cB-4tz0A:
13.75
2j9cC-4tz0A:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 4tz0 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 451
SER A 355
VAL A 515
VAL A 561
ILE A 555
 None
 1.01A 2nnhA-4tz0A:
undetectable		 2nnhA-4tz0A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 4tz0 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 10 SER A 254
ILE A 287
ILE A 247
VAL A 186
ILE A 299
 None
 1.15A 2nnhB-4tz0A:
undetectable		 2nnhB-4tz0A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOB_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4tz0 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 GLN A 134
PHE A 160
ALA A 161
THR A 130
LEU A 141
 None
GDP  A 601 (-4.1A)
None
GDP  A 601 (-3.6A)
None
 1.18A 3aobC-4tz0A:
undetectable		 3aobC-4tz0A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4tz0 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 4 ILE A 497
GLN A 502
ILE A 342
LEU A 485
 None
 1.15A 3dzyD-4tz0A:
undetectable		 3dzyD-4tz0A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 4tz0 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 10 THR A 558
GLY A 560
LEU A 562
LEU A 563
ILE A 526
 None
 1.08A 3kvrA-4tz0A:
2.3		 3kvrA-4tz0A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 4tz0 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 10 THR A 558
GLY A 560
LEU A 562
LEU A 563
ILE A 526
 None
 1.16A 3kvrB-4tz0A:
undetectable		 3kvrB-4tz0A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 4tz0 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 9 THR A 558
GLY A 560
LEU A 562
LEU A 563
ILE A 526
 None
 1.10A 3nbqA-4tz0A:
undetectable		 3nbqA-4tz0A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 4tz0 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 560
LEU A 562
LEU A 563
ILE A 526
 None
 0.90A 3nbqB-4tz0A:
undetectable		 3nbqB-4tz0A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)		 4tz0 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 560
LEU A 562
LEU A 563
ILE A 526
 None
 0.91A 3nbqC-4tz0A:
undetectable		 3nbqC-4tz0A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RZE_A_D7VA1201_1
(HISTAMINE H1
RECEPTOR, LYSOZYME
CHIMERA)		 4tz0 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 SER A 536
ILE A 555
TYR A 544
PHE A 546
PHE A 487
 A  B   2 ( 4.2A)
None
None
None
None
 1.43A 3rzeA-4tz0A:
undetectable		 3rzeA-4tz0A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4tz0 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 6 GLU A 484
ILE A 480
PHE A 352
VAL A 515
 None
 1.23A 4a97I-4tz0A:
undetectable		 4a97I-4tz0A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 4tz0 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 6 MET A 591
GLY A 588
GLU A 548
ARG A 538
 None
 1.49A 4bqfA-4tz0A:
undetectable		 4bqfA-4tz0A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 4tz0 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		3 / 3 GLY A 244
PRO A 243
ALA A 187
 A  B   6 ( 3.4A)
A  B   5 ( 4.1A)
None
 0.49A 4qn9B-4tz0A:
undetectable		 4qn9B-4tz0A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 4tz0 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 478
GLU A 484
SER A 349
VAL A 488
 None
 1.06A 4wnvD-4tz0A:
undetectable		 4wnvD-4tz0A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 4tz0 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 469
HIS A 462
ARG A 466
 BEF  A 602 ( 2.6A)
None
BEF  A 602 (-3.0A)
 1.11A 5iaoC-4tz0A:
2.6		 5iaoC-4tz0A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 4tz0 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 469
HIS A 462
ARG A 466
 BEF  A 602 ( 2.6A)
None
BEF  A 602 (-3.0A)
 1.15A 5iaoF-4tz0A:
2.5		 5iaoF-4tz0A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 4tz0 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 570
LEU A 533
LEU A 563
GLY A 560
ILE A 526
 None
 1.24A 5j7wC-4tz0A:
undetectable		 5j7wC-4tz0A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 4tz0 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 534
PRO A 553
ALA A 556
PHE A 592
 None
 0.99A 5m0oC-4tz0A:
undetectable		 5m0oC-4tz0A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4tz0 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 5 GLY A 436
ASP A 434
ARG A 466
ARG A 463
 None
A  B   3 ( 4.5A)
BEF  A 602 (-3.0A)
None
 1.33A 6dwdB-4tz0A:
undetectable
6dwdD-4tz0A:
undetectable		 6dwdB-4tz0A:
22.00
6dwdD-4tz0A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 4tz0 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 466
ARG A 463
GLY A 436
ASP A 434
 BEF  A 602 (-3.0A)
None
None
A  B   3 ( 4.5A)
 1.34A 6dwjB-4tz0A:
undetectable
6dwjD-4tz0A:
undetectable		 6dwjB-4tz0A:
22.00
6dwjD-4tz0A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_B_FOZB401_0
(THYMIDYLATE SYNTHASE)		 4tz0 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 570
LEU A 533
LEU A 563
GLY A 560
ILE A 526
 None
 1.22A 6qyaB-4tz0A:
undetectable		 6qyaB-4tz0A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QYA_D_FOZD401_0
(THYMIDYLATE SYNTHASE)		 4tz0 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 570
LEU A 533
LEU A 563
GLY A 560
ILE A 526
 None
 1.24A 6qyaD-4tz0A:
undetectable		 6qyaD-4tz0A:
23.15