SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4u1f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ALZ_B_DVAB8_0
(ILE-GRAMICIDIN C
VAL-GRAMICIDIN A)		 4u1f EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Saccharomyces
cerevisiae) 		4 / 5 VAL A 502
TRP A 515
VAL A 463
TRP A 499
 None
 1.25A 1alzA-4u1fA:
undetectable
1alzB-4u1fA:
undetectable		 1alzA-4u1fA:
1.97
1alzB-4u1fA:
3.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4u1f EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Saccharomyces
cerevisiae) 		4 / 8 SER A 200
SER A 239
TYR A 205
PHE A 207
 None
 1.20A 1eqbA-4u1fA:
undetectable
1eqbB-4u1fA:
undetectable		 1eqbA-4u1fA:
21.46
1eqbB-4u1fA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4u1f EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 205
PHE A 207
SER A 200
SER A 239
 None
 1.21A 1eqbA-4u1fA:
undetectable
1eqbB-4u1fA:
undetectable		 1eqbA-4u1fA:
21.46
1eqbB-4u1fA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4u1f EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Saccharomyces
cerevisiae) 		4 / 8 SER A 200
SER A 239
TYR A 205
PHE A 207
 None
 1.21A 1eqbC-4u1fA:
undetectable
1eqbD-4u1fA:
undetectable		 1eqbC-4u1fA:
21.46
1eqbD-4u1fA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 4u1f EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 205
PHE A 207
SER A 200
SER A 239
 None
 1.22A 1eqbC-4u1fA:
undetectable
1eqbD-4u1fA:
undetectable		 1eqbC-4u1fA:
21.46
1eqbD-4u1fA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA8_0
(GRAMICIDIN A)		 4u1f EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Saccharomyces
cerevisiae) 		3 / 4 VAL A 463
TRP A 499
TRP A 515
 None
 1.18A 1gmkA-4u1fA:
undetectable
1gmkB-4u1fA:
undetectable		 1gmkA-4u1fA:
3.50
1gmkB-4u1fA:
3.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC8_0
(GRAMICIDIN A)		 4u1f EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Saccharomyces
cerevisiae) 		3 / 4 VAL A 463
TRP A 499
TRP A 515
 None
 0.69A 1gmkC-4u1fA:
undetectable
1gmkD-4u1fA:
undetectable		 1gmkC-4u1fA:
3.50
1gmkD-4u1fA:
3.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC439_0
(ADP-RIBOSYL CYCLASE)		 4u1f EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Saccharomyces
cerevisiae) 		3 / 3 TRP A 455
PHE A 462
TRP A 499
 None
 1.48A 1r15C-4u1fA:
undetectable		 1r15C-4u1fA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF469_0
(ADP-RIBOSYL CYCLASE)		 4u1f EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Saccharomyces
cerevisiae) 		3 / 3 TRP A 455
PHE A 462
TRP A 499
 None
 1.48A 1r15F-4u1fA:
undetectable		 1r15F-4u1fA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_G_NCAG479_0
(ADP-RIBOSYL CYCLASE)		 4u1f EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Saccharomyces
cerevisiae) 		3 / 3 TRP A 455
PHE A 462
TRP A 499
 None
 1.49A 1r15G-4u1fA:
undetectable		 1r15G-4u1fA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_H_NCAH489_0
(ADP-RIBOSYL CYCLASE)		 4u1f EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Saccharomyces
cerevisiae) 		3 / 3 TRP A 455
PHE A 462
TRP A 499
 None
 1.49A 1r15H-4u1fA:
undetectable		 1r15H-4u1fA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_A_CHDA131_0
(FATTY ACID-BINDING
PROTEIN)		 4u1f EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Saccharomyces
cerevisiae) 		5 / 11 LEU A 501
ILE A 465
THR A 464
THR A 508
GLN A 538
 None
 1.26A 1tw4A-4u1fA:
1.9		 1tw4A-4u1fA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TW4_B_CHDB1131_0
(FATTY ACID-BINDING
PROTEIN)		 4u1f EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Saccharomyces
cerevisiae) 		5 / 10 LEU A 501
ILE A 465
THR A 464
THR A 508
GLN A 538
 None
 1.26A 1tw4B-4u1fA:
undetectable		 1tw4B-4u1fA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2002_1
(SERUM ALBUMIN)		 4u1f EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Saccharomyces
cerevisiae) 		5 / 10 PHE A 342
ALA A 381
LEU A 334
ALA A 331
VAL A 319
 None
 1.15A 2bxeA-4u1fA:
undetectable		 2bxeA-4u1fA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M56_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 4u1f EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 462
TYR A 485
LEU A 446
VAL A 450
 None
 1.23A 2m56A-4u1fA:
undetectable		 2m56A-4u1fA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 4u1f EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Saccharomyces
cerevisiae) 		3 / 3 GLU A 456
SER A 557
VAL A 556
 None
 0.81A 3eeoA-4u1fA:
undetectable		 3eeoA-4u1fA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_SAMA1000_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 4u1f EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Saccharomyces
cerevisiae) 		5 / 10 GLU A 469
PHE A 426
THR A 464
ARG A 483
PHE A 451
 None
 1.38A 3smtA-4u1fA:
0.0		 3smtA-4u1fA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UZZ_B_ASDB501_1
(3-OXO-5-BETA-STEROID
4-DEHYDROGENASE)		 4u1f EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Saccharomyces
cerevisiae) 		4 / 8 HIS A 592
TYR A 568
TRP A 586
LEU A 527
 None
 1.39A 3uzzB-4u1fA:
undetectable		 3uzzB-4u1fA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		 4u1f EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Saccharomyces
cerevisiae) 		5 / 12 THR A 464
PHE A 462
ILE A 431
PHE A 453
ASN A 414
 None
 1.34A 5hgcA-4u1fA:
undetectable		 5hgcA-4u1fA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 4u1f EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B
(Saccharomyces
cerevisiae) 		3 / 3 TRP A 455
GLU A 456
GLU A 409
 None
 0.99A 6fhwA-4u1fA:
undetectable		 6fhwA-4u1fA:
10.74