SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tzi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3B_B_FOLB401_1
(DIHYDROFOLATE
REDUCTASE)		 4tzi TYROSINE-PROTEIN
KINASE LYN
(Mus
musculus) 		3 / 3 GLU A 159
GLN A 142
ARG A 141
 None
 0.81A 2w3bB-4tziA:
undetectable		 2w3bB-4tziA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_R_TFPR202_1
(PROTEIN S100-A4)		 4tzi TYROSINE-PROTEIN
KINASE LYN
(Mus
musculus) 		5 / 11 GLU A 127
PHE A 130
CYH A 203
PHE A 201
PHE A 153
 None
 1.46A 3ko0Q-4tziA:
undetectable
3ko0R-4tziA:
undetectable
3ko0S-4tziA:
undetectable
3ko0T-4tziA:
undetectable		 3ko0Q-4tziA:
19.51
3ko0R-4tziA:
19.51
3ko0S-4tziA:
19.51
3ko0T-4tziA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 4tzi TYROSINE-PROTEIN
KINASE LYN
(Mus
musculus) 		4 / 7 TYR A 193
ASN A 122
ILE A 204
PHE A 130
 None
 0.85A 3tvxB-4tziA:
undetectable		 3tvxB-4tziA:
15.09