SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4u0z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2003_1
(SERUM ALBUMIN)		 4u0z ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE FICD
(Homo
sapiens) 		5 / 10 LEU A 426
HIS A 347
LEU A 381
ILE A 389
ALA A 419
 None
 1.11A 2bxeB-4u0zA:
undetectable		 2bxeB-4u0zA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q2H_B_ACTB501_0
(SECRETION CHAPERONE,
PHAGE-DISPLAY
DERIVED PEPTIDE)		 4u0z ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE FICD
(Homo
sapiens) 		3 / 3 ARG A 374
SER A 373
TYR A 399
 APC  A 501 (-3.3A)
None
APC  A 501 (-4.8A)
 0.86A 2q2hA-4u0zA:
undetectable
2q2hB-4u0zA:
undetectable		 2q2hA-4u0zA:
18.21
2q2hB-4u0zA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_D_BEZD194_0
(PUTATIVE KINASE)		 4u0z ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE FICD
(Homo
sapiens) 		4 / 5 PRO A 413
ILE A 157
ARG A 412
ASP A 160
 None
 1.46A 2rhmD-4u0zA:
undetectable		 2rhmD-4u0zA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 4u0z ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE FICD
(Homo
sapiens) 		4 / 8 PHE A 351
LEU A 376
ALA A 355
PHE A 334
 None
 0.85A 2vcvP-4u0zA:
undetectable		 2vcvP-4u0zA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 4u0z ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE FICD
(Homo
sapiens) 		5 / 10 GLU A 328
PHE A 309
GLY A 307
PHE A 365
LEU A 359
 None
 1.38A 3a3yA-4u0zA:
undetectable		 3a3yA-4u0zA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 4u0z ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE FICD
(Homo
sapiens) 		4 / 6 TYR A 163
GLY A 147
THR A 144
LEU A 143
 None
 0.99A 3ps9A-4u0zA:
undetectable		 3ps9A-4u0zA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)		 4u0z ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE FICD
(Homo
sapiens) 		4 / 6 LEU A 114
LEU A 110
LEU A 162
LEU A 143
 None
 0.98A 3q1eA-4u0zA:
undetectable
3q1eC-4u0zA:
undetectable		 3q1eA-4u0zA:
16.61
3q1eC-4u0zA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 4u0z ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE FICD
(Homo
sapiens) 		4 / 8 TYR A 194
HIS A 347
LEU A 381
MET A 377
 None
 1.42A 3uzzB-4u0zA:
undetectable		 3uzzB-4u0zA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9K_B_TYLB2198_1
(CREB-BINDING PROTEIN)		 4u0z ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE FICD
(Homo
sapiens) 		4 / 5 LEU A 247
ILE A 246
ASN A 236
VAL A 231
 None
 0.99A 4a9kB-4u0zA:
undetectable		 4a9kB-4u0zA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 4u0z ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE FICD
(Homo
sapiens) 		4 / 8 ILE A 156
ASP A 155
ILE A 157
SER A 196
 None
 0.80A 4acaC-4u0zA:
undetectable		 4acaC-4u0zA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4u0z ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE FICD
(Homo
sapiens) 		4 / 5 ARG A 165
GLY A 409
GLU A 408
ARG A 180
 None
 1.14A 5cdqA-4u0zA:
undetectable
5cdqB-4u0zA:
undetectable
5cdqC-4u0zA:
undetectable		 5cdqA-4u0zA:
21.10
5cdqB-4u0zA:
20.96
5cdqC-4u0zA:
21.10