SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tzn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4tzn PROTEIN HTP-2
(Caenorhabditis
elegans) 		4 / 6 ARG A  94
ILE A  43
GLY A  97
ALA A  96
 None
 0.91A 1wmqA-4tznA:
undetectable		 1wmqA-4tznA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4tzn PROTEIN HTP-2
(Caenorhabditis
elegans) 		4 / 6 ARG A  94
ILE A  43
GLY A  97
ALA A  96
 None
 0.91A 1wmqB-4tznA:
undetectable		 1wmqB-4tznA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4tzn PROTEIN HTP-2
(Caenorhabditis
elegans) 		4 / 6 ARG A  94
ILE A  43
GLY A  97
ALA A  96
 None
 0.90A 1wpuA-4tznA:
undetectable		 1wpuA-4tznA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4tzn PROTEIN HTP-2
(Caenorhabditis
elegans) 		4 / 6 ARG A  94
ILE A  43
GLY A  97
ALA A  96
 None
 0.90A 1wpuB-4tznA:
1.0		 1wpuB-4tznA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4tzn PROTEIN HTP-2
(Caenorhabditis
elegans) 		4 / 6 ARG A  94
ILE A  43
GLY A  97
ALA A  96
 None
 0.95A 1wrqA-4tznA:
undetectable		 1wrqA-4tznA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 4tzn PROTEIN HTP-2
(Caenorhabditis
elegans) 		4 / 6 ARG A  94
ILE A  43
GLY A  97
ALA A  96
 None
 0.94A 1wrqB-4tznA:
undetectable		 1wrqB-4tznA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4tzn PROTEIN HTP-2
(Caenorhabditis
elegans) 		4 / 5 SER A 109
PHE A  50
VAL A  53
TYR A 221
 None
 1.22A 2x7hA-4tznA:
undetectable		 2x7hA-4tznA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4tzn PROTEIN HTP-2
(Caenorhabditis
elegans) 		4 / 5 SER A 109
PHE A  50
VAL A  53
TYR A 221
 None
 1.20A 2x7hB-4tznA:
undetectable		 2x7hB-4tznA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4tzn PROTEIN HTP-2
(Caenorhabditis
elegans) 		4 / 7 GLN A 245
ILE A 227
SER A 126
TYR A 221
 None
 1.33A 2xz5D-4tznA:
undetectable
2xz5E-4tznA:
undetectable		 2xz5D-4tznA:
21.79
2xz5E-4tznA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_B_DX4B270_0
(PTERIDINE REDUCTASE
1)		 4tzn PROTEIN HTP-2
(Caenorhabditis
elegans) 		4 / 6 SER A 166
ASP A  17
TYR A 161
PRO A  29
 None
 1.31A 3jqaB-4tznA:
undetectable		 3jqaB-4tznA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 4tzn PROTEIN HTP-2
(Caenorhabditis
elegans) 		3 / 3 PHE A 193
VAL A 112
GLU A 123
 None
 0.79A 4fvqA-4tznA:
undetectable		 4fvqA-4tznA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 4tzn PROTEIN HTP-2
(Caenorhabditis
elegans) 		5 / 12 LEU A 141
PHE A 153
GLY A 103
ASP A 102
ALA A 139
 None
 1.05A 5h5fA-4tznA:
undetectable		 5h5fA-4tznA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 4tzn PROTEIN HTP-2
(Caenorhabditis
elegans) 		5 / 12 ASP A 116
PHE A 197
ILE A 108
THR A 194
ALA A  95
 None
 1.28A 5vcgA-4tznA:
undetectable		 5vcgA-4tznA:
18.54