SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4u02'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 4u02 AMINO ACID ABC
TRANSPORTER,
ATP-BINDING PROTEIN
(Thermus
thermophilus) 		5 / 11 THR A 195
LEU A 242
GLY A 199
VAL A 208
VAL A  34
 None
 1.21A 1phgA-4u02A:
undetectable		 1phgA-4u02A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 4u02 AMINO ACID ABC
TRANSPORTER,
ATP-BINDING PROTEIN
(Thermus
thermophilus) 		5 / 11 THR A 195
LEU A 242
GLY A 199
VAL A 208
VAL A  34
 None
 1.21A 2a1nA-4u02A:
undetectable		 2a1nA-4u02A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_0
(CATECHOL
O-METHYLTRANSFERASE)		 4u02 AMINO ACID ABC
TRANSPORTER,
ATP-BINDING PROTEIN
(Thermus
thermophilus) 		5 / 12 MET A 211
VAL A 217
GLY A  22
HIS A  24
ARG A   8
 None
 1.49A 2cl5B-4u02A:
undetectable		 2cl5B-4u02A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA142_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 4u02 AMINO ACID ABC
TRANSPORTER,
ATP-BINDING PROTEIN
(Thermus
thermophilus) 		4 / 5 GLU A 224
PRO A 222
ILE A 225
GLY A 220
 None
 1.13A 2qeuA-4u02A:
undetectable
2qeuC-4u02A:
undetectable		 2qeuA-4u02A:
19.26
2qeuC-4u02A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_0
(CATECHOL
O-METHYLTRANSFERASE)		 4u02 AMINO ACID ABC
TRANSPORTER,
ATP-BINDING PROTEIN
(Thermus
thermophilus) 		5 / 12 MET A 211
VAL A 217
GLY A  22
HIS A  24
ARG A   8
 None
 1.47A 2zvjA-4u02A:
undetectable		 2zvjA-4u02A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_0
(COMT PROTEIN)		 4u02 AMINO ACID ABC
TRANSPORTER,
ATP-BINDING PROTEIN
(Thermus
thermophilus) 		5 / 12 MET A 211
VAL A 217
GLY A  22
HIS A  24
ARG A   8
 None
 1.48A 3bwyA-4u02A:
undetectable		 3bwyA-4u02A:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 4u02 AMINO ACID ABC
TRANSPORTER,
ATP-BINDING PROTEIN
(Thermus
thermophilus) 		3 / 3 LYS A 134
SER A 140
GLN A 143
 None
 1.33A 3si7A-4u02A:
20.1		 3si7A-4u02A:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DO3_B_0LAB602_1
(FATTY-ACID AMIDE
HYDROLASE 1)		 4u02 AMINO ACID ABC
TRANSPORTER,
ATP-BINDING PROTEIN
(Thermus
thermophilus) 		4 / 6 LEU A  33
LEU A  25
ILE A  23
MET A 211
 None
 0.95A 4do3B-4u02A:
undetectable		 4do3B-4u02A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 4u02 AMINO ACID ABC
TRANSPORTER,
ATP-BINDING PROTEIN
(Thermus
thermophilus) 		4 / 8 LEU A 242
ILE A  36
VAL A  34
GLY A 199
 None
 0.95A 4eq4B-4u02A:
undetectable		 4eq4B-4u02A:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTQ_A_FLPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4u02 AMINO ACID ABC
TRANSPORTER,
ATP-BINDING PROTEIN
(Thermus
thermophilus) 		5 / 10 VAL A  68
VAL A  63
ILE A   5
LEU A  20
LEU A  10
 None
 1.37A 4jtqA-4u02A:
undetectable		 4jtqA-4u02A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_C_TMQC202_1
(DIHYDROFOLATE
REDUCTASE)		 4u02 AMINO ACID ABC
TRANSPORTER,
ATP-BINDING PROTEIN
(Thermus
thermophilus) 		5 / 12 ILE A  36
LEU A  25
LEU A  33
ILE A  35
THR A 234
 None
 0.92A 4m2xC-4u02A:
undetectable		 4m2xC-4u02A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O0U_A_ADNA501_1
(AURORA KINASE A)		 4u02 AMINO ACID ABC
TRANSPORTER,
ATP-BINDING PROTEIN
(Thermus
thermophilus) 		5 / 6 VAL A 208
ALA A 201
LEU A 242
THR A 234
LEU A 238
 None
 1.37A 4o0uA-4u02A:
undetectable		 4o0uA-4u02A:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 4u02 AMINO ACID ABC
TRANSPORTER,
ATP-BINDING PROTEIN
(Thermus
thermophilus) 		5 / 12 VAL A  19
LEU A  33
MET A  83
VAL A 192
GLY A  37
 None
 1.34A 6brdA-4u02A:
undetectable		 6brdA-4u02A:
16.39