SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tza'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 4tza FLUORESCENT PROTEIN
(synthetic
construct) 		4 / 6 TYR C  87
GLU C 144
ILE C 118
TYR C 116
 None
CRQ  C  62 ( 4.8A)
None
CRQ  C  62 ( 4.7A)
 1.12A 1maaB-4tzaC:
undetectable
1maaD-4tzaC:
undetectable		 1maaB-4tzaC:
15.88
1maaD-4tzaC:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U18_A_HSMA401_1
(NITROPHORIN 1)		 4tza FLUORESCENT PROTEIN
(synthetic
construct) 		4 / 4 ASP C  55
LEU C 162
LEU C 137
LEU C 161
 None
 1.19A 1u18A-4tzaC:
undetectable		 1u18A-4tzaC:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4tza FLUORESCENT PROTEIN
(synthetic
construct) 		3 / 3 ARG C 194
GLU C 211
THR C  37
 None
CRQ  C  62 ( 3.5A)
None
 0.88A 3v4tA-4tzaC:
undetectable		 3v4tA-4tzaC:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		 4tza FLUORESCENT PROTEIN
(synthetic
construct) 		5 / 12 LEU C  42
ALA C 103
TYR C 116
ILE C  10
GLY C  31
 None
None
CRQ  C  62 ( 4.7A)
None
None
 1.32A 4l9qA-4tzaC:
undetectable		 4l9qA-4tzaC:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		 4tza FLUORESCENT PROTEIN
(synthetic
construct) 		5 / 12 LEU C  42
ALA C 103
TYR C 116
ILE C  10
GLY C  31
 None
None
CRQ  C  62 ( 4.7A)
None
None
 1.24A 4l9qB-4tzaC:
undetectable		 4l9qB-4tzaC:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 4tza FLUORESCENT PROTEIN
(synthetic
construct) 		5 / 12 GLU C 211
ARG C  66
MET C  14
GLY C  27
LEU C  42
 CRQ  C  62 ( 3.5A)
CRQ  C  62 ( 4.2A)
None
None
None
 1.16A 5gs4A-4tzaC:
undetectable		 5gs4A-4tzaC:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)		 4tza FLUORESCENT PROTEIN
(synthetic
construct) 		4 / 6 PHE C 125
PRO C 126
GLY C 129
ASN C 128
 None
 0.82A 5x24A-4tzaC:
undetectable		 5x24A-4tzaC:
19.25