SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4u1c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 4u1c EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C
(Saccharomyces
cerevisiae) 		4 / 7 VAL C 717
VAL C 709
ILE C 560
LEU C 703
 None
 0.81A 1iepB-4u1cC:
undetectable		 1iepB-4u1cC:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 4u1c EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C
(Saccharomyces
cerevisiae) 		4 / 6 GLU C 416
LEU C 429
LEU C 486
GLY C 485
 None
 0.88A 1n13H-4u1cC:
undetectable
1n13K-4u1cC:
undetectable		 1n13H-4u1cC:
11.19
1n13K-4u1cC:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 4u1c EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C
(Saccharomyces
cerevisiae) 		4 / 7 LEU C 429
LEU C 486
GLY C 485
GLU C 416
 None
 0.81A 1n13G-4u1cC:
undetectable
1n13J-4u1cC:
undetectable		 1n13G-4u1cC:
6.56
1n13J-4u1cC:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_C_AICC5003_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 4u1c EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C
(Saccharomyces
cerevisiae) 		4 / 8 GLU C 657
GLN C 683
SER C 648
TYR C 647
 None
 1.25A 1nx9C-4u1cC:
undetectable		 1nx9C-4u1cC:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_D_AICD5004_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 4u1c EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C
(Saccharomyces
cerevisiae) 		4 / 8 GLU C 657
GLN C 683
SER C 648
TYR C 647
 None
 1.26A 1nx9D-4u1cC:
undetectable		 1nx9D-4u1cC:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_B_SNLB2001_1
(MINERALOCORTICOID
RECEPTOR)		 4u1c EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C
(Saccharomyces
cerevisiae) 		5 / 12 LEU C 713
LEU C 557
ALA C 554
LEU C 616
THR C 623
 None
 1.27A 2oaxB-4u1cC:
undetectable		 2oaxB-4u1cC:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_B_AG2B671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 4u1c EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C
(Saccharomyces
cerevisiae) 		4 / 8 GLU C 416
LEU C 429
LEU C 486
GLY C 485
 None
 0.77A 2qqdB-4u1cC:
undetectable
2qqdC-4u1cC:
undetectable		 2qqdB-4u1cC:
11.19
2qqdC-4u1cC:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 4u1c EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C
(Saccharomyces
cerevisiae) 		3 / 3 ASP C 618
PHE C 621
SER C 573
 None
 0.95A 3i5uB-4u1cC:
2.7		 3i5uB-4u1cC:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 4u1c EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C
(Saccharomyces
cerevisiae) 		3 / 3 LYS C 382
ARG C 603
ASP C 305
 None
 1.04A 3o7wA-4u1cC:
undetectable		 3o7wA-4u1cC:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 4u1c EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C
(Saccharomyces
cerevisiae) 		4 / 8 TYR C 442
HIS C 611
TYR C 394
LEU C 385
 None
 1.39A 3uzzB-4u1cC:
undetectable		 3uzzB-4u1cC:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_1
(GUANINE DEAMINASE)		 4u1c EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C
(Saccharomyces
cerevisiae) 		5 / 12 GLN C 412
LEU C 482
LEU C 486
GLU C 452
SER C 469
 None
 1.37A 4aqlA-4u1cC:
undetectable		 4aqlA-4u1cC:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 4u1c EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C
(Saccharomyces
cerevisiae) 		3 / 3 ARG C 436
THR C 453
TRP C 456
 None
 0.97A 4d7hA-4u1cC:
undetectable		 4d7hA-4u1cC:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB806_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 4u1c EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C
(Saccharomyces
cerevisiae) 		4 / 7 GLN C 757
PHE C 776
ASN C 770
ASP C 771
 None
 1.42A 4kcnB-4u1cC:
undetectable		 4kcnB-4u1cC:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 4u1c EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C
(Saccharomyces
cerevisiae) 		3 / 3 LEU C 258
ILE C 262
ARG C 265
 None
 0.67A 4mk4B-4u1cC:
undetectable		 4mk4B-4u1cC:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UGL_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 4u1c EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C
(Saccharomyces
cerevisiae) 		3 / 3 ARG C 436
THR C 453
TRP C 456
 None
 0.98A 4uglA-4u1cC:
undetectable		 4uglA-4u1cC:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 4u1c EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C
(Saccharomyces
cerevisiae) 		3 / 3 ARG C 436
THR C 453
TRP C 456
 None
 1.01A 5g6cA-4u1cC:
undetectable		 5g6cA-4u1cC:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A211_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 4u1c EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C
(Saccharomyces
cerevisiae) 		4 / 6 VAL C 498
LYS C 500
ALA C 502
VAL C 434
 None
 1.06A 5i8fA-4u1cC:
undetectable		 5i8fA-4u1cC:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN8_A_ACRA1016_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 4u1c EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C
(Saccharomyces
cerevisiae) 		4 / 5 ASP C 673
GLY C 666
PRO C 668
TRP A 253
 None
 1.43A 5nn8A-4u1cC:
undetectable		 5nn8A-4u1cC:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 4u1c EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C
(Saccharomyces
cerevisiae) 		4 / 5 VAL C 675
LEU C 627
CYH C 624
ASP C 618
 None
 1.37A 5vcvA-4u1cC:
2.7		 5vcvA-4u1cC:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5Y_C_9F2C302_1
(BETA-LACTAMASE)		 4u1c EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C
(Saccharomyces
cerevisiae) 		5 / 10 ARG C 436
ILE C 459
TYR C 414
THR C 418
ASP C 471
 None
 1.45A 6b5yC-4u1cC:
undetectable
6b5yD-4u1cC:
undetectable		 6b5yC-4u1cC:
8.69
6b5yD-4u1cC:
8.69