SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4u0t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AQB_A_RTLA185_0
(RETINOL-BINDING
PROTEIN)		 4u0t ADC-7 BETA-LACTAMASE
(Acinetobacter
baumannii) 		5 / 10 LEU A 232
ALA A 251
TYR A 244
LEU A 239
PHE A  69
 None
 1.28A 1aqbA-4u0tA:
undetectable		 1aqbA-4u0tA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C8L_A_CFFA940_1
(PROTEIN (GLYCOGEN
PHOSPHORYLASE))		 4u0t ADC-7 BETA-LACTAMASE
(Acinetobacter
baumannii) 		4 / 6 ASN A  79
ALA A 251
GLY A  74
TYR A  76
 None
 1.10A 1c8lA-4u0tA:
undetectable		 1c8lA-4u0tA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 4u0t ADC-7 BETA-LACTAMASE
(Acinetobacter
baumannii) 		4 / 6 GLN A 120
TYR A 222
VAL A 212
GLY A 215
 None
 0.99A 1ekjC-4u0tA:
undetectable
1ekjD-4u0tA:
undetectable		 1ekjC-4u0tA:
20.99
1ekjD-4u0tA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 4u0t ADC-7 BETA-LACTAMASE
(Acinetobacter
baumannii) 		4 / 6 VAL A 212
GLY A 215
GLN A 120
TYR A 222
 None
 1.06A 1ekjC-4u0tA:
undetectable
1ekjD-4u0tA:
undetectable		 1ekjC-4u0tA:
20.99
1ekjD-4u0tA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GAH_A_ACRA497_2
(GLUCOAMYLASE-471)		 4u0t ADC-7 BETA-LACTAMASE
(Acinetobacter
baumannii) 		4 / 6 ALA A 350
SER A 288
TRP A 271
LEU A 354
 None
 1.17A 1gahA-4u0tA:
undetectable		 1gahA-4u0tA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GFZ_A_CFFA940_1
(GLYCOGEN
PHOSPHORYLASE)		 4u0t ADC-7 BETA-LACTAMASE
(Acinetobacter
baumannii) 		4 / 6 ASN A  79
ALA A 251
GLY A  74
TYR A  76
 None
 1.05A 1gfzA-4u0tA:
undetectable		 1gfzA-4u0tA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_2
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)
IGG2B-KAPPA 40-50
FAB (LIGHT CHAIN))		 4u0t ADC-7 BETA-LACTAMASE
(Acinetobacter
baumannii) 		4 / 7 THR A 313
ARG A 346
TYR A  23
LEU A  19
 PO4  A 401 (-4.0A)
None
None
None
 1.14A 1ibgL-4u0tA:
undetectable		 1ibgL-4u0tA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_B_NIOB702_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 4u0t ADC-7 BETA-LACTAMASE
(Acinetobacter
baumannii) 		4 / 5 PHE A 135
GLY A 156
SER A 151
PHE A 121
 None
 1.36A 1icvA-4u0tA:
undetectable
1icvB-4u0tA:
undetectable		 1icvA-4u0tA:
21.41
1icvB-4u0tA:
21.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 4u0t ADC-7 BETA-LACTAMASE
(Acinetobacter
baumannii) 		7 / 10 GLY A  63
LEU A 119
GLN A 120
ASN A 152
TYR A 222
THR A 313
GLY A 314
 None
None
None
None
None
PO4  A 401 (-4.0A)
PO4  A 401 (-3.4A)
 1.12A 1kvlA-4u0tA:
53.1		 1kvlA-4u0tA:
41.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1KVL_A_CLSA371_1
(BETA-LACTAMASE)		 4u0t ADC-7 BETA-LACTAMASE
(Acinetobacter
baumannii) 		8 / 10 LEU A 119
GLN A 120
TYR A 150
ASN A 152
TYR A 222
LYS A 312
THR A 313
GLY A 314
 None
None
PO4  A 401 (-4.0A)
None
None
PO4  A 401 (-2.7A)
PO4  A 401 (-4.0A)
PO4  A 401 (-3.4A)
 0.32A 1kvlA-4u0tA:
53.1		 1kvlA-4u0tA:
41.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4u0t ADC-7 BETA-LACTAMASE
(Acinetobacter
baumannii) 		4 / 6 ASN A  79
ALA A 251
GLY A  74
TYR A  76
 None
 1.08A 1l5qA-4u0tA:
undetectable		 1l5qA-4u0tA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5Q_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4u0t ADC-7 BETA-LACTAMASE
(Acinetobacter
baumannii) 		4 / 6 ASN A  79
ALA A 251
GLY A  74
TYR A  76
 None
 1.09A 1l5qB-4u0tA:
undetectable		 1l5qB-4u0tA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4u0t ADC-7 BETA-LACTAMASE
(Acinetobacter
baumannii) 		4 / 6 ASN A  79
ALA A 251
GLY A  74
TYR A  76
 None
 1.09A 1l7xA-4u0tA:
undetectable		 1l7xA-4u0tA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4u0t ADC-7 BETA-LACTAMASE
(Acinetobacter
baumannii) 		4 / 6 ASN A  79
ALA A 251
GLY A  74
TYR A  76
 None
 1.10A 1l7xB-4u0tA:
undetectable		 1l7xB-4u0tA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 4u0t ADC-7 BETA-LACTAMASE
(Acinetobacter
baumannii) 		5 / 11 TYR A 322
VAL A 353
GLU A 345
LEU A 284
LEU A 280
 None
 1.34A 1mrqA-4u0tA:
undetectable		 1mrqA-4u0tA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVU_A_PRLA196_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 4u0t ADC-7 BETA-LACTAMASE
(Acinetobacter
baumannii) 		4 / 6 LEU A 283
GLU A 272
THR A 321
TYR A 322
 None
 1.41A 1qvuA-4u0tA:
undetectable		 1qvuA-4u0tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 4u0t ADC-7 BETA-LACTAMASE
(Acinetobacter
baumannii) 		3 / 3 LEU A  68
HIS A 256
ILE A 252
 None
 0.34A 1s9pB-4u0tA:
undetectable		 1s9pB-4u0tA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 4u0t ADC-7 BETA-LACTAMASE
(Acinetobacter
baumannii) 		3 / 3 ASN A 116
TRP A 138
GLN A 149
 None
 1.41A 1xoqA-4u0tA:
undetectable		 1xoqA-4u0tA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 4u0t ADC-7 BETA-LACTAMASE
(Acinetobacter
baumannii) 		4 / 5 PHE A 170
SER A 165
PHE A  69
ILE A  83
 None
 1.18A 2v0mD-4u0tA:
undetectable		 2v0mD-4u0tA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		 4u0t ADC-7 BETA-LACTAMASE
(Acinetobacter
baumannii) 		4 / 5 ASN A  79
ALA A 251
GLY A  74
TYR A  76
 None
 1.07A 3bcrA-4u0tA:
undetectable		 3bcrA-4u0tA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		 4u0t ADC-7 BETA-LACTAMASE
(Acinetobacter
baumannii) 		4 / 7 SER A 286
VAL A 324
TYR A 322
ILE A 347
 None
 1.10A 3bu1A-4u0tA:
undetectable		 3bu1A-4u0tA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4u0t ADC-7 BETA-LACTAMASE
(Acinetobacter
baumannii) 		4 / 6 ASN A  79
ALA A 251
GLY A  74
TYR A  76
 None
 1.06A 3dd1A-4u0tA:
undetectable		 3dd1A-4u0tA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4u0t ADC-7 BETA-LACTAMASE
(Acinetobacter
baumannii) 		4 / 6 ASN A  79
ALA A 251
GLY A  74
TYR A  76
 None
 1.07A 3dd1B-4u0tA:
undetectable		 3dd1B-4u0tA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_A_CFFA904_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4u0t ADC-7 BETA-LACTAMASE
(Acinetobacter
baumannii) 		4 / 6 ASN A  79
ALA A 251
GLY A  74
TYR A  76
 None
 1.08A 3ddsA-4u0tA:
undetectable		 3ddsA-4u0tA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDS_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4u0t ADC-7 BETA-LACTAMASE
(Acinetobacter
baumannii) 		4 / 6 ASN A  79
ALA A 251
GLY A  74
TYR A  76
 None
 1.07A 3ddsB-4u0tA:
undetectable		 3ddsB-4u0tA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4u0t ADC-7 BETA-LACTAMASE
(Acinetobacter
baumannii) 		4 / 6 ASN A  79
ALA A 251
GLY A  74
TYR A  76
 None
 1.07A 3ddwA-4u0tA:
undetectable		 3ddwA-4u0tA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDW_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 4u0t ADC-7 BETA-LACTAMASE
(Acinetobacter
baumannii) 		4 / 6 ASN A  79
ALA A 251
GLY A  74
TYR A  76
 None
 1.07A 3ddwB-4u0tA:
undetectable		 3ddwB-4u0tA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA300_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 4u0t ADC-7 BETA-LACTAMASE
(Acinetobacter
baumannii) 		5 / 12 LYS A  67
ASN A 152
LYS A 312
THR A 313
GLY A 314
 None
None
PO4  A 401 (-2.7A)
PO4  A 401 (-4.0A)
PO4  A 401 (-3.4A)
 0.55A 3huoA-4u0tA:
15.1		 3huoA-4u0tA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW4_A_TICA600_1
(CYTOCHROME P450 2B4)		 4u0t ADC-7 BETA-LACTAMASE
(Acinetobacter
baumannii) 		5 / 11 ILE A 357
ALA A 349
VAL A  30
VAL A  32
GLY A 332
 None
 0.96A 3kw4A-4u0tA:
undetectable		 3kw4A-4u0tA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 4u0t ADC-7 BETA-LACTAMASE
(Acinetobacter
baumannii) 		6 / 12 SER A  64
LYS A  67
ASN A 152
GLY A 314
THR A 316
ARG A 346
 PO4  A 401 (-2.8A)
None
None
PO4  A 401 (-3.4A)
None
None
 1.08A 3mzeA-4u0tA:
14.6		 3mzeA-4u0tA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MZE_A_CFXA364_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACA)		 4u0t ADC-7 BETA-LACTAMASE
(Acinetobacter
baumannii) 		6 / 12 SER A  64
LYS A  67
ASN A 152
THR A 313
GLY A 314
THR A 316
 PO4  A 401 (-2.8A)
None
None
PO4  A 401 (-4.0A)
PO4  A 401 (-3.4A)
None
 0.77A 3mzeA-4u0tA:
14.6		 3mzeA-4u0tA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_1
(PROTEASE)		 4u0t ADC-7 BETA-LACTAMASE
(Acinetobacter
baumannii) 		5 / 12 GLY A 223
ALA A 219
GLY A 156
ILE A 155
VAL A 173
 None
 1.14A 3n3iA-4u0tA:
undetectable		 3n3iA-4u0tA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_A_LLTA261_1
(DEOXYCYTIDINE KINASE)		 4u0t ADC-7 BETA-LACTAMASE
(Acinetobacter
baumannii) 		5 / 10 VAL A 353
LEU A 333
MET A 335
TYR A 322
LEU A  19
 None
 1.28A 3qeoA-4u0tA:
undetectable		 3qeoA-4u0tA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB323_0
(INVASIN IPAD)		 4u0t ADC-7 BETA-LACTAMASE
(Acinetobacter
baumannii) 		5 / 7 LEU A 232
ILE A 331
ILE A 357
VAL A 353
LEU A 354
 None
 1.32A 3r9vA-4u0tA:
undetectable
3r9vB-4u0tA:
undetectable		 3r9vA-4u0tA:
21.78
3r9vB-4u0tA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SGL_A_SAMA692_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 4u0t ADC-7 BETA-LACTAMASE
(Acinetobacter
baumannii) 		5 / 12 GLY A 318
GLY A 320
THR A 321
LEU A  62
GLY A 202
 None
 1.09A 3sglA-4u0tA:
undetectable		 3sglA-4u0tA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ2_A_FK5A200_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4u0t ADC-7 BETA-LACTAMASE
(Acinetobacter
baumannii) 		5 / 11 PHE A 179
VAL A 224
ILE A 155
PHE A 170
MET A 231
 None
 1.40A 4dz2A-4u0tA:
undetectable
4dz2B-4u0tA:
undetectable		 4dz2A-4u0tA:
16.71
4dz2B-4u0tA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ2_B_FK5B200_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 4u0t ADC-7 BETA-LACTAMASE
(Acinetobacter
baumannii) 		5 / 11 MET A 231
PHE A 179
VAL A 224
ILE A 155
PHE A 170
 None
 1.40A 4dz2A-4u0tA:
undetectable
4dz2B-4u0tA:
undetectable		 4dz2A-4u0tA:
16.71
4dz2B-4u0tA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K87_A_ADNA602_1
(PROLINE--TRNA LIGASE)		 4u0t ADC-7 BETA-LACTAMASE
(Acinetobacter
baumannii) 		4 / 8 ARG A 211
GLY A 320
THR A 321
THR A 316
 None
 0.99A 4k87A-4u0tA:
undetectable		 4k87A-4u0tA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_B_STRB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 4u0t ADC-7 BETA-LACTAMASE
(Acinetobacter
baumannii) 		5 / 9 TYR A 322
VAL A 353
GLU A 345
LEU A 284
LEU A 280
 None
 1.29A 4l1xB-4u0tA:
undetectable		 4l1xB-4u0tA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 4u0t ADC-7 BETA-LACTAMASE
(Acinetobacter
baumannii) 		5 / 11 GLN A 257
ALA A  77
GLY A  74
THR A  72
ALA A 251
 None
 1.24A 5bxnV-4u0tA:
undetectable
5bxnW-4u0tA:
undetectable		 5bxnV-4u0tA:
19.50
5bxnW-4u0tA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 4u0t ADC-7 BETA-LACTAMASE
(Acinetobacter
baumannii) 		4 / 8 ILE A 155
MET A 166
LEU A 174
ILE A 178
 None
 0.90A 5ieoA-4u0tA:
undetectable		 5ieoA-4u0tA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 4u0t ADC-7 BETA-LACTAMASE
(Acinetobacter
baumannii) 		5 / 12 HIS A 311
TYR A 322
LEU A 333
ILE A 357
LEU A 284
 None
 1.44A 5ycpA-4u0tA:
undetectable		 5ycpA-4u0tA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B6A_D_9F2D301_1
(BETA-LACTAMASE)		 4u0t ADC-7 BETA-LACTAMASE
(Acinetobacter
baumannii) 		5 / 12 SER A  64
ARG A 346
LYS A 312
THR A 313
GLY A 314
 PO4  A 401 (-2.8A)
None
PO4  A 401 (-2.7A)
PO4  A 401 (-4.0A)
PO4  A 401 (-3.4A)
 0.46A 6b6aD-4u0tA:
14.3		 6b6aD-4u0tA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_B_EY4B500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 4u0t ADC-7 BETA-LACTAMASE
(Acinetobacter
baumannii) 		4 / 6 GLN A 172
VAL A 173
ALA A  73
THR A  72
 None
 0.95A 6cduB-4u0tA:
undetectable
6cduC-4u0tA:
undetectable		 6cduB-4u0tA:
24.25
6cduC-4u0tA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 4u0t ADC-7 BETA-LACTAMASE
(Acinetobacter
baumannii) 		4 / 5 PHE A  69
VAL A 191
MET A 231
VAL A  65
 None
 1.34A 6ekzA-4u0tA:
undetectable		 6ekzA-4u0tA:
13.43