SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4u10'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA140_0
(LYSOZYME C)		 4u10 POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE
(Aggregatibacter
actinomycetemcom
itans) 		3 / 3 ASN A 146
ALA A 102
ASN A 106
 None
 0.80A 1n4fA-4u10A:
undetectable		 1n4fA-4u10A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 4u10 POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE
(Aggregatibacter
actinomycetemcom
itans) 		3 / 3 LYS A 259
ASP A  26
ASN A 262
 None
 1.18A 2bm9A-4u10A:
undetectable		 2bm9A-4u10A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCD_A_RAPA138_1
(OUTER MEMBRANE
PROTEIN MIP)		 4u10 POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE
(Aggregatibacter
actinomycetemcom
itans) 		5 / 11 TYR A 204
PHE A 212
GLN A 184
VAL A 176
VAL A 124
 None
 1.44A 2vcdA-4u10A:
undetectable		 2vcdA-4u10A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 4u10 POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE
(Aggregatibacter
actinomycetemcom
itans) 		5 / 12 ILE A 274
LEU A  57
ASN A  56
VAL A  36
ILE A  59
 None
 1.21A 2vn0A-4u10A:
undetectable		 2vn0A-4u10A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)		 4u10 POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE
(Aggregatibacter
actinomycetemcom
itans) 		4 / 8 SER A  96
LEU A  31
TYR A  33
PHE A  62
 None
 1.03A 3i45A-4u10A:
2.0		 3i45A-4u10A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEL_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 4u10 POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE
(Aggregatibacter
actinomycetemcom
itans) 		5 / 12 ALA A 255
PHE A 237
ILE A  78
TRP A  75
HIS A 252
 None
 1.18A 3welA-4u10A:
4.9		 3welA-4u10A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEO_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 4u10 POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE
(Aggregatibacter
actinomycetemcom
itans) 		5 / 12 ALA A 255
PHE A 237
ILE A 264
TRP A  75
HIS A 252
 None
 1.39A 3weoA-4u10A:
3.7		 3weoA-4u10A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_H_ZPCH1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 4u10 POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE
(Aggregatibacter
actinomycetemcom
itans) 		4 / 7 ILE A 283
TYR A  33
HIS A  34
VAL A  37
 None
None
ZN  A 402 ( 3.3A)
None
 1.10A 4a97H-4u10A:
undetectable		 4a97H-4u10A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K7G_B_ACTB902_0
(3-HYDROXYPROLINE
DEHYDRATSE)		 4u10 POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE
(Aggregatibacter
actinomycetemcom
itans) 		4 / 7 ASP A 129
ASP A 170
SER A 215
SER A 125
 None
 1.23A 4k7gB-4u10A:
undetectable		 4k7gB-4u10A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4u10 POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE
(Aggregatibacter
actinomycetemcom
itans) 		4 / 6 PHE A 254
ILE A 229
ARG A 228
VAL A  73
 None
 1.25A 4mk4B-4u10A:
undetectable		 4mk4B-4u10A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWR_A_ZMRA513_2
(NEURAMINIDASE)		 4u10 POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE
(Aggregatibacter
actinomycetemcom
itans) 		4 / 5 LEU A  88
ASP A  26
ARG A  27
ILE A 261
 None
 1.41A 4mwrA-4u10A:
undetectable		 4mwrA-4u10A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YP2_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 4u10 POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE
(Aggregatibacter
actinomycetemcom
itans) 		5 / 9 ILE A 219
GLY A 224
ILE A 165
ALA A 166
GLU A 164
 None
 1.37A 4yp2B-4u10A:
undetectable		 4yp2B-4u10A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CF9_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 4u10 POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE
(Aggregatibacter
actinomycetemcom
itans) 		5 / 9 ILE A 219
GLY A 224
ILE A 165
ALA A 166
GLU A 164
 None
 1.37A 5cf9B-4u10A:
undetectable		 5cf9B-4u10A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_A_ACTA301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 4u10 POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE
(Aggregatibacter
actinomycetemcom
itans) 		5 / 6 ASP A  98
ASP A  99
HIS A 168
HIS A 173
HIS A  34
 ZN  A 402 ( 3.1A)
ZN  A 401 (-2.4A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 402 ( 3.3A)
 0.42A 5ncdA-4u10A:
9.3
5ncdD-4u10A:
9.4		 5ncdA-4u10A:
23.23
5ncdD-4u10A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_C_ACTC301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 4u10 POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE
(Aggregatibacter
actinomycetemcom
itans) 		5 / 6 ASP A  98
ASP A  99
HIS A 168
HIS A 173
HIS A  34
 ZN  A 402 ( 3.1A)
ZN  A 401 (-2.4A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 402 ( 3.3A)
 0.42A 5ncdB-4u10A:
4.3
5ncdC-4u10A:
9.5		 5ncdB-4u10A:
23.23
5ncdC-4u10A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_D_ACTD301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 4u10 POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE
(Aggregatibacter
actinomycetemcom
itans) 		4 / 4 ASP A  98
HIS A 168
HIS A 173
HIS A  34
 ZN  A 402 ( 3.1A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 402 ( 3.3A)
 0.46A 5ncdD-4u10A:
3.6		 5ncdD-4u10A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_B_AZMB302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 4u10 POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE
(Aggregatibacter
actinomycetemcom
itans) 		6 / 8 ASP A  98
ASP A  99
HIS A 168
HIS A 173
PRO A 233
HIS A  34
 ZN  A 402 ( 3.1A)
ZN  A 401 (-2.4A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 401 ( 4.9A)
ZN  A 402 ( 3.3A)
 0.60A 5nekB-4u10A:
3.6		 5nekB-4u10A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_D_AZMD302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 4u10 POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE
(Aggregatibacter
actinomycetemcom
itans) 		5 / 8 ASP A  98
ASP A  99
HIS A 168
HIS A 173
HIS A  34
 ZN  A 402 ( 3.1A)
ZN  A 401 (-2.4A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 402 ( 3.3A)
 0.57A 5nekD-4u10A:
9.4		 5nekD-4u10A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_A_ACTA302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 4u10 POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE
(Aggregatibacter
actinomycetemcom
itans) 		5 / 6 ASP A  98
ASP A  99
HIS A 168
HIS A 173
HIS A  34
 ZN  A 402 ( 3.1A)
ZN  A 401 (-2.4A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 402 ( 3.3A)
 0.47A 5nelA-4u10A:
3.9
5nelD-4u10A:
4.2		 5nelA-4u10A:
23.23
5nelD-4u10A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 4u10 POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE
(Aggregatibacter
actinomycetemcom
itans) 		4 / 6 ASP A  98
HIS A 168
HIS A 173
HIS A  34
 ZN  A 402 ( 3.1A)
ZN  A 401 (-3.3A)
ZN  A 401 (-3.2A)
ZN  A 402 ( 3.3A)
 0.44A 5nelB-4u10A:
9.2
5nelC-4u10A:
9.4		 5nelB-4u10A:
23.23
5nelC-4u10A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB601_0
(THIOCYANATE
DEHYDROGENASE)		 4u10 POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE
(Aggregatibacter
actinomycetemcom
itans) 		3 / 3 HIS A  34
ASP A  99
HIS A 168
 ZN  A 402 ( 3.3A)
ZN  A 401 (-2.4A)
ZN  A 401 (-3.3A)
 0.73A 5oexB-4u10A:
undetectable		 5oexB-4u10A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC601_0
(THIOCYANATE
DEHYDROGENASE)		 4u10 POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE
(Aggregatibacter
actinomycetemcom
itans) 		3 / 3 HIS A  34
ASP A  99
HIS A 168
 ZN  A 402 ( 3.3A)
ZN  A 401 (-2.4A)
ZN  A 401 (-3.3A)
 0.72A 5oexC-4u10A:
undetectable		 5oexC-4u10A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD601_0
(THIOCYANATE
DEHYDROGENASE)		 4u10 POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE
(Aggregatibacter
actinomycetemcom
itans) 		3 / 3 HIS A  34
ASP A  99
HIS A 168
 ZN  A 402 ( 3.3A)
ZN  A 401 (-2.4A)
ZN  A 401 (-3.3A)
 0.73A 5oexD-4u10A:
undetectable		 5oexD-4u10A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE SIGMA
FACTOR SIGA)		 4u10 POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE
(Aggregatibacter
actinomycetemcom
itans) 		4 / 4 LEU A 128
ASP A 129
GLN A 222
VAL A  94
 None
 1.45A 6bzoF-4u10A:
undetectable		 6bzoF-4u10A:
18.16