SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4u1d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 4u1d EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A
(Saccharomyces
cerevisiae) 		5 / 12 LEU C 454
LEU C 404
VAL C 400
ALA C 435
PHE C 395
 None
 0.97A 1gseB-4u1dC:
4.0		 1gseB-4u1dC:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4u1d EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A
(Saccharomyces
cerevisiae) 		5 / 10 PHE C 157
PHE C 189
VAL C 165
PHE C  96
VAL C 100
 None
 1.42A 1q23E-4u1dC:
undetectable		 1q23E-4u1dC:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4u1d EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A
(Saccharomyces
cerevisiae) 		5 / 10 PHE C 157
PHE C 189
VAL C 165
PHE C  96
VAL C 100
 None
 1.45A 1q23K-4u1dC:
undetectable		 1q23K-4u1dC:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4u1d EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A
(Saccharomyces
cerevisiae) 		4 / 8 LYS C 364
LEU C 367
GLN C 368
PHE C 329
 None
 0.93A 2dyrP-4u1dC:
2.2
2dyrW-4u1dC:
undetectable		 2dyrP-4u1dC:
18.18
2dyrW-4u1dC:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 4u1d EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A
(Saccharomyces
cerevisiae) 		4 / 8 LYS C 364
LEU C 367
GLN C 368
PHE C 329
 None
 0.92A 2eikP-4u1dC:
2.2
2eikW-4u1dC:
undetectable		 2eikP-4u1dC:
18.18
2eikW-4u1dC:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1498_1
(CYTOCHROME P450 3A4)		 4u1d EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A
(Saccharomyces
cerevisiae) 		5 / 11 SER C 369
ILE C 370
ALA C 332
THR C 335
LEU C 297
 None
 1.22A 2v0mD-4u1dC:
undetectable		 2v0mD-4u1dC:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_C_ASDC1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 4u1d EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A
(Saccharomyces
cerevisiae) 		4 / 8 ILE C  58
GLY C  59
LEU C  68
LEU C  72
 None
 0.87A 2vctC-4u1dC:
1.1		 2vctC-4u1dC:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_3
(PHOSPHOLIPASE A2)		 4u1d EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A
(Saccharomyces
cerevisiae) 		4 / 5 VAL C 182
VAL C 183
THR C 158
THR C 178
 None
 1.27A 3bjwG-4u1dC:
undetectable		 3bjwG-4u1dC:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_2
(PHOSPHOLIPASE A2)		 4u1d EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A
(Saccharomyces
cerevisiae) 		4 / 5 VAL C 182
VAL C 183
THR C 158
THR C 178
 None
 1.25A 3bjwD-4u1dC:
undetectable		 3bjwD-4u1dC:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4u1d EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A
(Saccharomyces
cerevisiae) 		4 / 5 HIS C 484
THR C 481
GLU C 466
ASP C 464
 None
 1.28A 3tm4A-4u1dC:
undetectable		 3tm4A-4u1dC:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 4u1d EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A
(Saccharomyces
cerevisiae) 		4 / 5 HIS C 484
THR C 481
GLU C 466
ASP C 464
 None
 1.30A 3tm4B-4u1dC:
undetectable		 3tm4B-4u1dC:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 4u1d EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A
(Saccharomyces
cerevisiae) 		4 / 8 SER C 106
GLU C  61
GLU C  57
GLY C  65
 None
 0.91A 4fgzA-4u1dC:
undetectable
4fgzB-4u1dC:
undetectable		 4fgzA-4u1dC:
20.84
4fgzB-4u1dC:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_C_HQEC503_1
(CATALASE)		 4u1d EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A
(Saccharomyces
cerevisiae) 		4 / 8 PRO C 457
PHE C 417
LEU C 424
LEU C 408
 None
 0.65A 4qopC-4u1dC:
undetectable		 4qopC-4u1dC:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZ8_A_GCSA208_1
(GLUCANASE/CHITOSANAS
E)		 4u1d EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A
(Saccharomyces
cerevisiae) 		4 / 7 GLU C 466
TYR C 449
ASP C 483
ALA C 487
 None
 1.21A 4zz8A-4u1dC:
undetectable		 4zz8A-4u1dC:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 4u1d EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A
(Saccharomyces
cerevisiae) 		5 / 12 PHE C 433
VAL C 434
PHE C 491
ILE C 482
VAL C 478
 None
 1.22A 6ap6A-4u1dC:
undetectable		 6ap6A-4u1dC:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 4u1d EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A
(Saccharomyces
cerevisiae) 		5 / 12 PHE C 433
VAL C 434
PHE C 491
ILE C 482
VAL C 478
 None
 1.22A 6ap6B-4u1dC:
undetectable		 6ap6B-4u1dC:
19.55