SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '4u2n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 4u2n ZINC FINGER AND BTB
DOMAIN-CONTAINING
PROTEIN 17,NUCLEUS
ACCUMBENS-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		5 / 12 PHE A  53
HIS A  38
TYR A  78
LEU A  74
LEU A  99
 None
 1.46A 1zgyA-4u2nA:
undetectable		 1zgyA-4u2nA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_E_SAME1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 4u2n ZINC FINGER AND BTB
DOMAIN-CONTAINING
PROTEIN 17,NUCLEUS
ACCUMBENS-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		5 / 12 GLY A  69
GLY A  71
ILE A  64
ALA A  94
ASP A  31
 None
 1.23A 2vdvE-4u2nA:
undetectable		 2vdvE-4u2nA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDV_F_SAMF1287_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 4u2n ZINC FINGER AND BTB
DOMAIN-CONTAINING
PROTEIN 17,NUCLEUS
ACCUMBENS-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		5 / 11 GLY A  69
GLY A  71
ILE A  64
ALA A  94
ASP A  31
 None
 1.23A 2vdvF-4u2nA:
undetectable		 2vdvF-4u2nA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 4u2n ZINC FINGER AND BTB
DOMAIN-CONTAINING
PROTEIN 17,NUCLEUS
ACCUMBENS-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		5 / 12 HIS A   6
LEU A 174
ILE A 235
GLU A 237
PHE A 204
 None
 1.20A 2weyA-4u2nA:
undetectable		 2weyA-4u2nA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I45_A_NIOA500_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN)		 4u2n ZINC FINGER AND BTB
DOMAIN-CONTAINING
PROTEIN 17,NUCLEUS
ACCUMBENS-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 8 SER A  46
LEU A  99
TYR A  48
LEU A  62
 None
 0.98A 3i45A-4u2nA:
undetectable		 3i45A-4u2nA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEO_B_LLTB261_1
(DEOXYCYTIDINE KINASE)		 4u2n ZINC FINGER AND BTB
DOMAIN-CONTAINING
PROTEIN 17,NUCLEUS
ACCUMBENS-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 7 VAL A  60
LEU A  52
TYR A  48
LEU A  70
 None
 0.93A 3qeoB-4u2nA:
undetectable		 3qeoB-4u2nA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 4u2n ZINC FINGER AND BTB
DOMAIN-CONTAINING
PROTEIN 17,NUCLEUS
ACCUMBENS-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 6 GLY A 139
VAL A  10
HIS A   6
SER A   7
 None
 1.00A 3tj7A-4u2nA:
undetectable
3tj7B-4u2nA:
undetectable		 3tj7A-4u2nA:
20.38
3tj7B-4u2nA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 4u2n ZINC FINGER AND BTB
DOMAIN-CONTAINING
PROTEIN 17,NUCLEUS
ACCUMBENS-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 6 GLY A 139
VAL A  10
HIS A   6
SER A   7
 None
 1.03A 3tj7C-4u2nA:
undetectable
3tj7D-4u2nA:
undetectable		 3tj7C-4u2nA:
20.38
3tj7D-4u2nA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 4u2n ZINC FINGER AND BTB
DOMAIN-CONTAINING
PROTEIN 17,NUCLEUS
ACCUMBENS-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 6 VAL A  10
HIS A   6
SER A   7
GLY A 139
 None
 1.05A 3tj7C-4u2nA:
undetectable
3tj7D-4u2nA:
undetectable		 3tj7C-4u2nA:
20.38
3tj7D-4u2nA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 4u2n ZINC FINGER AND BTB
DOMAIN-CONTAINING
PROTEIN 17,NUCLEUS
ACCUMBENS-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 5 GLY A  71
GLY A  69
ASN A  66
GLU A  75
 None
 1.11A 4fglC-4u2nA:
undetectable		 4fglC-4u2nA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))		 4u2n ZINC FINGER AND BTB
DOMAIN-CONTAINING
PROTEIN 17,NUCLEUS
ACCUMBENS-ASSOCIATED
PROTEIN 1
(Homo
sapiens) 		4 / 8 VAL A 160
PRO A 196
GLN A 200
ILE A 207
 None
 1.10A 4iilA-4u2nA:
undetectable		 4iilA-4u2nA:
21.61