SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4tzo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 4tzo PROTEIN HTP-1
C. ELEGANS HIM-3
CLOSURE MOTIF
(Caenorhabditis
elegans;
Caenorhabditis
elegans) 		5 / 10 ALA A 195
GLY B 284
ARG A  57
LEU A 189
GLU A 123
 None
 1.41A 1cmcA-4tzoA:
undetectable
1cmcB-4tzoA:
undetectable		 1cmcA-4tzoA:
19.44
1cmcB-4tzoA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 4tzo PROTEIN HTP-1
C. ELEGANS HIM-3
CLOSURE MOTIF
(Caenorhabditis
elegans;
Caenorhabditis
elegans) 		5 / 10 ARG A  57
LEU A 189
GLU A 123
ALA A 195
GLY B 284
 None
 1.41A 1cmcA-4tzoA:
undetectable
1cmcB-4tzoA:
undetectable		 1cmcA-4tzoA:
19.44
1cmcB-4tzoA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 4tzo PROTEIN HTP-1
C. ELEGANS HIM-3
CLOSURE MOTIF
(Caenorhabditis
elegans;
Caenorhabditis
elegans) 		5 / 11 LEU A 189
GLU A 123
LEU A 110
ALA A 195
GLY B 284
 None
 1.27A 1mjqA-4tzoA:
undetectable
1mjqB-4tzoA:
undetectable		 1mjqA-4tzoA:
19.44
1mjqB-4tzoA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 4tzo PROTEIN HTP-1
C. ELEGANS HIM-3
CLOSURE MOTIF
(Caenorhabditis
elegans;
Caenorhabditis
elegans) 		5 / 10 ARG A  57
LEU A 189
GLU A 123
ALA A 195
GLY B 284
 None
 1.39A 1mjqC-4tzoA:
undetectable
1mjqD-4tzoA:
undetectable		 1mjqC-4tzoA:
19.44
1mjqD-4tzoA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 4tzo PROTEIN HTP-1
C. ELEGANS HIM-3
CLOSURE MOTIF
(Caenorhabditis
elegans;
Caenorhabditis
elegans) 		5 / 10 LEU A 189
GLU A 123
LEU A 110
ALA A 195
GLY B 284
 None
 1.29A 1mjqC-4tzoA:
undetectable
1mjqD-4tzoA:
undetectable		 1mjqC-4tzoA:
19.44
1mjqD-4tzoA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 4tzo PROTEIN HTP-1
C. ELEGANS HIM-3
CLOSURE MOTIF
(Caenorhabditis
elegans;
Caenorhabditis
elegans) 		5 / 11 LEU A 189
GLU A 123
LEU A 110
ALA A 195
GLY B 284
 None
 1.32A 1mjqI-4tzoA:
undetectable
1mjqJ-4tzoA:
undetectable		 1mjqI-4tzoA:
19.44
1mjqJ-4tzoA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_A_PFNA1375_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4tzo PROTEIN HTP-1
(Caenorhabditis
elegans) 		4 / 5 SER A 109
PHE A  50
VAL A  53
TYR A 221
 None
 1.26A 2x7hA-4tzoA:
undetectable		 2x7hA-4tzoA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1372_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 4tzo PROTEIN HTP-1
(Caenorhabditis
elegans) 		4 / 5 SER A 109
PHE A  50
VAL A  53
TYR A 221
 None
 1.24A 2x7hB-4tzoA:
undetectable		 2x7hB-4tzoA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 4tzo PROTEIN HTP-1
(Caenorhabditis
elegans) 		3 / 3 TYR A 221
GLU A 107
ASN A 243
 None
 1.02A 2y7hC-4tzoA:
undetectable		 2y7hC-4tzoA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4tzo PROTEIN HTP-1
(Caenorhabditis
elegans) 		5 / 9 GLN A  91
ASN A  95
LEU A 199
VAL A 108
ILE A 211
 None
 1.31A 3claA-4tzoA:
undetectable		 3claA-4tzoA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_B_DX4B270_0
(PTERIDINE REDUCTASE
1)		 4tzo PROTEIN HTP-1
(Caenorhabditis
elegans) 		4 / 6 SER A 166
ASP A  17
TYR A 161
PRO A  29
 None
 1.33A 3jqaB-4tzoA:
undetectable		 3jqaB-4tzoA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4tzo C. ELEGANS HIM-3
CLOSURE MOTIF
PROTEIN HTP-1
(Caenorhabditis
elegans) 		5 / 12 LEU A 110
LEU A  93
ILE B 285
GLY B 284
SER B 282
 None
 1.10A 3kk6B-4tzoA:
undetectable		 3kk6B-4tzoA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 4tzo C. ELEGANS HIM-3
CLOSURE MOTIF
PROTEIN HTP-1
(Caenorhabditis
elegans) 		4 / 6 SER B 282
GLU A 215
GLN B 283
THR B 286
 None
 1.20A 4lnxA-4tzoB:
undetectable		 4lnxA-4tzoB:
6.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 4tzo PROTEIN HTP-1
(Caenorhabditis
elegans) 		3 / 3 SER A  38
MET A  42
ASP A 165
 None
 0.67A 4mm4B-4tzoA:
undetectable		 4mm4B-4tzoA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_C_HISC402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4tzo PROTEIN HTP-1
C. ELEGANS HIM-3
CLOSURE MOTIF
(Caenorhabditis
elegans;
Caenorhabditis
elegans) 		5 / 9 ASN A 196
VAL A 111
LEU A  92
GLY B 280
VAL A 108
 None
 1.32A 6czmB-4tzoA:
undetectable
6czmC-4tzoA:
undetectable		 6czmB-4tzoA:
23.42
6czmC-4tzoA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4tzo PROTEIN HTP-1
C. ELEGANS HIM-3
CLOSURE MOTIF
(Caenorhabditis
elegans;
Caenorhabditis
elegans) 		5 / 9 ASN A 196
VAL A 111
LEU A  92
GLY B 280
VAL A 108
 None
 1.32A 6czmD-4tzoA:
undetectable
6czmE-4tzoA:
undetectable		 6czmD-4tzoA:
23.42
6czmE-4tzoA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 4tzo PROTEIN HTP-1
C. ELEGANS HIM-3
CLOSURE MOTIF
(Caenorhabditis
elegans;
Caenorhabditis
elegans) 		5 / 10 ASN A 196
VAL A 111
LEU A  92
GLY B 280
VAL A 108
 None
 1.31A 6czmE-4tzoA:
undetectable
6czmF-4tzoA:
undetectable		 6czmE-4tzoA:
23.42
6czmF-4tzoA:
23.42