SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4u0p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KLM_A_SPPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 4u0p LIPOYL SYNTHASE 2
(Thermosynechococ
cus
elongatus) 		5 / 11 LEU B  11
LYS B   5
PRO B 243
LEU B 241
TYR B 253
 None
 1.37A 1klmA-4u0pB:
undetectable		 1klmA-4u0pB:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 4u0p LIPOYL SYNTHASE 2
(Thermosynechococ
cus
elongatus) 		5 / 12 ILE B 158
ALA B 161
MET B 123
LEU B  58
ILE B  89
 None
 1.25A 1xzxX-4u0pB:
undetectable		 1xzxX-4u0pB:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 4u0p LIPOYL SYNTHASE 2
(Thermosynechococ
cus
elongatus) 		5 / 12 ILE B 158
ALA B 161
MET B 123
LEU B  58
ILE B  89
 None
 1.28A 1y0xX-4u0pB:
undetectable		 1y0xX-4u0pB:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 4u0p LIPOYL SYNTHASE 2
(Thermosynechococ
cus
elongatus) 		4 / 8 VAL B 280
LEU B 224
GLY B 263
ALA B 266
 None
 0.92A 2xfsA-4u0pB:
undetectable		 2xfsA-4u0pB:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 4u0p LIPOYL SYNTHASE 2
(Thermosynechococ
cus
elongatus) 		4 / 8 VAL B 280
LEU B 224
GLY B 263
ALA B 266
 None
 0.95A 2xh9A-4u0pB:
undetectable		 2xh9A-4u0pB:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4u0p LIPOYL SYNTHASE 2
(Thermosynechococ
cus
elongatus) 		3 / 3 THR B  55
SER B 282
LYS B 206
 NA  B 304 (-4.0A)
NA  B 304 ( 4.9A)
None
 1.14A 3aocC-4u0pB:
undetectable		 3aocC-4u0pB:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O01_B_DXCB1_0
(CELL INVASION
PROTEIN SIPD)		 4u0p LIPOYL SYNTHASE 2
(Thermosynechococ
cus
elongatus) 		5 / 9 ILE B 220
ASN B 264
ALA B 266
LEU B 209
VAL B 274
 None
 1.50A 3o01A-4u0pB:
undetectable
3o01B-4u0pB:
undetectable		 3o01A-4u0pB:
21.79
3o01B-4u0pB:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		 4u0p LIPOYL SYNTHASE 2
(Thermosynechococ
cus
elongatus) 		5 / 10 ILE B 220
ALA B 266
LEU B 209
LEU B 235
VAL B 274
 None
 1.01A 3o02A-4u0pB:
undetectable
3o02B-4u0pB:
undetectable		 3o02A-4u0pB:
22.02
3o02B-4u0pB:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 4u0p LIPOYL SYNTHASE 2
(Thermosynechococ
cus
elongatus) 		3 / 3 SER B 188
ASP B 141
GLN B 114
 None
 0.85A 4oltA-4u0pB:
undetectable
4oltB-4u0pB:
undetectable		 4oltA-4u0pB:
24.20
4oltB-4u0pB:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 4u0p LIPOYL SYNTHASE 2
(Thermosynechococ
cus
elongatus) 		3 / 3 GLN B 114
SER B 188
ASP B 141
 None
 0.86A 4qwpA-4u0pB:
undetectable
4qwpB-4u0pB:
undetectable		 4qwpA-4u0pB:
24.20
4qwpB-4u0pB:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_A_ADNA301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 4u0p LIPOYL SYNTHASE 2
(Thermosynechococ
cus
elongatus) 		5 / 9 PRO B 179
GLY B 214
GLU B 219
VAL B 173
THR B 172
 None
 1.42A 4x3mA-4u0pB:
undetectable		 4x3mA-4u0pB:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 4u0p LIPOYL SYNTHASE 2
(Thermosynechococ
cus
elongatus) 		4 / 5 ILE B  89
THR B 122
THR B  35
LEU B  96
 None
 1.14A 6f3mD-4u0pB:
undetectable		 6f3mD-4u0pB:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 4u0p LIPOYL SYNTHASE 2
(Thermosynechococ
cus
elongatus) 		4 / 5 ILE B  89
THR B 122
THR B  35
LEU B  98
 None
 0.97A 6f3mD-4u0pB:
undetectable		 6f3mD-4u0pB:
20.26