SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4u1r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Y_B_MK1B524_2
(PROTEIN (PROTEASE))		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 12 GLY A 599
ALA A 600
ASP A 601
ILE A 566
THR A 582
 PO4  A 804 (-3.9A)
None
None
None
None
 0.95A 1c6yB-4u1rA:
undetectable		 1c6yB-4u1rA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_1
(ESTROGEN RECEPTOR)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 12 ALA A 134
LEU A 131
LEU A 165
ILE A 119
LEU A  30
 None
 1.13A 1errA-4u1rA:
undetectable		 1errA-4u1rA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FB7_A_ROCA100_1
(HIV-1 PROTEASE)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 12 GLY A 599
ALA A 600
ASP A 601
ILE A 566
THR A 582
 PO4  A 804 (-3.9A)
None
None
None
None
 0.99A 1fb7A-4u1rA:
undetectable		 1fb7A-4u1rA:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_1
(DNA GYRASE SUBUNIT B)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 12 GLU A 273
ARG A 219
ASP A 128
ILE A 174
ALA A 190
 None
None
ATP  A 801 (-2.6A)
None
None
 1.10A 1kijB-4u1rA:
undetectable		 1kijB-4u1rA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_1
(ASPARTYLPROTEASE)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 11 GLY A 233
ALA A 234
ASP A 235
VAL A 216
ILE A 270
 PO4  A 802 (-4.0A)
None
PO4  A 802 ( 4.6A)
None
None
 0.89A 1ohrA-4u1rA:
undetectable		 1ohrA-4u1rA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P91_A_SAMA1401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE A)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 11 GLU A 639
GLY A 585
ILE A 605
TYR A 604
LEU A 634
 None
 0.93A 1p91A-4u1rA:
undetectable		 1p91A-4u1rA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 10 ARG A 324
GLY A 186
ASP A 177
GLY A 126
ILE A 125
 None
None
ATP  A 801 ( 4.8A)
None
None
 1.01A 1sh9B-4u1rA:
undetectable		 1sh9B-4u1rA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 12 ALA A 190
ILE A 194
GLN A 309
ILE A 174
LEU A 239
 None
 1.01A 1uduB-4u1rA:
undetectable		 1uduB-4u1rA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		4 / 6 VAL A 367
VAL A 216
ILE A 174
ILE A 194
 None
 0.81A 1uwhA-4u1rA:
undetectable		 1uwhA-4u1rA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 12 ALA A 190
ILE A 194
GLN A 309
ILE A 174
LEU A 239
 None
 0.96A 1xozA-4u1rA:
undetectable		 1xozA-4u1rA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 9 GLY A  63
SER A  32
LEU A  30
PHE A 101
LEU A 122
 None
ATP  A 801 (-3.5A)
None
ATP  A 801 (-4.7A)
None
 1.36A 1y7iA-4u1rA:
3.9		 1y7iA-4u1rA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_1
(HIV-1 PROTEASE)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 10 GLY A 233
ALA A 234
ASP A 235
VAL A 216
ILE A 270
 PO4  A 802 (-4.0A)
None
PO4  A 802 ( 4.6A)
None
None
 0.89A 2aquA-4u1rA:
undetectable		 2aquA-4u1rA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_2
(HIV-1 PROTEASE)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 11 GLY A 233
ALA A 234
ASP A 235
VAL A 216
ILE A 270
 PO4  A 802 (-4.0A)
None
PO4  A 802 ( 4.6A)
None
None
 0.90A 2aquB-4u1rA:
undetectable		 2aquB-4u1rA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H79_A_T3A1_1
(THRA PROTEIN)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 12 ILE A 269
ILE A 268
ALA A 234
ALA A 225
LEU A 305
 None
 1.02A 2h79A-4u1rA:
undetectable		 2h79A-4u1rA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_A_017A201_2
(PROTEASE)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 12 ALA A 234
ASP A 235
ILE A 201
VAL A 216
ILE A 270
 None
PO4  A 802 ( 4.6A)
None
None
None
 0.96A 2hs2B-4u1rA:
undetectable		 2hs2B-4u1rA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		4 / 6 LEU A 483
MET A 532
MET A 495
LEU A 503
 None
 1.32A 2oz7A-4u1rA:
undetectable		 2oz7A-4u1rA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_1
(PROTEASE)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 9 ALA A 234
ASP A 235
ILE A 201
VAL A 216
ILE A 270
 None
PO4  A 802 ( 4.6A)
None
None
None
 1.02A 2q5kA-4u1rA:
undetectable		 2q5kA-4u1rA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA801_1
(TRANSPORTER)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 11 LEU A 114
ARG A 117
GLN A 116
ILE A  60
ASP A  69
 None
 1.10A 2q6hA-4u1rA:
0.0		 2q6hA-4u1rA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA801_1
(TRANSPORTER)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 11 LEU A 114
ARG A 117
GLN A 116
ILE A  60
ASP A  69
 None
 1.18A 2q72A-4u1rA:
undetectable		 2q72A-4u1rA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VJ1_A_BEZA1303_0
(SARS CORONAVIRUS
MAIN PROTEINASE)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		3 / 3 HIS A 441
MET A 443
MET A 694
 None
 1.18A 2vj1A-4u1rA:
undetectable		 2vj1A-4u1rA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1470_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		4 / 5 ARG A 375
ALA A 370
ASP A 372
GLU A 373
 None
 1.42A 2xrzA-4u1rA:
2.0		 2xrzA-4u1rA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_1
(HIV-1 PROTEASE)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 12 GLY A 233
ALA A 234
ASP A 235
VAL A 216
ILE A 270
 PO4  A 802 (-4.0A)
None
PO4  A 802 ( 4.6A)
None
None
 0.90A 2z54A-4u1rA:
undetectable		 2z54A-4u1rA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 12 ILE A 119
ASN A 113
GLY A  70
ASP A  69
TYR A  58
 None
 1.20A 2zw9A-4u1rA:
2.4		 2zw9A-4u1rA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOB_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 12 PHE A 317
ALA A 316
PHE A 548
GLY A 595
LEU A 590
 None
 1.35A 3aobC-4u1rA:
undetectable		 3aobC-4u1rA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 12 LEU A 757
LEU A 761
ALA A  45
VAL A  46
LEU A 131
 None
 0.94A 3b0wA-4u1rA:
undetectable		 3b0wA-4u1rA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		4 / 4 SER A 189
GLY A 186
GLY A 312
GLY A  89
 None
 0.92A 3bogB-4u1rA:
undetectable
3bogD-4u1rA:
undetectable		 3bogB-4u1rA:
undetectable
3bogD-4u1rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_1
(PROTEASE)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 10 GLY A 233
ALA A 234
ASP A 235
VAL A 216
ILE A 270
 PO4  A 802 (-4.0A)
None
PO4  A 802 ( 4.6A)
None
None
 0.93A 3ekyA-4u1rA:
undetectable		 3ekyA-4u1rA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_1
(PROTEASE)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		4 / 8 GLY A 599
ALA A 600
ASP A 601
THR A 582
 PO4  A 804 (-3.9A)
None
None
None
 0.52A 3el0A-4u1rA:
undetectable		 3el0A-4u1rA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_1
(PROTEASE)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 11 GLY A 233
ALA A 234
ASP A 235
VAL A 216
ILE A 270
 PO4  A 802 (-4.0A)
None
PO4  A 802 ( 4.6A)
None
None
 0.90A 3el1A-4u1rA:
undetectable		 3el1A-4u1rA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		4 / 5 PRO A 544
THR A 479
VAL A 418
GLY A 419
 None
 1.17A 3elzA-4u1rA:
undetectable		 3elzA-4u1rA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_1
(PROTEASE)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 11 GLY A 233
ALA A 234
ASP A 235
VAL A 216
ILE A 270
 PO4  A 802 (-4.0A)
None
PO4  A 802 ( 4.6A)
None
None
 0.89A 3em4A-4u1rA:
undetectable		 3em4A-4u1rA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_1
(PROTEASE)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 11 GLY A 233
ALA A 234
ASP A 235
VAL A 216
ILE A 270
 PO4  A 802 (-4.0A)
None
PO4  A 802 ( 4.6A)
None
None
 0.90A 3em4U-4u1rA:
undetectable		 3em4U-4u1rA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCZ_A_SAMA4633_0
(POLYPROTEIN)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 12 SER A 130
GLY A 126
GLY A  94
GLY A  63
GLY A  33
 ATP  A 801 (-3.2A)
None
None
None
ATP  A 801 (-3.3A)
 1.02A 3gczA-4u1rA:
undetectable		 3gczA-4u1rA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWS_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 12 ILE A 269
ILE A 268
ALA A 234
ALA A 225
LEU A 305
 None
 1.00A 3gwsX-4u1rA:
undetectable		 3gwsX-4u1rA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N3I_A_ROCA201_1
(PROTEASE)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 12 GLY A 186
ASP A 175
GLY A 126
ILE A 125
ALA A 322
 None
 0.89A 3n3iA-4u1rA:
undetectable		 3n3iA-4u1rA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_1
(PROTEASE)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 12 GLY A 233
ALA A 234
ASP A 235
VAL A 216
ILE A 270
 PO4  A 802 (-4.0A)
None
PO4  A 802 ( 4.6A)
None
None
 0.89A 3ndwA-4u1rA:
undetectable		 3ndwA-4u1rA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_2
(PROTEASE)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 9 ALA A 234
ASP A 235
ILE A 201
VAL A 216
ILE A 270
 None
PO4  A 802 ( 4.6A)
None
None
None
 1.06A 3ndwB-4u1rA:
undetectable		 3ndwB-4u1rA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_1
(PROTEASE)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 12 GLY A 233
ALA A 234
ASP A 235
VAL A 216
ILE A 270
 PO4  A 802 (-4.0A)
None
PO4  A 802 ( 4.6A)
None
None
 0.88A 3ndxA-4u1rA:
undetectable		 3ndxA-4u1rA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_2
(FIV PROTEASE)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 9 GLY A 599
ALA A 600
ASP A 601
ILE A 566
LEU A 636
 PO4  A 804 (-3.9A)
None
None
None
None
 1.04A 3ogpB-4u1rA:
undetectable		 3ogpB-4u1rA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_1
(PROTEASE)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 12 GLY A 599
ALA A 600
ASP A 601
ILE A 566
THR A 582
 PO4  A 804 (-3.9A)
None
None
None
None
 1.06A 3s56A-4u1rA:
undetectable		 3s56A-4u1rA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		4 / 5 ILE A 689
PRO A 536
SER A 723
GLY A 721
 None
 0.98A 3tkdB-4u1rA:
undetectable		 3tkdB-4u1rA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		4 / 5 ILE A 689
PRO A 536
SER A 723
GLY A 721
 None
 0.98A 3tkdA-4u1rA:
undetectable		 3tkdA-4u1rA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_C_SVRC516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 9 PRO A 536
GLY A 507
ALA A 537
ALA A 423
ASP A 682
 None
 1.48A 3ur0C-4u1rA:
undetectable		 3ur0C-4u1rA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		3 / 3 LYS A 567
ARG A  48
LEU A  86
 PO4  A 804 ( 3.9A)
PO4  A 804 (-3.2A)
None
 1.11A 3v4tE-4u1rA:
undetectable		 3v4tE-4u1rA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AGA_A_ACTA1131_0
(LYSOZYME C)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		3 / 3 ASN A 259
ASP A 235
ASN A 267
 None
PO4  A 802 ( 4.6A)
None
 0.66A 4agaA-4u1rA:
undetectable		 4agaA-4u1rA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		4 / 8 ALA A 570
SER A 569
ARG A 665
ARG A 576
 None
None
PO4  A 803 (-3.7A)
PO4  A 803 (-3.8A)
 0.94A 4ijiF-4u1rA:
undetectable		 4ijiF-4u1rA:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_H_BEZH501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		4 / 7 ALA A 570
SER A 569
ARG A 665
ARG A 576
 None
None
PO4  A 803 (-3.7A)
PO4  A 803 (-3.8A)
 0.94A 4ijiH-4u1rA:
undetectable		 4ijiH-4u1rA:
14.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_A_FOLA301_1
(FOLATE RECEPTOR
ALPHA)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		3 / 3 ASP A 188
TRP A 750
SER A 679
 None
 0.77A 4lrhA-4u1rA:
undetectable		 4lrhA-4u1rA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 12 VAL A  43
GLY A 172
SER A 323
GLY A 326
THR A  31
 None
 1.17A 4mm8A-4u1rA:
undetectable		 4mm8A-4u1rA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJT_D_017D101_2
(PROTEASE)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 9 GLY A 599
ALA A 600
ASP A 601
ILE A 566
THR A 582
 PO4  A 804 (-3.9A)
None
None
None
None
 1.03A 4njtD-4u1rA:
undetectable		 4njtD-4u1rA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 12 ILE A 416
GLY A 507
ALA A 537
ALA A 427
VAL A 429
 None
 0.99A 4nkxC-4u1rA:
undetectable		 4nkxC-4u1rA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 12 ILE A 416
GLY A 507
ALA A 537
ALA A 427
VAL A 429
 None
 1.00A 4nkxD-4u1rA:
undetectable		 4nkxD-4u1rA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 12 ASN A 417
ILE A 416
GLY A 686
SER A 690
ILE A 550
 None
 1.09A 4o1eB-4u1rA:
undetectable		 4o1eB-4u1rA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		4 / 7 ASN A 684
ILE A 194
ILE A 195
VAL A 198
 None
 0.87A 4ojbA-4u1rA:
undetectable		 4ojbA-4u1rA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		4 / 6 ASN A 684
ILE A 194
ILE A 195
VAL A 198
 None
 0.95A 4olmA-4u1rA:
undetectable		 4olmA-4u1rA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 11 GLY A 449
GLY A 452
ILE A 446
GLY A 514
ILE A 491
 None
 1.13A 4qoiA-4u1rA:
5.2
4qoiB-4u1rA:
5.6		 4qoiA-4u1rA:
16.71
4qoiB-4u1rA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 11 THR A 698
THR A 409
ARG A 396
GLY A 436
ALA A 438
 None
 1.36A 4qvlV-4u1rA:
undetectable
4qvlb-4u1rA:
undetectable		 4qvlV-4u1rA:
16.35
4qvlb-4u1rA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 11 THR A 698
THR A 409
ARG A 396
GLY A 436
ALA A 438
 None
 1.36A 4qvlH-4u1rA:
undetectable
4qvlN-4u1rA:
undetectable		 4qvlH-4u1rA:
16.35
4qvlN-4u1rA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 11 THR A 698
THR A 409
ARG A 396
GLY A 436
ALA A 438
 None
 1.38A 4qvmV-4u1rA:
undetectable
4qvmb-4u1rA:
undetectable		 4qvmV-4u1rA:
16.35
4qvmb-4u1rA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 11 THR A 698
THR A 409
ARG A 396
GLY A 436
ALA A 438
 None
 1.37A 4qvmH-4u1rA:
undetectable
4qvmN-4u1rA:
undetectable		 4qvmH-4u1rA:
16.35
4qvmN-4u1rA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 11 THR A 698
THR A 409
ARG A 396
GLY A 436
ALA A 438
 None
 1.37A 4qvpV-4u1rA:
undetectable
4qvpb-4u1rA:
undetectable		 4qvpV-4u1rA:
16.35
4qvpb-4u1rA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 11 THR A 698
THR A 409
ARG A 396
GLY A 436
ALA A 438
 None
 1.36A 4qvpH-4u1rA:
undetectable
4qvpN-4u1rA:
undetectable		 4qvpH-4u1rA:
16.35
4qvpN-4u1rA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 11 THR A 698
THR A 409
ARG A 396
GLY A 436
ALA A 438
 None
 1.36A 4qvqV-4u1rA:
undetectable
4qvqb-4u1rA:
undetectable		 4qvqV-4u1rA:
16.35
4qvqb-4u1rA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 11 THR A 698
THR A 409
ARG A 396
GLY A 436
ALA A 438
 None
 1.37A 4qvqH-4u1rA:
undetectable
4qvqN-4u1rA:
undetectable		 4qvqH-4u1rA:
16.35
4qvqN-4u1rA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 11 THR A 698
THR A 409
ARG A 396
GLY A 436
ALA A 438
 None
 1.36A 4qvwV-4u1rA:
undetectable
4qvwb-4u1rA:
undetectable		 4qvwV-4u1rA:
16.35
4qvwb-4u1rA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 11 THR A 698
THR A 409
ARG A 396
GLY A 436
ALA A 438
 None
 1.35A 4qvwH-4u1rA:
undetectable
4qvwN-4u1rA:
undetectable		 4qvwH-4u1rA:
16.35
4qvwN-4u1rA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 11 THR A 698
THR A 409
ARG A 396
GLY A 436
ALA A 438
 None
 1.36A 4qw0V-4u1rA:
undetectable
4qw0b-4u1rA:
undetectable		 4qw0V-4u1rA:
16.35
4qw0b-4u1rA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 11 THR A 698
THR A 409
ARG A 396
GLY A 436
ALA A 438
 None
 1.36A 4qw0H-4u1rA:
undetectable
4qw0N-4u1rA:
undetectable		 4qw0H-4u1rA:
16.35
4qw0N-4u1rA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 11 THR A 698
THR A 409
ARG A 396
GLY A 436
ALA A 438
 None
 1.37A 4qw1V-4u1rA:
undetectable
4qw1b-4u1rA:
undetectable		 4qw1V-4u1rA:
16.35
4qw1b-4u1rA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 11 THR A 698
THR A 409
ARG A 396
GLY A 436
ALA A 438
 None
 1.37A 4qw1H-4u1rA:
undetectable
4qw1N-4u1rA:
undetectable		 4qw1H-4u1rA:
16.35
4qw1N-4u1rA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 11 THR A 698
THR A 409
ARG A 396
GLY A 436
ALA A 438
 None
 1.36A 4qw3V-4u1rA:
undetectable
4qw3b-4u1rA:
undetectable		 4qw3V-4u1rA:
16.35
4qw3b-4u1rA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 11 THR A 698
THR A 409
ARG A 396
GLY A 436
ALA A 438
 None
 1.36A 4qw3H-4u1rA:
undetectable
4qw3N-4u1rA:
undetectable		 4qw3H-4u1rA:
16.35
4qw3N-4u1rA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 11 THR A 698
THR A 409
ARG A 396
GLY A 436
ALA A 438
 None
 1.37A 4qwuV-4u1rA:
undetectable
4qwub-4u1rA:
undetectable		 4qwuV-4u1rA:
16.35
4qwub-4u1rA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 9 ALA A  42
ALA A  41
GLY A 126
GLY A 172
ASP A 318
 None
 1.16A 4qwuK-4u1rA:
undetectable
4qwuL-4u1rA:
undetectable		 4qwuK-4u1rA:
16.48
4qwuL-4u1rA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 11 THR A 698
THR A 409
ARG A 396
GLY A 436
ALA A 438
 None
 1.37A 4qwuH-4u1rA:
undetectable
4qwuN-4u1rA:
undetectable		 4qwuH-4u1rA:
16.35
4qwuN-4u1rA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_B_LOCB502_1
(TUBULIN BETA CHAIN)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 12 LEU A 636
LEU A 556
ALA A 597
ALA A 600
ILE A 320
 None
 1.02A 4x20B-4u1rA:
undetectable		 4x20B-4u1rA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZPH_A_PRLA501_0
(ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
ENDOTHELIAL PAS
DOMAIN-CONTAINING
PROTEIN 1)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		4 / 7 ARG A  48
VAL A  47
SER A  83
GLU A  80
 PO4  A 804 (-3.2A)
None
PO4  A 804 (-4.3A)
None
 0.93A 4zphA-4u1rA:
undetectable
4zphB-4u1rA:
0.0		 4zphA-4u1rA:
19.50
4zphB-4u1rA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 11 THR A 698
THR A 409
ARG A 396
GLY A 436
ALA A 438
 None
 1.35A 5bxnV-4u1rA:
undetectable
5bxnb-4u1rA:
undetectable		 5bxnV-4u1rA:
16.62
5bxnb-4u1rA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 11 THR A 698
THR A 409
ARG A 396
GLY A 436
ALA A 438
 None
 1.35A 5bxnH-4u1rA:
undetectable
5bxnN-4u1rA:
undetectable		 5bxnH-4u1rA:
16.62
5bxnN-4u1rA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_N_EVPN2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		4 / 6 SER A 285
GLU A 286
GLY A 222
GLY A 218
 None
 0.91A 5cdnR-4u1rA:
undetectable
5cdnS-4u1rA:
3.1		 5cdnR-4u1rA:
20.52
5cdnS-4u1rA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 11 THR A 698
THR A 409
ARG A 396
GLY A 436
ALA A 438
 None
 1.37A 5cz7H-4u1rA:
undetectable
5cz7N-4u1rA:
undetectable		 5cz7H-4u1rA:
16.35
5cz7N-4u1rA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 11 THR A 698
THR A 409
ARG A 396
GLY A 436
ALA A 438
 None
 1.36A 5d0xV-4u1rA:
undetectable
5d0xb-4u1rA:
undetectable		 5d0xV-4u1rA:
16.35
5d0xb-4u1rA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 11 THR A 698
THR A 409
ARG A 396
GLY A 436
ALA A 438
 None
 1.37A 5d0xH-4u1rA:
undetectable
5d0xN-4u1rA:
undetectable		 5d0xH-4u1rA:
16.35
5d0xN-4u1rA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		3 / 3 ALA A 110
ASN A 113
LEU A 114
 None
 0.38A 5i1pA-4u1rA:
undetectable		 5i1pA-4u1rA:
4.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 12 VAL A  29
ALA A  42
VAL A  46
THR A 184
PHE A 178
 None
 1.22A 5igiA-4u1rA:
undetectable		 5igiA-4u1rA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_2
(PROTEASE PR5-DRV)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 8 GLY A 326
ALA A  45
VAL A  82
GLY A  50
ILE A  27
 None
 1.31A 5kr1B-4u1rA:
undetectable		 5kr1B-4u1rA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 11 THR A 698
THR A 409
ARG A 396
GLY A 436
ALA A 438
 None
 1.35A 5l66V-4u1rA:
undetectable
5l66b-4u1rA:
undetectable		 5l66V-4u1rA:
16.35
5l66b-4u1rA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 11 THR A 698
THR A 409
ARG A 396
GLY A 436
ALA A 438
 None
 1.34A 5l66H-4u1rA:
undetectable
5l66N-4u1rA:
undetectable		 5l66H-4u1rA:
16.35
5l66N-4u1rA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 12 VAL A 168
VAL A 124
ILE A  51
ALA A  55
VAL A  47
 None
 1.18A 5n0sB-4u1rA:
2.4		 5n0sB-4u1rA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_1
(SCRFP-TAG,GP41)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 12 GLY A 449
LEU A 515
LEU A 516
GLU A 517
LEU A 518
 None
 0.92A 5nwwA-4u1rA:
undetectable		 5nwwA-4u1rA:
5.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		3 / 3 THR A 493
MET A 495
HIS A 498
 None
 0.93A 5uunA-4u1rA:
undetectable		 5uunA-4u1rA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VC0_A_RITA602_2
(CYTOCHROME P450 3A4)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		4 / 7 ILE A 689
LEU A 504
THR A 698
ARG A 434
 None
None
None
PO4  A 802 (-2.9A)
 1.02A 5vc0A-4u1rA:
undetectable		 5vc0A-4u1rA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_B_LOCB504_2
(TUBULIN BETA CHAIN)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 12 LEU A 636
LEU A 556
ALA A 597
ALA A 600
ILE A 320
 None
 1.01A 5xiwB-4u1rA:
undetectable		 5xiwB-4u1rA:
7.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 12 GLY A 633
GLY A 599
ASP A 663
CYH A 664
ASP A 601
 None
PO4  A 804 (-3.9A)
None
None
None
 1.30A 5ynmA-4u1rA:
undetectable		 5ynmA-4u1rA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CJK_C_ACTC301_0
(IMMUNOGLOBULIN FAB
LIGHT CHAIN)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		4 / 4 VAL A 171
GLY A 127
ASP A 128
ASP A 175
 None
ATP  A 801 (-3.4A)
ATP  A 801 (-2.6A)
None
 1.25A 6cjkC-4u1rA:
undetectable		 6cjkC-4u1rA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CK2_C_IPHC101_0
(INSULIN A CHAIN
INSULIN B CHAIN)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		4 / 4 ILE A 491
LEU A 503
HIS A 498
ALA A 414
 None
 1.03A 6ck2C-4u1rA:
undetectable
6ck2D-4u1rA:
undetectable		 6ck2C-4u1rA:
2.75
6ck2D-4u1rA:
5.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_0
(CYTOCHROME P450 1A1)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		5 / 12 ILE A 491
LEU A 483
GLY A 449
ILE A 500
LEU A 503
 None
 1.04A 6dwnC-4u1rA:
undetectable		 6dwnC-4u1rA:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE
(Homo
sapiens) 		4 / 6 ILE A 476
LEU A 477
ARG A 683
THR A 687
 None
 0.90A 6nmfN-4u1rA:
undetectable
6nmfW-4u1rA:
undetectable		 6nmfN-4u1rA:
21.55
6nmfW-4u1rA:
6.75