SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4u06'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 4u06 LIC10831
(Leptospira
interrogans) 		5 / 12 LEU A 137
LEU A 127
LEU A 143
LEU A 145
LEU A 160
 None
 1.13A 1mx1C-4u06A:
undetectable		 1mx1C-4u06A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 4u06 LIC10831
(Leptospira
interrogans) 		5 / 12 LEU A 222
LEU A 278
LEU A 260
LEU A 281
LEU A 237
 None
 1.15A 1mx1C-4u06A:
undetectable		 1mx1C-4u06A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 4u06 LIC10831
(Leptospira
interrogans) 		5 / 12 LEU A 298
LEU A 288
LEU A 304
LEU A 306
LEU A 321
 None
 1.20A 1mx1C-4u06A:
undetectable		 1mx1C-4u06A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 4u06 LIC10831
(Leptospira
interrogans) 		4 / 4 LEU A 191
SER A 169
TYR A 190
LEU A 189
 None
CL  A 406 (-3.0A)
CL  A 406 (-4.5A)
None
 1.31A 1xz1A-4u06A:
undetectable		 1xz1A-4u06A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 4u06 LIC10831
(Leptospira
interrogans) 		4 / 4 LEU A 191
SER A 169
TYR A 190
LEU A 189
 None
CL  A 406 (-3.0A)
CL  A 406 (-4.5A)
None
 1.32A 1xz3A-4u06A:
undetectable		 1xz3A-4u06A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_2
(MINERALOCORTICOID
RECEPTOR)		 4u06 LIC10831
(Leptospira
interrogans) 		4 / 5 LEU A 314
LEU A 291
LEU A 321
LEU A 327
 None
 0.95A 2ab2B-4u06A:
undetectable		 2ab2B-4u06A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_1
(HYPOTHETICAL PROTEIN
LMO1582)		 4u06 LIC10831
(Leptospira
interrogans) 		4 / 4 THR A 303
THR A 257
ASP A 259
ASP A 239
 None
 1.50A 2f8lA-4u06A:
undetectable		 2f8lA-4u06A:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FT9_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN 2, LIVER)		 4u06 LIC10831
(Leptospira
interrogans) 		5 / 11 LEU A 209
LEU A 229
ILE A 180
PRO A 177
ASN A 178
 None
None
None
None
ZN  A 403 (-2.6A)
 1.24A 2ft9A-4u06A:
undetectable		 2ft9A-4u06A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NOA_A_3TCA302_1
(DEOXYCYTIDINE KINASE)		 4u06 LIC10831
(Leptospira
interrogans) 		5 / 12 ILE A 341
GLU A 361
LEU A 352
PHE A 376
ARG A 364
 None
 1.22A 2noaA-4u06A:
undetectable		 2noaA-4u06A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4u06 LIC10831
(Leptospira
interrogans) 		5 / 12 LEU A 209
LEU A 232
LEU A 252
LEU A 245
PRO A 246
 None
 1.06A 2pnjA-4u06A:
undetectable		 2pnjA-4u06A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O01_B_DXCB1_0
(CELL INVASION
PROTEIN SIPD)		 4u06 LIC10831
(Leptospira
interrogans) 		5 / 9 ILE A  65
ASN A  44
ALA A  41
LEU A  74
VAL A  48
 None
 1.43A 3o01A-4u06A:
undetectable
3o01B-4u06A:
undetectable		 3o01A-4u06A:
21.47
3o01B-4u06A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		 4u06 LIC10831
(Leptospira
interrogans) 		6 / 10 ILE A  65
ASN A  44
ALA A  41
LEU A  74
LEU A  51
VAL A  48
 None
 1.50A 3o02A-4u06A:
undetectable
3o02B-4u06A:
undetectable		 3o02A-4u06A:
21.47
3o02B-4u06A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 4u06 LIC10831
(Leptospira
interrogans) 		4 / 5 ASN A  79
LEU A  81
SER A 101
ASN A 148
 None
 1.19A 4n09C-4u06A:
undetectable		 4n09C-4u06A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 4u06 LIC10831
(Leptospira
interrogans) 		5 / 12 PRO A  85
LEU A  84
GLY A  66
LEU A  42
GLU A  64
 None
 1.36A 5emlA-4u06A:
undetectable		 5emlA-4u06A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ITZ_B_LOCB502_1
(TUBULIN BETA-2B
CHAIN)		 4u06 LIC10831
(Leptospira
interrogans) 		5 / 12 LEU A 350
LEU A 304
LEU A 329
ASN A 309
ILE A 318
 None
 1.07A 5itzB-4u06A:
undetectable		 5itzB-4u06A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F5U_A_CQNA610_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 4u06 LIC10831
(Leptospira
interrogans) 		5 / 10 ALA A 227
LEU A 255
LEU A 275
LEU A 222
LEU A 235
 None
 0.94A 6f5uA-4u06A:
undetectable
6f5uB-4u06A:
undetectable		 6f5uA-4u06A:
12.37
6f5uB-4u06A:
14.56