SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tzh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 4tzh LIC12234
(Leptospira
interrogans) 		5 / 10 THR A  55
LEU A  49
ASP A  48
LEU A  47
ILE A  84
 None
None
CL  A 306 ( 4.1A)
None
None
 1.21A 1i18A-4tzhA:
undetectable
1i18B-4tzhA:
undetectable		 1i18A-4tzhA:
20.74
1i18B-4tzhA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 4tzh LIC12234
(Leptospira
interrogans) 		5 / 12 LEU A 133
LEU A 123
LEU A 139
LEU A 141
LEU A 156
 None
 1.09A 1mx1C-4tzhA:
undetectable		 1mx1C-4tzhA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NR6_A_DIFA501_1
(CYTOCHROME P450 2C5)		 4tzh LIC12234
(Leptospira
interrogans) 		5 / 9 LEU A 203
PHE A 204
GLY A 154
LEU A 164
LEU A 185
 None
 0.91A 1nr6A-4tzhA:
undetectable		 1nr6A-4tzhA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4tzh LIC12234
(Leptospira
interrogans) 		5 / 12 LEU A  90
LEU A 113
LEU A 133
LEU A 126
PRO A 127
 None
 1.13A 2pnjA-4tzhA:
undetectable		 2pnjA-4tzhA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 4tzh LIC12234
(Leptospira
interrogans) 		5 / 12 ILE A  95
LEU A  72
LEU A  87
ILE A  84
LEU A 113
 None
 1.12A 3a50D-4tzhA:
undetectable		 3a50D-4tzhA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4tzh LIC12234
(Leptospira
interrogans) 		5 / 10 GLY A 177
LEU A 149
LEU A 185
LEU A 203
ILE A 172
 None
 1.16A 3wdmD-4tzhA:
undetectable		 3wdmD-4tzhA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4tzh LIC12234
(Leptospira
interrogans) 		5 / 12 LEU A 187
LEU A 193
ILE A 209
GLN A 207
THR A 148
 None
 0.93A 4f4dA-4tzhA:
undetectable		 4f4dA-4tzhA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 4tzh LIC12234
(Leptospira
interrogans) 		4 / 4 HIS A  71
GLU A  27
HIS A  31
LEU A  38
 ZN  A 301 (-3.1A)
None
ZN  A 302 ( 3.2A)
None
 1.40A 4m2rA-4tzhA:
undetectable		 4m2rA-4tzhA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_C_MTXC604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4tzh LIC12234
(Leptospira
interrogans) 		5 / 12 LEU A 185
LEU A 176
SER A 163
LEU A 126
THR A 195
 None
 1.27A 4q0dC-4tzhA:
undetectable		 4q0dC-4tzhA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_D_MTXD604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 4tzh LIC12234
(Leptospira
interrogans) 		5 / 12 LEU A 185
LEU A 176
SER A 163
LEU A 126
THR A 195
 None
 1.27A 4q0dD-4tzhA:
undetectable		 4q0dD-4tzhA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4tzh LIC12234
(Leptospira
interrogans) 		4 / 7 ILE A 153
LEU A 176
THR A 147
LEU A 169
 None
 0.95A 5b1bA-4tzhA:
undetectable
5b1bJ-4tzhA:
undetectable		 5b1bA-4tzhA:
14.99
5b1bJ-4tzhA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)		 4tzh LIC12234
(Leptospira
interrogans) 		4 / 4 ASN A 167
LEU A 169
SER A 165
LEU A 185
 None
 1.30A 5kb5A-4tzhA:
undetectable		 5kb5A-4tzhA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_1
(SCRFP-TAG,GP41)		 4tzh LIC12234
(Leptospira
interrogans) 		5 / 12 GLY A 131
LYS A 151
LEU A 176
LEU A 203
LEU A 179
 None
 1.22A 5nwwA-4tzhA:
undetectable		 5nwwA-4tzhA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4tzh LIC12234
(Leptospira
interrogans) 		5 / 10 LEU A  87
LEU A  47
ASP A  48
ILE A  84
PRO A  81
 None
None
CL  A 306 ( 4.1A)
None
None
 1.34A 6dlzB-4tzhA:
undetectable
6dlzC-4tzhA:
undetectable		 6dlzB-4tzhA:
18.02
6dlzC-4tzhA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4tzh LIC12234
(Leptospira
interrogans) 		5 / 11 ILE A  84
PRO A  81
LEU A  87
LEU A  47
ASP A  48
 None
None
None
None
CL  A 306 ( 4.1A)
 1.34A 6dlzA-4tzhA:
undetectable
6dlzD-4tzhA:
undetectable		 6dlzA-4tzhA:
18.02
6dlzD-4tzhA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4tzh LIC12234
(Leptospira
interrogans) 		5 / 10 LEU A  87
LEU A  47
ASP A  48
ILE A  84
PRO A  81
 None
None
CL  A 306 ( 4.1A)
None
None
 1.34A 6dm1B-4tzhA:
undetectable
6dm1C-4tzhA:
undetectable		 6dm1B-4tzhA:
18.02
6dm1C-4tzhA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4tzh LIC12234
(Leptospira
interrogans) 		5 / 11 ILE A  84
PRO A  81
LEU A  87
LEU A  47
ASP A  48
 None
None
None
None
CL  A 306 ( 4.1A)
 1.34A 6dm1A-4tzhA:
undetectable
6dm1D-4tzhA:
undetectable		 6dm1A-4tzhA:
18.02
6dm1D-4tzhA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4tzh LIC12234
(Leptospira
interrogans) 		5 / 10 LEU A  87
LEU A  47
ASP A  48
ILE A  84
PRO A  81
 None
None
CL  A 306 ( 4.1A)
None
None
 1.35A 6dm2B-4tzhA:
undetectable
6dm2C-4tzhA:
undetectable		 6dm2B-4tzhA:
18.02
6dm2C-4tzhA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4tzh LIC12234
(Leptospira
interrogans) 		5 / 10 ILE A  84
PRO A  81
LEU A  87
LEU A  47
ASP A  48
 None
None
None
None
CL  A 306 ( 4.1A)
 1.35A 6dm2A-4tzhA:
undetectable
6dm2D-4tzhA:
undetectable		 6dm2A-4tzhA:
18.02
6dm2D-4tzhA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4tzh LIC12234
(Leptospira
interrogans) 		4 / 5 ILE A 153
LEU A 176
THR A 147
LEU A 169
 None
 0.89A 6nmpN-4tzhA:
undetectable
6nmpW-4tzhA:
undetectable		 6nmpN-4tzhA:
14.99
6nmpW-4tzhA:
15.92