SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tz5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1CQP_B_803B311_1 (ANTIGEN CD11A (P180))	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	4 / 7	VAL A 68 LEU A 330 VAL A 309 LEU A 271	None	0.88A	1cqpA-4tz5A: undetectable 1cqpB-4tz5A: undetectable	1cqpA-4tz5A: 15.72 1cqpB-4tz5A: 15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FXV_B_PNNB1001_0 (PENICILLIN ACYLASE)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	4 / 7	SER A 205 PHE A 133 ALA A 156 PHE A 178	None	0.99A	1fxvA-4tz5A: undetectable 1fxvB-4tz5A: undetectable	1fxvA-4tz5A: 15.45 1fxvB-4tz5A: 23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GM7_B_PNNB1577_0 (PENICILLIN G ACYLASE ALPHA SUBUNIT PENICILLIN G ACYLASE BETA SUBUNIT)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	4 / 8	SER A 205 PHE A 133 ALA A 156 PHE A 178	None	0.97A	1gm7A-4tz5A: undetectable 1gm7B-4tz5A: undetectable	1gm7A-4tz5A: 15.45 1gm7B-4tz5A: 23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GM7_B_PNNB1577_0 (PENICILLIN G ACYLASE ALPHA SUBUNIT PENICILLIN G ACYLASE BETA SUBUNIT)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	4 / 8	SER A 205 SER A 120 ALA A 156 PHE A 178	None	0.85A	1gm7A-4tz5A: undetectable 1gm7B-4tz5A: undetectable	1gm7A-4tz5A: 15.45 1gm7B-4tz5A: 23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1GMK_C_DVAC6_0 (GRAMICIDIN A)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	3 / 3	ALA A 190 VAL A 172 TRP A 170	None	0.93A	1gmkC-4tz5A: undetectable 1gmkD-4tz5A: undetectable	1gmkC-4tz5A: 3.34 1gmkD-4tz5A: 3.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HRK_A_CHDA1502_0 (FERROCHELATASE)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	4 / 8	ARG A 169 VAL A 211 GLY A 212 TRP A 229	BGC A 709 ( 3.9A) None None None	0.97A	1hrkA-4tz5A: undetectable	1hrkA-4tz5A: 21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1HRK_B_CHDB2502_0 (FERROCHELATASE)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	4 / 8	ARG A 169 VAL A 211 GLY A 212 TRP A 229	BGC A 709 ( 3.9A) None None None	0.95A	1hrkB-4tz5A: undetectable	1hrkB-4tz5A: 21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JHR_A_NIOA991_1 (NICOTINATE MONONUCLEOTIDE:5,6-D IMETHYLBENZIMIDAZOLE PHOSPHORIBOSYLTRANSF ERASE)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	5 / 9	LEU A 354 SER A 155 GLU A 157 ARG A 179 GLY A 380	None	1.22A	1jhrA-4tz5A: undetectable	1jhrA-4tz5A: 21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JHY_A_NIOA991_1 (NICOTINATE MONONUCLEOTIDE:5,6-D IMETHYLBENZIMIDAZOLE PHOSPHORIBOSYLTRANSF ERASE)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	5 / 9	LEU A 354 SER A 155 GLU A 157 ARG A 179 GLY A 380	None	1.24A	1jhyA-4tz5A: undetectable	1jhyA-4tz5A: 21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1L5K_A_NIOA991_1 (NICOTINATE-NUCLEOTID E--DIMETHYLBENZIMIDA ZOLE PHOSPHORIBOSYLTRANSF ERASE)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	5 / 9	LEU A 354 SER A 155 GLU A 157 ARG A 179 GLY A 380	None	1.28A	1l5kA-4tz5A: undetectable	1l5kA-4tz5A: 21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1W5U_B_DVAB6_0 (GRAMICIDIN D)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	3 / 3	TRP A 170 ALA A 190 VAL A 172	None	0.98A	1w5uA-4tz5A: undetectable 1w5uB-4tz5A: undetectable	1w5uA-4tz5A: 3.34 1w5uB-4tz5A: 3.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2AOJ_C_FRDC305_1 (POL POLYPROTEIN PEPTIDE INHIBITOR)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	4 / 5	ASP A 437 GLY A 494 PRO A 261 VAL A 262	None	0.86A	2aojA-4tz5A: undetectable	2aojA-4tz5A: 13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BR4_B_SAMB301_0 (CEPHALOSPORIN HYDROXYLASE CMCI)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	5 / 12	LYS A 266 GLU A 157 GLY A 123 TYR A 270 ALA A 160	None	1.09A	2br4B-4tz5A: undetectable	2br4B-4tz5A: 16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2IZQ_A_DVAA6_0 (GRAMICIDIN D)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	3 / 3	ALA A 190 VAL A 172 TRP A 170	None	0.91A	2izqA-4tz5A: undetectable 2izqB-4tz5A: undetectable	2izqA-4tz5A: 3.34 2izqB-4tz5A: 3.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OXT_D_SAMD300_0 (NUCLEOSIDE-2'-O-METH YLTRANSFERASE)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	6 / 12	GLY A 95 ASP A 384 GLY A 420 GLY A 423 GLU A 452 HIS A 481	None None None None None BGC A 707 (-4.2A)	1.36A	2oxtD-4tz5A: undetectable	2oxtD-4tz5A: 18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QMZ_B_LDPB502_1 (RIBOSYLDIHYDRONICOTI NAMIDE DEHYDROGENASE)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	4 / 5	GLN A 150 PHE A 152 TRP A 444 GLY A 421	BGC A 707 ( 4.6A) BGC A 707 (-4.9A) None None	0.94A	2qmzA-4tz5A: undetectable 2qmzB-4tz5A: undetectable	2qmzA-4tz5A: 17.43 2qmzB-4tz5A: 17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QX6_B_ML1B233_1 (RIBOSYLDIHYDRONICOTI NAMIDE DEHYDROGENASE [QUINONE])	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	4 / 6	TRP A 444 GLY A 421 GLN A 150 PHE A 152	None None BGC A 707 ( 4.6A) BGC A 707 (-4.9A)	0.90A	2qx6A-4tz5A: undetectable 2qx6B-4tz5A: undetectable	2qx6A-4tz5A: 17.43 2qx6B-4tz5A: 17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2RCT_A_RTLA140_1 (RETINOL-BINDING PROTEIN II, CELLULAR)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	3 / 3	GLN A 218 THR A 596 TRP A 196	None BGC A 703 (-3.5A) BGC A 703 (-3.7A)	1.08A	2rctA-4tz5A: undetectable	2rctA-4tz5A: 14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2RLF_D_RIMD499_1 (MATRIX PROTEIN 2)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	4 / 6	ILE A 497 ARG A 222 LEU A 473 ASP A 223	None	1.00A	2rlfA-4tz5A: undetectable 2rlfD-4tz5A: undetectable	2rlfA-4tz5A: 6.04 2rlfD-4tz5A: 6.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2V41_G_BEZG1222_0 (PEROXIREDOXIN 6.)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	4 / 8	THR A 260 PRO A 261 VAL A 262 SER A 263	None	1.16A	2v41G-4tz5A: undetectable 2v41H-4tz5A: undetectable	2v41G-4tz5A: 18.21 2v41H-4tz5A: 18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AXZ_A_ADNA401_1 (TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	5 / 12	GLY A 209 GLY A 186 SER A 224 GLY A 228 GLY A 227	None	0.84A	3axzA-4tz5A: undetectable	3axzA-4tz5A: 18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ELZ_C_CHDC150_0 (ILEAL BILE ACID-BINDING PROTEIN)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	5 / 12	VAL A 376 VAL A 383 LEU A 393 ILE A 359 THR A 366	None	1.28A	3elzC-4tz5A: undetectable	3elzC-4tz5A: 13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IX9_B_MTXB200_1 (DIHYDROFOLATE REDUCTASE)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	5 / 12	ALA A 122 LEU A 124 GLU A 157 LEU A 330 VAL A 68	None	1.17A	3ix9B-4tz5A: undetectable	3ix9B-4tz5A: 15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MBH_A_PXLA400_1 (PUTATIVE PHOSPHOMETHYLPYRIMID INE KINASE)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	5 / 11	VAL A 467 LEU A 477 THR A 496 TYR A 524 VAL A 526	None	1.50A	3mbhA-4tz5A: undetectable	3mbhA-4tz5A: 19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MBH_B_PXLB400_1 (PUTATIVE PHOSPHOMETHYLPYRIMID INE KINASE)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	5 / 12	VAL A 467 LEU A 477 THR A 496 TYR A 524 VAL A 526	None	1.48A	3mbhB-4tz5A: undetectable	3mbhB-4tz5A: 19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MBH_D_PXLD400_1 (PUTATIVE PHOSPHOMETHYLPYRIMID INE KINASE)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	5 / 12	VAL A 467 LEU A 477 THR A 496 TYR A 524 VAL A 526	None	1.49A	3mbhD-4tz5A: undetectable	3mbhD-4tz5A: 19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RQW_C_ACHC323_0 (ELIC PENTAMERIC LIGAND GATED ION CHANNEL FROM ERWINIA CHRYSANTHEMI)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	4 / 8	PHE A 249 ASN A 235 LEU A 570 PHE A 556	None	1.08A	3rqwC-4tz5A: undetectable 3rqwD-4tz5A: undetectable	3rqwC-4tz5A: 18.26 3rqwD-4tz5A: 18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RQW_J_ACHJ323_0 (ELIC PENTAMERIC LIGAND GATED ION CHANNEL FROM ERWINIA CHRYSANTHEMI)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	4 / 8	LEU A 570 PHE A 556 PHE A 249 ASN A 235	None	1.08A	3rqwF-4tz5A: undetectable 3rqwJ-4tz5A: undetectable	3rqwF-4tz5A: 18.26 3rqwJ-4tz5A: 18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3W9T_B_W9TB501_1 (HEMOLYTIC LECTIN CEL-III)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	4 / 5	ASP A 204 SER A 224 GLY A 289 TRP A 292	None	1.23A	3w9tB-4tz5A: undetectable	3w9tB-4tz5A: 24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3W9T_C_W9TC1003_1 (HEMOLYTIC LECTIN CEL-III)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	4 / 5	ASP A 204 SER A 224 GLY A 289 TRP A 292	None	1.23A	3w9tC-4tz5A: undetectable	3w9tC-4tz5A: 24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3W9T_D_W9TD501_1 (HEMOLYTIC LECTIN CEL-III)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	4 / 5	ASP A 204 SER A 224 GLY A 289 TRP A 292	None	1.24A	3w9tD-4tz5A: undetectable	3w9tD-4tz5A: 24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3W9T_F_W9TF501_1 (HEMOLYTIC LECTIN CEL-III)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	4 / 4	ASP A 204 SER A 224 GLY A 289 TRP A 292	None	1.23A	3w9tF-4tz5A: 0.0	3w9tF-4tz5A: 24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WQW_A_GCSA502_1 (CHITINASE)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	4 / 5	TRP A 153 GLY A 451 ALA A 422 PHE A 117	None	1.32A	3wqwA-4tz5A: undetectable	3wqwA-4tz5A: 21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4CUT_A_TYLA2971_1 (BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 2B)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	4 / 4	VAL A 526 VAL A 564 ASN A 585 ILE A 584	None	1.23A	4cutA-4tz5A: undetectable	4cutA-4tz5A: 12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FFW_B_715B801_2 (DIPEPTIDYL PEPTIDASE 4)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	3 / 3	ARG A 551 TYR A 485 ASN A 501	None	0.82A	4ffwB-4tz5A: undetectable	4ffwB-4tz5A: 20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FGJ_A_1PQA304_0 (RIBOSYLDIHYDRONICOTI NAMIDE DEHYDROGENASE [QUINONE])	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	4 / 8	GLN A 150 PHE A 152 TRP A 444 GLY A 421	BGC A 707 ( 4.6A) BGC A 707 (-4.9A) None None	0.95A	4fgjA-4tz5A: undetectable 4fgjB-4tz5A: undetectable	4fgjA-4tz5A: 17.74 4fgjB-4tz5A: 17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4G19_D_ACTD305_0 (GLUTATHIONE TRANSFERASE GTE1)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	4 / 4	ILE A 344 LEU A 368 LYS A 369 ASN A 320	None	1.15A	4g19D-4tz5A: undetectable	4g19D-4tz5A: 18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L1A_A_AB1A101_2 (MDR769 HIV-1 PROTEASE)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	4 / 6	ASN A 158 ASP A 204 GLY A 293 THR A 131	None	1.08A	4l1aB-4tz5A: undetectable	4l1aB-4tz5A: 12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L64_A_C2FA802_0 (5-METHYLTETRAHYDROPT EROYLTRIGLUTAMATE--H OMOCYSTEINE METHYLTRANSFERASE)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	4 / 7	TYR A 220 ARG A 222 VAL A 241 TRP A 229	None	1.49A	4l64A-4tz5A: undetectable	4l64A-4tz5A: 22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4O33_A_TZNA501_1 (PHOSPHOGLYCERATE KINASE 1)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	5 / 12	GLY A 453 GLY A 420 GLY A 421 THR A 96 GLY A 425	None	0.88A	4o33A-4tz5A: undetectable	4o33A-4tz5A: 22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4O3F_A_TZNA501_1 (PHOSPHOGLYCERATE KINASE 1)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	5 / 12	GLY A 453 GLY A 420 GLY A 421 THR A 96 GLY A 425	None	0.93A	4o3fA-4tz5A: undetectable	4o3fA-4tz5A: 22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QB9_D_PARD500_1 (ENHANCED INTRACELLULAR SURVIVAL PROTEIN)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	4 / 8	PHE A 478 THR A 221 ASP A 223 TYR A 254	None	1.35A	4qb9D-4tz5A: undetectable	4qb9D-4tz5A: 23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YGF_H_AZMH303_1 (ALPHA-CARBONIC ANHYDRASE)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	5 / 9	HIS A 533 VAL A 465 VAL A 487 LEU A 477 THR A 496	None	1.49A	4ygfH-4tz5A: undetectable	4ygfH-4tz5A: 17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YVG_A_SAMA301_0 (TRNA (GUANINE-N(1)-)-METH YLTRANSFERASE)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	5 / 12	GLY A 209 GLY A 186 SER A 224 GLY A 228 GLY A 227	None	0.86A	4yvgA-4tz5A: undetectable	4yvgA-4tz5A: 18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BPH_A_ACTA403_0 (D-ALANINE--D-ALANINE LIGASE)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	4 / 6	TYR A 505 GLY A 576 SER A 573 LEU A 574	BGC A 702 (-4.6A) None None BGC A 702 ( 4.0A)	1.04A	5bphA-4tz5A: undetectable	5bphA-4tz5A: 20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BPH_B_ACTB404_0 (D-ALANINE--D-ALANINE LIGASE)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	4 / 7	TYR A 505 GLY A 576 SER A 573 LEU A 574	BGC A 702 (-4.6A) None None BGC A 702 ( 4.0A)	1.04A	5bphB-4tz5A: undetectable	5bphB-4tz5A: 20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BPH_C_ACTC403_0 (D-ALANINE--D-ALANINE LIGASE)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	4 / 4	TYR A 505 GLY A 575 SER A 573 LEU A 574	BGC A 702 (-4.6A) None None BGC A 702 ( 4.0A)	1.30A	5bphC-4tz5A: undetectable	5bphC-4tz5A: 20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BPH_C_ACTC403_0 (D-ALANINE--D-ALANINE LIGASE)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	4 / 4	TYR A 505 GLY A 576 SER A 573 LEU A 574	BGC A 702 (-4.6A) None None BGC A 702 ( 4.0A)	1.07A	5bphC-4tz5A: undetectable	5bphC-4tz5A: 20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5BPH_D_ACTD403_0 (D-ALANINE--D-ALANINE LIGASE)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	4 / 6	TYR A 505 GLY A 576 SER A 573 LEU A 574	BGC A 702 (-4.6A) None None BGC A 702 ( 4.0A)	1.02A	5bphD-4tz5A: undetectable	5bphD-4tz5A: 20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5INZ_D_DVAD2_0 (THETA DEFENSIN-2, D-PEPTIDE THETA DEFENSIN-2, L-PEPTIDE)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	4 / 4	GLY A 578 CYH A 542 ARG A 551 GLY A 576	None	1.21A	5inzA-4tz5A: undetectable 5inzC-4tz5A: undetectable 5inzD-4tz5A: undetectable	5inzA-4tz5A: 2.01 5inzC-4tz5A: 2.01 5inzD-4tz5A: 2.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5L5F_H_BO2H301_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-3)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	5 / 12	GLN A 413 GLY A 476 THR A 475 ALA A 474 THR A 496	None	1.08A	5l5fH-4tz5A: undetectable 5l5fI-4tz5A: undetectable	5l5fH-4tz5A: 18.89 5l5fI-4tz5A: 17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5L5F_V_BO2V301_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-3)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	5 / 12	GLN A 413 GLY A 476 THR A 475 ALA A 474 THR A 496	None	1.08A	5l5fV-4tz5A: undetectable 5l5fW-4tz5A: undetectable	5l5fV-4tz5A: 18.89 5l5fW-4tz5A: 17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5L66_H_BO2H301_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-3)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	5 / 12	GLN A 413 GLY A 476 THR A 475 ALA A 474 THR A 496	None	1.00A	5l66H-4tz5A: undetectable 5l66I-4tz5A: undetectable	5l66H-4tz5A: 18.89 5l66I-4tz5A: 17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5L66_V_BO2V301_1 (PROTEASOME SUBUNIT BETA TYPE-2 PROTEASOME SUBUNIT BETA TYPE-3)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	5 / 12	GLN A 413 GLY A 476 THR A 475 ALA A 474 THR A 496	None	0.99A	5l66V-4tz5A: undetectable 5l66W-4tz5A: undetectable	5l66V-4tz5A: 18.89 5l66W-4tz5A: 17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MVM_B_PFLB510_1 (PROTON-GATED ION CHANNEL)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	4 / 6	ILE A 497 ALA A 474 LEU A 473 TYR A 201	None	0.82A	5mvmB-4tz5A: undetectable 5mvmC-4tz5A: undetectable	5mvmB-4tz5A: 9.90 5mvmC-4tz5A: 9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VCG_A_08YA602_2 (CYTOCHROME P450 3A4)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	3 / 3	ARG A 264 ARG A 222 ARG A 180	None	0.99A	5vcgA-4tz5A: undetectable	5vcgA-4tz5A: 21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WZ1_C_SAMC601_0 (NS5 METHYLTRANSFERASE)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	5 / 12	GLY A 166 GLY A 185 THR A 132 ASP A 136 ILE A 111	None None None BGC A 709 ( 4.5A) None	1.03A	5wz1C-4tz5A: undetectable	5wz1C-4tz5A: 18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WZ1_E_SAME601_0 (NS5 METHYLTRANSFERASE)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	5 / 12	GLY A 166 GLY A 185 THR A 132 ASP A 136 ILE A 111	None None None BGC A 709 ( 4.5A) None	1.01A	5wz1E-4tz5A: undetectable	5wz1E-4tz5A: 18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WZ1_F_SAMF601_0 (NS5 METHYLTRANSFERASE)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	5 / 12	GLY A 166 GLY A 185 THR A 132 ASP A 136 ILE A 111	None None None BGC A 709 ( 4.5A) None	1.05A	5wz1F-4tz5A: undetectable	5wz1F-4tz5A: 18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WZ1_G_SAMG601_0 (NS5 METHYLTRANSFERASE)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	5 / 12	GLY A 166 GLY A 185 THR A 132 ASP A 136 ILE A 111	None None None BGC A 709 ( 4.5A) None	1.00A	5wz1G-4tz5A: undetectable	5wz1G-4tz5A: 18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WZ1_H_SAMH601_0 (NS5 METHYLTRANSFERASE)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	5 / 12	GLY A 166 GLY A 185 THR A 132 ASP A 136 ILE A 111	None None None BGC A 709 ( 4.5A) None	1.00A	5wz1H-4tz5A: undetectable	5wz1H-4tz5A: 18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X7F_A_SAMA301_0 (PUTATIVE O-METHYLTRANSFERASE RV1220C)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	5 / 12	GLY A 520 GLY A 555 ALA A 523 ASP A 486 TYR A 499	EDO A 701 (-2.6A) None None EDO A 701 ( 4.9A) None	1.09A	5x7fA-4tz5A: undetectable	5x7fA-4tz5A: 17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EXI_A_ADNA503_1 (ADENOSYLHOMOCYSTEINA SE)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	3 / 3	LEU A 302 GLN A 306 LYS A 377	None	0.79A	6exiB-4tz5A: undetectable	6exiB-4tz5A: 10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EXI_B_ADNB503_0 (ADENOSYLHOMOCYSTEINA SE)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	3 / 3	LEU A 302 GLN A 306 LYS A 377	None	0.82A	6exiA-4tz5A: undetectable	6exiA-4tz5A: 10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6GTQ_B_ACTB207_0 (DUF1778 DOMAIN-CONTAINING PROTEIN N-ACETYLTRANSFERASE)	4tz5	PUTATIVE SECRETED PROTEIN (Streptomyces sp. SirexAA-E)	4 / 6	LEU A 159 THR A 131 GLY A 125 ARG A 180	None	1.26A	6gtqB-4tz5A: undetectable 6gtqD-4tz5A: undetectable	6gtqB-4tz5A: 16.47 6gtqD-4tz5A: 6.64

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1CQP_B_803B311_1","ANTIGEN CD11A (P180);ANTIGEN CD11A (P180)","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",4,"VAL A  68;LEU A 330;VAL A 309;LEU A 271","None","0.88A","1cqpA-4tz5A:undetectable;1cqpB-4tz5A:undetectable","1cqpA-4tz5A:15.72;1cqpB-4tz5A:15.72"],["1FXV_B_PNNB1001_0","PENICILLIN ACYLASE","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",4,"SER A 205;PHE A 133;ALA A 156;PHE A 178","None","0.99A","1fxvA-4tz5A:undetectable;1fxvB-4tz5A:undetectable","1fxvA-4tz5A:15.45;1fxvB-4tz5A:23.61"],["1GM7_B_PNNB1577_0","PENICILLIN G ACYLASE ALPHA SUBUNIT;PENICILLIN G ACYLASE BETA SUBUNIT","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",4,"SER A 205;PHE A 133;ALA A 156;PHE A 178","None","0.97A","1gm7A-4tz5A:undetectable;1gm7B-4tz5A:undetectable","1gm7A-4tz5A:15.45;1gm7B-4tz5A:23.61"],["1GM7_B_PNNB1577_0","PENICILLIN G ACYLASE ALPHA SUBUNIT;PENICILLIN G ACYLASE BETA SUBUNIT","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",4,"SER A 205;SER A 120;ALA A 156;PHE A 178","None","0.85A","1gm7A-4tz5A:undetectable;1gm7B-4tz5A:undetectable","1gm7A-4tz5A:15.45;1gm7B-4tz5A:23.61"],["1GMK_C_DVAC6_0","GRAMICIDIN A","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",3,"ALA A 190;VAL A 172;TRP A 170","None","0.93A","1gmkC-4tz5A:undetectable;1gmkD-4tz5A:undetectable","1gmkC-4tz5A:3.34;1gmkD-4tz5A:3.34"],["1HRK_A_CHDA1502_0","FERROCHELATASE","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",4,"ARG A 169;VAL A 211;GLY A 212;TRP A 229","BGC A 709 ( 3.9A);None;None;None","0.97A","1hrkA-4tz5A:undetectable","1hrkA-4tz5A:21.16"],["1HRK_B_CHDB2502_0","FERROCHELATASE","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",4,"ARG A 169;VAL A 211;GLY A 212;TRP A 229","BGC A 709 ( 3.9A);None;None;None","0.95A","1hrkB-4tz5A:undetectable","1hrkB-4tz5A:21.16"],["1JHR_A_NIOA991_1","NICOTINATE MONONUCLEOTIDE:5,6-DIMETHYLBENZIMIDAZOLE PHOSPHORIBOSYLTRANSFERASE","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",5,"LEU A 354;SER A 155;GLU A 157;ARG A 179;GLY A 380","None","1.22A","1jhrA-4tz5A:undetectable","1jhrA-4tz5A:21.60"],["1JHY_A_NIOA991_1","NICOTINATE MONONUCLEOTIDE:5,6-DIMETHYLBENZIMIDAZOLE PHOSPHORIBOSYLTRANSFERASE","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",5,"LEU A 354;SER A 155;GLU A 157;ARG A 179;GLY A 380","None","1.24A","1jhyA-4tz5A:undetectable","1jhyA-4tz5A:21.60"],["1L5K_A_NIOA991_1","NICOTINATE-NUCLEOTIDE--DIMETHYLBENZIMIDAZOLE PHOSPHORIBOSYLTRANSFERASE","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",5,"LEU A 354;SER A 155;GLU A 157;ARG A 179;GLY A 380","None","1.28A","1l5kA-4tz5A:undetectable","1l5kA-4tz5A:21.60"],["1W5U_B_DVAB6_0","GRAMICIDIN D","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",3,"TRP A 170;ALA A 190;VAL A 172","None","0.98A","1w5uA-4tz5A:undetectable;1w5uB-4tz5A:undetectable","1w5uA-4tz5A:3.34;1w5uB-4tz5A:3.34"],["2AOJ_C_FRDC305_1","POL POLYPROTEIN;PEPTIDE INHIBITOR","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",4,"ASP A 437;GLY A 494;PRO A 261;VAL A 262","None","0.86A","2aojA-4tz5A:undetectable","2aojA-4tz5A:13.85"],["2BR4_B_SAMB301_0","CEPHALOSPORIN HYDROXYLASE CMCI","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",5,"LYS A 266;GLU A 157;GLY A 123;TYR A 270;ALA A 160","None","1.09A","2br4B-4tz5A:undetectable","2br4B-4tz5A:16.15"],["2IZQ_A_DVAA6_0","GRAMICIDIN D","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",3,"ALA A 190;VAL A 172;TRP A 170","None","0.91A","2izqA-4tz5A:undetectable;2izqB-4tz5A:undetectable","2izqA-4tz5A:3.34;2izqB-4tz5A:3.34"],["2OXT_D_SAMD300_0","NUCLEOSIDE-2'-O-METHYLTRANSFERASE","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",6,"GLY A  95;ASP A 384;GLY A 420;GLY A 423;GLU A 452;HIS A 481","None;None;None;None;None;BGC A 707 (-4.2A)","1.36A","2oxtD-4tz5A:undetectable","2oxtD-4tz5A:18.46"],["2QMZ_B_LDPB502_1","RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE;RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",4,"GLN A 150;PHE A 152;TRP A 444;GLY A 421","BGC A 707 ( 4.6A);BGC A 707 (-4.9A);None;None","0.94A","2qmzA-4tz5A:undetectable;2qmzB-4tz5A:undetectable","2qmzA-4tz5A:17.43;2qmzB-4tz5A:17.43"],["2QX6_B_ML1B233_1","RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE [QUINONE];RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE [QUINONE]","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",4,"TRP A 444;GLY A 421;GLN A 150;PHE A 152","None;None;BGC A 707 ( 4.6A);BGC A 707 (-4.9A)","0.90A","2qx6A-4tz5A:undetectable;2qx6B-4tz5A:undetectable","2qx6A-4tz5A:17.43;2qx6B-4tz5A:17.43"],["2RCT_A_RTLA140_1","RETINOL-BINDING PROTEIN II, CELLULAR","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",3,"GLN A 218;THR A 596;TRP A 196","None;BGC A 703 (-3.5A);BGC A 703 (-3.7A)","1.08A","2rctA-4tz5A:undetectable","2rctA-4tz5A:14.71"],["2RLF_D_RIMD499_1","MATRIX PROTEIN 2;MATRIX PROTEIN 2","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",4,"ILE A 497;ARG A 222;LEU A 473;ASP A 223","None","1.00A","2rlfA-4tz5A:undetectable;2rlfD-4tz5A:undetectable","2rlfA-4tz5A:6.04;2rlfD-4tz5A:6.04"],["2V41_G_BEZG1222_0","PEROXIREDOXIN 6.","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",4,"THR A 260;PRO A 261;VAL A 262;SER A 263","None","1.16A","2v41G-4tz5A:undetectable;2v41H-4tz5A:undetectable","2v41G-4tz5A:18.21;2v41H-4tz5A:18.21"],["3AXZ_A_ADNA401_1","TRNA (GUANINE-N(1)-)-METHYLTRANSFERASE","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",5,"GLY A 209;GLY A 186;SER A 224;GLY A 228;GLY A 227","None","0.84A","3axzA-4tz5A:undetectable","3axzA-4tz5A:18.45"],["3ELZ_C_CHDC150_0","ILEAL BILE ACID-BINDING PROTEIN","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",5,"VAL A 376;VAL A 383;LEU A 393;ILE A 359;THR A 366","None","1.28A","3elzC-4tz5A:undetectable","3elzC-4tz5A:13.19"],["3IX9_B_MTXB200_1","DIHYDROFOLATE REDUCTASE","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",5,"ALA A 122;LEU A 124;GLU A 157;LEU A 330;VAL A  68","None","1.17A","3ix9B-4tz5A:undetectable","3ix9B-4tz5A:15.69"],["3MBH_A_PXLA400_1","PUTATIVE PHOSPHOMETHYLPYRIMIDINE KINASE","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",5,"VAL A 467;LEU A 477;THR A 496;TYR A 524;VAL A 526","None","1.50A","3mbhA-4tz5A:undetectable","3mbhA-4tz5A:19.64"],["3MBH_B_PXLB400_1","PUTATIVE PHOSPHOMETHYLPYRIMIDINE KINASE","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",5,"VAL A 467;LEU A 477;THR A 496;TYR A 524;VAL A 526","None","1.48A","3mbhB-4tz5A:undetectable","3mbhB-4tz5A:19.64"],["3MBH_D_PXLD400_1","PUTATIVE PHOSPHOMETHYLPYRIMIDINE KINASE","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",5,"VAL A 467;LEU A 477;THR A 496;TYR A 524;VAL A 526","None","1.49A","3mbhD-4tz5A:undetectable","3mbhD-4tz5A:19.64"],["3RQW_C_ACHC323_0","ELIC PENTAMERIC LIGAND GATED ION CHANNEL FROM ERWINIA CHRYSANTHEMI","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",4,"PHE A 249;ASN A 235;LEU A 570;PHE A 556","None","1.08A","3rqwC-4tz5A:undetectable;3rqwD-4tz5A:undetectable","3rqwC-4tz5A:18.26;3rqwD-4tz5A:18.26"],["3RQW_J_ACHJ323_0","ELIC PENTAMERIC LIGAND GATED ION CHANNEL FROM ERWINIA CHRYSANTHEMI","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",4,"LEU A 570;PHE A 556;PHE A 249;ASN A 235","None","1.08A","3rqwF-4tz5A:undetectable;3rqwJ-4tz5A:undetectable","3rqwF-4tz5A:18.26;3rqwJ-4tz5A:18.26"],["3W9T_B_W9TB501_1","HEMOLYTIC LECTIN CEL-III","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",4,"ASP A 204;SER A 224;GLY A 289;TRP A 292","None","1.23A","3w9tB-4tz5A:undetectable","3w9tB-4tz5A:24.42"],["3W9T_C_W9TC1003_1","HEMOLYTIC LECTIN CEL-III","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",4,"ASP A 204;SER A 224;GLY A 289;TRP A 292","None","1.23A","3w9tC-4tz5A:undetectable","3w9tC-4tz5A:24.42"],["3W9T_D_W9TD501_1","HEMOLYTIC LECTIN CEL-III","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",4,"ASP A 204;SER A 224;GLY A 289;TRP A 292","None","1.24A","3w9tD-4tz5A:undetectable","3w9tD-4tz5A:24.42"],["3W9T_F_W9TF501_1","HEMOLYTIC LECTIN CEL-III","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",4,"ASP A 204;SER A 224;GLY A 289;TRP A 292","None","1.23A","3w9tF-4tz5A:0.0","3w9tF-4tz5A:24.42"],["3WQW_A_GCSA502_1","CHITINASE","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",4,"TRP A 153;GLY A 451;ALA A 422;PHE A 117","None","1.32A","3wqwA-4tz5A:undetectable","3wqwA-4tz5A:21.65"],["4CUT_A_TYLA2971_1","BROMODOMAIN ADJACENT TO ZINC FINGER DOMAIN PROTEIN 2B","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",4,"VAL A 526;VAL A 564;ASN A 585;ILE A 584","None","1.23A","4cutA-4tz5A:undetectable","4cutA-4tz5A:12.38"],["4FFW_B_715B801_2","DIPEPTIDYL PEPTIDASE 4","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",3,"ARG A 551;TYR A 485;ASN A 501","None","0.82A","4ffwB-4tz5A:undetectable","4ffwB-4tz5A:20.73"],["4FGJ_A_1PQA304_0","RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE [QUINONE]","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",4,"GLN A 150;PHE A 152;TRP A 444;GLY A 421","BGC A 707 ( 4.6A);BGC A 707 (-4.9A);None;None","0.95A","4fgjA-4tz5A:undetectable;4fgjB-4tz5A:undetectable","4fgjA-4tz5A:17.74;4fgjB-4tz5A:17.74"],["4G19_D_ACTD305_0","GLUTATHIONE TRANSFERASE GTE1","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",4,"ILE A 344;LEU A 368;LYS A 369;ASN A 320","None","1.15A","4g19D-4tz5A:undetectable","4g19D-4tz5A:18.40"],["4L1A_A_AB1A101_2","MDR769 HIV-1 PROTEASE;MDR769 HIV-1 PROTEASE","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",4,"ASN A 158;ASP A 204;GLY A 293;THR A 131","None","1.08A","4l1aB-4tz5A:undetectable","4l1aB-4tz5A:12.20"],["4L64_A_C2FA802_0","5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",4,"TYR A 220;ARG A 222;VAL A 241;TRP A 229","None","1.49A","4l64A-4tz5A:undetectable","4l64A-4tz5A:22.96"],["4O33_A_TZNA501_1","PHOSPHOGLYCERATE KINASE 1","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",5,"GLY A 453;GLY A 420;GLY A 421;THR A  96;GLY A 425","None","0.88A","4o33A-4tz5A:undetectable","4o33A-4tz5A:22.49"],["4O3F_A_TZNA501_1","PHOSPHOGLYCERATE KINASE 1","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",5,"GLY A 453;GLY A 420;GLY A 421;THR A  96;GLY A 425","None","0.93A","4o3fA-4tz5A:undetectable","4o3fA-4tz5A:22.75"],["4QB9_D_PARD500_1","ENHANCED INTRACELLULAR SURVIVAL PROTEIN","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",4,"PHE A 478;THR A 221;ASP A 223;TYR A 254","None","1.35A","4qb9D-4tz5A:undetectable","4qb9D-4tz5A:23.13"],["4YGF_H_AZMH303_1","ALPHA-CARBONIC ANHYDRASE","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",5,"HIS A 533;VAL A 465;VAL A 487;LEU A 477;THR A 496","None","1.49A","4ygfH-4tz5A:undetectable","4ygfH-4tz5A:17.13"],["4YVG_A_SAMA301_0","TRNA (GUANINE-N(1)-)-METHYLTRANSFERASE","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",5,"GLY A 209;GLY A 186;SER A 224;GLY A 228;GLY A 227","None","0.86A","4yvgA-4tz5A:undetectable","4yvgA-4tz5A:18.45"],["5BPH_A_ACTA403_0","D-ALANINE--D-ALANINE LIGASE","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",4,"TYR A 505;GLY A 576;SER A 573;LEU A 574","BGC A 702 (-4.6A);None;None;BGC A 702 ( 4.0A)","1.04A","5bphA-4tz5A:undetectable","5bphA-4tz5A:20.18"],["5BPH_B_ACTB404_0","D-ALANINE--D-ALANINE LIGASE","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",4,"TYR A 505;GLY A 576;SER A 573;LEU A 574","BGC A 702 (-4.6A);None;None;BGC A 702 ( 4.0A)","1.04A","5bphB-4tz5A:undetectable","5bphB-4tz5A:20.18"],["5BPH_C_ACTC403_0","D-ALANINE--D-ALANINE LIGASE","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",4,"TYR A 505;GLY A 575;SER A 573;LEU A 574","BGC A 702 (-4.6A);None;None;BGC A 702 ( 4.0A)","1.30A","5bphC-4tz5A:undetectable","5bphC-4tz5A:20.18"],["5BPH_C_ACTC403_0","D-ALANINE--D-ALANINE LIGASE","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",4,"TYR A 505;GLY A 576;SER A 573;LEU A 574","BGC A 702 (-4.6A);None;None;BGC A 702 ( 4.0A)","1.07A","5bphC-4tz5A:undetectable","5bphC-4tz5A:20.18"],["5BPH_D_ACTD403_0","D-ALANINE--D-ALANINE LIGASE","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",4,"TYR A 505;GLY A 576;SER A 573;LEU A 574","BGC A 702 (-4.6A);None;None;BGC A 702 ( 4.0A)","1.02A","5bphD-4tz5A:undetectable","5bphD-4tz5A:20.18"],["5INZ_D_DVAD2_0","THETA DEFENSIN-2, D-PEPTIDE;THETA DEFENSIN-2, L-PEPTIDE","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",4,"GLY A 578;CYH A 542;ARG A 551;GLY A 576","None","1.21A","5inzA-4tz5A:undetectable;5inzC-4tz5A:undetectable;5inzD-4tz5A:undetectable","5inzA-4tz5A:2.01;5inzC-4tz5A:2.01;5inzD-4tz5A:2.01"],["5L5F_H_BO2H301_1","PROTEASOME SUBUNIT BETA TYPE-2;PROTEASOME SUBUNIT BETA TYPE-3","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",5,"GLN A 413;GLY A 476;THR A 475;ALA A 474;THR A 496","None","1.08A","5l5fH-4tz5A:undetectable;5l5fI-4tz5A:undetectable","5l5fH-4tz5A:18.89;5l5fI-4tz5A:17.07"],["5L5F_V_BO2V301_1","PROTEASOME SUBUNIT BETA TYPE-2;PROTEASOME SUBUNIT BETA TYPE-3","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",5,"GLN A 413;GLY A 476;THR A 475;ALA A 474;THR A 496","None","1.08A","5l5fV-4tz5A:undetectable;5l5fW-4tz5A:undetectable","5l5fV-4tz5A:18.89;5l5fW-4tz5A:17.07"],["5L66_H_BO2H301_1","PROTEASOME SUBUNIT BETA TYPE-2;PROTEASOME SUBUNIT BETA TYPE-3","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",5,"GLN A 413;GLY A 476;THR A 475;ALA A 474;THR A 496","None","1.00A","5l66H-4tz5A:undetectable;5l66I-4tz5A:undetectable","5l66H-4tz5A:18.89;5l66I-4tz5A:17.07"],["5L66_V_BO2V301_1","PROTEASOME SUBUNIT BETA TYPE-2;PROTEASOME SUBUNIT BETA TYPE-3","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",5,"GLN A 413;GLY A 476;THR A 475;ALA A 474;THR A 496","None","0.99A","5l66V-4tz5A:undetectable;5l66W-4tz5A:undetectable","5l66V-4tz5A:18.89;5l66W-4tz5A:17.07"],["5MVM_B_PFLB510_1","PROTON-GATED ION CHANNEL;PROTON-GATED ION CHANNEL","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",4,"ILE A 497;ALA A 474;LEU A 473;TYR A 201","None","0.82A","5mvmB-4tz5A:undetectable;5mvmC-4tz5A:undetectable","5mvmB-4tz5A:9.90;5mvmC-4tz5A:9.90"],["5VCG_A_08YA602_2","CYTOCHROME P450 3A4","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",3,"ARG A 264;ARG A 222;ARG A 180","None","0.99A","5vcgA-4tz5A:undetectable","5vcgA-4tz5A:21.54"],["5WZ1_C_SAMC601_0","NS5 METHYLTRANSFERASE","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",5,"GLY A 166;GLY A 185;THR A 132;ASP A 136;ILE A 111","None;None;None;BGC A 709 ( 4.5A);None","1.03A","5wz1C-4tz5A:undetectable","5wz1C-4tz5A:18.87"],["5WZ1_E_SAME601_0","NS5 METHYLTRANSFERASE","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",5,"GLY A 166;GLY A 185;THR A 132;ASP A 136;ILE A 111","None;None;None;BGC A 709 ( 4.5A);None","1.01A","5wz1E-4tz5A:undetectable","5wz1E-4tz5A:18.87"],["5WZ1_F_SAMF601_0","NS5 METHYLTRANSFERASE","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",5,"GLY A 166;GLY A 185;THR A 132;ASP A 136;ILE A 111","None;None;None;BGC A 709 ( 4.5A);None","1.05A","5wz1F-4tz5A:undetectable","5wz1F-4tz5A:18.87"],["5WZ1_G_SAMG601_0","NS5 METHYLTRANSFERASE","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",5,"GLY A 166;GLY A 185;THR A 132;ASP A 136;ILE A 111","None;None;None;BGC A 709 ( 4.5A);None","1.00A","5wz1G-4tz5A:undetectable","5wz1G-4tz5A:18.87"],["5WZ1_H_SAMH601_0","NS5 METHYLTRANSFERASE","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",5,"GLY A 166;GLY A 185;THR A 132;ASP A 136;ILE A 111","None;None;None;BGC A 709 ( 4.5A);None","1.00A","5wz1H-4tz5A:undetectable","5wz1H-4tz5A:18.87"],["5X7F_A_SAMA301_0","PUTATIVE O-METHYLTRANSFERASE RV1220C","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",5,"GLY A 520;GLY A 555;ALA A 523;ASP A 486;TYR A 499","EDO A 701 (-2.6A);None;None;EDO A 701 ( 4.9A);None","1.09A","5x7fA-4tz5A:undetectable","5x7fA-4tz5A:17.80"],["6EXI_A_ADNA503_1","ADENOSYLHOMOCYSTEINASE","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",3,"LEU A 302;GLN A 306;LYS A 377","None","0.79A","6exiB-4tz5A:undetectable","6exiB-4tz5A:10.27"],["6EXI_B_ADNB503_0","ADENOSYLHOMOCYSTEINASE","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",3,"LEU A 302;GLN A 306;LYS A 377","None","0.82A","6exiA-4tz5A:undetectable","6exiA-4tz5A:10.27"],["6GTQ_B_ACTB207_0","DUF1778 DOMAIN-CONTAINING PROTEIN;N-ACETYLTRANSFERASE","4tz5","PUTATIVE SECRETED PROTEIN","Streptomyces sp. SirexAA-E",4,"LEU A 159;THR A 131;GLY A 125;ARG A 180","None","1.26A","6gtqB-4tz5A:undetectable;6gtqD-4tz5A:undetectable","6gtqB-4tz5A:16.47;6gtqD-4tz5A:6.64"]]