SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4u09'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_A_ADNA601_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4u09 LIC12759
(Leptospira
interrogans) 		5 / 12 LEU A 276
LEU A 319
LEU A 316
GLY A 291
PHE A 263
 None
 1.43A 1d4fA-4u09A:
undetectable		 1d4fA-4u09A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4u09 LIC12759
(Leptospira
interrogans) 		5 / 12 LEU A 276
LEU A 319
LEU A 316
GLY A 291
PHE A 263
 None
 1.41A 1d4fB-4u09A:
undetectable		 1d4fB-4u09A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_D_ADND604_1
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 4u09 LIC12759
(Leptospira
interrogans) 		5 / 12 LEU A 276
LEU A 319
LEU A 316
GLY A 291
PHE A 263
 None
 1.44A 1d4fD-4u09A:
undetectable		 1d4fD-4u09A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_C_THAC3_1
(LIVER
CARBOXYLESTERASE I)		 4u09 LIC12759
(Leptospira
interrogans) 		5 / 12 LEU A 178
LEU A 168
LEU A 184
LEU A 186
LEU A 201
 None
 1.14A 1mx1C-4u09A:
undetectable		 1mx1C-4u09A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1130_0
(FATTY ACID-BINDING
PROTEIN)		 4u09 LIC12759
(Leptospira
interrogans) 		5 / 12 LEU A 296
LEU A 322
ILE A 306
ILE A 267
LEU A 268
 None
 1.19A 1tw4B-4u09A:
undetectable		 1tw4B-4u09A:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO0_A_GEOA302_1
(DEOXYCYTIDINE KINASE)		 4u09 LIC12759
(Leptospira
interrogans) 		5 / 12 ILE A 382
GLU A 402
LEU A 393
PHE A 417
ARG A 405
 None
 1.09A 2no0A-4u09A:
undetectable		 2no0A-4u09A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NO0_B_GEOB302_1
(DEOXYCYTIDINE KINASE)		 4u09 LIC12759
(Leptospira
interrogans) 		5 / 12 ILE A 382
GLU A 402
LEU A 393
PHE A 417
ARG A 405
 None
 1.08A 2no0B-4u09A:
undetectable		 2no0B-4u09A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4u09 LIC12759
(Leptospira
interrogans) 		5 / 12 LEU A 296
LEU A 319
LEU A 339
LEU A 332
PRO A 333
 None
 1.08A 2pnjA-4u09A:
undetectable		 2pnjA-4u09A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4u09 LIC12759
(Leptospira
interrogans) 		5 / 12 LEU A  92
LEU A 115
ILE A  78
LEU A 125
PRO A 126
 None
 1.23A 2po7B-4u09A:
undetectable		 2po7B-4u09A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		 4u09 LIC12759
(Leptospira
interrogans) 		5 / 11 LEU A 276
LEU A 253
SER A 239
LEU A 240
LEU A 270
 None
 1.08A 2xn5A-4u09A:
undetectable		 2xn5A-4u09A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_A_ACHA1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4u09 LIC12759
(Leptospira
interrogans) 		4 / 7 TYR A 302
SER A 300
ILE A 306
SER A 346
 PEG  A 507 ( 4.1A)
None
None
PEG  A 507 (-2.6A)
 1.17A 2xz5A-4u09A:
undetectable
2xz5B-4u09A:
undetectable		 2xz5A-4u09A:
19.80
2xz5B-4u09A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 4u09 LIC12759
(Leptospira
interrogans) 		4 / 8 TYR A 302
SER A 300
ILE A 306
SER A 346
 PEG  A 507 ( 4.1A)
None
None
PEG  A 507 (-2.6A)
 1.15A 2xz5B-4u09A:
undetectable
2xz5E-4u09A:
undetectable		 2xz5B-4u09A:
19.80
2xz5E-4u09A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 4u09 LIC12759
(Leptospira
interrogans) 		5 / 10 GLY A 291
PHE A 286
GLU A 289
LEU A 293
LEU A 316
 None
 0.96A 3kvrA-4u09A:
undetectable		 3kvrA-4u09A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 4u09 LIC12759
(Leptospira
interrogans) 		5 / 10 GLY A 291
PHE A 286
GLU A 289
LEU A 293
LEU A 316
 None
 0.95A 3kvrB-4u09A:
undetectable		 3kvrB-4u09A:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_D_VIBD223_1
(THIAMINE
PYROPHOSPHOKINASE)		 4u09 LIC12759
(Leptospira
interrogans) 		4 / 8 HIS A 118
LEU A  56
LEU A  69
ASN A  74
 None
 0.98A 3lm8B-4u09A:
undetectable
3lm8D-4u09A:
undetectable		 3lm8B-4u09A:
18.81
3lm8D-4u09A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4u09 LIC12759
(Leptospira
interrogans) 		4 / 8 VAL A 313
LEU A 299
LEU A 322
ILE A 306
 None
 0.87A 3u5kA-4u09A:
undetectable		 3u5kA-4u09A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4u09 LIC12759
(Leptospira
interrogans) 		4 / 7 VAL A 313
LEU A 299
LEU A 322
ILE A 306
 None
 0.97A 3u5kB-4u09A:
undetectable		 3u5kB-4u09A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 4u09 LIC12759
(Leptospira
interrogans) 		4 / 8 VAL A 313
LEU A 299
LEU A 322
ILE A 306
 None
 0.92A 3u5kD-4u09A:
undetectable		 3u5kD-4u09A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_C_TYLC1184_1
(BROMODOMAIN
CONTAINING 2)		 4u09 LIC12759
(Leptospira
interrogans) 		4 / 5 VAL A 313
LEU A 299
LEU A 322
ILE A 306
 None
 0.94A 4a9jC-4u09A:
undetectable		 4a9jC-4u09A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 4u09 LIC12759
(Leptospira
interrogans) 		4 / 5 ASN A 143
LEU A 145
SER A 165
ASN A 212
 None
 1.17A 4n09C-4u09A:
undetectable		 4n09C-4u09A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4u09 LIC12759
(Leptospira
interrogans) 		5 / 12 ALA A  34
ILE A  78
ASN A  74
LEU A  53
GLN A  51
 None
 1.19A 4r3aA-4u09A:
undetectable		 4r3aA-4u09A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 4u09 LIC12759
(Leptospira
interrogans) 		5 / 12 ALA A  36
ILE A  78
ASN A  74
LEU A  53
GLN A  51
 None
 0.99A 4r3aA-4u09A:
undetectable		 4r3aA-4u09A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_1
(THYROXINE-BINDING
GLOBULIN)		 4u09 LIC12759
(Leptospira
interrogans) 		5 / 10 LEU A 276
LEU A 253
SER A 239
LEU A 240
LEU A 270
 None
 1.11A 4yiaA-4u09A:
undetectable		 4yiaA-4u09A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)		 4u09 LIC12759
(Leptospira
interrogans) 		5 / 12 ILE A  78
LEU A  66
LEU A 109
GLY A 107
LEU A  48
 None
 1.11A 5ienA-4u09A:
undetectable		 5ienA-4u09A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 4u09 LIC12759
(Leptospira
interrogans) 		5 / 12 LEU A 117
ASP A  70
GLY A  72
ASN A  96
ASN A 143
 None
 1.41A 5kc0A-4u09A:
undetectable		 5kc0A-4u09A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 4u09 LIC12759
(Leptospira
interrogans) 		5 / 12 LEU A 117
ASP A  70
GLY A  72
ASN A  96
ASN A 143
 None
 1.37A 5kc4E-4u09A:
undetectable		 5kc4E-4u09A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)		 4u09 LIC12759
(Leptospira
interrogans) 		5 / 12 LEU A 268
LEU A 273
ASN A 277
THR A 233
ILE A 244
 None
 1.05A 5mioB-4u09A:
undetectable		 5mioB-4u09A:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 4u09 LIC12759
(Leptospira
interrogans) 		5 / 12 LEU A 268
LEU A 273
ASN A 277
THR A 233
ILE A 244
 None
 0.97A 5xiwB-4u09A:
undetectable		 5xiwB-4u09A:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)		 4u09 LIC12759
(Leptospira
interrogans) 		5 / 10 LEU A  86
ILE A  78
LEU A  53
ALA A  36
LEU A  37
 None
 1.20A 5y7pB-4u09A:
undetectable		 5y7pB-4u09A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)		 4u09 LIC12759
(Leptospira
interrogans) 		5 / 10 LEU A  86
ILE A  78
LEU A  53
ALA A  36
LEU A  37
 None
 1.20A 5y7pD-4u09A:
undetectable		 5y7pD-4u09A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 4u09 LIC12759
(Leptospira
interrogans) 		4 / 8 ILE A  60
ASN A  97
LEU A  46
LEU A  94
 None
 0.85A 5y7pE-4u09A:
undetectable		 5y7pE-4u09A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4u09 LIC12759
(Leptospira
interrogans) 		5 / 10 LEU A 224
LEU A 184
ASP A 185
ILE A 221
PRO A 218
 None
 1.40A 6dlzB-4u09A:
undetectable
6dlzC-4u09A:
undetectable		 6dlzB-4u09A:
8.64
6dlzC-4u09A:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4u09 LIC12759
(Leptospira
interrogans) 		5 / 11 ILE A 221
PRO A 218
LEU A 224
LEU A 184
ASP A 185
 None
 1.40A 6dlzA-4u09A:
undetectable
6dlzD-4u09A:
undetectable		 6dlzA-4u09A:
8.64
6dlzD-4u09A:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4u09 LIC12759
(Leptospira
interrogans) 		5 / 10 LEU A 224
LEU A 184
ASP A 185
ILE A 221
PRO A 218
 None
 1.39A 6dm1B-4u09A:
undetectable
6dm1C-4u09A:
undetectable		 6dm1B-4u09A:
8.64
6dm1C-4u09A:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4u09 LIC12759
(Leptospira
interrogans) 		5 / 11 ILE A 221
PRO A 218
LEU A 224
LEU A 184
ASP A 185
 None
 1.40A 6dm1A-4u09A:
undetectable
6dm1D-4u09A:
undetectable		 6dm1A-4u09A:
8.64
6dm1D-4u09A:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4u09 LIC12759
(Leptospira
interrogans) 		5 / 10 LEU A 224
LEU A 184
ASP A 185
ILE A 221
PRO A 218
 None
 1.40A 6dm2B-4u09A:
undetectable
6dm2C-4u09A:
undetectable		 6dm2B-4u09A:
8.64
6dm2C-4u09A:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 4u09 LIC12759
(Leptospira
interrogans) 		5 / 10 ILE A 221
PRO A 218
LEU A 224
LEU A 184
ASP A 185
 None
 1.41A 6dm2A-4u09A:
undetectable
6dm2D-4u09A:
undetectable		 6dm2A-4u09A:
8.64
6dm2D-4u09A:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_A_IXXA609_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 4u09 LIC12759
(Leptospira
interrogans) 		4 / 7 LEU A 171
LEU A 161
LEU A 158
LEU A 125
 None
 0.70A 6g9bA-4u09A:
undetectable
6g9bB-4u09A:
undetectable		 6g9bA-4u09A:
14.13
6g9bB-4u09A:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G9B_A_IXXA609_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 4u09 LIC12759
(Leptospira
interrogans) 		4 / 7 VAL A 198
LEU A 204
LEU A 227
LEU A 186
 None
 0.73A 6g9bA-4u09A:
undetectable
6g9bB-4u09A:
undetectable		 6g9bA-4u09A:
14.13
6g9bB-4u09A:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 4u09 LIC12759
(Leptospira
interrogans) 		6 / 12 LEU A  53
ILE A  78
LEU A 102
LEU A  69
ASN A  95
ILE A  83
 None
 1.36A 6qxsB-4u09A:
undetectable		 6qxsB-4u09A:
22.00