SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4u2m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 4u2m ZINC FINGER AND BTB
DOMAIN-CONTAINING
PROTEIN 17,B-CELL
LYMPHOMA 6 PROTEIN
(Homo
sapiens) 		5 / 12 ALA A 175
MET A 174
GLY A 178
TYR A 181
LEU A  23
 None
 1.35A 1brpA-4u2mA:
undetectable		 1brpA-4u2mA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 4u2m ZINC FINGER AND BTB
DOMAIN-CONTAINING
PROTEIN 17,B-CELL
LYMPHOMA 6 PROTEIN
(Homo
sapiens) 		5 / 12 VAL A 228
LEU A 209
LEU A 235
MET A 213
LEU A 173
 None
 1.27A 1mx1E-4u2mA:
undetectable		 1mx1E-4u2mA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4u2m ZINC FINGER AND BTB
DOMAIN-CONTAINING
PROTEIN 17,B-CELL
LYMPHOMA 6 PROTEIN
(Homo
sapiens) 		4 / 5 VAL A  10
LEU A  14
MET A 101
ARG A 149
 None
 0.79A 2oiqA-4u2mA:
undetectable		 2oiqA-4u2mA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 4u2m ZINC FINGER AND BTB
DOMAIN-CONTAINING
PROTEIN 17,B-CELL
LYMPHOMA 6 PROTEIN
(Homo
sapiens) 		4 / 5 VAL A 141
LEU A 145
MET A 237
ARG A  18
 None
 0.68A 2oiqA-4u2mA:
undetectable		 2oiqA-4u2mA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA505_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 4u2m ZINC FINGER AND BTB
DOMAIN-CONTAINING
PROTEIN 17,B-CELL
LYMPHOMA 6 PROTEIN
(Homo
sapiens) 		3 / 3 THR A  79
ASN A  15
GLU A  75
 None
 0.78A 3v4tA-4u2mA:
undetectable
3v4tC-4u2mA:
undetectable		 3v4tA-4u2mA:
21.69
3v4tC-4u2mA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_B_ADNB301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 4u2m ZINC FINGER AND BTB
DOMAIN-CONTAINING
PROTEIN 17,B-CELL
LYMPHOMA 6 PROTEIN
(Homo
sapiens) 		5 / 10 ALA A 232
GLY A 205
LEU A 220
ASN A 224
ILE A 225
 None
 1.12A 3wdmB-4u2mA:
undetectable		 3wdmB-4u2mA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FCT_B_C2FB402_0
(THYMIDYLATE SYNTHASE)		 4u2m ZINC FINGER AND BTB
DOMAIN-CONTAINING
PROTEIN 17,B-CELL
LYMPHOMA 6 PROTEIN
(Homo
sapiens) 		5 / 12 VAL A 158
PHE A 166
LEU A 142
LEU A 173
ALA A 175
 None
 1.45A 5fctB-4u2mA:
undetectable		 5fctB-4u2mA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 4u2m ZINC FINGER AND BTB
DOMAIN-CONTAINING
PROTEIN 17,B-CELL
LYMPHOMA 6 PROTEIN
(Homo
sapiens) 		5 / 12 LEU A  23
GLY A  21
THR A  27
LEU A 145
LEU A  14
 None
 0.95A 5nfjB-4u2mA:
undetectable		 5nfjB-4u2mA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 4u2m ZINC FINGER AND BTB
DOMAIN-CONTAINING
PROTEIN 17,B-CELL
LYMPHOMA 6 PROTEIN
(Homo
sapiens) 		4 / 5 ILE A 195
PHE A 184
ARG A 149
THR A 155
 None
 1.25A 5z84N-4u2mA:
undetectable
5z84W-4u2mA:
undetectable		 5z84N-4u2mA:
19.77
5z84W-4u2mA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 4u2m ZINC FINGER AND BTB
DOMAIN-CONTAINING
PROTEIN 17,B-CELL
LYMPHOMA 6 PROTEIN
(Homo
sapiens) 		3 / 3 PHE A 184
ASP A 186
LYS A 189
 None
 0.82A 6awtD-4u2mA:
undetectable		 6awtD-4u2mA:
18.42