SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4u28'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 4u28 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sviceus) 		3 / 3 VAL A  14
VAL A  22
TRP A  45
 None
 0.93A 1bdwA-4u28A:
undetectable
1bdwB-4u28A:
undetectable		 1bdwA-4u28A:
6.90
1bdwB-4u28A:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_4
(HIV-1 PROTEASE)		 4u28 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sviceus) 		4 / 4 GLY A  27
ASP A  15
GLY A  86
THR A  64
 None
None
PO4  A 302 (-3.5A)
None
 1.05A 1hxbB-4u28A:
undetectable		 1hxbB-4u28A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 4u28 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sviceus) 		5 / 12 GLY A 176
ASP A  15
ALA A 173
SER A 200
LEU A 185
 PO4  A 301 (-3.4A)
None
None
PO4  A 301 ( 4.4A)
None
 1.33A 1kiaD-4u28A:
undetectable		 1kiaD-4u28A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4u28 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sviceus) 		5 / 10 THR A 170
SER A 200
LEU A  58
VAL A  22
VAL A  56
 None
PO4  A 301 ( 4.4A)
None
None
None
 1.44A 1q23K-4u28A:
undetectable		 1q23K-4u28A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 4u28 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sviceus) 		5 / 12 ALA A 211
GLY A 202
LEU A 178
ASP A 208
SER A 223
 None
PO4  A 301 (-3.7A)
None
None
None
 1.27A 2nv4A-4u28A:
undetectable		 2nv4A-4u28A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 4u28 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sviceus) 		5 / 10 ALA A  92
ALA A  96
THR A 100
LEU A  84
VAL A  71
 None
 1.34A 2wuzA-4u28A:
undetectable		 2wuzA-4u28A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 4u28 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sviceus) 		5 / 10 ALA A  92
ALA A  96
THR A 100
LEU A  84
VAL A  71
 None
 1.34A 2wuzB-4u28A:
undetectable		 2wuzB-4u28A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_B_SAMB400_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 4u28 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sviceus) 		5 / 9 ALA A 228
VAL A 203
GLY A 202
GLY A 176
LEU A 229
 None
None
PO4  A 301 (-3.7A)
PO4  A 301 (-3.4A)
None
 0.95A 2z0yB-4u28A:
3.5		 2z0yB-4u28A:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_C_VD3C2001_1
(VITAMIN D
HYDROXYLASE)		 4u28 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sviceus) 		5 / 11 ILE A 129
LEU A  84
LEU A 107
ILE A  88
LEU A  98
 None
 1.28A 3a50C-4u28A:
undetectable		 3a50C-4u28A:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_2
(PROTEASE)		 4u28 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sviceus) 		5 / 10 LEU A 215
ALA A 199
GLY A 202
ALA A 211
ILE A 212
 None
None
PO4  A 301 (-3.7A)
None
None
 0.89A 3ekpB-4u28A:
undetectable		 3ekpB-4u28A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_1
(PROTEASE)		 4u28 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sviceus) 		5 / 10 LEU A 215
ALA A 199
GLY A 202
ALA A 211
ILE A 212
 None
None
PO4  A 301 (-3.7A)
None
None
 0.95A 3ekpC-4u28A:
undetectable		 3ekpC-4u28A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_B_EPAB3_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 4u28 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sviceus) 		5 / 12 LEU A 185
ILE A 129
VAL A 197
VAL A 189
LEU A 156
 None
 1.13A 3gwxB-4u28A:
undetectable		 3gwxB-4u28A:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8W_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4u28 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sviceus) 		5 / 12 VAL A 189
VAL A 135
LEU A 152
GLY A 201
LEU A 185
 None
None
None
PO4  A 301 (-3.6A)
None
 1.03A 3n8wA-4u28A:
undetectable		 3n8wA-4u28A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 4u28 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sviceus) 		3 / 3 VAL A  56
VAL A 168
SER A 200
 None
None
PO4  A 301 ( 4.4A)
 0.73A 3n8xB-4u28A:
undetectable		 3n8xB-4u28A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_2
(PROTEASE)		 4u28 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sviceus) 		5 / 10 LEU A 215
ALA A 199
VAL A 225
GLY A 202
ILE A 212
 None
None
PO4  A 301 ( 4.5A)
PO4  A 301 (-3.7A)
None
 1.02A 3s43B-4u28A:
undetectable		 3s43B-4u28A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_B_CLMB221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4u28 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sviceus) 		5 / 12 THR A 170
SER A 200
LEU A  58
VAL A  22
VAL A  56
 None
PO4  A 301 ( 4.4A)
None
None
None
 1.42A 3u9fB-4u28A:
undetectable
3u9fC-4u28A:
undetectable		 3u9fB-4u28A:
19.84
3u9fC-4u28A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4u28 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sviceus) 		5 / 10 THR A 170
SER A 200
LEU A  58
VAL A  22
VAL A  56
 None
PO4  A 301 ( 4.4A)
None
None
None
 1.48A 3u9fE-4u28A:
undetectable		 3u9fE-4u28A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4u28 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sviceus) 		5 / 12 THR A 170
SER A 200
LEU A  58
VAL A  22
VAL A  56
 None
PO4  A 301 ( 4.4A)
None
None
None
 1.41A 3u9fJ-4u28A:
undetectable
3u9fK-4u28A:
undetectable		 3u9fJ-4u28A:
19.84
3u9fK-4u28A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 4u28 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sviceus) 		5 / 12 THR A 170
SER A 200
LEU A  58
VAL A  22
VAL A  56
 None
PO4  A 301 ( 4.4A)
None
None
None
 1.34A 3u9fP-4u28A:
undetectable
3u9fS-4u28A:
undetectable		 3u9fP-4u28A:
19.84
3u9fS-4u28A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA502_1
(CYTOCHROME P450 2B6)		 4u28 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sviceus) 		5 / 11 ARG A 104
GLU A   9
LEU A  11
PRO A 196
VAL A 216
 None
 1.33A 3ua5A-4u28A:
undetectable		 3ua5A-4u28A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 4u28 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sviceus) 		5 / 12 GLY A 176
GLY A 201
ASP A 175
ALA A 228
GLU A  32
 PO4  A 301 (-3.4A)
PO4  A 301 (-3.6A)
PO4  A 301 (-3.4A)
None
None
 0.80A 4lg1A-4u28A:
undetectable		 4lg1A-4u28A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		 4u28 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sviceus) 		5 / 12 VAL A  22
ALA A  21
VAL A  14
PHE A  62
GLY A  19
 None
 1.12A 4mm4B-4u28A:
undetectable		 4mm4B-4u28A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4u28 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sviceus) 		5 / 10 VAL A 189
VAL A 135
LEU A 152
GLY A 201
LEU A 185
 None
None
None
PO4  A 301 (-3.6A)
None
 1.00A 4ph9A-4u28A:
undetectable		 4ph9A-4u28A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4u28 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sviceus) 		5 / 10 VAL A 189
VAL A 135
LEU A 152
GLY A 201
LEU A 185
 None
None
None
PO4  A 301 (-3.6A)
None
 0.99A 4ph9B-4u28A:
undetectable		 4ph9B-4u28A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4u28 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sviceus) 		5 / 11 ALA A  96
ALA A  95
GLY A  86
GLY A  87
ASP A  90
 None
None
PO4  A 302 (-3.5A)
PO4  A 302 (-3.8A)
None
 1.11A 4qvwK-4u28A:
undetectable
4qvwL-4u28A:
undetectable		 4qvwK-4u28A:
21.63
4qvwL-4u28A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 4u28 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sviceus) 		5 / 11 ALA A  96
ALA A  95
GLY A  86
GLY A  87
ASP A  90
 None
None
PO4  A 302 (-3.5A)
PO4  A 302 (-3.8A)
None
 1.11A 4qvwY-4u28A:
undetectable
4qvwZ-4u28A:
undetectable		 4qvwY-4u28A:
21.63
4qvwZ-4u28A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 4u28 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sviceus) 		4 / 7 LEU A 209
SER A 223
GLY A 202
GLY A 201
 None
None
PO4  A 301 (-3.7A)
PO4  A 301 (-3.6A)
 0.72A 4yjiA-4u28A:
undetectable		 4yjiA-4u28A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 4u28 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sviceus) 		6 / 12 LEU A 112
VAL A 118
ILE A 122
ALA A 123
VAL A 131
GLY A 108
 None
None
None
None
None
PO4  A 302 (-3.3A)
 1.42A 5j2tC-4u28A:
undetectable		 5j2tC-4u28A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 4u28 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sviceus) 		4 / 7 VAL A  16
ALA A  21
LEU A  55
LEU A  53
 None
 0.66A 5jq7A-4u28A:
undetectable		 5jq7A-4u28A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 4u28 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sviceus) 		4 / 6 VAL A  56
VAL A 168
SER A 200
ILE A 212
 None
None
PO4  A 301 ( 4.4A)
None
 0.85A 5jw1B-4u28A:
undetectable		 5jw1B-4u28A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 4u28 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sviceus) 		4 / 5 VAL A  22
ASN A  67
ASP A  57
LEU A  58
 None
 1.23A 5m0iB-4u28A:
undetectable		 5m0iB-4u28A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNI_A_SAMA401_0
(NSP16 PROTEIN)		 4u28 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sviceus) 		5 / 12 GLY A 176
PRO A 181
GLY A 180
ASP A 175
LEU A  24
 PO4  A 301 (-3.4A)
None
None
PO4  A 301 (-3.4A)
None
 1.21A 5yniA-4u28A:
undetectable		 5yniA-4u28A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YNM_A_SAMA401_0
(NSP16 PROTEIN)		 4u28 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sviceus) 		5 / 12 GLY A 176
PRO A 181
GLY A 180
ASP A 175
LEU A  24
 PO4  A 301 (-3.4A)
None
None
PO4  A 301 (-3.4A)
None
 1.23A 5ynmA-4u28A:
undetectable		 5ynmA-4u28A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_A_STRA502_1
(CYTOCHROME P450
CYP260A1)		 4u28 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sviceus) 		4 / 6 PHE A  62
LEU A  58
ALA A  61
THR A 170
 None
None
PO4  A 302 (-3.3A)
None
 0.96A 6f88A-4u28A:
undetectable		 6f88A-4u28A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IEY_A_CLMA401_0
(ESTERASE)		 4u28 PHOSPHORIBOSYL
ISOMERASE A
(Streptomyces
sviceus) 		5 / 11 ASP A 175
LEU A 178
GLY A 202
SER A 200
ALA A  13
 PO4  A 301 (-3.4A)
None
PO4  A 301 (-3.7A)
PO4  A 301 ( 4.4A)
None
 1.26A 6ieyA-4u28A:
undetectable
6ieyB-4u28A:
undetectable		 6ieyA-4u28A:
25.53
6ieyB-4u28A:
25.53