SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4u08'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1501_0
(FERROCHELATASE)		 4u08 LIC11098
(Leptospira
interrogans) 		5 / 12 LEU A 215
LEU A 238
ILE A 179
LEU A 248
PRO A 249
 None
 1.24A 1hrkA-4u08A:
undetectable		 1hrkA-4u08A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 4u08 LIC11098
(Leptospira
interrogans) 		5 / 12 LEU A 278
LEU A 268
LEU A 284
LEU A 286
LEU A 301
 None
 1.23A 1mx1C-4u08A:
undetectable		 1mx1C-4u08A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 4u08 LIC11098
(Leptospira
interrogans) 		5 / 12 LEU A 301
LEU A 291
LEU A 307
LEU A 309
LEU A 324
 None
 1.24A 1mx1C-4u08A:
undetectable		 1mx1C-4u08A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4u08 LIC11098
(Leptospira
interrogans) 		5 / 12 LEU A  54
LEU A  77
LEU A 100
ILE A  41
PRO A 111
 None
 1.09A 2pnjA-4u08A:
undetectable		 2pnjA-4u08A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4u08 LIC11098
(Leptospira
interrogans) 		5 / 12 LEU A 166
LEU A 189
LEU A 209
LEU A 202
PRO A 203
 None
 1.01A 2pnjA-4u08A:
undetectable		 2pnjA-4u08A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4u08 LIC11098
(Leptospira
interrogans) 		5 / 12 LEU A 189
LEU A 212
LEU A 232
LEU A 225
PRO A 226
 None
 1.09A 2pnjA-4u08A:
undetectable		 2pnjA-4u08A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4u08 LIC11098
(Leptospira
interrogans) 		5 / 12 LEU A  77
LEU A 100
ILE A  41
LEU A 110
PRO A 111
 None
 1.25A 2po7B-4u08A:
undetectable		 2po7B-4u08A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4u08 LIC11098
(Leptospira
interrogans) 		5 / 12 LEU A 169
LEU A 192
ILE A 133
LEU A 202
PRO A 203
 None
 1.21A 2po7B-4u08A:
undetectable		 2po7B-4u08A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4u08 LIC11098
(Leptospira
interrogans) 		5 / 12 LEU A 215
LEU A 238
ILE A 179
LEU A 248
PRO A 249
 None
 1.20A 2po7B-4u08A:
undetectable		 2po7B-4u08A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 4u08 LIC11098
(Leptospira
interrogans) 		4 / 8 LEU A 386
LEU A 418
LEU A 376
ARG A 415
 None
 1.15A 2xn3A-4u08A:
undetectable
2xn3B-4u08A:
undetectable		 2xn3A-4u08A:
23.13
2xn3B-4u08A:
4.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4u08 LIC11098
(Leptospira
interrogans) 		5 / 12 GLY A 216
ILE A 229
LEU A 255
LEU A 245
LEU A 222
 ZN  A 504 ( 4.2A)
None
None
None
None
 1.32A 3cs8A-4u08A:
undetectable		 3cs8A-4u08A:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4u08 LIC11098
(Leptospira
interrogans) 		5 / 12 LEU A 317
GLY A 345
ILE A 367
ARG A 348
LEU A 353
 None
 0.91A 3uj6A-4u08A:
undetectable		 3uj6A-4u08A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UT5_B_LOCB502_1
(TUBULIN BETA CHAIN)		 4u08 LIC11098
(Leptospira
interrogans) 		5 / 12 LEU A  84
LEU A  56
ASN A  55
ILE A  68
ILE A  41
 None
 1.14A 3ut5B-4u08A:
undetectable		 3ut5B-4u08A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 4u08 LIC11098
(Leptospira
interrogans) 		4 / 6 HIS A 196
GLU A 127
ASP A  80
ASN A 147
 ZN  A 505 (-3.2A)
None
None
None
 1.13A 3vywA-4u08A:
undetectable		 3vywA-4u08A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD507_1
(HEMOLYTIC LECTIN
CEL-III)		 4u08 LIC11098
(Leptospira
interrogans) 		4 / 5 ASP A 308
GLU A 288
GLY A 311
ASP A 354
 None
 1.39A 3w9tD-4u08A:
undetectable		 3w9tD-4u08A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 4u08 LIC11098
(Leptospira
interrogans) 		5 / 12 LEU A 386
LEU A 376
ILE A 411
ILE A 423
LEU A 417
 None
 1.09A 4j24A-4u08A:
undetectable		 4j24A-4u08A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_A_BRLA501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4u08 LIC11098
(Leptospira
interrogans) 		4 / 5 GLY A  66
LEU A  74
ILE A  41
LEU A  79
 None
 0.79A 4o8fA-4u08A:
undetectable		 4o8fA-4u08A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 4u08 LIC11098
(Leptospira
interrogans) 		5 / 12 LEU A 309
GLY A 311
LEU A 284
ASN A 264
LEU A 263
 None
 1.09A 5nfjC-4u08A:
undetectable		 5nfjC-4u08A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4u08 LIC11098
(Leptospira
interrogans) 		5 / 10 LEU A 393
LEU A 353
ASP A 354
ILE A 390
PRO A 387
 None
 1.48A 6dlzB-4u08A:
undetectable
6dlzC-4u08A:
undetectable		 6dlzB-4u08A:
13.20
6dlzC-4u08A:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4u08 LIC11098
(Leptospira
interrogans) 		5 / 10 LEU A 393
LEU A 353
ASP A 354
ILE A 390
PRO A 387
 None
 1.48A 6dm1B-4u08A:
undetectable
6dm1C-4u08A:
undetectable		 6dm1B-4u08A:
13.20
6dm1C-4u08A:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4u08 LIC11098
(Leptospira
interrogans) 		5 / 10 LEU A 393
LEU A 353
ASP A 354
ILE A 390
PRO A 387
 None
 1.47A 6dm2B-4u08A:
undetectable
6dm2C-4u08A:
undetectable		 6dm2B-4u08A:
13.20
6dm2C-4u08A:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4u08 LIC11098
(Leptospira
interrogans) 		5 / 10 ILE A 390
PRO A 387
LEU A 393
LEU A 353
ASP A 354
 None
 1.47A 6dm2A-4u08A:
undetectable
6dm2D-4u08A:
undetectable		 6dm2A-4u08A:
13.20
6dm2D-4u08A:
13.20